-
1
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O,. On the origin of cancer cells. Science. 1956; 123: 309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
3
-
-
44449147036
-
Tumor cell metabolism: Cancer's achilles' heel
-
DOI 10.1016/j.ccr.2008.05.005, PII S1535610808001608
-
Kroemer G, Pouyssegur J,. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell. 2008; 13: 472-482. (Pubitemid 351766797)
-
(2008)
Cancer Cell
, vol.13
, Issue.6
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
4
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB,. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009; 324: 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
5
-
-
84858604270
-
Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate
-
Ward PS, Thompson CB,. Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell. 2012; 21: 297-308.
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
-
6
-
-
55349136976
-
A history of cancer chemotherapy
-
DeVita VT Jr, Chu E,. A history of cancer chemotherapy. Cancer Res. 2008; 68: 8643-8653.
-
(2008)
Cancer Res
, vol.68
, pp. 8643-8653
-
-
Devita, Jr.V.T.1
Chu, E.2
-
7
-
-
0031825771
-
New antimetabolites in cancer chemotherapy and their clinical impact
-
Kaye SB,. New antimetabolites in cancer chemotherapy and their clinical impact. Br J Cancer. 1998; 78 (suppl 3): 1-7. (Pubitemid 128710590)
-
(1998)
British Journal of Cancer
, vol.78
, Issue.SUPPL. 1
, pp. 1-7
-
-
Kaye, S.B.1
-
8
-
-
76549218304
-
Treatment of acute leukemia with amethopterin (4-amino, 10-methyl pteroyl glutamic acid)
-
Meyer LM, Miller FR, Rowen MJ, Bock G, Rutzky J,. Treatment of acute leukemia with amethopterin (4-amino, 10-methyl pteroyl glutamic acid). Acta Haematol. 1950; 4: 157-167.
-
(1950)
Acta Haematol
, vol.4
, pp. 157-167
-
-
Meyer, L.M.1
Miller, F.R.2
Rowen, M.J.3
Bock, G.4
Rutzky, J.5
-
9
-
-
0019737171
-
L-Asparaginase: Discovery and development as a tumor-inhibitory agent
-
Broome JD,. L-Asparaginase: discovery and development as a tumor-inhibitory agent. Cancer Treat Rep. 1981; 65 (suppl 4): 111-114. (Pubitemid 13243416)
-
(1981)
Cancer Treatment Reports
, vol.65
, Issue.4
, pp. 111-114
-
-
Broome, J.D.1
-
10
-
-
80052242132
-
Targeting cancer metabolism: A therapeutic window opens
-
Vander Heiden MG,. Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov. 2011; 10: 671-684.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 671-684
-
-
Vander Heiden, M.G.1
-
12
-
-
26644441651
-
ATP citrate lyase inhibition can suppress tumor cell growth
-
DOI 10.1016/j.ccr.2005.09.008, PII S1535610805003016
-
Hatzivassiliou G, Zhao F, Bauer DE, et al. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell. 2005; 8: 311-321. (Pubitemid 41443416)
-
(2005)
Cancer Cell
, vol.8
, Issue.4
, pp. 311-321
-
-
Hatzivassiliou, G.1
Zhao, F.2
Bauer, D.E.3
Andreadis, C.4
Shaw, A.N.5
Dhanak, D.6
Hingorani, S.R.7
Tuveson, D.A.8
Thompson, C.B.9
-
13
-
-
76649126249
-
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
-
Le A, Cooper CR, Gouw AM, et al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A. 2010; 107: 2037-2042.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 2037-2042
-
-
Le, A.1
Cooper, C.R.2
Gouw, A.M.3
-
14
-
-
33846002728
-
+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
DOI 10.1016/j.ccr.2006.10.020, PII S1535610806003722
-
Bonnet S, Archer SL, Allalunis-Turner J, et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007; 11: 37-51. (Pubitemid 46054520)
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
Haromy, A.4
Beaulieu, C.5
Thompson, R.6
Lee, C.T.7
Lopaschuk, G.D.8
Puttagunta, L.9
Bonnet, S.10
Harry, G.11
Hashimoto, K.12
Porter, C.J.13
Andrade, M.A.14
Thebaud, B.15
Michelakis, E.D.16
-
15
-
-
48749093935
-
Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation
-
Cao W, Yacoub S, Shiverick KT, et al. Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation. Prostate. 2008; 68: 1223-1231.
-
(2008)
Prostate
, vol.68
, pp. 1223-1231
-
-
Cao, W.1
Yacoub, S.2
Shiverick, K.T.3
-
16
-
-
53049103850
-
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
-
Michelakis ED, Webster L, Mackey JR,. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer. 2008; 99: 989-994.
