-
1
-
-
33748929841
-
Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy
-
Liu X, Gu X, Li Z, Li X, Li H, Chang J, et al. Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy. J Am Coll Cardiol 2006; 48: 1438-1447.
-
(2006)
J Am Coll Cardiol
, vol.48
, pp. 1438-1447
-
-
Liu, X.1
Gu, X.2
Li, Z.3
Li, X.4
Li, H.5
Chang, J.6
-
2
-
-
77952317892
-
A phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure
-
Gao R, Zhang J, Cheng L, Wu X, Dong W, Yang X, et al. A phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure. J Am Coll Cardiol 2010; 55: 1907-1914.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 1907-1914
-
-
Gao, R.1
Zhang, J.2
Cheng, L.3
Wu, X.4
Dong, W.5
Yang, X.6
-
3
-
-
62249192069
-
Neuregulin-1/ErbB signaling: A druggable target for treating heart failure
-
Xu Y, Li X, Zhou M. Neuregulin-1/ErbB signaling: a druggable target for treating heart failure. Curr Opin Pharmacol 2009; 9: 214-219.
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 214-219
-
-
Xu, Y.1
Li, X.2
Zhou, M.3
-
4
-
-
0028785406
-
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
-
Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R, et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 1995; 378: 390-394.
-
(1995)
Nature
, vol.378
, pp. 390-394
-
-
Gassmann, M.1
Casagranda, F.2
Orioli, D.3
Simon, H.4
Lai, C.5
Klein, R.6
-
5
-
-
0028884413
-
Requirement for neuregulin receptor erbB2 in neural and cardiac development
-
Lee KF, Simon H, Chen H, Bates B, Hung MC, Hauser C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 1995; 378:394-398.
-
(1995)
Nature
, vol.378
, pp. 394-398
-
-
Lee, K.F.1
Simon, H.2
Chen, H.3
Bates, B.4
Hung, M.C.5
Hauser, C.6
-
6
-
-
0028827104
-
Multiple essential functions of neuregulin in development
-
Meyer D, Birchmeier C. Multiple essential functions of neuregulin in development. Nature 1995; 378: 386-390.
-
(1995)
Nature
, vol.378
, pp. 386-390
-
-
Meyer, D.1
Birchmeier, C.2
-
7
-
-
0036099675
-
ErbB2 is essential in the prevention of dilated cardiomyopathy
-
Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, et al. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 2002; 8: 459-465.
-
(2002)
Nat Med
, vol.8
, pp. 459-465
-
-
Crone, S.A.1
Zhao, Y.Y.2
Fan, L.3
Gu, Y.4
Minamisawa, S.5
Liu, Y.6
-
8
-
-
34250332921
-
Cardiovascular risk profile of patients with HER2/neu-positive breast cancer treated with anthracycline-taxane-containing adjuvant chemotherapy and/or trastuzumab
-
Jones LW, Haykowsky M, Peddle CJ, Joy AA, Pituskin EN, Tkachuk LM, et al. Cardiovascular risk profile of patients with HER2/neu-positive breast cancer treated with anthracycline-taxane-containing adjuvant chemotherapy and/or trastuzumab. Cancer Epidemiol Biomarkers Prev 2007; 16: 1026-1031.
-
(2007)
Cancer Epidemiol Biomarkers Prev
, vol.16
, pp. 1026-1031
-
-
Jones, L.W.1
Haykowsky, M.2
Peddle, C.J.3
Joy, A.A.4
Pituskin, E.N.5
Tkachuk, L.M.6
-
9
-
-
34548132413
-
Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: Implications for therapy of heart failure
-
Lemmens K, Doggen K, De Keulenaer GW. Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure. Circulation 2007; 116: 954-960.
-
(2007)
Circulation
, vol.116
, pp. 954-960
-
-
Lemmens, K.1
Doggen, K.2
de Keulenaer, G.W.3
-
10
-
-
0033951542
-
Mitochondrial dysfunction in heart failure: Potential for therapeutic interventions?
-
Stanley WC, Hoppel CL. Mitochondrial dysfunction in heart failure: potential for therapeutic interventions? Cardiovasc Res 2000; 45: 805-806.
