A network of players in H3 histone variant deposition and maintenance at centromeres

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1839, Issue 3, 2014, Pages 241-250

  Müller, Sebastian ^a   Almouzni, Geneviève ^a  

^a INSTITUT CURIE   (France)

Author keywords

Cell cycle; CenH3; CENP A; Centromere; HJURP

Indexed keywords

CENTROMERE PROTEIN A; CHAPERONE; HISTONE H3; HJURP PROTEIN; PROTEIN; PROTEIN VARIANT; SCM3 PROTEIN; UNCLASSIFIED DRUG;

CELL CYCLE; CENTROMERE; CHROMATIN; DNA MODIFICATION; DNA REPLICATION; EPIGENETICS; HISTONE MODIFICATION; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW;

ANIMALIA; MAMMALIA;

CELL CYCLE; CENH3; CENP-A; CENTROMERE; HJURP;

ANIMALS; CENTROMERE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMOSOME SEGREGATION; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; HISTONES; HUMANS;

EID: 84896720721     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2013.11.008     Document Type: Review

References (137)

1. Flemming W. Chromosomen in sich teilenden Tumorzellen, Book chapter. Zellsubstanz. Kern und Zelltheilung 1882, F.C.W. Vogel, Leipzig.
2. Melters D.P., Bradnam K.R., Young H.A., Telis N., May M.R., Ruby J.G., Sebra R., Peluso P., Eid J., Rank D., Fernando Garcia J., Derisi J.L., Smith T., Tobias C., Ross-Ibarra J., Korf I., Chan S.W. Comparative analysis of tandem repeats from hundreds of species reveals unique insights into centromere evolution. Genome Biol. 2013, 14:R10.
3. Black B.E., Bassett E.A. The histone variant CENP-A and centromere specification. Curr. Opin. Cell Biol. 2008, 20:91-100.
4. Valente L.P., Silva M.C., Jansen L.E. Temporal control of epigenetic centromere specification. Chromosom. Res. 2012, 20:481-492.
5. Foltz D.R., Jansen L.E., Black B.E., Bailey A.O., Yates J.R., Cleveland D.W. The human CENP-A centromeric nucleosome-associated complex. Nat. Cell Biol. 2006, 8:458-469.
6. Dunleavy E.M., Roche D., Tagami H., Lacoste N., Ray-Gallet D., Nakamura Y., Daigo Y., Nakatani Y., Almouzni-Pettinotti G. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. Cell 2009, 137:485-497.
7. Foltz D.R., Jansen L.E., Bailey A.O., Yates J.R., Bassett E.A., Wood S., Black B.E., Cleveland D.W. Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. Cell 2009, 137:472-484.
8. Camahort R., Li B., Florens L., Swanson S.K., Washburn M.P., Gerton J.L. Scm3 is essential to recruit the histone H3 variant Cse4 to centromeres and to maintain a functional kinetochore. Mol. Cell 2007, 26:853-865.
9. Pidoux A.L., Choi E.S., Abbott J.K., Liu X., Kagansky A., Castillo A.G., Hamilton G.L., Richardson W., Rappsilber J., He X., Allshire R.C. Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin. Mol. Cell 2009, 33:299-311.
10. Shivaraju M., Camahort R., Mattingly M., Gerton J.L. Scm3 is a centromeric nucleosome assembly factor. J. Biol. Chem. 2011, 286:12016-12023.
11. Mellone B.G., Grive K.J., Shteyn V., Bowers S.R., Oderberg I., Karpen G.H. Assembly of Drosophila centromeric chromatin proteins during mitosis. PLoS Genet. 2011, 7:e1002068.
12. Guldner H.H., Lakomek H.J., Bautz F.A. Human anti-centromere sera recognise a 19.5kD non-histone chromosomal protein from HeLa cells. Clin. Exp. Immunol. 1984, 58:13-20.
13. Earnshaw W.C., Rothfield N. Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma 1985, 91:313-321.
14. Valdivia M.M., Brinkley B.R. Fractionation and initial characterization of the kinetochore from mammalian metaphase chromosomes. J. Cell Biol. 1985, 101:1124-1134.
15. Earnshaw W., Bordwell B., Marino C., Rothfield N. Three human chromosomal autoantigens are recognized by sera from patients with anti-centromere antibodies. J. Clin. Invest. 1986, 77:426-430.