-
(2008)
Br J Cancer
, vol.99
, pp. 989-994
-
-
Michelakis, E.D.1
Webster, L.2
MacKey, J.R.3
-
17
-
-
77957937428
-
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
-
Wang JB, Erickson JW, Fuji R, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010; 18: 207-219.
-
(2010)
Cancer Cell
, vol.18
, pp. 207-219
-
-
Wang, J.B.1
Erickson, J.W.2
Fuji, R.3
-
18
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
DOI 10.1038/nature06734, PII NATURE06734
-
Christofk HR, Vander Heiden MG, Harris MH, et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008; 452: 230-233. (Pubitemid 351380249)
-
(2008)
Nature
, vol.452
, Issue.7184
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
19
-
-
23044500915
-
Pyruvate kinase type M2 and its role in tumor growth and spreading
-
DOI 10.1016/j.semcancer.2005.04.009, PII S1044579X0500026X, Tumor Metabolome
-
Mazurek S, Boschek CB, Hugo F, Eigenbrodt E,. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol. 2005; 15: 300-308. (Pubitemid 41058775)
-
(2005)
Seminars in Cancer Biology
, vol.15
, Issue.4
, pp. 300-308
-
-
Mazurek, S.1
Boschek, C.B.2
Hugo, F.3
Eigenbrodt, E.4
-
20
-
-
21844468220
-
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
-
DOI 10.1021/bi0474923
-
Dombrauckas JD, Santarsiero BD, Mesecar AD,. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry. 2005; 44: 9417-9429. (Pubitemid 40962040)
-
(2005)
Biochemistry
, vol.44
, Issue.27
, pp. 9417-9429
-
-
Dombrauckas, J.D.1
Santarsiero, B.D.2
Mesecar, A.D.3
-
21
-
-
77449131347
-
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
-
Hitosugi T, Kang S, Vander Heiden MG, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal. 2009; 2: ra73.
-
(2009)
Sci Signal
, vol.2
-
-
Hitosugi, T.1
Kang, S.2
Vander Heiden, M.G.3
-
22
-
-
79959371914
-
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
-
Lv L, Li D, Zhao D, et al. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell. 2011; 42: 719-730.
-
(2011)
Mol Cell
, vol.42
, pp. 719-730
-
-
Lv, L.1
Li, D.2
Zhao, D.3
-
23
-
-
84866842363
-
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
-
Anastasiou D, Yu Y, Israelsen WJ, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012; 8: 839-847.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 839-847
-
-
Anastasiou, D.1
Yu, Y.2
Israelsen, W.J.3
-
25
-
-
40149095758
-
Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription
-
Lee J, Kim HK, Han YM, Kim J,. Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int J Biochem Cell Biol. 2008; 40: 1043-1054.
-
(2008)
Int J Biochem Cell Biol
, vol.40
, pp. 1043-1054
-
-
Lee, J.1
Kim, H.K.2
Han, Y.M.3
Kim, J.4
-
26
-
-
79957567239
-
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
-
Luo W, Hu H, Chang R, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 2011; 145: 732-744.
-
(2011)
Cell
, vol.145
, pp. 732-744
-
-
Luo, W.1
Hu, H.2
Chang, R.3
-
27
-
-
82555170271
-
Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation
-
Yang W, Xia Y, Ji H, et al. Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature. 2011; 480: 118-122.
-
(2011)
Nature
, vol.480
, pp. 118-122
-
-
Yang, W.1
Xia, Y.2
Ji, H.3
-
28
-
-
77950919036
-
Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma
-
Ren F, Wu H, Lei Y, et al. Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. Mol Cancer. 2010; 9: 81.
-
(2010)
Mol Cancer
, vol.9
, pp. 81
-
-
Ren, F.1
Wu, H.2
Lei, Y.3
-
29
-
-
52949107258
-
Identification of potential genes/proteins regulated by Tiam1 in colorectal cancer by microarray analysis and proteome analysis
-
Liu L, Wang S, Zhang Q, Ding Y,. Identification of potential genes/proteins regulated by Tiam1 in colorectal cancer by microarray analysis and proteome analysis. Cell Biol Int. 2008; 32: 1215-1222.
-
(2008)
Cell Biol Int
, vol.32
, pp. 1215-1222
-
-
Liu, L.1
Wang, S.2
Zhang, Q.3
Ding, Y.4
-
30
-
-
84869077946
-
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth
-
Hitosugi T, Zhou L, Elf S, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012; 22: 585-600.
