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Volumn 19, Issue 1, 2014, Pages 79-97

Emerging drugs for acromegaly

Author keywords

Acromegaly; Antisense drugs; Lanreotide; Octreotide; Pasireotide; Pegvisomant; Somatoprim; Somatostatin analogs; Temozolomide

Indexed keywords

ANGIOPEPTIN; ATL 1103; BIM 23A 760; BIM 23A760; HEPTAPEPTIDE; LIGAND; OCTREOTIDE; PASIREOTIDE; PEGVISOMANT; SOMATOPRIM; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

EID: 84896715491     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.2014.875529     Document Type: Review
Times cited : (11)

References (200)
  • 1
    • 0023886723 scopus 로고
    • Epidemiology and long-term survival in acromegaly. A study of 166 cases diagnosed between 1955 and 1984
    • Bengtsson BA, Eden S, Ernest I, et al. Epidemiology and long-term survival in acromegaly. A study of 166 cases diagnosed between 1955 and 1984. Acta Med Scand 1988;223:327-35
    • (1988) Acta Med Scand , vol.223 , pp. 327-335
    • Bengtsson, B.A.1    Eden, S.2    Ernest, I.3
  • 3
    • 0025409756 scopus 로고
    • Ascertainment and natural history of treated acromegaly in Northern Ireland
    • Ritchie CM, Atkinson AB, Kennedy AL, et al. Ascertainment and natural history of treated acromegaly in Northern Ireland. Ulster Med J 1990;59:55-62
    • (1990) Ulster Med J , vol.59 , pp. 55-62
    • Ritchie, C.M.1    Atkinson, A.B.2    Kennedy, A.L.3
  • 4
    • 0033139863 scopus 로고    scopus 로고
    • Epidemiology of acromegaly
    • A comprehensive analysis of the epidemiology of acromegaly
    • Holdaway IM, Rajasoorya C. Epidemiology of acromegaly. Pituitary 1999;2:29-41 . A comprehensive analysis of the epidemiology of acromegaly.
    • (1999) Pituitary , vol.2 , pp. 29-41
    • Holdaway, I.M.1    Rajasoorya, C.2
  • 6
    • 84885383850 scopus 로고    scopus 로고
    • Epidemiology of acromegaly in Spain
    • Sesmilo G. Epidemiology of acromegaly in Spain. Endocrinol Nutr 2013;60:470-4
    • (2013) Endocrinol Nutr , vol.60 , pp. 470-474
    • Sesmilo, G.1
  • 7
    • 33845489470 scopus 로고    scopus 로고
    • High prevalence of pituitary adenomas: A cross-sectional study in the province of Liege, Belgium
    • Daly AF, Rixhon M, Adam C, et al. High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium. J Clin Endocrinol Metab 2006;91:4769-75
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4769-4775
    • Daly, A.F.1    Rixhon, M.2    Adam, C.3
  • 8
    • 49649113676 scopus 로고    scopus 로고
    • High prevalence of biochemical acromegaly in primary care patients with elevated IGF-1 levels
    • Schneider HJ, Sievers C, Saller B, et al. High prevalence of biochemical acromegaly in primary care patients with elevated IGF-1 levels. Clin Endocrinol (Oxf) 2008;69:432-5
    • (2008) Clin Endocrinol (Oxf) , vol.69 , pp. 432-5
    • Schneider, H.J.1    Sievers, C.2    Saller, B.3
  • 9
    • 45149091776 scopus 로고    scopus 로고
    • Changing patterns in diagnosis and therapy of acromegaly over two decades
    • Nachtigall L, Delgado A, Swearingen B, et al. Changing patterns in diagnosis and therapy of acromegaly over two decades. J Clin Endocrinol Metab 2008;93:2035-41
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2035-2041
    • Nachtigall, L.1    Delgado, A.2    Swearingen, B.3
  • 11
    • 74549215580 scopus 로고    scopus 로고
    • Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006: Acromegaly remains underrecognized and under-diagnosed
    • Reid TJ, Post KD, Bruce JN, et al. Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006: acromegaly remains underrecognized and under-diagnosed. Clin Endocrinol (Oxf) 2010;72:203-8
    • (2010) Clin Endocrinol (Oxf) , vol.72 , pp. 203-208
    • Reid, T.J.1    Post, K.D.2    Bruce, J.N.3
  • 12
    • 77956574952 scopus 로고    scopus 로고
    • Approach to the patient with persistent acromegaly after pituitary surgery
    • A useful and clinically oriented description of approaching patients with persistent acromegaly
    • Katznelson L. Approach to the patient with persistent acromegaly after pituitary surgery. J Clin Endocrinol Metab 2010;95:4114-23 . A useful and clinically oriented description of approaching patients with persistent acromegaly.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 4114-4123
    • Katznelson, L.1
  • 13
    • 79960108314 scopus 로고    scopus 로고
    • A novel approach to the detection of acromegaly: Accuracy of diagnosis by automatic face classification
    • Schneider HJ, Kosilek RP, Gunther M, et al. A novel approach to the detection of acromegaly: accuracy of diagnosis by automatic face classification. J Clin Endocrinol Metab 2011;96:2074-80
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2074-2080
    • Schneider, H.J.1    Kosilek, R.P.2    Gunther, M.3
  • 14
    • 84881373958 scopus 로고    scopus 로고
    • A consensus on the diagnosis and treatment of acromegaly complications