16. Palmer D.K., O'Day K., Trong H.L., Charbonneau H., Margolis R.L. Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone. Proc. Natl. Acad. Sci. U. S. A. 1991, 88:3734-3738.
17. Stoler S., Keith K.C., Curnick K.E., Fitzgerald-Hayes M. A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis. Genes Dev. 1995, 9:573-586.
18. Buchwitz B.J., Ahmad K., Moore L.L., Roth M.B., Henikoff S. A histone-H3-like protein in C. elegans. Nature 1999, 401:547-548.
19. Blower M.D., Karpen G.H. The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions. Nat. Cell Biol. 2001, 3:730-739.
20. Takahashi K., Chen E.S., Yanagida M. Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast. Science 2000, 288:2215-2219.
21. Talbert P.B., Masuelli R., Tyagi A.P., Comai L., Henikoff S. Centromeric localization and adaptive evolution of an Arabidopsis histone H3 variant. Plant Cell 2002, 14:1053-1066.
22. Sullivan B.A., Karpen G.H. Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. Nat. Struct. Mol. Biol. 2004, 11:1076-1083.
23. Yoda K., Ando S., Morishita S., Houmura K., Hashimoto K., Takeyasu K., Okazaki T. Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:7266-7271.
24. Szenker E., Ray-Gallet D., Almouzni G. The double face of the histone variant H3.3. Cell Res. 2011, 21:421-434.
25. Shelby R.D., Vafa O., Sullivan K.F. Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites. J. Cell Biol. 1997, 136:501-513.
26. Allshire R.C., Karpen G.H. Epigenetic regulation of centromeric chromatin: old dogs, new tricks?. Nat. Rev. Genet. 2008, 9:923-937.
27. Boyarchuk E., Montes de Oca R., Almouzni G. Cell cycle dynamics of histone variants at the centromere, a model for chromosomal landmarks. Curr. Opin. Cell Biol. 2011, 23:266-276.
28. Pearson C.G., Yeh E., Gardner M., Odde D., Salmon E.D., Bloom K. Stable kinetochore-microtubule attachment constrains centromere positioning in metaphase. Curr. Biol. 2004, 14:1962-1967.
29. Takayama Y., Sato H., Saitoh S., Ogiyama Y., Masuda F., Takahashi K. Biphasic incorporation of centromeric histone CENP-A in fission yeast. Mol. Biol. Cell 2008, 19:682-690.
30. Jansen L.E., Black B.E., Foltz D.R., Cleveland D.W. Propagation of centromeric chromatin requires exit from mitosis. J. Cell Biol. 2007, 176:795-805.
31. Talbert P.B., Henikoff S. Histone variants-ancient wrap artists of the epigenome. Nat. Rev. Mol. Cell Biol. 2010, 11:264-275.
32. Wieland G., Orthaus S., Ohndorf S., Diekmann S., Hemmerich P. Functional complementation of human centromere protein A (CENP-A) by Cse4p from Saccharomyces cerevisiae. Mol. Cell. Biol. 2004, 24:6620-6630.
33. Black B.E., Jansen L.E., Maddox P.S., Foltz D.R., Desai A.B., Shah J.V., Cleveland D.W. Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. Mol. Cell 2007, 25:309-322.
34. Vermaak D., Hayden H.S., Henikoff S. Centromere targeting element within the histone fold domain of Cid. Mol. Cell. Biol. 2002, 22:7553-7561.
35. Okamoto Y., Nakano M., Ohzeki J., Larionov V., Masumoto H. A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere. EMBO J. 2007, 26:1279-1291.
36. Sekulic N., Bassett E.A., Rogers D.J., Black B.E. The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres. Nature 2010, 467:347-351.
37. Tachiwana H., Kagawa W., Shiga T., Osakabe A., Miya Y., Saito K., Hayashi-Takanaka Y., Oda T., Sato M., Park S.Y., Kimura H., Kurumizaka H. Crystal structure of the human centromeric nucleosome containing CENP-A. Nature 2011, 476:232-235.
38. Fujita Y., Hayashi T., Kiyomitsu T., Toyoda Y., Kokubu A., Obuse C., Yanagida M. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. Dev. Cell 2007, 12:17-30.
39. Hayashi T., Fujita Y., Iwasaki O., Adachi Y., Takahashi K., Yanagida M. Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres. Cell 2004, 118:715-729.