-
(2012)
Cancer Cell
, vol.22
, pp. 585-600
-
-
Hitosugi, T.1
Zhou, L.2
Elf, S.3
-
31
-
-
67650165225
-
Metabolic transformation in cancer
-
Tennant DA, Duran RV, Boulahbel H, Gottlieb E,. Metabolic transformation in cancer. Carcinogenesis. 2009; 30: 1269-1280.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1269-1280
-
-
Tennant, D.A.1
Duran, R.V.2
Boulahbel, H.3
Gottlieb, E.4
-
32
-
-
77949967131
-
Targeting metabolic transformation for cancer therapy
-
Tennant DA, Duran RV, Gottlieb E,. Targeting metabolic transformation for cancer therapy. Nat Rev Cancer. 2010; 10: 267-277.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 267-277
-
-
Tennant, D.A.1
Duran, R.V.2
Gottlieb, E.3
-
33
-
-
33846948971
-
The regulation of energy generating metabolic pathways by p53
-
Corcoran CA, Huang Y, Sheikh MS,. The regulation of energy generating metabolic pathways by p53. Cancer Biol Ther. 2006; 5: 1610-1613.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 1610-1613
-
-
Corcoran, C.A.1
Huang, Y.2
Sheikh, M.S.3
-
34
-
-
27144510184
-
Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling
-
DOI 10.1038/nbt1149, PII N1149
-
Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF,. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nat Biotechnol. 2005; 23: 1303-1307. (Pubitemid 41486859)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.10
, pp. 1303-1307
-
-
Evans, M.J.1
Saghatelian, A.2
Sorensen, E.J.3
Cravatt, B.F.4
-
35
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009; 361: 1058-1066.
-
(2009)
N Engl J Med
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
-
36
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009; 360: 765-773.
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
-
37
-
-
77149134353
-
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
-
Gross S, Cairns RA, Minden MD, et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med. 2010; 207: 339-344.
-
(2010)
J Exp Med
, vol.207
, pp. 339-344
-
-
Gross, S.1
Cairns, R.A.2
Minden, M.D.3
-
38
-
-
79951542753
-
2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations
-
Jin G, Reitman ZJ, Spasojevic I, et al. 2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. PLoS One. 2011; 6: e16812.
-
(2011)
PLoS One
, vol.6
-
-
Jin, G.1
Reitman, Z.J.2
Spasojevic, I.3
-
39
-
-
77953702324
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2010; 465: 966.
-
(2010)
Nature
, vol.465
, pp. 966
-
-
Dang, L.1
White, D.W.2
Gross, S.3
-
40
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward PS, Patel J, Wise DR, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010; 17: 225-234.
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
-
41
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010; 18: 553-567.
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
-
42
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu C, Ward PS, Kapoor GS, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012; 483: 474-478.
-
(2012)
Nature
, vol.483
, pp. 474-478
-
-
Lu, C.1
Ward, P.S.2
Kapoor, G.S.3
-
43
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
Rohle D, Popovici-Muller J, Palaskas N, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013; 340: 626-630.
-
(2013)
Science
, vol.340
, pp. 626-630
-
-
Rohle, D.1
Popovici-Muller, J.2
Palaskas, N.3
-
44
-
-
84877620952
-
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
-
Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013; 340: 622-626.
-
(2013)
Science
, vol.340
, pp. 622-626
-
-
Wang, F.1
Travins, J.2
Delabarre, B.3
-
45
-
-
77950191479
-
Targeting cancer cell metabolism: The combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells
-
Ben Sahra I, Laurent K, Giuliano S, et al. Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res. 2010; 70: 2465-2475.
-
(2010)
Cancer Res
, vol.70
, pp. 2465-2475
-
-
Ben Sahra, I.1
Laurent, K.2
Giuliano, S.3
-
46
-
-
78650181190
-
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
-
Wellen KE, Lu C, Mancuso A, et al. The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev. 2010; 24: 2784-2799.
-
(2010)
Genes Dev
, vol.24
, pp. 2784-2799
-
-
Wellen, K.E.1
Lu, C.2
Mancuso, A.3
-
47
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
Metallo CM, Gameiro PA, Bell EL, et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. 2012; 481: 380-384.
-
(2012)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
-
48
-
-
83255171153
-
Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells
-
Fan J, Hitosugi T, Chung TW, et al. Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells. Mol Cell Biol. 2011; 31: 4938-4950.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 4938-4950
-
-
Fan, J.1
Hitosugi, T.2
Chung, T.W.3
-
49
-
-
84255162057
-
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
-
Hitosugi T, Fan J, Chung TW, et al. Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell. 2011; 44: 864-877.
-
(2011)
Mol Cell
, vol.44
, pp. 864-877
-
-
Hitosugi, T.1
Fan, J.2
Chung, T.W.3
-
50
-
-
84877781067
-
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
-
Hitosugi T, Zhou L, Fan J, et al. Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nat Commun. 2013; 4: 1790.
-
(2013)
Nat Commun
, vol.4
, pp. 1790
-
-
Hitosugi, T.1
Zhou, L.2
Fan, J.3
|