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Volumn 18, Issue 17-18, 2013, Pages 836-842

Therapeutic potential of neuregulin-1 in cardiovascular disease

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; NEU DIFFERENTIATION FACTOR; S6 KINASE; TRASTUZUMAB;

EID: 84883242344     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2013.01.010     Document Type: Review
Times cited : (56)

References (62)
  • 1
    • 34247863773 scopus 로고    scopus 로고
    • The neuregulin-I/ErbB signaling system in development and disease
    • S. Britsch The neuregulin-I/ErbB signaling system in development and disease Adv. Anat. Embryol. Cell Biol. 190 2007 1 65
    • (2007) Adv. Anat. Embryol. Cell Biol. , vol.190 , pp. 1-65
    • Britsch, S.1
  • 2
    • 79959895698 scopus 로고    scopus 로고
    • Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination
    • X. Luo Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination J. Biol. Chem. 286 2011 23967 23974
    • (2011) J. Biol. Chem. , vol.286 , pp. 23967-23974
    • Luo, X.1
  • 3
    • 0037429649 scopus 로고    scopus 로고
    • Neuregulins: Functions, forms, and signaling strategies
    • D.L. Falls Neuregulins: functions, forms, and signaling strategies Exp. Cell Res. 284 2003 14 30
    • (2003) Exp. Cell Res. , vol.284 , pp. 14-30
    • Falls, D.L.1
  • 4
    • 33745805840 scopus 로고    scopus 로고
    • Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk
    • K. Lemmens Role of neuregulin-1/ErbB2 signaling in endothelium- cardiomyocyte cross-talk J. Biol. Chem. 281 2006 19469 19477
    • (2006) J. Biol. Chem. , vol.281 , pp. 19469-19477
    • Lemmens, K.1
  • 6
    • 0028827104 scopus 로고
    • Multiple essential functions of neuregulin in development
    • D. Meyer, and C. Birchmeier Multiple essential functions of neuregulin in development Nature 378 1995 386 390
    • (1995) Nature , vol.378 , pp. 386-390
    • Meyer, D.1    Birchmeier, C.2
  • 7
    • 27344447301 scopus 로고    scopus 로고
    • Neuregulin-1 alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro
    • G.M. Cote Neuregulin-1 alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro Exp. Cell Res. 311 2005 135 146
    • (2005) Exp. Cell Res. , vol.311 , pp. 135-146
    • Cote, G.M.1
  • 8
    • 0037207468 scopus 로고    scopus 로고
    • Cardiac endothelial-myocardial signaling: Its role in cardiac growth, contractile performance, and rhythmicity
    • D.L. Brutsaert Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity Physiol. Rev. 83 2003 59 115
    • (2003) Physiol. Rev. , vol.83 , pp. 59-115
    • Brutsaert, D.L.1
  • 9
    • 0028785406 scopus 로고
    • Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
    • M. Gassmann Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor Nature 378 1995 390 394
    • (1995) Nature , vol.378 , pp. 390-394
    • Gassmann, M.1
  • 10
    • 0028884413 scopus 로고
    • Requirement for neuregulin receptor erbB2 in neural and cardiac development
    • K.F. Lee Requirement for neuregulin receptor erbB2 in neural and cardiac development Nature 378 1995 394 398
    • (1995) Nature , vol.378 , pp. 394-398
    • Lee, K.F.1
  • 11
    • 0031454062 scopus 로고    scopus 로고
    • ErbB3 is required for normal cerebellar and cardiac development: A comparison with ErbB2- and heregulin-deficient mice
    • S.L. Erickson ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2- and heregulin-deficient mice Development 124 1997 4999 5011
    • (1997) Development , vol.124 , pp. 4999-5011
    • Erickson, S.L.1
  • 12
    • 0036677402 scopus 로고    scopus 로고
    • Neuregulin-1 promotes formation of the murine cardiac conduction system
    • S. Rentschler Neuregulin-1 promotes formation of the murine cardiac conduction system Proc. Natl. Acad. Sci. U. S. A. 99 2002 10464 10469
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 10464-10469
    • Rentschler, S.1
  • 13
    • 0042443521 scopus 로고    scopus 로고
    • Expression of ErbB receptors in ES cell-derived cardiomyocytes
    • H. Suk Kim Expression of ErbB receptors in ES cell-derived cardiomyocytes Biochem. Biophys. Res. Commun. 309 2003 241 246