    • Melmed S, Casanueva FF, Klibanski A, et al. A consensus on the diagnosis and treatment of acromegaly complications. Pituitary 2013;16:294-302
    • (2013) Pituitary , vol.16 , pp. 294-302
    • Melmed, S.1    Casanueva, F.F.2    Klibanski, A.3
  • 15
    • 84871376575 scopus 로고    scopus 로고
    • Acromegaly: Role of surgery in the therapeutic armamentarium
    • Guinto G, Abdo M, Zepeda E, et al. Acromegaly: role of surgery in the therapeutic armamentarium. Int J Endocrinol 2012;2012:306094
    • (2012) Int J Endocrinol , vol.2012 , pp. 306094
    • Guinto, G.1    Abdo, M.2    Zepeda, E.3
  • 16
    • 84879551291 scopus 로고    scopus 로고
    • Ectopic acromegaly due to growth hormone releasing hormone
    • Ghazi AA, Amirbaigloo A, Dezfooli AA, et al. Ectopic acromegaly due to growth hormone releasing hormone. Endocrine 2013;43:293-302
    • (2013) Endocrine , vol.43 , pp. 293-302
    • Ghazi, A.A.1    Amirbaigloo, A.2    Dezfooli, A.A.3
  • 17
    • 0030832510 scopus 로고    scopus 로고
    • Pathophysiology and clinical aspects of the ectopic GH-releasing hormone syndrome
    • Losa M, von Werder K. Pathophysiology and clinical aspects of the ectopic GH-releasing hormone syndrome. Clin Endocrinol (Oxf) 1997;47:123-35
    • (1997) Clin Endocrinol (Oxf) , vol.47 , pp. 123-135
    • Losa, M.1    Von Werder, K.2
  • 18
    • 84861997432 scopus 로고    scopus 로고
    • Clinical characteristics and outcome of acromegaly induced by ectopic secretion of growth hormone-releasing hormone (GHRH): A French nationwide series of 21 cases
    • Garby L, Caron P, Claustrat F, et al. Clinical characteristics and outcome of acromegaly induced by ectopic secretion of growth hormone-releasing hormone (GHRH): a French nationwide series of 21 cases. J Clin Endocrinol Metab 2012;97:2093-104
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2093-2104
    • Garby, L.1    Caron, P.2    Claustrat, F.3
  • 19
    • 33845491265 scopus 로고    scopus 로고
    • Medical progress: Acromegaly
    • A concise review of the disease: pathogenesis, clinical features, diagnosis and treatment
    • Melmed S. Medical progress: acromegaly. N Engl J Med 2006;355:2558-73 . A concise review of the disease: pathogenesis, clinical features, diagnosis and treatment.
    • (2006) N Engl J Med , vol.355 , pp. 2558-2573
    • Melmed, S.1
  • 22
    • 70449366466 scopus 로고    scopus 로고
    • Acromegaly pathogenesis and treatment
    • Melmed S. Acromegaly pathogenesis and treatment. J Clin Invest 2009;119:3189-202
    • (2009) J Clin Invest , vol.119 , pp. 3189-3202
    • Melmed, S.1
  • 23
    • 1442326975 scopus 로고    scopus 로고
    • Systemic complications of acromegaly: Epidemiology, pathogenesis, and management
    • Colao A, Ferone D, Marzullo P, Lombardi G. Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev 2004;25:102-52
    • (2004) Endocr Rev , vol.25 , pp. 102-152
    • Colao, A.1    Ferone, D.2    Marzullo, P.3    Lombardi, G.4
  • 26
    • 0031759850 scopus 로고    scopus 로고
    • Mortality and cancer incidence in acromegaly: A retrospective cohort study. United Kingdom Acromegaly Study Group
    • Orme SM, McNally RJ, Cartwright RA, Belchetz PE. Mortality and cancer incidence in acromegaly: a retrospective cohort study. United Kingdom Acromegaly Study Group. J Clin Endocrinol Metab 1998;83:2730-4
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2730-2734
    • Orme, S.M.1    McNally, R.J.2    Cartwright, R.A.3    Belchetz, P.E.4
  • 28
    • 1442303361 scopus 로고    scopus 로고
    • Factors influencing mortality in acromegaly
    • Holdaway IM. Factors influencing mortality in acromegaly. J Clin Endocrinol Metab 2004;89:667-74
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 667-674
    • Holdaway, I.M.1
  • 29
    • 49649124901 scopus 로고    scopus 로고
    • A meta-analysis of the effect of lowering serum levels of GH and IGF-I on mortality in acromegaly
    • Holdaway IM, Bolland MJ, Gamble GD. A meta-analysis of the effect of lowering serum levels of GH and IGF-I on mortality in acromegaly. Eur J Endocrinol 2008;159:89-95
    • (2008) Eur J Endocrinol , vol.159 , pp. 89-95
    • Holdaway, I.M.1    Bolland, M.J.2    Gamble, G.D.3
  • 30
  • 31
    • 0035404392 scopus 로고    scopus 로고
    • Acromegaly and cancer: Not a problem?
    • Melmed S. Acromegaly and cancer: not a problem? J Clin Endocrinol Metab 2001;86:2929-34
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2929-2934
    • Melmed, S.1
  • 33
    • 80053923341 scopus 로고    scopus 로고
    • Clinical, quality of life, and economic value of acromegaly disease control
    • A paper that focuses on patientcentered and economic aspects of disease control
    • Ben-Shlomo A, Sheppard MC, Stephens JM, et al. Clinical, quality of life, and economic value of acromegaly disease control. Pituitary 2011;14:284-94 . A paper that focuses on patientcentered and economic aspects of disease control.