40. Barnhart M.C., Kuich P.H., Stellfox M.E., Ward J.A., Bassett E.A., Black B.E., Foltz D.R. HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore. J. Cell Biol. 2011, 194:229-243.
41. Dambacher S., Deng W., Hahn M., Sadic D., Frohlich J., Nuber A., Hoischen C., Diekmann S., Leonhardt H., Schotta G. CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin. Nucleus 2012, 3:101-110.
42. Moree B., Meyer C.B., Fuller C.J., Straight A.F. CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly. J. Cell Biol. 2011, 194:855-871.
43. Maddox P.S., Hyndman F., Monen J., Oegema K., Desai A. Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. J. Cell Biol. 2007, 176:757-763.
44. Kato H., Jiang J., Zhou B.R., Rozendaal M., Feng H., Ghirlando R., Xiao T.S., Straight A.F., Bai Y. A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C. Science 2013, 340:1110-1113.
45. Carroll C.W., Milks K.J., Straight A.F. Dual recognition of CENP-A nucleosomes is required for centromere assembly. J. Cell Biol. 2010, 189:1143-1155.
46. Goutte-Gattat D., Shuaib M., Ouararhni K., Gautier T., Skoufias D.A., Hamiche A., Dimitrov S. Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:8579-8584.
47. Fachinetti D., Folco H.D., Nechemia-Arbely Y., Valente L.P., Nguyen K., Wong A.J., Zhu Q., Holland A.J., Desai A., Jansen L.E., Cleveland D.W. A two-step mechanism for epigenetic specification of centromere identity and function. Nat. Cell Biol. 2013, 15:1056-1066.
48. Silva M.C., Bodor D.L., Stellfox M.E., Martins N.M., Hochegger H., Foltz D.R., Jansen L.E. Cdk activity couples epigenetic centromere inheritance to cell cycle progression. Dev. Cell 2012, 22:52-63.
49. Furuyama T., Dalal Y., Henikoff S. Chaperone-mediated assembly of centromeric chromatin in vitro. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:6172-6177.
50. Ohzeki J., Bergmann J.H., Kouprina N., Noskov V.N., Nakano M., Kimura H., Earnshaw W.C., Larionov V., Masumoto H. Breaking the HAC barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly. EMBO J. 2012, 31:2391-2402.
51. Lejeune E., Bortfeld M., White S.A., Pidoux A.L., Ekwall K., Allshire R.C., Ladurner A.G. The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi. Curr. Biol. 2007, 17:1219-1224.
52. Okada M., Okawa K., Isobe T., Fukagawa T. CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1. Mol. Biol. Cell 2009, 20:3986-3995.
53. Hemmerich P., Weidtkamp-Peters S., Hoischen C., Schmiedeberg L., Erliandri I., Diekmann S. Dynamics of inner kinetochore assembly and maintenance in living cells. J. Cell Biol. 2008, 180:1101-1114.
54. Nishino T., Takeuchi K., Gascoigne K.E., Suzuki A., Hori T., Oyama T., Morikawa K., Cheeseman I.M., Fukagawa T. CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold. Cell 2012, 148:487-501.
55. Hori T., Amano M., Suzuki A., Backer C.B., Welburn J.P., Dong Y., McEwen B.F., Shang W.H., Suzuki E., Okawa K., Cheeseman I.M., Fukagawa T. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. Cell 2008, 135:1039-1052.
56. Hellwig D., Emmerth S., Ulbricht T., Doring V., Hoischen C., Martin R., Samora C.P., McAinsh A.D., Carroll C.W., Straight A.F., Meraldi P., Diekmann S. Dynamics of CENP-N kinetochore binding during the cell cycle. J. Cell Sci. 2011, 124:3871-3883.
57. Cheeseman I.M., Desai A. Molecular architecture of the kinetochore-microtubule interface. Nat. Rev. Mol. Cell Biol. 2008, 9:33-46.
58. Hori T., Shang W.H., Takeuchi K., Fukagawa T. The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly. J. Cell Biol. 2013, 200:45-60.
59. Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R., Desai A., Fukagawa T. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat. Cell Biol. 2006, 8:446-457.