    • (2003) Biochem. Biophys. Res. Commun. , vol.309 , pp. 241-246
    • Suk Kim, H.1
  • 14
    • 77957270888 scopus 로고    scopus 로고
    • Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells
    • W.Z. Zhu Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells Circ. Res. 107 2010 776 786
    • (2010) Circ. Res. , vol.107 , pp. 776-786
    • Zhu, W.Z.1
  • 15
    • 10944236872 scopus 로고    scopus 로고
    • Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling
    • Y. Kuramochi Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling J. Biol. Chem. 279 2004 51141 51147
    • (2004) J. Biol. Chem. , vol.279 , pp. 51141-51147
    • Kuramochi, Y.1
  • 16
    • 0742305448 scopus 로고    scopus 로고
    • Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1beta
    • Y. Kuramochi Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1beta Am. J. Physiol. Cell Physiol. 286 2004 222 229
    • (2004) Am. J. Physiol. Cell Physiol. , vol.286 , pp. 222-229
    • Kuramochi, Y.1
  • 17
    • 0344924865 scopus 로고    scopus 로고
    • Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt
    • R. Fukazawa Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt J. Mol. Cell. Cardiol. 35 2003 1473 1479
    • (2003) J. Mol. Cell. Cardiol. , vol.35 , pp. 1473-1479
    • Fukazawa, R.1
  • 18
    • 14744291620 scopus 로고    scopus 로고
    • Apoptosis-modulating interaction of the neuregulin/ErbB pathway with anthracyclines in regulating Bcl-xS and Bcl-xL in cardiomyocytes
    • S. Rohrbach Apoptosis-modulating interaction of the neuregulin/ErbB pathway with anthracyclines in regulating Bcl-xS and Bcl-xL in cardiomyocytes J. Mol. Cell. Cardiol. 38 2005 485 493
    • (2005) J. Mol. Cell. Cardiol. , vol.38 , pp. 485-493
    • Rohrbach, S.1
  • 19
    • 67650569135 scopus 로고    scopus 로고
    • Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury
    • K. Bersell Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury Cell 138 2009 257 270
    • (2009) Cell , vol.138 , pp. 257-270
    • Bersell, K.1
  • 20
    • 0032714208 scopus 로고    scopus 로고
    • NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK
    • R.R. Baliga NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK Am. J. Physiol. 277 1999 2026 2037
    • (1999) Am. J. Physiol. , vol.277 , pp. 2026-2037
    • Baliga, R.R.1
  • 21
    • 33746048823 scopus 로고    scopus 로고
    • Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes
    • Y. Kuramochi Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes J. Mol. Cell. Cardiol. 41 2006 228 235
    • (2006) J. Mol. Cell. Cardiol. , vol.41 , pp. 228-235
    • Kuramochi, Y.1
  • 22
    • 0037007076 scopus 로고    scopus 로고
    • Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1 beta and anti-erbB2: Potential mechanism for trastuzumab-induced cardiotoxicity
    • D.B. Sawyer Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1 beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity Circulation 105 2002 1551 1554
    • (2002) Circulation , vol.105 , pp. 1551-1554
    • Sawyer, D.B.1
  • 23
    • 1642458136 scopus 로고    scopus 로고
    • Neuregulin-1 induces a negative inotropic effect in cardiac muscle: Role of nitric oxide synthase
    • K. Lemmens Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase Circulation 109 2004 324 326
    • (2004) Circulation , vol.109 , pp. 324-326
    • Lemmens, K.1
  • 24
    • 0033603308 scopus 로고    scopus 로고
    • Neuregulin signaling in the heart. Dynamic targeting of erbB4 to caveolar microdomains in cardiac myocytes
    • Y.Y. Zhao Neuregulin signaling in the heart. Dynamic targeting of erbB4 to caveolar microdomains in cardiac myocytes Circ. Res. 84 1999 1380 1387
    • (1999) Circ. Res. , vol.84 , pp. 1380-1387
    • Zhao, Y.Y.1
  • 25
    • 4043110498 scopus 로고    scopus 로고
    • Neuregulins regulate cardiac parasympathetic activity: Muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion
    • K. Okoshi Neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion Circulation 110 2004 713 717
    • (2004) Circulation , vol.110 , pp. 713-717
    • Okoshi, K.1
  • 26
    • 78149338262 scopus 로고    scopus 로고
