Time-dependent regulation of neuregulin-1β/ErbB/ERK pathways in cardiac differentiation of mouse embryonic stem cells

Molecular and Cellular Biochemistry

Volumn 380, Issue 1-2, 2013, Pages 67-72

  Chen, Ming ^a   Bi, Lin Lin ^b   Wang, Zhi Quan ^a   Zhao, Fang ^a   Gan, Xue Dong ^a   Wang, Yang Gan ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Cardiomyocyte; Embryonic stem cells; Extracellular signal related kinases; Neuregulin

Indexed keywords

ALPHA ACTIN; ATRIAL NATRIURETIC FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOSIN LIGHT CHAIN 2; NEU DIFFERENTIATION FACTOR; NEU DIFFERENTIATION FACTOR BETA; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG; UO 126;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYOID BODY; EMBRYONIC STEM CELL; GENE EXPRESSION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; SIGNAL TRANSDUCTION; UPREGULATION;

ACTINS; ANIMALS; ATRIAL NATRIURETIC FACTOR; BUTADIENES; CELL DIFFERENTIATION; CELL LINE; EMBRYOID BODIES; EMBRYONIC STEM CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GATA4 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; MICE; MYOCYTES, CARDIAC; MYOSIN LIGHT CHAINS; NEUREGULIN-1; NITRILES; PHOSPHORYLATION; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; TIME FACTORS; TRANSCRIPTION FACTORS; TYRPHOSTINS;

EID: 84879797348     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1658-y     Document Type: Article

References (32)

1. Bongso A, Fong CY, Gauthaman K (2008) Taking stem cells to the clinic: major challenges. J Cell Biochem 105:1352-1360
2. Murry CE, Keller G (2008) Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 132:661-680
3. Maltsev VA, Rohwedel J, Hescheler J, Wobus AM (1993) Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mech Dev 44:41-50
4. Maltsev VA, Wobus AM, Rohwedel J, Bader M, Hescheler J (1994) Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ Res 75:233-244
5. Chen HS, Kim C, Mercola M (2009) Electrophysiological challenges of cell-based myocardial repair. Circulation 120:2496-2508
6. Chen K, Wu L, Wang ZZ (2008) Extrinsic regulation of cardiomyocyte differentiation of embryonic stem cells. J Cell Biochem 104:119-128
7. Behfar A, Zingman LV, Hodgson DM, Rauzier JM, Kane GC, Terzic A, Puceat M (2002) Stem cell differentiation requires a paracrine pathway in the heart. FASEB J 16:1558-1566
8. Naito AT, Shiojima I, Akazawa H, Hidaka K, Morisaki T, Kikuchi A, Komuro I (2006) Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis. Proc Natl Acad Sci USA 103:19812-19817
9. Sun X, Jin X, Zhang X, Liu C, Lei L, Jin L, Liu H (2011) Icariin induces mouse embryonic stem cell differentiation into beating functional cardiomyocytes. Mol Cell Biochem 349:117-123
10. Wiese C, Nikolova T, Zahanich I, Sulzbacher S, Fuchs J, Yamanaka S, Graf E, Ravens U, Boheler KR, Wobus AM (2011) Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin. Int J Cardiol 147:95-111
11. Chen M, Lin YQ, Xie SL, Wang JF (2009) Mitogen-activated protein kinase in endothelin-1-induced cardiac differentiation of mouse embryonic stem cells. J Cell Biochem 111:1619-1628
12. Suk Kim H, Hidaka K, Morisaki T (2003) Expression of ErbB receptors in ES cell-derived cardiomyocytes. Biochem Biophys Res Commun 309:241-246
13. Kim HS, Cho JW, Hidaka K, Morisaki T (2007) Activation of MEK-ERK by heregulin-beta1 promotes the development of cardiomyocytes derived from ES cells. Biochem Biophys Res Commun 361:732-738
14. Wang Z, Xu G, Wu Y, Guan Y, Cui L, Lei X, Zhang J, Mou L, Sun B, Dai Q (2009) Neuregulin-1 enhances differentiation of cardiomyocytes from embryonic stem cells. Med Biol Eng Comput 47:41-48
15. Zhu WZ, Xie Y, Moyes KW, Gold JD, Askari B, Laflamme MA (2010) Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells. Circ Res 107:776-786
16. Chen M, Lin YQ, Xie SL, Wu HF, Wang JF (2010) Enrichment of cardiac differentiation of mouse embryonic stem cells by optimizing the hanging drop method. Biotechnol Lett 33:853-858
17. Falls DL (2003) Neuregulins: functions, forms, and signaling strategies. Exp Cell Res 284:14-30
18. Cote GM, Miller TA, Lebrasseur NK, Kuramochi Y, Sawyer DB (2005) Neuregulin-1alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro. Exp Cell Res 311:135-146
19. Zhao YY, Sawyer DR, Baliga RR, Opel DJ, Han X, Marchionni MA, Kelly RA (1998) Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem 273:10261-10269
20. Lemmens K, Fransen P, Sys SU, Brutsaert DL, De Keulenaer GW (2004) Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase. Circulation 109:324-326
21. Rohrbach S, Niemann B, Silber RE, Holtz J (2005) Neuregulin receptors erbB2 and erbB4 in failing human myocardium: depressed expression and attenuated activation. Basic Res Cardiol 100:240-249
22. Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R, Lemke G (1995) Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378:390-394
23. Lee KF, Simon H, Chen H, Bates B, Hung MC, Hauser C (1995) Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378:394-398
24. Meyer D, Birchmeier C (1995) Multiple essential functions of neuregulin in development. Nature 378:386-390
25. Rentschler S, Zander J, Meyers K, France D, Levine R, Porter G, Rivkees SA, Morley GE, Fishman GI (2002) Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc Natl Acad Sci USA 99:10464-10469
26. Patel R, Kos L (2005) Endothelin-1 and neuregulin-1 convert embryonic cardiomyocytes into cells of the conduction system in the mouse. Dev Dyn 233:20-28
27. Zeller R, Bloch KD, Williams BS, Arceci RJ, Seidman CE (1987) Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis. Genes Dev 1:693-698
28. Kubalak SW, Miller-Hance WC, O'Brien TX, Dyson E, Chien KR (1994) Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. J Biol Chem 269:16961-16970
29. Garcia-Frigola C, Shi Y, Evans SM (2003) Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development. Gene Expr Patterns 3:777-783
30. Hoogaars WM, Tessari A, Moorman AF, de Boer PA, Hagoort J, Soufan AT, Campione M, Christoffels VM (2004) The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart. Cardiovasc Res 62:489-499
31. Christoffels VM, Smits GJ, Kispert A, Moorman AF (2010) Development of the pacemaker tissues of the heart. Circ Res 106:240-254
32. Baliga RR, Pimental DR, Zhao YY, Simmons WW, Marchionni MA, Sawyer DB, Kelly RA (1999) NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK. Am J Physiol 277:H2026-H2037