    • (2011) Pituitary , vol.14 , pp. 284-294
    • Ben-Shlomo, A.1    Sheppard, M.C.2    Stephens, J.M.3
  • 34
    • 84874717906 scopus 로고    scopus 로고
    • Acromegaly: The disease, its impact on patients, and managing the burden of long-term treatment
    • Adelman DT, Liebert KJ, Nachtigall LB, et al. Acromegaly: the disease, its impact on patients, and managing the burden of long-term treatment. Int J Gen Med 2013;6:31-8
    • (2013) Int J Gen Med , vol.6 , pp. 31-38
    • Adelman, D.T.1    Liebert, K.J.2    Nachtigall, L.B.3
  • 35
    • 84879276193 scopus 로고    scopus 로고
    • An update on the treatment of acromegaly
    • Heaney A, Edling K. An update on the treatment of acromegaly. Res Rep Endocr Disord 2013;3:1-11
    • (2013) Res Rep Endocr Disord , vol.3 , pp. 1-11
    • Heaney, A.1    Edling, K.2
  • 36
    • 84877666408 scopus 로고    scopus 로고
    • The place of medical treatment of acromegaly: Current status and perspectives
    • Jallad RS, Bronstein MD. The place of medical treatment of acromegaly: current status and perspectives. Expert Opin Pharmacother 2013;14:1001-15
    • (2013) Expert Opin Pharmacother , vol.14 , pp. 1001-1015
    • Jallad, R.S.1    Bronstein, M.D.2
  • 37
    • 84871944971 scopus 로고    scopus 로고
    • Long-term outcome in patients with acromegaly: Analysis of 1344 patients from the German Acromegaly Register
    • Schofl C, Franz H, Grussendorf M, et al. Long-term outcome in patients with acromegaly: analysis of 1344 patients from the German Acromegaly Register. Eur J Endocrinol 2013;168:39-47
    • (2013) Eur J Endocrinol , vol.168 , pp. 39-47
    • Schofl, C.1    Franz, H.2    Grussendorf, M.3
  • 38
    • 84873704038 scopus 로고    scopus 로고
    • Changes in acromegaly treatment over four decades in Spain: Analysis of the Spanish Acromegaly Registry (REA)
    • Sesmilo G, Gaztambide S, Venegas E, et al. Changes in acromegaly treatment over four decades in Spain: analysis of the Spanish Acromegaly Registry (REA). Pituitary 2013;16:115-21
    • (2013) Pituitary , vol.16 , pp. 115-121
    • Sesmilo, G.1    Gaztambide, S.2    Venegas, E.3
  • 40
    • 84874860258 scopus 로고    scopus 로고
    • A comprehensive study of clinical, biochemical, radiological, vascular, cardiac, and sleep parameters in an unselected cohort of patients with acromegaly undergoing presurgical somatostatin receptor ligand therapy
    • Annamalai AK, Webb A, Kandasamy N, et al. A comprehensive study of clinical, biochemical, radiological, vascular, cardiac, and sleep parameters in an unselected cohort of patients with acromegaly undergoing presurgical somatostatin receptor ligand therapy. J Clin Endocrinol Metab 2013;98:1040-50
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 1040-1050
    • Annamalai, A.K.1    Webb, A.2    Kandasamy, N.3
  • 41
    • 39149093032 scopus 로고    scopus 로고
    • Medical consequences of acromegaly: What are the effects of biochemical control?
    • Colao A, Auriemma RS, Pivonello R, et al. Medical consequences of acromegaly: what are the effects of biochemical control? Rev Endocr Metab Disord 2008;9:21-31
    • (2008) Rev Endocr Metab Disord , vol.9 , pp. 21-31
    • Colao, A.1    Auriemma, R.S.2    Pivonello, R.3
  • 42
    • 84864351447 scopus 로고    scopus 로고
    • Progression of acromegalic arthropathy despite long-term biochemical control: A prospective, radiological study
    • Claessen KM, Ramautar SR, Pereira AM, et al. Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study. Eur J Endocrinol 2012;167:235-44
    • (2012) Eur J Endocrinol , vol.167 , pp. 235-244
    • Claessen, K.M.1    Ramautar, S.R.2    Pereira, A.M.3
  • 43
    • 84859542868 scopus 로고    scopus 로고
    • Update on pituitary surgery
    • Swearingen B. Update on pituitary surgery. J Clin Endocrinol Metab 2012;97:1073-81
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1073-1081
    • Swearingen, B.1
  • 44
    • 77956181344 scopus 로고    scopus 로고
    • Endocrine outcomes in endoscopic pituitary surgery: A literature review
    • Dorward NL. Endocrine outcomes in endoscopic pituitary surgery: a literature review. Acta Neurochir (Wien) 2010;152:1275-9
    • (2010) Acta Neurochir (Wien) , vol.152 , pp. 1275-1279
    • Dorward, N.L.1
  • 45
    • 80052517177 scopus 로고    scopus 로고
    • Endoscopic transsphenoidal surgery for acromegaly: Remission using modern criteria, complications, and predictors of outcome
    • Jane JA, Starke RM, Elzoghby MA, et al. Endoscopic transsphenoidal surgery for acromegaly: remission using modern criteria, complications, and predictors of outcome. J Clin Endocrinol Metab 2011;96:2732-40
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2732-2740
    • Jane, J.A.1    Starke, R.M.2    Elzoghby, M.A.3
  • 46
    • 23844445201 scopus 로고    scopus 로고
    • Predictors and rates of treatment-resistant tumor growth in acromegaly
    • Besser GM, Burman P, Daly AF. Predictors and rates of treatment-resistant tumor growth in acromegaly. Eur J Endocrinol 2005;153:187-93
    • (2005) Eur J Endocrinol , vol.153 , pp. 187-193
    • Besser, G.M.1    Burman, P.2    Daly, A.F.3
  • 47
    • 0023930012 scopus 로고
    • Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients
    • Ross DA, Wilson CB. Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients. J Neurosurg 1988;68:854-67
    • (1988) J Neurosurg , vol.68 , pp. 854-867
    • Ross, D.A.1    Wilson, C.B.2
  • 48
    • 0027448417 scopus 로고
    • Transsphenoidal adenomectomy for growth hormone-secreting pituitary adenomas in acromegaly: Outcome analysis and determinants of failure
