Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 21, 2013, Pages 8579-8584

  Goutte Gattat, Damien ^a   Shuaib, Muhammad ^b   Ouararhni, Khalid ^b   Gautier, Thierry ^a   Skoufias, Dimitrios A ^c   Hamiche, Ali ^b   Dimitrov, Stefan ^a  

^a INSERM   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c DIF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CENTROMERE PROTEIN A; CENTROMERE PROTEIN C; NUCLEAR PROTEIN; PROTEIN 14 3 3; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL FUNCTION; CENTROMERE; CHROMATIN; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

14-3-3 PROTEINS; AMINO ACID SUBSTITUTION; AUTOANTIGENS; CHROMOSOMAL PROTEINS, NON-HISTONE; HELA CELLS; HUMANS; KINETOCHORES; MITOSIS; MUTATION, MISSENSE; NUCLEOSOMES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY;

EID: 84878140645     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1302955110     Document Type: Article

References (23)

1. Doyen C-M, et al. (2006) Dissection of the unusual structural and functional properties of the variant H2A.Bbd nucleosome. EMBO J 25(18): 4234-4244.
2. Palmer DK, O'Day K, Trong HL, Charbonneau H, Margolis RL (1991) Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone. Proc Natl Acad Sci USA 88(9): 3734-3738.
3. Henikoff S, Dalal Y (2005) Centromeric chromatin: What makes it unique? Curr Opin Genet Dev 15(2): 177-184.
4. Buscaino A, Allshire R, Pidoux A (2010) Building centromeres: Home sweet home or a nomadic existence? Curr Opin Genet Dev 20(2): 118-126.
5. Régnier V, et al. (2005) CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol Cell Biol 25(10): 3967-3981.
6. Shelby RD, Vafa O, Sullivan KF (1997) Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites. J Cell Biol 136(3): 501-513.
7. Vermaak D, Hayden HS, Henikoff S (2002) Centromere targeting element within the histone fold domain of Cid. Mol Cell Biol 22(21): 7553-7561.
8. Chen Y, et al. (2000) The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain. Mol Cell Biol 20(18): 7037-7048.
9. Ravi M, et al. (2011) Meiosis-specific loading of the centromere-specific histone CENH3 in Arabidopsis thaliana. PLoS Genet 7(6):e1002121.
10. Zeitlin SG, Shelby RD, Sullivan KF (2001) CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J Cell Biol 155(7): 1147-1157.
11. Kunitoku N, et al. (2003) CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev Cell 5(6): 853-864.
12. Morey L, Barnes K, Chen Y, Fitzgerald-Hayes M, Baker RE (2004) The histone fold domain of Cse4 is sufficient for CEN targeting and propagation of active centromeres in budding yeast. Eukaryot Cell 3(6): 1533-1543.
13. Ravi M, et al. (2010) The rapidly evolving centromere-specific histone has stringent functional requirements in Arabidopsis thaliana. Genetics 186(2): 461-471.
14. Foltz DR, et al. (2006) The human CENP-A centromeric nucleosome- associated complex. Nat Cell Biol 8(5): 458-469.
15. Gascoigne KE, et al. (2011) Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes. Cell 145(3): 410-422.
16. Aitken A (2011) Post-translational modification of 14-3-3 isoforms and regulation of cellular function. Semin Cell Dev Biol 22(7): 673-680.
17. Shuaib M, Ouararhni K, Dimitrov S, Hamiche A (2010) HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres. Proc Natl Acad Sci USA 107(4): 1349-1354.
18. Przewloka MR, et al. (2011) CENP-C is a structural platform for kinetochore assembly. Curr Biol 21(5): 399-405.
19. Carroll CW, Milks KJ, Straight AF (2010) Dual recognition of CENP-A nucleosomes is required for centromere assembly. J Cell Biol 189(7): 1143-1155.
20. Yoda K, et al. (2000) Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro. Proc Natl Acad Sci USA 97(13): 7266-7271.
21. Tanaka Y, et al. (2004) Expression and purification of recombinant human histones. Methods 33(1): 3-11.
22. Swift S, Lorens J, Achacoso P, Nolan GP (2001) Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systems. Curr Protoc Immunol Chapter 10:10-17C.
23. Winter S, et al. (2008) 14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation. EMBO J 27(1): 88-99.