-
(2000)
Cardiovasc Res
, vol.45
, pp. 805-806
-
-
Stanley, W.C.1
Hoppel, C.L.2
-
11
-
-
0034960785
-
Mitochondrial dysfunction in cardiac disease: Ischemia-reperfusion, aging, and heart failure
-
Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL. Mitochondrial dysfunction in cardiac disease: ischemia-reperfusion, aging, and heart failure. J Mol Cell Cardiol 2001; 33: 1065-1089.
-
(2001)
J Mol Cell Cardiol
, vol.33
, pp. 1065-1089
-
-
Lesnefsky, E.J.1
Moghaddas, S.2
Tandler, B.3
Kerner, J.4
Hoppel, C.L.5
-
12
-
-
14744291620
-
Apoptosis-modulating interaction of the neuregulin/erbB pathway with anthracyclines in regulating Bcl-xS and Bcl-xL in cardiomyocytes
-
Rohrbach S, Muller-Werdan U, Werdan K, Koch S, Gellerich NF, Holtz J. Apoptosis-modulating interaction of the neuregulin/erbB pathway with anthracyclines in regulating Bcl-xS and Bcl-xL in cardiomyocytes. J Mol Cell Cardiol 2005; 38: 485-493.
-
(2005)
J Mol Cell Cardiol
, vol.38
, pp. 485-493
-
-
Rohrbach, S.1
Muller-Werdan, U.2
Werdan, K.3
Koch, S.4
Gellerich, N.F.5
Holtz, J.6
-
13
-
-
34548394227
-
Neuregulins increase mitochondrial oxidative capacity and insulin sensitivity in skeletal muscle cells
-
Canto C, Pich S, Paz JC, Sanches R, Martinez V, Orpinell M, et al. Neuregulins increase mitochondrial oxidative capacity and insulin sensitivity in skeletal muscle cells. Diabetes 2007; 56: 2185-2193.
-
(2007)
Diabetes
, vol.56
, pp. 2185-2193
-
-
Canto, C.1
Pich, S.2
Paz, J.C.3
Sanches, R.4
Martinez, V.5
Orpinell, M.6
-
14
-
-
0034283407
-
Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: Role of oxidative stress
-
Kinugawa S, Tsutsui H, Hayashidani S, Ide T, Suematsu N, Satoh S, et al. Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress. Circ Res 2000; 87: 392-398.
-
(2000)
Circ Res
, vol.87
, pp. 392-398
-
-
Kinugawa, S.1
Tsutsui, H.2
Hayashidani, S.3
Ide, T.4
Suematsu, N.5
Satoh, S.6
-
15
-
-
0022492812
-
Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: Spectral and metabolic properties
-
Emaus R, Grunwald R, Lemasters JJ. Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim Biophys Acta 1986; 850: 436-448.
-
(1986)
Biochim Biophys Acta
, vol.850
, pp. 436-448
-
-
Emaus, R.1
Grunwald, R.2
Lemasters, J.J.3
-
17
-
-
0037007076
-
Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: Potential mechanism for trastuzumab-induced cardiotoxicity
-
Sawyer DB, Zuppinger C, Miller TA, Eppenberger HM, Suter TM. Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity. Circulation 2002; 105: 1551-1554.
-
(2002)
Circulation
, vol.105
, pp. 1551-1554
-
-
Sawyer, D.B.1
Zuppinger, C.2
Miller, T.A.3
Eppenberger, H.M.4
Suter, T.M.5
-
18
-
-
4043110498
-
Neuregulins regulate cardiac parasympathetic activity: Muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion
-
Okoshi K, Nakayama M, Yan X, Okoshi MP, Schuldt AJ, Marchionni MA, et al. Neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion. Circulation 2004; 110: 713-717.
-
(2004)
Circulation
, vol.110
, pp. 713-717
-
-
Okoshi, K.1
Nakayama, M.2
Yan, X.3
Okoshi, M.P.4
Schuldt, A.J.5
Marchionni, M.A.6
-
19
-
-
77958086724
-
Cardiac functional improvement in rats with myocardial infarction by upregulating cardiac myosin light chain kinase with neuregulin
-
Gu X, Liu X, Xu D, Li X, Yan M, Qi Y, et al. Cardiac functional improvement in rats with myocardial infarction by upregulating cardiac myosin light chain kinase with neuregulin. Cardiovasc Res 2010; 88: 334-343.