    • Tindall GT, Oyesiku NM, Watts NB, et al. Transsphenoidal adenomectomy for growth hormone-secreting pituitary adenomas in acromegaly: outcome analysis and determinants of failure. J Neurosurg 1993;78:205-15
    • (1993) J Neurosurg , vol.78 , pp. 205-215
    • Tindall, G.T.1    Oyesiku, N.M.2    Watts, N.B.3
  • 49
    • 0032717285 scopus 로고    scopus 로고
    • Outcome of surgery for acromegaly-The experience of a dedicated pituitary surgeon
    • Gittoes NJ, Sheppard MC, Johnson a P, Stewart PM. Outcome of surgery for acromegaly-the experience of a dedicated pituitary surgeon. QJM 1999;92:741-5
    • (1999) QJM , vol.92 , pp. 741-745
    • Gittoes, N.J.1    Sheppard, M.C.2    Johnson, A.P.3    Stewart, P.M.4
  • 50
    • 0032939537 scopus 로고    scopus 로고
    • Outcome of transphenoidal surgery for acromegaly and its relationship to surgical experience
    • Ahmed S, Elsheikh M, Stratton IM, et al. Outcome of transphenoidal surgery for acromegaly and its relationship to surgical experience. Clin Endocrinol (Oxf) 1999;50:561-7
    • (1999) Clin Endocrinol (Oxf) , vol.50 , pp. 561-567
    • Ahmed, S.1    Elsheikh, M.2    Stratton, I.M.3
  • 51
    • 0027999707 scopus 로고
    • Factors determining the long-term outcome of surgery for acromegaly
    • Osman IA, James RA, Chatterjee S, et al. Factors determining the long-term outcome of surgery for acromegaly. QJM 1994;87:617-23
    • (1994) QJM , vol.87 , pp. 617-623
    • Osman, I.A.1    James, R.A.2    Chatterjee, S.3
  • 52
    • 84878262389 scopus 로고    scopus 로고
    • Intraoperative magnetic resonance imaging during surgery for pituitary adenomas: Pros and cons
    • Buchfelder M, Schlaffer S-M. Intraoperative magnetic resonance imaging during surgery for pituitary adenomas: pros and cons. Endocrine 2012;42:483-95
    • (2012) Endocrine , vol.42 , pp. 483-495
    • Buchfelder, M.1    Schlaffer, S.-M.2
  • 53
    • 66149130384 scopus 로고    scopus 로고
    • Guidelines for acromegaly management: An update
    • Current guidelines for the treatment and management of acromegaly
    • Melmed S, Colao A, Barkan A, et al. Guidelines for acromegaly management: an update. J Clin Endocrinol Metab 2009;94:1509-17 . Current guidelines for the treatment and management of acromegaly.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1509-1517
    • Melmed, S.1    Colao, A.2    Barkan, A.3
  • 54
    • 79960108666 scopus 로고    scopus 로고
    • Radiation therapy in the management of pituitary adenomas
    • A carefully crafted review of radiation therapy in pituitary adenomas
    • Loeffler JS, Shih HA. Radiation therapy in the management of pituitary adenomas. J Clin Endocrinol Metab 2011;96:1992-2003 . A carefully crafted review of radiation therapy in pituitary adenomas.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1992-2003
    • Loeffler, J.S.1    Shih, H.A.2
  • 56
    • 33646060089 scopus 로고    scopus 로고
    • Conventional pituitary irradiation is effective in lowering serum growth hormone and insulin-like growth factor-I in patients with acromegaly
    • Jenkins PJ, Bates P, Carson MN, et al. Conventional pituitary irradiation is effective in lowering serum growth hormone and insulin-like growth factor-I in patients with acromegaly. J Clin Endocrinol Metab 2006;91:1239-45
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1239-1245
    • Jenkins, P.J.1    Bates, P.2    Carson, M.N.3
  • 57
    • 0033756532 scopus 로고    scopus 로고
    • Hormonal and metabolic effects of radiotherapy in acromegaly: Long-term results in 128 patients followed in a single center
    • Barrande G, Pittino-Lungo M, Coste J, et al. Hormonal and metabolic effects of radiotherapy in acromegaly: long-term results in 128 patients followed in a single center. J Clin Endocrinol Metab 2000;85:3779-85
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3779-3785
    • Barrande, G.1    Pittino-Lungo, M.2    Coste, J.3
  • 58
    • 34247899048 scopus 로고    scopus 로고
    • Radiosurgery of growth hormone-producing pituitary adenomas: Factors associated with biochemical remission
    • Pollock BE, Jacob JT, Brown PD, Nippoldt TB. Radiosurgery of growth hormone-producing pituitary adenomas: factors associated with biochemical remission. J Neurosurg 2007;106:833-8
    • (2007) J Neurosurg , vol.106 , pp. 833-838
    • Pollock, B.E.1    Jacob, J.T.2    Brown, P.D.3    Nippoldt, T.B.4
  • 59
    • 56849130523 scopus 로고    scopus 로고
    • Gamma knife radiosurgery for acromegaly: Outcomes after failed transsphenoidal surgery
    • Jagannathan J, Sheehan JP, Pouratian N, et al. Gamma knife radiosurgery for acromegaly: outcomes after failed transsphenoidal surgery. Neurosurgery 2008;62:1262-70
    • (2008) Neurosurgery , vol.62 , pp. 1262-1270
    • Jagannathan, J.1    Sheehan, J.P.2    Pouratian, N.3
  • 61
    • 18244370517 scopus 로고    scopus 로고
    • Role of medical therapy in the management of acromegaly
    • Vance ML, Laws ER. Role of medical therapy in the management of acromegaly. Neurosurgery 2005;56:877-85
    • (2005) Neurosurgery , vol.56 , pp. 877-885
    • Vance, M.L.1    Laws, E.R.2
  • 62
    • 84873244450 scopus 로고    scopus 로고
    • Advanced materials and processing for drug delivery: The past and the future
    • A comprehensive review of innovation in materials and processing of drug delivery systems
    • Zhang Y, Chan HF, Leong KW. Advanced materials and processing for drug delivery: the past and the future. Adv Drug Deliv Rev 2013;65:104-20 . A comprehensive review of innovation in materials and processing of drug delivery systems.
