Effects of neuregulin on expression of MMP-9 and NSE in brain of ischemia/reperfusion rat

Journal of Molecular Neuroscience

Volumn 38, Issue 2, 2009, Pages 207-215

  Li, Qin ^a,b   Zhang, Rui ^a   Ge, Yin Lin ^a   Mei, Yuan Wu ^b   Guo, Yun Liang ^a  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cerebral ischemia reperfusion injury; Immunofluorescent double Labeling; MMP 9; Neuregulins; NSE; Western blotting

Indexed keywords

GELATINASE B; NEU DIFFERENTIATION FACTOR; NEURON SPECIFIC ENOLASE; NEUROPROTECTIVE AGENT; RECOMBINANT NEUREGULIN 1BETA; UNCLASSIFIED DRUG; ENOLASE; NEUREGULIN BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN TISSUE; CELL SWELLING; CEREBROVASCULAR ACCIDENT; CHROMATIN CONDENSATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENCEPHALITIS; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; EXTERNAL CAROTID ARTERY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERNAL CAROTID ARTERY; MALE; MICROENVIRONMENT; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SHAM PROCEDURE; SINGLE DRUG DOSE; SUTURE; TARGET CELL; WESTERN BLOTTING; WISTAR RAT; ANIMAL; BRAIN; GENETICS; HUMAN; METABOLISM; PATHOLOGY; RANDOMIZATION;

RATTUS; RATTUS NORVEGICUS;

ANIMALS; BRAIN; HUMANS; MALE; MATRIX METALLOPROTEINASE 9; NEUREGULIN-1; PHOSPHOPYRUVATE HYDRATASE; RANDOM ALLOCATION; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 69249229915     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-008-9150-y     Document Type: Article

References (17)

1. Celtik, C., Acunas, B., Oner, N., et al. (2004). Neuron-specific enolase as a marker of the severity and outcome of hypoxic ischemic encephalopathy. Brain Research. Developmental Brain Research, 26(6), 398-402.
2. Feng, C. S., Ma, H. C., Yue, Y., et al. (2004). Effect of propofol on the activation of nuclear factor-kappa B and expression of inflammatory cytokines in cerebral cortex during transient focal cerebral ischemia-reperfusion: Experiment with rats. Zhonghua Yi Xue Za Zhi, 84(24), 2110-2114.
3. Gidday, J. M., Gasche, Y. G., Copin, J. C., et al. (2005). Leukocytederived matrix metalloproteinase-9 mediates blood brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. American Journal of Physiology. Heart and Circulatory Physiology, 289(2), H558-H568. doi:10.1152/ajpheart.01275.2004. (Pubitemid 41129369)
4. Gu, Z., Cui, J., Brown, S., et al. (2005). A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. The Journal of Neuroscience, 25(27), 6401-6408. doi:10.1523/JNEUROSCI.1563-05.2005. (Pubitemid 40962536)
5. Lee, S. R., Tsuji, K., Lee, S. R., et al. (2004). Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia. Neuroscience, 24(3), 671-678. doi:10.1523/JNEUROSCI.4243-03.2004. (Pubitemid 38166493)
6. Liu, D., Smith, C. L., Barone, F. C., et al. (1999). Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain. Brain Research. Molecular Brain Research, 68(1), 29-41. doi:10.1016/S0169-328X(99)00063-7. (Pubitemid 29243992)
7. Opdenakker, G., Van den Steen, P. E., Dubois, B., et al. (2001). Gelatinase B functions as regulator and effector in leukocyte biology. Journal of Leukocyte Biology, 69(6), 851-859.
8. Rohrbach, S., Yan, X., Weinberg, E. O., et al. (1999). Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors. Circulation, 100(4), 407-412.
9. Rosenberg, G. A., Estrada, E. Y., & Dencoff, J. E. (1998). Matrix metalloproteinases and TIMPS are associated with blood brain barrier opening after reperfusion in rat brain. Stroke, 29(10), 2189-2195.
10. Sasaki, T., Kitagawa, K., & Yagita, Y. (2006). Bcl-2 enhances survival of newborn neurons in the normal and ischemic hippocampus. Journal of Neuroscience Research, 84(6), 1187-1196. doi:10.1002/jnr.21036. (Pubitemid 44654442)
11. Sulemanji, D. S., Dönmez, A., Aldemir, D., et al. (2007). Dexmedetomidine during coronary artery bypass grafting surgery: Is it neuroprotective? - A preliminary study. Acta Anaesthesiologica Scandinavica, 51(8), 1093-1098. doi:10.1111/j.13996576.2007.01377.x.
12. Swartz, K. R., Liu, F., Sewell, D., et al. (2001). Interleukin-6 promotes post-traumatic healing in the central nervous system. Brain Research, 896(1-2), 86-95. doi:10.1016/S0006-8993(01)02013-3. (Pubitemid 32244151)
13. Tayebjee, M. H., Nadar, S., Blann, A. D., et al. (2004). Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in hypertension and their relationship to cardiovascular risk and treatment: A substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). American Journal of Hypertension, 17(9), 764-769.
14. Wang, T., Du, F., Guo, Y. L., et al. (2008). The interfering effect and probable mechanism of neuregulin-1 on cerebral ischemia reperfusion injury in mice. Acta Anatomica Sinica, 39(1), 37-41.
15. Xu, Z. F., & Ford, B. D. (2005). Upregulation of erbB receptors in rat brain after middle cerebral arterial occlusion. Neuroscience Letters, 375(3), 181-186. doi:10.1016/j.bbrc.2004.07.149.
16. Xu, Z. F., Jiang, J., Ford, G., et al. (2004). Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke. Biochemical and Biophysical Research Communications, 322(2), 440-446. doi:10.1016/j.neu let.2004.11.039.
17. Zhang, L. T., Zhang, X., & Zhang, X. (2007). Effect of hyperbaric oxygen on the level of NSE, MBP of newborn with hypoxic and ischemic encephalopathy. Chinese Journal of Practical Nervous Diseases, 10(8), 9-11.