    • Neuregulin-1 beta1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes
    • A. Brero Neuregulin-1 beta1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes Cardiovasc. Res. 88 2010 443 452
    • (2010) Cardiovasc. Res. , vol.88 , pp. 443-452
    • Brero, A.1
  • 27
    • 34547191653 scopus 로고    scopus 로고
    • Intra- and extracellular signaling by endothelial neuregulin-1
    • E. Iivanainen Intra- and extracellular signaling by endothelial neuregulin-1 Exp. Cell Res. 313 2007 2896 2909
    • (2007) Exp. Cell Res. , vol.313 , pp. 2896-2909
    • Iivanainen, E.1
  • 28
    • 0033393696 scopus 로고    scopus 로고
    • Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis
    • K.S. Russell Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis Am. J. Physiol. 277 1999 2205 2211
    • (1999) Am. J. Physiol. , vol.277 , pp. 2205-2211
    • Russell, K.S.1
  • 29
    • 0034691674 scopus 로고    scopus 로고
    • Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis
    • L. Yen Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis Oncogene 19 2000 3460 3469
    • (2000) Oncogene , vol.19 , pp. 3460-3469
    • Yen, L.1
  • 30
    • 84863265688 scopus 로고    scopus 로고
    • Endothelial derived neuregulin is an important mediator of ischemic induced angiogenesis and arteriogenesis
    • N. Hedhli Endothelial derived neuregulin is an important mediator of ischemic induced angiogenesis and arteriogenesis Cardiovasc. Res. 93 2011 516 524
    • (2011) Cardiovasc. Res. , vol.93 , pp. 516-524
    • Hedhli, N.1
  • 31
    • 27344455451 scopus 로고    scopus 로고
    • Expression of heregulin in human coronary atherosclerotic lesions
    • D. Panutsopulos Expression of heregulin in human coronary atherosclerotic lesions J. Vasc. Res. 42 2005 463 474
    • (2005) J. Vasc. Res. , vol.42 , pp. 463-474
    • Panutsopulos, D.1
  • 32
    • 34250722576 scopus 로고    scopus 로고
    • Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells
    • C.M. Clement Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells J. Vasc. Res. 44 2007 303 312
    • (2007) J. Vasc. Res. , vol.44 , pp. 303-312
    • Clement, C.M.1
  • 33
    • 62249192069 scopus 로고    scopus 로고
    • Neuregulin-1/ErbB signaling: A druggable target for treating heart failure
    • Y. Xu Neuregulin-1/ErbB signaling: a druggable target for treating heart failure Curr. Opin. Pharmacol. 9 2009 214 219
    • (2009) Curr. Opin. Pharmacol. , vol.9 , pp. 214-219
    • Xu, Y.1
  • 34
    • 0037172982 scopus 로고    scopus 로고
    • Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy
    • C. Ozcelik Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy Proc. Natl. Acad. Sci. U. S. A. 99 2002 8880 8885
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 8880-8885
    • Ozcelik, C.1
  • 35
    • 0036099675 scopus 로고    scopus 로고
    • ErbB2 is essential in the prevention of dilated cardiomyopathy
    • S.A. Crone ErbB2 is essential in the prevention of dilated cardiomyopathy Nat. Med. 8 2002 459 465
    • (2002) Nat. Med. , vol.8 , pp. 459-465
    • Crone, S.A.1
  • 36
    • 23944477855 scopus 로고    scopus 로고
    • Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle
    • H. Garcia-Rivello Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle Am. J. Physiol. Heart Circ. Physiol. 289 2005 1153 1160
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.289 , pp. 1153-1160
    • Garcia-Rivello, H.1
  • 37
    • 78650612002 scopus 로고    scopus 로고
    • Neuregulin-1 preconditioning protects the heart against ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism
    • S.J. Fang Neuregulin-1 preconditioning protects the heart against ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism Chin. Med. J. (Engl.) 123 2010 3597 3604
    • (2010) Chin. Med. J. (Engl.) , vol.123 , pp. 3597-3604
    • Fang, S.J.1
  • 38
    • 84894606216 scopus 로고    scopus 로고
    • Cardioprotective effect of neuregulin-1 in myocardial ischemia-reperfusion injury relies on eNOS
    • K. Lemmens Cardioprotective effect of neuregulin-1 in myocardial ischemia-reperfusion injury relies on eNOS Circulation 124 2011 A9815