60. Jaramillo-Lambert A., Hao J., Xiao H., Li Y., Han Z., Zhu W. Acidic nucleoplasmic DNA-binding protein (And-1) controls chromosome congression by regulating the assembly of CENP-A at centromeres. J. Biol. Chem. 2012, 288:1480-1488.
61. Hanna J.S., Kroll E.S., Lundblad V., Spencer F.A. Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion. Mol. Cell. Biol. 2001, 21:3144-3158.
62. Petronczki M., Chwalla B., Siomos M.F., Yokobayashi S., Helmhart W., Deutschbauer A.M., Davis R.W., Watanabe Y., Nasmyth K. Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II. J. Cell Sci. 2004, 117:3547-3559.
63. Mamnun Y.M., Katayama S., Toda T. Fission yeast Mcl1 interacts with SCF(Pof3) and is required for centromere formation. Biochem. Biophys. Res. Commun. 2006, 350:125-130.
64. Li Y., Jaramillo-Lambert A.N., Yang Y., Williams R., Lee N.H., Zhu W. And-1 is required for the stability of histone acetyltransferase Gcn5. Oncogene 2012, 31:643-652.
65. Bernad R., Sanchez P., Rivera T., Rodriguez-Corsino M., Boyarchuk E., Vassias I., Ray-Gallet D., Arnaoutov A., Dasso M., Almouzni G., Losada A. Xenopus HJURP and condensin II are required for CENP-A assembly. J. Cell Biol. 2011, 192:569-582.
66. Samoshkin A., Arnaoutov A., Jansen L.E., Ouspenski I., Dye L., Karpova T., McNally J., Dasso M., Cleveland D.W., Strunnikov A. Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. PLoS One 2009, 4:e6831.
67. Ono T., Losada A., Hirano M., Myers M.P., Neuwald A.F., Hirano T. Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Cell 2003, 115:109-121.
68. Sanchez-Pulido L., Pidoux A.L., Ponting C.P., Allshire R.C. Common ancestry of the CENP-A chaperones Scm3 and HJURP. Cell 2009, 137:1173-1174.
69. Williams J.S., Hayashi T., Yanagida M., Russell P. Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin. Mol. Cell 2009, 33:287-298.
70. Phansalkar R., Lapierre P., Mellone B.G. Evolutionary insights into the role of the essential centromere protein CAL1 in Drosophila. Chromosom. Res. 2012, 20:493-504.
71. Mishra P.K., Au W.C., Choy J.S., Kuich P.H., Baker R.E., Foltz D.R., Basrai M.A. Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells. PLoS Genet. 2011, 7:e1002303.
72. Kato T., Sato N., Hayama S., Yamabuki T., Ito T., Miyamoto M., Kondo S., Nakamura Y., Daigo Y. Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Cancer Res. 2007, 67:8544-8553.
73. Hu Z., Huang G., Sadanandam A., Gu S., Lenburg M.E., Pai M., Bayani N., Blakely E.A., Gray J.W., Mao J.-H. The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer. Breast Cancer 2010, 12:R18.
74. Shuaib M., Ouararhni K., Dimitrov S., Hamiche A. HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:1349-1354.
75. Hu H., Liu Y., Wang M., Fang J., Huang H., Yang N., Li Y., Wang J., Yao X., Shi Y., Li G., Xu R.M. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. Genes Dev. 2011, 25:901-906.
76. Zhou Z., Feng H., Zhou B.R., Ghirlando R., Hu K., Zwolak A., Miller Jenkins L.M., Xiao H., Tjandra N., Wu C., Bai Y. Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3. Nature 2011, 472:234-237.
77. Cho U.S., Harrison S.C. Recognition of the centromere-specific histone Cse4 by the chaperone Scm3. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:9367-9371.
78. Hong J., Feng H., Zhou Z., Ghirlando R., Bai Y. Identification of functionally conserved regions in the structure of the chaperone/CenH3/H4 complex. J. Mol. Biol. 2013, 425:536-545.
79. Bassett E.A., DeNizio J., Barnhart-Dailey M.C., Panchenko T., Sekulic N., Rogers D.J., Foltz D.R., Black B.E. HJURP uses distinct CENP-A surfaces to recognize and to stabilize CENP-A/histone H4 for centromere assembly. Dev. Cell 2012, 22:749-762.