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 104-120
    • Zhang, Y.1    Chan, H.F.2    Leong, K.W.3
  • 63
    • 84866006612 scopus 로고    scopus 로고
    • Differential expression of somatostatin receptor subtype 1-5 proteins in numerous human normal tissues
    • Unger N, Ueberberg B, Schulz S, et al. Differential expression of somatostatin receptor subtype 1-5 proteins in numerous human normal tissues. Exp Clin Endocrinol Diabetes 2012;120:482-9
    • (2012) Exp Clin Endocrinol Diabetes , vol.120 , pp. 482-489
    • Unger, N.1    Ueberberg, B.2    Schulz, S.3
  • 65
    • 0036319414 scopus 로고    scopus 로고
    • Somatostatin analogs in acromegaly
    • Freda PU. Somatostatin analogs in acromegaly. J Clin Endocrinol Metab 2002;87:3013-18
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3013-3018
    • Freda, P.U.1
  • 66
    • 0028864383 scopus 로고
    • Depot long-acting somatostatin analog (Sandostatin-LAR) is an effective treatment for acromegaly
    • Stewart PM, Kane KF, Stewart SE, et al. Depot long-acting somatostatin analog (Sandostatin-LAR) is an effective treatment for acromegaly. J Clin Endocrinol Metab 1995;80:3267-72
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3267-3272
    • Stewart, P.M.1    Kane, K.F.2    Stewart, S.E.3
  • 67
    • 84896712583 scopus 로고    scopus 로고
    • Efficacy and safety in the Somatuline-depot (lanreotide) injection for acromegaly (SODA) study conducted in the U.S.: Overall year 1 data and comparison of home injection versus office injection
    • SUN-33:746
    • Salvatori R, Woodmansee W, Clary C, et al. Efficacy and safety in the Somatuline- depot (lanreotide) injection for acromegaly (SODA) study conducted in the U.S.: overall year 1 data and comparison of home injection versus office injection. Endocr Rev 2012;33:SUN-746
    • (2012) Endocr Rev , vol.33
    • Salvatori, R.1    Woodmansee, W.2    Clary, C.3
  • 68
    • 15944427116 scopus 로고    scopus 로고
    • Clinical review: The antitumoral effects of somatostatin analog therapy in acromegaly
    • Bevan JS. Clinical review: the antitumoral effects of somatostatin analog therapy in acromegaly. J Clin Endocrinol Metab 2005;90:1856-63
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1856-1863
    • Bevan, J.S.1
  • 69
    • 34447513998 scopus 로고    scopus 로고
    • Long-term (up to 18 years) effects on GH/IGF-1 hypersecretion and tumour size of primary somatostatin analogue (SSTa) therapy in patients with GH-secreting pituitary adenoma responsive to SSTa
    • Maiza JC, Vezzosi D, Matta M, et al. Long-term (up to 18 years) effects on GH/IGF-1 hypersecretion and tumour size of primary somatostatin analogue (SSTa) therapy in patients with GH-secreting pituitary adenoma responsive to SSTa. Clin Endocrinol (Oxf) 2007;67:282-9
    • (2007) Clin Endocrinol (Oxf) , vol.67 , pp. 282-289
    • Maiza, J.C.1    Vezzosi, D.2    Matta, M.3
  • 70
    • 84896707338 scopus 로고    scopus 로고
    • Early and sustained tumour volume reduction and GH/IGF1 control in patients with GH-secreting pituitary macroadenoma primarily treated with lanreotide Autogel 120 mg for 48 weeks: The PRIMARYS study
    • Caron P, Bevan JS, Clermont A, Maisonobe P. Early and sustained tumour volume reduction and GH/IGF1 control in patients with GH-secreting pituitary macroadenoma primarily treated with lanreotide Autogel 120 mg for 48 weeks: the PRIMARYS study. Endocr Abstr 2013;32:P840
    • (2013) Endocr Abstr , vol.32
    • Caron, P.1    Bevan, J.S.2    Clermont, A.3    Maisonobe, P.4
  • 72
    • 23844540615 scopus 로고    scopus 로고
    • Long-acting somatostatin analog therapy of acromegaly: A meta-analysis
    • Freda PU, Katznelson L, van der Lely AJ, et al. Long-acting somatostatin analog therapy of acromegaly: a meta-analysis. J Clin Endocrinol Metab 2005;90:4465-73
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4465-4473
    • Freda, P.U.1    Katznelson, L.2    Van Der Lely, A.J.3
  • 73
    • 49249113074 scopus 로고    scopus 로고
    • A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly
    • Murray RD, Melmed S. A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly. J Clin Endocrinol Metab 2008;93:2957-68
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2957-2968
    • Murray, R.D.1    Melmed, S.2
  • 74
    • 0037726803 scopus 로고    scopus 로고
    • Somatostatin and somatostatin receptor physiology
    • An extensive look into somatostatin and somatostatin receptor physiology
    • Barnett P. Somatostatin and somatostatin receptor physiology. Endocrine 2003;20:255-64 . An extensive look into somatostatin and somatostatin receptor physiology.