-
(2010)
Cardiovasc Res
, vol.88
, pp. 334-343
-
-
Gu, X.1
Liu, X.2
Xu, D.3
Li, X.4
Yan, M.5
Qi, Y.6
-
20
-
-
78149338262
-
Neuregulin-1{beta}1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes
-
Brero A, Ramella R, Fitou A, Dati C, Alloatti G, Gallo MP, et al. Neuregulin-1{beta}1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes. Cardiovasc Res 2010; 88: 443-452.
-
(2010)
Cardiovasc Res
, vol.88
, pp. 443-452
-
-
Brero, A.1
Ramella, R.2
Fitou, A.3
Dati, C.4
Alloatti, G.5
Gallo, M.P.6
-
21
-
-
0032168434
-
Abnormal mitochondrial function in myocardium of dogs with chronic heart failure
-
Sharov VG, Goussev A, Lesch M, Goldstein S, Sabbah HN. Abnormal mitochondrial function in myocardium of dogs with chronic heart failure. J Mol Cell Cardiol 1998; 30: 1757-1762.
-
(1998)
J Mol Cell Cardiol
, vol.30
, pp. 1757-1762
-
-
Sharov, V.G.1
Goussev, A.2
Lesch, M.3
Goldstein, S.4
Sabbah, H.N.5
-
22
-
-
9644310269
-
Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: Implications for herceptin-induced cardiomyopathy
-
Grazette LP, Boecker W, Matsui T, Semigran M, Force TL, Hajjar RJ, et al. Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy. J Am Coll Cardiol 2004; 44: 2231-2238.
-
(2004)
J Am Coll Cardiol
, vol.44
, pp. 2231-2238
-
-
Grazette, L.P.1
Boecker, W.2
Matsui, T.3
Semigran, M.4
Force, T.L.5
Hajjar, R.J.6
-
23
-
-
59049093631
-
Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways
-
Gordon LI, Burke MA, Singh AT, Prachand S, Lieberman ED, Sun L, et al. Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways. J Biol Chem 2009; 284: 2080-2087.
-
(2009)
J Biol Chem
, vol.284
, pp. 2080-2087
-
-
Gordon, L.I.1
Burke, M.A.2
Singh, A.T.3
Prachand, S.4
Lieberman, E.D.5
Sun, L.6
-
24
-
-
0032562770
-
Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
-
Zhao YY, Sawyer DR, Baliga RR, Opel DJ, Han X, Marchionni MA, et al. Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem 1998; 273: 10261-10269.
-
(1998)
J Biol Chem
, vol.273
, pp. 10261-10269
-
-
Zhao, Y.Y.1
Sawyer, D.R.2
Baliga, R.R.3
Opel, D.J.4
Han, X.5
Marchionni, M.A.6
-
25
-
-
0344924865
-
Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt
-
Fukazawa R, Miller TA, Kuramochi Y, Frantz S, Kim YD, Marchionni MA, et al. Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt. J Mol Cell Cardiol 2003; 35: 1473-1479.
-
(2003)
J Mol Cell Cardiol
, vol.35
, pp. 1473-1479
-
-
Fukazawa, R.1
Miller, T.A.2
Kuramochi, Y.3
Frantz, S.4
Kim, Y.D.5
Marchionni, M.A.6
-
26
-
-
10944236872
-
Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling
-
Kuramochi Y, Cote GM, Guo X, Lebrasseur NK, Cui L, Liao R, et al. Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling. J Biol Chem 2004; 279: 51141-51147.
-
(2004)
J Biol Chem
, vol.279
, pp. 51141-51147
-
-
Kuramochi, Y.1
Cote, G.M.2
Guo, X.3
Lebrasseur, N.K.4
Cui, L.5
Liao, R.6
-
27
-
-
0742305448
-
Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1beta
-
Kuramochi Y, Lim CC, Guo X, Colucci WS, Liao R, Sawyer DB. Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1beta. Am J Physiol Cell Physiol 2004; 286: C222-C229.
-
(2004)
Am J Physiol Cell Physiol
, vol.286
-
-
Kuramochi, Y.1
Lim, C.C.2
Guo, X.3
Colucci, W.S.4
Liao, R.5
Sawyer, D.B.6
-
28
-
-
33750915424
-
Mitochondrial oxidative stress, DNA damage, and heart failure
-
Tsutsui H, Ide T, Kinugawa S. Mitochondrial oxidative stress, DNA damage, and heart failure. Antioxid Redox Signal 2006; 8: 1737-1744.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 1737-1744
-
-
Tsutsui, H.1
Ide, T.2
Kinugawa, S.3
-
29
-
-
0035896205
-
Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction
-
Ide T, Tsutsui H, Hayashidani S, Kang D, Suematsu N, Nakamura K, et al. Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circ Res 2001; 88: 529-535.