80. Xiao H., Mizuguchi G., Wisniewski J., Huang Y., Wei D., Wu C. Nonhistone Scm3 binds to AT-rich DNA to organize atypical centromeric nucleosome of budding yeast. Mol. Cell 2011, 43:369-380.
81. Malik H.S., Vermaak D., Henikoff S. Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:1449-1454.
82. Churchill M.E., Suzuki M. 'SPKK' motifs prefer to bind to DNA at A/T-rich sites. EMBO J. 1989, 8:4189-4195.
83. Mizuguchi G., Xiao H., Wisniewski J., Smith M.M., Wu C. Nonhistone Scm3 and histones CenH3-H4 assemble the core of centromere-specific nucleosomes. Cell 2007, 129:1153-1164.
84. Dechassa M.L., Wyns K., Li M., Hall M.A., Wang M.D., Luger K. Structure and Scm3-mediated assembly of budding yeast centromeric nucleosomes. Nat. Commun. 2011, 2:313.
85. Zasadzinska E., Barnhart-Dailey M.C., Kuich P.H., Foltz D.R. Dimerization of the CENP-A assembly factor HJURP is required for centromeric nucleosome deposition. EMBO J. 2013, 32:2113-2124.
86. Perpelescu M., Nozaki N., Obuse C., Yang H., Yoda K. Active establishment of centromeric CENP-A chromatin by RSF complex. J. Cell Biol. 2009, 185:397-407.
87. Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. Genes Cells 2006, 11:673-684.
88. Mishima M., Kaitna S., Glotzer M. Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Dev. Cell 2002, 2:41-54.
89. Lagana A., Dorn J.F., De Rop V., Ladouceur A.M., Maddox A.S., Maddox P.S. A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A. Nat. Cell Biol. 2010, 12:1186-1193.
90. Black B.E., Foltz D.R., Chakravarthy S., Luger K., Woods V.L., Cleveland D.W. Structural determinants for generating centromeric chromatin. Nature 2004, 430:578-582.
91. Conde e Silva N., Black B.E., Sivolob A., Filipski J., Cleveland D.W., Prunell A. CENP-A-containing nucleosomes: easier disassembly versus exclusive centromeric localization. J. Mol. Biol. 2007, 370:555-573.
92. Dalal Y., Wang H., Lindsay S., Henikoff S. Tetrameric structure of centromeric nucleosomes in interphase Drosophila cells. PLoS Biol. 2007, 5:e218.
93. Dimitriadis E.K., Weber C., Gill R.K., Diekmann S., Dalal Y. Tetrameric organization of vertebrate centromeric nucleosomes. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:20317-20322.
94. Furuyama T., Codomo C.A., Henikoff S. Reconstitution of hemisomes on budding yeast centromeric DNA. Nucleic Acids Res. 2013, 41:5769-5783.
95. Shivaraju M., Unruh J.R., Slaughter B.D., Mattingly M., Berman J., Gerton J.L. Cell-cycle-coupled structural oscillation of centromeric nucleosomes in yeast. Cell 2012, 150:304-316.
96. Bui M., Dimitriadis E.K., Hoischen C., An E., Quenet D., Giebe S., Nita-Lazar A., Diekmann S., Dalal Y. Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo. Cell 2012, 150:317-326.
97. Miell M.D., Fuller C.J., Guse A., Barysz H.M., Downes A., Owen-Hughes T., Rappsilber J., Straight A.F., Allshire R.C. CENP-A confers a reduction in height on octameric nucleosomes. Nat. Struct. Mol. Biol. 2013, 20:763-765.
98. Dunleavy E.M., Almouzni G., Karpen G.H. H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G(1) phase. Nucleus 2011, 2:146-157.
99. Tagami H., Ray-Gallet D., Almouzni G., Nakatani Y. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell 2004, 116:51-61.
100. Ray-Gallet D., Quivy J.P., Scamps C., Martini E.M., Lipinski M., Almouzni G. HIRA is critical for a nucleosome assembly pathway independent of DNA synthesis. Mol. Cell 2002, 9:1091-1100.
101. Jullien J., Astrand C., Szenker E., Garrett N., Almouzni G., Gurdon J. HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes. Epigenetics Chromatin 2012, 5:17.
102. Szenker E., Lacoste N., Almouzni G. A developmental requirement for HIRA-dependent H3.3 deposition revealed at gastrulation in Xenopus. Cell Rep. 2012, 1:730-740.