    • (2011) Circulation , vol.124 , pp. 9815
    • Lemmens, K.1
  • 39
    • 22544475191 scopus 로고    scopus 로고
    • Heterozygous knockout of neuregulin-1 gene in mice exacerbates doxorubicin-induced heart failure
    • F.F. Liu Heterozygous knockout of neuregulin-1 gene in mice exacerbates doxorubicin-induced heart failure Am. J. Physiol. Heart Circ. Physiol. 289 2005 660 666
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.289 , pp. 660-666
    • Liu, F.F.1
  • 40
    • 84894603379 scopus 로고    scopus 로고
    • Doxorubicin and NRG-1/erbB4-deficiency affect gene expression profile: Involving protein homeostasis in mouse
    • C. Vasti Doxorubicin and NRG-1/erbB4-deficiency affect gene expression profile: involving protein homeostasis in mouse ISRN Cardiol. 2012 2012 745185
    • (2012) ISRN Cardiol. , vol.2012 , pp. 745185
    • Vasti, C.1
  • 41
    • 84894605247 scopus 로고    scopus 로고
    • Deficient cardiac neuregulin-ErbB signaling in type 2 diabetes, and beneficial effects of treatment with neuregulin-1
    • K. Doggen Deficient cardiac neuregulin-ErbB signaling in type 2 diabetes, and beneficial effects of treatment with neuregulin-1 Circulation 120 2009 828
    • (2009) Circulation , vol.120 , pp. 828
    • Doggen, K.1
  • 42
    • 84866013214 scopus 로고    scopus 로고
    • Neuregulin-1/ErbB signaling is impaired in the rat model of diabetic cardiomyopathy
    • C. Gui Neuregulin-1/ErbB signaling is impaired in the rat model of diabetic cardiomyopathy Cardiovasc. Pathol. 21 2012 414 420
    • (2012) Cardiovasc. Pathol. , vol.21 , pp. 414-420
    • Gui, C.1
  • 43
    • 57149098209 scopus 로고    scopus 로고
    • Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure
    • K. Doggen Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure J. Mol. Cell. Cardiol. 46 2009 33 38
    • (2009) J. Mol. Cell. Cardiol. , vol.46 , pp. 33-38
    • Doggen, K.1
  • 44
    • 0033609458 scopus 로고    scopus 로고
    • Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors
    • S. Rohrbach Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors Circulation 100 1999 407 412
    • (1999) Circulation , vol.100 , pp. 407-412
    • Rohrbach, S.1
  • 45
    • 0036498781 scopus 로고    scopus 로고
    • Cardiac dysfunction in the trastuzumab clinical trials experience
    • A. Seidman Cardiac dysfunction in the trastuzumab clinical trials experience J. Clin. Oncol. 20 2002 1215 1221
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1215-1221
    • Seidman, A.1
  • 46
    • 74049164266 scopus 로고    scopus 로고
    • The vulnerability of the heart as a pluricellular paracrine organ: Lessons from unexpected triggers of heart failure in targeted ErbB2 anticancer therapy
    • G.W. De Keulenaer The vulnerability of the heart as a pluricellular paracrine organ: lessons from unexpected triggers of heart failure in targeted ErbB2 anticancer therapy Circ. Res. 106 2010 35 46
    • (2010) Circ. Res. , vol.106 , pp. 35-46
    • De Keulenaer, G.W.1
  • 47
    • 25144465666 scopus 로고    scopus 로고
    • Neuregulin receptors erbB2 and erbB4 in failing human myocardium - Depressed expression and attenuated activation
    • S. Rohrbach Neuregulin receptors erbB2 and erbB4 in failing human myocardium - depressed expression and attenuated activation Basic Res. Cardiol. 100 2005 240 249
    • (2005) Basic Res. Cardiol. , vol.100 , pp. 240-249
    • Rohrbach, S.1
  • 48
    • 68249087127 scopus 로고    scopus 로고
    • Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure
    • B. Ky Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure Circulation 120 2009 310 317
    • (2009) Circulation , vol.120 , pp. 310-317
    • Ky, B.1
  • 49
    • 70149110196 scopus 로고    scopus 로고
    • Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis
    • G. Xu Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis Circ. Res. 105 2009 500 510
    • (2009) Circ. Res. , vol.105 , pp. 500-510
    • Xu, G.1
  • 50
    • 81855175973 scopus 로고    scopus 로고
    • Circulating neuregulin-1beta levels vary according to the angiographic severity of coronary artery disease and ischemia