-
(2001)
Circ Res
, vol.88
, pp. 529-535
-
-
Ide, T.1
Tsutsui, H.2
Hayashidani, S.3
Kang, D.4
Suematsu, N.5
Nakamura, K.6
-
30
-
-
0028356959
-
Antioxidant changes in hypertrophied and failing guinea pig hearts
-
Dhalla AK, Singal PK. Antioxidant changes in hypertrophied and failing guinea pig hearts. Am J Physiol 1994; 266: H1280-H1285.
-
(1994)
Am J Physiol
, vol.266
-
-
Dhalla, A.K.1
Singal, P.K.2
-
31
-
-
0030754792
-
Right and left myocardial antioxidant responses during heart failure subsequent to myocardial infarction
-
Hill MF, Singal PK. Right and left myocardial antioxidant responses during heart failure subsequent to myocardial infarction. Circulation 1997; 96: 2414-2420.
-
(1997)
Circulation
, vol.96
, pp. 2414-2420
-
-
Hill, M.F.1
Singal, P.K.2
-
32
-
-
21644470216
-
Expressional reprogramming of survival pathways in rat cardiocytes by neuregulin-1beta
-
Giraud MN, Fluck M, Zuppinger C, Suter TM. Expressional reprogramming of survival pathways in rat cardiocytes by neuregulin-1beta. J Appl Physiol 2005; 99: 313-322.
-
(2005)
J Appl Physiol
, vol.99
, pp. 313-322
-
-
Giraud, M.N.1
Fluck, M.2
Zuppinger, C.3
Suter, T.M.4
-
33
-
-
0000350066
-
Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA
-
De la Asuncion JG, Millan A, Pla R, Bruseghini L, Esteras A, Pallardo FV, et al. Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. Faseb J 1996; 10: 333-338.
-
(1996)
Faseb J
, vol.10
, pp. 333-338
-
-
de la Asuncion, J.G.1
Millan, A.2
Pla, R.3
Bruseghini, L.4
Esteras, A.5
Pallardo, F.V.6
-
34
-
-
0031984178
-
A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress
-
Sastre J, Millan A, Garcia de la Asuncion J, Pla R, Juan G, Pallardo, et al. A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress. Free Radic Biol Med 1998; 24: 298-304.
-
(1998)
Free Radic Biol Med
, vol.24
, pp. 298-304
-
-
Sastre, J.1
Millan, A.2
Garcia de la Asuncion, J.3
Pla, R.4
Juan, G.5
Pallardo6
-
35
-
-
0038718692
-
Enalapril and losartan attenuate mitochondrial dysfunction in aged rats
-
De Cavanagh EM, Piotrkowski B, Basso N, Stella I, Inserra F, Ferder L, et al. Enalapril and losartan attenuate mitochondrial dysfunction in aged rats. Faseb J 2003; 17: 1096-1098.
-
(2003)
Faseb J
, vol.17
, pp. 1096-1098
-
-
de Cavanagh, E.M.1
Piotrkowski, B.2
Basso, N.3
Stella, I.4
Inserra, F.5
Ferder, L.6
-
36
-
-
0037423550
-
β-Adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway
-
Remondino A, Kwon SH, Communal C, Pimentel DR, Sawyer DB, Singh K, et al. β-Adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway. Circ Res 2003; 92: 136-138.
-
(2003)
Circ Res
, vol.92
, pp. 136-138
-
-
Remondino, A.1
Kwon, S.H.2
Communal, C.3
Pimentel, D.R.4
Sawyer, D.B.5
Singh, K.6
-
37
-
-
41949104144
-
Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: Linking mitochondrial oxidative damage and vascular endothelial dysfunction
-
Doughan AK, Harrison DG, Dikalov SI. Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Circ Res 2008; 102: 488-496.
-
(2008)
Circ Res
, vol.102
, pp. 488-496
-
-
Doughan, A.K.1
Harrison, D.G.2
Dikalov, S.I.3
|