Roles of Mis18α in Epigenetic Regulation of Centromeric Chromatin and CENP-A Loading

Molecular Cell

Volumn 46, Issue 3, 2012, Pages 260-273

  Kim, Ik Soo ^a   Lee, Minkyoung ^a   Park, Koog Chan ^b   Jeon, Yoon ^c   Park, Joo Hyeon ^b   Hwang, Eun Ju ^a,b   Jeon, Tae Im ^b   Ko, Seoyoung ^a   Lee, Ho ^c   Baek, Sung Hee ^a   Kim, Keun Il ^b  

^a Seoul National University   (South Korea)

^b Sookmyung Women's University   (South Korea)

^c National Cancer Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CENTROMERE PROTEIN A; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; UNTRANSLATED RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMATIN; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; EPIGENETICS; GENE; GENE INTERACTION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HISTONE MODIFICATION; KNOCKOUT MOUSE; MIS18ALPHA GENE; MOUSE; NONHUMAN; PROTEIN DEFICIENCY; PROTEIN LOCALIZATION;

ANIMALS; AUTOANTIGENS; BINDING SITES; CENTROMERE; CHROMATIN; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME SEGREGATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPIGENESIS, GENETIC; HELA CELLS; HISTONES; HUMANS; MICE; MICE, KNOCKOUT; PROTEIN INTERACTION MAPPING;

MAMMALIA; MUS;

EID: 84860759279     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.03.021     Document Type: Article

References (33)