    • C. Anna Geisberg Circulating neuregulin-1beta levels vary according to the angiographic severity of coronary artery disease and ischemia Coron. Artery Dis. 22 2011 577 582
    • (2011) Coron. Artery Dis. , vol.22 , pp. 577-582
    • Anna Geisberg, C.1
  • 51
    • 33847785150 scopus 로고    scopus 로고
    • Serum HER2 levels are increased in patients with chronic heart failure
    • P.J. Perik Serum HER2 levels are increased in patients with chronic heart failure Eur. J. Heart Fail. 9 2007 173 177
    • (2007) Eur. J. Heart Fail. , vol.9 , pp. 173-177
    • Perik, P.J.1
  • 52
    • 78049476152 scopus 로고    scopus 로고
    • Plasma HER2 levels are not associated with cardiac function or hypertrophy in control subjects and heart failure patients
    • M.G. Posch Plasma HER2 levels are not associated with cardiac function or hypertrophy in control subjects and heart failure patients Int. J. Cardiol. 145 2010 105 106
    • (2010) Int. J. Cardiol. , vol.145 , pp. 105-106
    • Posch, M.G.1
  • 53
    • 84863368665 scopus 로고    scopus 로고
    • Neuregulin-1 attenuates mitochondrial dysfunction in a rat model of heart failure
    • Y.F. Guo Neuregulin-1 attenuates mitochondrial dysfunction in a rat model of heart failure Chin. Med. J. (Engl.) 125 2012 807 814
    • (2012) Chin. Med. J. (Engl.) , vol.125 , pp. 807-814
    • Guo, Y.F.1
  • 54
    • 33748929841 scopus 로고    scopus 로고
    • Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy
    • X. Liu Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy J. Am. Coll. Cardiol. 48 2006 1438 1447
    • (2006) J. Am. Coll. Cardiol. , vol.48 , pp. 1438-1447
    • Liu, X.1
  • 55
    • 77958086724 scopus 로고    scopus 로고
    • Cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin
    • X. Gu Cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin Cardiovasc. Res. 88 2010 334 343
    • (2010) Cardiovasc. Res. , vol.88 , pp. 334-343
    • Gu, X.1
  • 56
    • 84867579183 scopus 로고    scopus 로고
    • Therapeutic effects of neuregulin-1 gene transduction in rats with myocardial infarction
    • J. Xiao Therapeutic effects of neuregulin-1 gene transduction in rats with myocardial infarction Coron. Artery Dis. 23 2012 460 468
    • (2012) Coron. Artery Dis. , vol.23 , pp. 460-468
    • Xiao, J.1
  • 57
    • 72249094133 scopus 로고    scopus 로고
    • Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins
    • Y. Bian Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins Am. J. Physiol. Heart Circ. Physiol. 297 2009 1974 1983
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.297 , pp. 1974-1983
    • Bian, Y.1
  • 58
    • 79960888603 scopus 로고    scopus 로고
    • Therapeutic effects of neuregulin-1 in diabetic cardiomyopathy rats
    • B. Li Therapeutic effects of neuregulin-1 in diabetic cardiomyopathy rats Cardiovasc. Diabetol. 10 2011 69
    • (2011) Cardiovasc. Diabetol. , vol.10 , pp. 69
    • Li, B.1
  • 59
    • 33750347979 scopus 로고    scopus 로고
    • Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes
    • F. Timolati Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes J. Mol. Cell. Cardiol. 41 2006 845 854
    • (2006) J. Mol. Cell. Cardiol. , vol.41 , pp. 845-854
    • Timolati, F.1
  • 60
    • 77952317892 scopus 로고    scopus 로고
    • A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure
    • R. Gao A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure J. Am. Coll. Cardiol. 55 2010 1907 1914
    • (2010) J. Am. Coll. Cardiol. , vol.55 , pp. 1907-1914
    • Gao, R.1
  • 61
    • 78650412123 scopus 로고    scopus 로고
    • Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses
    • A. Jabbour Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses Eur. J. Heart Fail. 13 2011 83 92
    • (2011) Eur. J. Heart Fail. , vol.13 , pp. 83-92
    • Jabbour, A.1
  • 62
    • 84863265688 scopus 로고    scopus 로고
    • Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis
    • N. Hedhli Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis Cardiovasc. Res. 93 2012 516 524
    • (2012) Cardiovasc. Res. , vol.93 , pp. 516-524
    • Hedhli, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.