103. Drane P., Ouararhni K., Depaux A., Shuaib M., Hamiche A. The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev. 2010, 24:1253-1265.
104. Goldberg A.D., Banaszynski L.A., Noh K.M., Lewis P.W., Elsaesser S.J., Stadler S., Dewell S., Law M., Guo X., Li X., Wen D., Chapgier A., DeKelver R.C., Miller J.C., Lee Y.L., Boydston E.A., Holmes M.C., Gregory P.D., Greally J.M., Rafii S., Yang C., Scambler P.J., Garrick D., Gibbons R.J., Higgs D.R., Cristea I.M., Urnov F.D., Zheng D., Allis C.D. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell 2010, 140:678-691.
105. Elsässer S.J., Huang H., Lewis P.W., Chin J.W., Allis C.D., Patel D.J. DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature 2012, 491:560-565.
106. Lewis P.W., Elsaesser S.J., Noh K.M., Stadler S.C., Allis C.D. DAXX is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:14075-14080.
107. Cedar H., Bergman Y. Linking DNA methylation and histone modification: patterns and paradigms. Nat. Rev. Genet. 2009, 10:295-304.
108. Tan M., Luo H., Lee S., Jin F., Yang J.S., Montellier E., Buchou T., Cheng Z., Rousseaux S., Rajagopal N., Lu Z., Ye Z., Zhu Q., Wysocka J., Ye Y., Khochbin S., Ren B., Zhao Y. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 2011, 146:1016-1028.
109. Kim I.S., Lee M., Park K.C., Jeon Y., Park J.H., Hwang E.J., Jeon T.I., Ko S., Lee H., Baek S.H., Kim K.I. Roles of Mis18alpha in epigenetic regulation of centromeric chromatin and CENP-A loading. Mol. Cell 2012, 46:260-273.
110. Gopalakrishnan S., Sullivan B.A., Trazzi S., Della Valle G., Robertson K.D. DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. Hum. Mol. Genet. 2009, 18:3178-3193.
111. Kunitoku N., Sasayama T., Marumoto T., Zhang D., Honda S., Kobayashi O., Hatakeyama K., Ushio Y., Saya H., Hirota T. CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev. Cell 2003, 5:853-864.
112. Zeitlin S.G., Shelby R.D., Sullivan K.F. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J. Cell Biol. 2001, 155:1147-1157.
113. Bailey A.O., Panchenko T., Sathyan K.M., Petkowski J.J., Pai P.J., Bai D.L., Russell D.H., Macara I.G., Shabanowitz J., Hunt D.F., Black B.E., Foltz D.R. Posttranslational modification of CENP-A influences the conformation of centromeric chromatin. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:11827-11832.
114. Bui M., Walkiewicz M.P., Dimitriadis E.K., Dalal Y. The CENP-A nucleosome: a battle between Dr Jekyll and Mr Hyde. Nucleus 2013, 4:37-42.
115. Manohar M., Mooney A.M., North J.A., Nakkula R.J., Picking J.W., Edon A., Fishel R., Poirier M.G., Ottesen J.J. Acetylation of histone H3 at the nucleosome dyad alters DNA-histone binding. J. Biol. Chem. 2009, 284:23312-23321.
116. Tropberger P., Pott S., Keller C., Kamieniarz-Gdula K., Caron M., Richter F., Li G., Mittler G., Liu E.T., Buhler M., Margueron R., Schneider R. Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. Cell 2013, 152:859-872.
117. Bergmann J.H., Rodriguez M.G., Martins N.M., Kimura H., Kelly D.A., Masumoto H., Larionov V., Jansen L.E., Earnshaw W.C. Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. EMBO J. 2011, 30:328-340.
118. Gassmann R., Rechtsteiner A., Yuen K.W., Muroyama A., Egelhofer T., Gaydos L., Barron F., Maddox P., Essex A., Monen J., Ercan S., Lieb J.D., Oegema K., Strome S., Desai A. An inverse relationship to germline transcription defines centromeric chromatin in C. elegans. Nature 2012, 484:534-537.
119. Chan F.L., Marshall O.J., Saffery R., Kim B.W., Earle E., Choo K.H., Wong L.H. Active transcription and essential role of RNA polymerase II at the centromere during mitosis. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:1979-1984.
120. Hall L.E., Mitchell S.E., O'Neill R.J. Pericentric and centromeric transcription: a perfect balance required. Chromosome Res. 2012, 20:535-546.