1. Allshire R.C., Karpen G.H. Epigenetic regulation of centromeric chromatin: old dogs, new tricks?. Nat. Rev. Genet. 2008, 9:923-937.
2. Baek S.H., Ohgi K.A., Rose D.W., Koo E.H., Glass C.K., Rosenfeld M.G. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-κB and beta-amyloid precursor protein. Cell 2002, 110:55-67.
3. Barnhart M.C., Kuich P.H.J.L., Stellfox M.E., Ward J.A., Bassett E.A., Black B.E., Foltz D.R. HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore. J. Cell Biol. 2011, 194:229-243.
4. Bergmann J.H., Rodriguez M.G., Martins N.M.C., Kimura H., Kelly D.A., Masumoto H., Larionov V., Jansen L.E.T., Earnshaw W.C. Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. EMBO J. 2011, 30:328-340.
5. Bouzinba-Segard H., Guais A., Francastel C. Accumulation of small murine minor satellite transcripts leads to impaired centromeric architecture and function. Proc. Natl. Acad. Sci. USA 2006, 103:8709-8714.
6. Carroll C.W., Silva M.C.C., Godek K.M., Jansen L.E.T., Straight A.F. Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. Nat. Cell Biol. 2009, 11:896-902.
7. Carroll C.W., Milks K.J., Straight A.F. Dual recognition of CENP-A nucleosomes is required for centromere assembly. J. Cell Biol. 2010, 189:1143-1155.
8. Chen T., Ueda Y., Dodge J.E., Wang Z., Li E. Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol. Cell. Biol. 2003, 23:5594-5605.
9. Cleveland D.W., Mao Y., Sullivan K.F. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 2003, 112:407-421.
10. Dunleavy E.M., Roche D., Tagami H., Lacoste N., Ray-Gallet D., Nakamura Y., Daigo Y., Nakatani Y., Almouzni-Pettinotti G. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. Cell 2009, 137:485-497.
11. Ehrlich M., Sanchez C., Shao C., Nishiyama R., Kehrl J., Kuick R., Kubota T., Hanash S.M. ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation. Autoimmunity 2008, 41:253-271.
12. Foltz D.R., Jansen L.E.T., Black B.E., Bailey A.O., Yates J.R., Cleveland D.W. The human CENP-A centromeric nucleosome-associated complex. Nat. Cell Biol. 2006, 8:458-469.
13. Foltz D.R., Jansen L.E.T., Bailey A.O., Yates Iii J.R., Bassett E.A., Wood S., Black B.E., Cleveland D.W. Centromere-specific assembly of CENP-A nucleosomes is mediated by HJURP. Cell 2009, 137:472-484.
14. Fujita Y., Hayashi T., Kiyomitsu T., Toyoda Y., Kokubu A., Obuse C., Yanagida M. Priming of centromere for CENP-A recruitment by human hMis18α, hMis18β, and M18BP1. Dev. Cell 2007, 12:17-30.
15. Gopalakrishnan S., Sullivan B.A., Trazzi S., Della Valle G., Robertson K.D. DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. Hum. Mol. Genet. 2009, 18:3178-3193.
16. Guenatri M., Bailly D., Maison C., Almouzni G. Mouse centric and pericentric satellite repeats form distinct functional heterochromatin. J. Cell Biol. 2004, 166:493-505.
17. Howman E.V., Fowler K.J., Newson A.J., Redward S., MacDonald A.C., Kalitsis P., Choo K.H.A. Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice. Proc. Natl. Acad. Sci. USA 2000, 97:1148-1153.
18. Jeon Y., Ko E., Lee K.Y., Ko M.J., Park S.Y., Kang J., Jeon C.H., Lee H., Hwang D.S. TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells. J. Biol. Chem. 2011, 286:5414-5422.
19. Kim J.H., Kim B., Ling C., Choi H.J., Ohgi K.A., Chen C., Chung C.H., Huber O., Rose D.W., Sawyers C.L., et al. Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-Catenin Complexes. Nature 2005, 434:921-926.
20. Kim K.I., Yan M., Malakhova O., Luo J.-K., Shen M.-F., Zou W., de la Torre J.C., Zhang D.-E. Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Mol. Cell. Biol. 2006, 26:472-479.
21. Kobe B., Kajava A.V. The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol. 2001, 11:725-732.
22. Kwon M.-S., Hori T., Okada M., Fukagawa T. CENP-C is involved in chromosome segregation, mitotic checkpoint function, and kinetochore assembly. Mol. Biol. Cell 2007, 18:2155-2168.
23. Lagana A., Dorn J.F., De Rop V., Ladouceur A.-M., Maddox A.S., Maddox P.S. A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A. Nat. Cell Biol. 2010, 12:1186-1193.
24. Lee H., Lee D.J., Oh S.P., Park H.D., Nam H.H., Kim J.M., Lim D.-S. Mouse emi1 has an essential function in mitotic progression during early embryogenesis. Mol. Cell. Biol. 2006, 26:5373-5381.
25. Lippman Z., Martienssen R. The role of RNA interference in heterochromatic silencing. Nature 2004, 431:364-370.
26. Martens J.H.A., O'Sullivan R.J., Braunschweig U., Opravil S., Radolf M., Steinlein P., Jenuwein T. The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J. 2005, 24:800-812.
27. Moree B., Meyer C.B., Fuller C.J., Straight A.F. CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly. J. Cell Biol. 2011, 194:855-871.
28. Nakano M., Cardinale S., Noskov V.N., Gassmann R., Vagnarelli P., Kandels-Lewis S., Larionov V., Earnshaw W.C., Masumoto H. Inactivation of a human kinetochore by specific targeting of chromatin modifiers. Dev. Cell 2008, 14:507-522.
29. Okano M., Bell D.W., Haber D.A., Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99:247-257.
30. Silva M.C.C., Jansen L.E.T. At the right place at the right time: novel CENP-A binding proteins shed light on centromere assembly. Chromosoma 2009, 118:567-574.
31. Sullivan B.A., Blower M.D., Karpen G.H. Determining centromere identity: cyclical stories and forking paths. Nat. Rev. Genet. 2001, 2:584-596.
32. Tsumura A., Hayakawa T., Kumaki Y., Takebayashi S.i., Sakaue M., Matsuoka C., Shimotohno K., Ishikawa F., Li E., Ueda H.R., et al. Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells 2006, 11:805-814.
33. Yamagata K., Yamazaki T., Miki H., Ogonuki N., Inoue K., Ogura A., Baba T. Centromeric DNA hypomethylation as an epigenetic signature discriminates between germ and somatic cell lineages. Dev. Biol. 2007, 312:419-426.