    • (2003) Endocrine , vol.20 , pp. 255-264
    • Barnett, P.1
  • 75
    • 78049416796 scopus 로고    scopus 로고
    • Pharmacological management of acromegaly: A current perspective
    • Manjila S, Wu OC, Khan FR, et al. Pharmacological management of acromegaly: a current perspective. Neurosurg Focus 2010;29:E14
    • (2010) Neurosurg Focus , vol.29
    • Manjila, S.1    Wu, O.C.2    Khan, F.R.3
  • 76
    • 0025641087 scopus 로고
    • Gastrointestinal side-effects of octreotide during long-term treatment of acromegaly
    • Plockinger U, Dienemann D, Quabbe HJ. Gastrointestinal side-effects of octreotide during long-term treatment of acromegaly. J Clin Endocrinol Metab 1990;71:1658-62
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 1658-1662
    • Plockinger, U.1    Dienemann, D.2    Quabbe, H.J.3
  • 77
    • 4744375607 scopus 로고    scopus 로고
    • Efficacy and tolerability of lanreotide Autogel therapy in acromegalic patients previously treated with octreotide LAR
    • Alexopoulou O, Abrams P, Verhelst J, et al. Efficacy and tolerability of lanreotide Autogel therapy in acromegalic patients previously treated with octreotide LAR. Eur J Endocrinol 2004;151:317-24
    • (2004) Eur J Endocrinol , vol.151 , pp. 317-324
    • Alexopoulou, O.1    Abrams, P.2    Verhelst, J.3
  • 78
    • 43549109282 scopus 로고    scopus 로고
    • Somatostatin agonists for treatment of acromegaly
    • Ben-Shlomo A, Melmed S. Somatostatin agonists for treatment of acromegaly. Mol Cell Endocrinol 2008;286:192-8
    • (2008) Mol Cell Endocrinol , vol.286 , pp. 192-198
    • Ben-Shlomo, A.1    Melmed, S.2
  • 79
    • 77955908499 scopus 로고    scopus 로고
    • Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors
    • Di Cianni A, Carotenuto A, Brancaccio D, et al. Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors. J Med Chem 2010;53:6188-97
    • (2010) J Med Chem , vol.53 , pp. 6188-6197
    • Di Cianni, A.1    Carotenuto, A.2    Brancaccio, D.3
  • 80
    • 84857099623 scopus 로고    scopus 로고
    • Lanreotide depot deep subcutaneous injection: A new method of delivery and its associated benefits
    • Carmichael JD. Lanreotide depot deep subcutaneous injection: a new method of delivery and its associated benefits. Patient Prefer Adherence 2012;6:73-82
    • (2012) Patient Prefer Adherence , vol.6 , pp. 73-82
    • Carmichael, J.D.1
  • 81
    • 79952440348 scopus 로고    scopus 로고
    • Efficacy and acceptability of lanreotide Autogel- 120 mg at different dose intervals in patients with acromegaly previously treated with octreotide LAR
    • Schopohl J, Strasburger CJ, Caird D, et al. Efficacy and acceptability of lanreotide Autogel- 120 mg at different dose intervals in patients with acromegaly previously treated with octreotide LAR. Exp Clin Endocrinol Diabetes 2011;119:156-62
    • (2011) Exp Clin Endocrinol Diabetes , vol.119 , pp. 156-162
    • Schopohl, J.1    Strasburger, C.J.2    Caird, D.3
  • 82
    • 36549054677 scopus 로고    scopus 로고
    • Optimalization and cost management of lanreotide-Autogel therapy in acromegaly
    • Abrams P, Alexopoulou O, Abs R, et al. Optimalization and cost management of lanreotide-Autogel therapy in acromegaly. Eur J Endocrinol 2007;157:571-7
    • (2007) Eur J Endocrinol , vol.157 , pp. 571-577
    • Abrams, P.1    Alexopoulou, O.2    Abs, R.3
  • 83
    • 77955877150 scopus 로고    scopus 로고
    • Effectiveness of self- or partneradministration of an extended-release aqueous-gel formulation of lanreotide in lanreotide-naive patients with acromegaly
    • Salvatori R, Nachtigall LB, Cook DM, et al. Effectiveness of self- or partneradministration of an extended-release aqueous-gel formulation of lanreotide in lanreotide-naive patients with acromegaly. Pituitary 2010;13:115-22
    • (2010) Pituitary , vol.13 , pp. 115-122
    • Salvatori, R.1    Nachtigall, L.B.2    Cook, D.M.3
  • 84
    • 39149094648 scopus 로고    scopus 로고
    • Home administration of lanreotide Autogel by patients with acromegaly, or their partners, is safe and effective
    • Bevan JS, Newell-Price J, Wass JA, et al. Home administration of lanreotide Autogel by patients with acromegaly, or their partners, is safe and effective. Clin Endocrinol (Oxf) 2008;68:343-9
    • (2008) Clin Endocrinol (Oxf) , vol.68 , pp. 343-349
    • Bevan, J.S.1    Newell-Price, J.2    Wass, J.A.3
  • 85
    • 38949140254 scopus 로고    scopus 로고
    • Preliminary data on biochemical remission of acromegaly after somatostatin analogs withdrawal
    • Ronchi CL, Rizzo E, Lania AG, et al. Preliminary data on biochemical remission of acromegaly after somatostatin analogs withdrawal. Eur J Endocrinol 2008;158:19-25
    • (2008) Eur J Endocrinol , vol.158 , pp. 19-25
    • Ronchi, C.L.1    Rizzo, E.2    Lania, A.G.3
  • 86
    • 84055190592 scopus 로고    scopus 로고
    • Discontinuation of octreotide LAR after long term, successful treatment of patients with acromegaly: Is it worth trying?