121. Chan F.L., Wong L.H. Transcription in the maintenance of centromere chromatin identity. Nucleic Acids Res. 2012, 40:11178-11188.
122. Choi E.S., Stralfors A., Catania S., Castillo A.G., Svensson J.P., Pidoux A.L., Ekwall K., Allshire R.C. Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast. PLoS Genet. 2012, 8:e1002985.
123. Amato A., Schillaci T., Lentini L., Di Leonardo A. CENPA overexpression promotes genome instability in pRb-depleted human cells. Mol. Cancer 2009, 8:119.
124. Tomonaga T., Matsushita K., Yamaguchi S., Oohashi T., Shimada H., Ochiai T., Yoda K., Nomura F. Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer. Cancer Res. 2003, 63:3511-3516.
125. Wu Q., Qian Y.M., Zhao X.L., Wang S.M., Feng X.J., Chen X.F., Zhang S.H. Expression and prognostic significance of centromere protein A in human lung adenocarcinoma. Lung Cancer 2012, 77:407-414.
126. McGovern S.L., Qi Y., Pusztai L., Symmans W.F., Buchholz T.A. Centromere protein-A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor-positive breast cancer. Breast Cancer Res. 2012, 14:R72.
127. Qiu J.J., Guo J.J., Lv T.J., Jin H.Y., Ding J.X., Feng W.W., Zhang Y., Hua K.Q. Prognostic value of centromere protein-A expression in patients with epithelial ovarian cancer. Tumour Biol. 2013, 34:2971-2975.
128. Moreno-Moreno O., Torras-Llort M., Azorin F. Proteolysis restricts localization of CID, the centromere-specific histone H3 variant of Drosophila, to centromeres. Nucleic Acids Res. 2006, 34:6247-6255.
129. Collins K.A., Camahort R., Seidel C., Gerton J.L., Biggins S. The overexpression of a Saccharomyces cerevisiae centromeric histone H3 variant mutant protein leads to a defect in kinetochore biorientation. Genetics 2007, 175:513-525.
130. Gkikopoulos T., Singh V., Tsui K., Awad S., Renshaw M.J., Scholfield P., Barton G.J., Nislow C., Tanaka T.U., Owen-Hughes T. The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4. EMBO J. 2011, 30:1919-1927.
131. Hewawasam G., Shivaraju M., Mattingly M., Venkatesh S., Martin-Brown S., Florens L., Workman J.L., Gerton J.L. Psh1 is an E3 ubiquitin ligase that targets the centromeric histone variant Cse4. Mol. Cell 2010, 40:444-454.
132. Ranjitkar P., Press M.O., Yi X., Baker R., MacCoss M.J., Biggins S. An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain. Mol. Cell 2010, 40:455-464.
133. Schittenhelm R.B., Althoff F., Heidmann S., Lehner C.F. Detrimental incorporation of excess Cenp-A/Cid and Cenp-C into Drosophila centromeres is prevented by limiting amounts of the bridging factor Cal1. J. Cell Sci. 2010, 123:3768-3779.
134. Talbert P.B., Ahmad K., Almouzni G., Ausio J., Berger F., Bhalla P.L., Bonner W.M., Cande W.Z., Chadwick B.P., Chan S.W., Cross G.A., Cui L., Dimitrov S.I., Doenecke D., Eirin-Lopez J.M., Gorovsky M.A., Hake S.B., Hamkalo B.A., Holec S., Jacobsen S.E., Kamieniarz K., Khochbin S., Ladurner A.G., Landsman D., Latham J.A., Loppin B., Malik H.S., Marzluff W.F., Pehrson J.R., Postberg J., Schneider R., Singh M.B., Smith M.M., Thompson E., Torres-Padilla M.E., Tremethick D.J., Turner B.M., Waterborg J.H., Wollmann H., Yelagandula R., Zhu B., Henikoff S. A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin 2012, 5:7.
135. Earnshaw W.C., Cleveland D.W. CENP-A and the CENP nomenclature: response to Talbert and Henikoff. Trends Genet. 2013, 29:500-502.
136. Talbert P.B., Henikoff S. Phylogeny as the basis for naming histones. Trends Genet. 2013, 29:499-500.
137. Allis C.D., Berger S.L., Cote J., Dent S., Jenuwien T., Kouzarides T., Pillus L., Reinberg D., Shi Y., Shiekhattar R., Shilatifard A., Workman J., Zhang Y. New nomenclature for chromatin-modifying enzymes. Cell 2007, 131:633-636.