    • Ramirez C, Vargas G, Gonzalez B, et al. Discontinuation of octreotide LAR after long term, successful treatment of patients with acromegaly: is it worth trying? Eur J Endocrinol 2012;166:21-6
    • (2012) Eur J Endocrinol , vol.166 , pp. 21-26
    • Ramirez, C.1    Vargas, G.2    Gonzalez, B.3
  • 87
    • 6044276093 scopus 로고    scopus 로고
    • Future aspects of somatostatin-receptor-mediated therapy
    • Oberg K. Future aspects of somatostatin-receptor-mediated therapy. Neuroendocrinology 2004;80(Suppl 1):57-61
    • (2004) Neuroendocrinology , vol.80 , Issue.SUPPL. 1 , pp. 57-61
    • Oberg, K.1
  • 88
    • 36549040940 scopus 로고    scopus 로고
    • Beneficial effect of dose escalation of octreotide-LAR as first-line therapy in patients with acromegaly
    • Colao A, Pivonello R, Auriemma RS, et al. Beneficial effect of dose escalation of octreotide-LAR as first-line therapy in patients with acromegaly. Eur J Endocrinol 2007;157:579-87
    • (2007) Eur J Endocrinol , vol.157 , pp. 579-587
    • Colao, A.1    Pivonello, R.2    Auriemma, R.S.3
  • 89
    • 68349141978 scopus 로고    scopus 로고
    • High-dose intramuscular octreotide in patients with acromegaly inadequately controlled on conventional somatostatin analogue therapy: A randomised controlled trial
    • Giustina A, Bonadonna S, Bugari G, et al. High-dose intramuscular octreotide in patients with acromegaly inadequately controlled on conventional somatostatin analogue therapy: a randomised controlled trial. Eur J Endocrinol 2009;161:331-8
    • (2009) Eur J Endocrinol , vol.161 , pp. 331-338
    • Giustina, A.1    Bonadonna, S.2    Bugari, G.3
  • 90
    • 82355175321 scopus 로고    scopus 로고
    • Safety review: Dose optimization of somatostatin analogs in patients with acromegaly and neuroendocrine tumors
    • Ludlam WH, Anthony L. Safety review: dose optimization of somatostatin analogs in patients with acromegaly and neuroendocrine tumors. Adv Ther 2011;28:825-41
    • (2011) Adv Ther , vol.28 , pp. 825-841
    • Ludlam, W.H.1    Anthony, L.2
  • 91
    • 79958171697 scopus 로고    scopus 로고
    • Clinical efficacy and safety results for dose escalation of somatostatin receptor ligands in patients with acromegaly: A literature review
    • Fleseriu M. Clinical efficacy and safety results for dose escalation of somatostatin receptor ligands in patients with acromegaly: a literature review. Pituitary 2011;14:184-93
    • (2011) Pituitary , vol.14 , pp. 184-193
    • Fleseriu, M.1
  • 92
    • 0033305394 scopus 로고    scopus 로고
    • Growth hormone (GH) receptor blockade with a PEG-modified GH (B2036-PEG) lowers serum insulin-like growth factor-I but does not acutely stimulate serum GH
    • Thorner MO, Strasburger CJ, Wu Z, et al. Growth hormone (GH) receptor blockade with a PEG-modified GH (B2036-PEG) lowers serum insulin-like growth factor-I but does not acutely stimulate serum GH. J Clin Endocrinol Metab 1999;84:2098-103
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2098-2103
    • Thorner, M.O.1    Strasburger, C.J.2    Wu, Z.3
  • 93
    • 0024403619 scopus 로고
    • High-resolution epitope mapping of hGH-receptor interactions by alaninescanning mutagenesis
    • Cunningham BC, Wells JA. High-resolution epitope mapping of hGH-receptor interactions by alaninescanning mutagenesis. Science 1989;244:1081-5
    • (1989) Science , vol.244 , pp. 1081-1085
    • Cunningham, B.C.1    Wells, J.A.2
  • 95
    • 0035040522 scopus 로고    scopus 로고
    • Binding and functional studies with the growth hormone receptor antagonist, B2036-PEG (pegvisomant), reveal effects of pegylation and evidence that it binds to a receptor dimer
    • Ross RJ, Leung KC, Maamra M, et al. Binding and functional studies with the growth hormone receptor antagonist, B2036-PEG (pegvisomant), reveal effects of pegylation and evidence that it binds to a receptor dimer. J Clin Endocrinol Metab 2001;86:1716-23
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1716-1723
    • Ross, R.J.1    Leung, K.C.2    Maamra, M.3
  • 96
    • 0032755252 scopus 로고    scopus 로고
    • Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization
    • Zhang Y, Jiang J, Kopchick JJ, Frank SJ. Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization. J Biol Chem 1999;274:33072-84
    • (1999) J Biol Chem , vol.274 , pp. 33072-33084
    • Zhang, Y.1    Jiang, J.2    Kopchick, J.J.3    Frank, S.J.4
  • 97
    • 0029989302 scopus 로고    scopus 로고
    • Growth hormone (GH) and a GH antagonist promote GH receptor dimerization and internalization
    • Harding PA, Wang X, Okada S, et al. Growth hormone (GH) and a GH antagonist promote GH receptor dimerization and internalization. J Biol Chem 1996;271:6708-12
    • (1996) J Biol Chem , vol.271 , pp. 6708-6712
    • Harding, P.A.1    Wang, X.2    Okada, S.3
  • 98
    • 0033591392 scopus 로고    scopus 로고
    • Studies with a growth hormone antagonist and dual-fluorescent confocal microscopy demonstrate that the full-length human growth hormone receptor, but not the truncated isoform, is very rapidly internalized independent of Jak2-Stat5 signaling
    • Maamra M, Finidori J, Von Laue S, et al. Studies with a growth hormone antagonist and dual-fluorescent confocal microscopy demonstrate that the full-length human growth hormone receptor, but not the truncated isoform, is very rapidly internalized independent of Jak2-Stat5 signaling. J Biol Chem 1999;274:14791-8
    • (1999) J Biol Chem , vol.274 , pp. 14791-14798
    • Maamra, M.1    Finidori, J.2    Von Laue, S.3
  • 99
    • 0033521670 scopus 로고    scopus 로고
    • Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor
    • Govers R, ten Broeke T, van Kerkhof P, et al. Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor. EMBO J 1999;18:28-36
    • (1999) EMBO J , vol.18 , pp. 28-36
    • Govers, R.1    Ten Broeke, T.2    Van Kerkhof, P.3
  • 100
    • 0032568841 scopus 로고    scopus 로고
    • Di-leucine-mediated internalization of ligand by a truncated growth hormone receptor is independent of the ubiquitin conjugation system
    • Govers R, van Kerkhof P, Schwartz AL, Strous GJ. Di-leucine-mediated internalization of ligand by a truncated growth hormone receptor is independent of the ubiquitin conjugation system. J Biol Chem 1998;273:16426-33
    • (1998) J Biol Chem , vol.273 , pp. 16426-16433
    • Govers, R.1    Van Kerkhof, P.2    Schwartz, A.L.3    Strous, G.J.4
  • 101
    • 0030797998 scopus 로고    scopus 로고
    • Linkage of the ubiquitinconjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor
    • Govers R, van Kerkhof P, Schwartz a L, Strous GJ. Linkage of the ubiquitinconjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor. EMBO J 1997;16:4851-8
    • (1997) EMBO J , vol.16 , pp. 4851-4858
    • Govers, R.1    Van Kerkhof Schwartz, P.A.L.2    Strous, G.J.3
  • 102
    • 0034690311 scopus 로고    scopus 로고
    • Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant
    • The first paper reporting the effectiveness of pegvisomant
    • Trainer PJ, Drake WM, Katznelson L, et al. Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med 2000;342:1171-7 . The first paper reporting the effectiveness of pegvisomant.
    • (2000) N Engl J Med , vol.342 , pp. 1171-1177
    • Trainer, P.J.1    Drake, W.M.2    Katznelson, L.3
  • 103
    • 0035944825 scopus 로고    scopus 로고
    • Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist
    • Van der Lely AJ, Hutson RK, Trainer PJ, et al. Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. Lancet 2001;358:1754-9
    • (2001) Lancet , vol.358 , pp. 1754-1759
    • Van Der Lely, A.J.1    Hutson, R.K.2    Trainer, P.J.3
  • 105
    • 84879107985 scopus 로고    scopus 로고
    • Long-term treatment of somatostatin analog-refractory growth hormonesecreting pituitary tumors with pegvisomant alone or combined with long-acting somatostatin analogs: A retrospective analysis of clinical practice and outcomes
    • Bianchi A, Valentini F, Iuorio R, et al. Long-term treatment of somatostatin analog-refractory growth hormonesecreting pituitary tumors with pegvisomant alone or combined with long-acting somatostatin analogs: a retrospective analysis of clinical practice and outcomes. J Exp Clin Cancer Res 2013;32:40
    • (2013) J Exp Clin Cancer Res , vol.32 , pp. 40
    • Bianchi, A.1    Valentini, F.2    Iuorio, R.3
  • 106
    • 84860764307 scopus 로고    scopus 로고
    • Van der Lely a J, Biller B.M.K., Brue T, et al.
    • Van der Lely a J, Biller BMK, Brue T, et al. Long-term safety of pegvisomant in patients with acromegaly: comprehensive review of 1288 subjects in ACROSTUDY. J Clin Endocrinol Metab 2012;97:1589-97
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1589-1597
  • 107
    • 67650755038 scopus 로고    scopus 로고
    • Successful use of weekly pegvisomant administration in patients with acromegaly
    • Higham CE, Thomas JDJ, Bidlingmaier M, et al. Successful use of weekly pegvisomant administration in patients with acromegaly. Eur J Endocrinol 2009;161:21-5
    • (2009) Eur J Endocrinol , vol.161 , pp. 21-25
    • Higham, C.E.1    Jdj, T.2    Bidlingmaier, M.3
  • 108
    • 15944375488 scopus 로고    scopus 로고
    • Alternate-day administration of pegvisomant maintains normal serum insulin-like growth factor-I levels in patients with acromegaly
    • Jehle S, Reyes CM, Sundeen RE, Freda PU. Alternate-day administration of pegvisomant maintains normal serum insulin-like growth factor-I levels in patients with acromegaly. J Clin Endocrinol Metab 2005;90:1588-93
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1588-1593
    • Jehle, S.1    Reyes, C.M.2    Sundeen, R.E.3    Freda, P.U.4
  • 109
    • 33644594740 scopus 로고    scopus 로고
    • Elevated transaminases during medical treatment of acromegaly: A review of the German pegvisomant surveillance experience and a report of a patient with histologically proven chronic mild active hepatitis
    • Biering H, Saller B, Bauditz J, et al. Elevated transaminases during medical treatment of acromegaly: a review of the German pegvisomant surveillance experience and a report of a patient with histologically proven chronic mild active hepatitis. Eur J Endocrinol 2006;154:213-20
    • (2006) Eur J Endocrinol , vol.154 , pp. 213-220
    • Biering, H.1    Saller, B.2    Bauditz, J.3
  • 110
    • 84859525079 scopus 로고    scopus 로고
    • Fat content in liver and skeletal muscle changes in a reciprocal manner in patients with acromegaly during combination therapy with a somatostatin analog and a GH receptor antagonist: A randomized clinical trial
    • Madsen M, Krusenstjerna-Hafstrøm T, Møller L, et al. Fat content in liver and skeletal muscle changes in a reciprocal manner in patients with acromegaly during combination therapy with a somatostatin analog and a GH receptor antagonist: a randomized clinical trial. J Clin Endocrinol Metab 2012;97:1227-35
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1227-1235
    • Madsen, M.1    Krusenstjerna-Hafstrøm, T.2    Møller, L.3
  • 111
    • 67650761129 scopus 로고    scopus 로고
    • Pituitary tumor size in acromegaly during pegvisomant treatment: Experience from MR re-evaluations of the German Pegvisomant Observational Study
    • An important analysis showing that pegvisomant does not lead to significantly increased tumor growth as initially feared
    • Buchfelder M, Weigel D, Droste M, et al. Pituitary tumor size in acromegaly during pegvisomant treatment: experience from MR re-evaluations of the German Pegvisomant Observational Study. Eur J Endocrinol 2009;161:27-35 . An important analysis showing that pegvisomant does not lead to significantly increased tumor growth as initially feared.
    • (2009) Eur J Endocrinol , vol.161 , pp. 27-35
    • Buchfelder, M.1    Weigel, D.2    Droste, M.3
  • 113
    • 0031792509 scopus 로고    scopus 로고
    • Cabergoline in the treatment of acromegaly: A study in 64 patients
    • Abs R, Verhelst J, Maiter D, et al. Cabergoline in the treatment of acromegaly: a study in 64 patients. J Clin Endocrinol Metab 1998;83:374-8
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 374-378
    • Abs, R.1    Verhelst, J.2    Maiter, D.3
  • 114
    • 56749098338 scopus 로고    scopus 로고
    • Clinical use of cabergoline as primary and adjunctive treatment for acromegaly
    • Moyes VJ, Metcalfe KA, Drake WM. Clinical use of cabergoline as primary and adjunctive treatment for acromegaly. Eur J Endocrinol 2008;159:541-5
    • (2008) Eur J Endocrinol , vol.159 , pp. 541-54545
    • Moyes, V.J.1    Metcalfe, K.A.2    Drake, W.M.3
  • 115
    • 79955672862 scopus 로고    scopus 로고
    • Place of cabergoline in acromegaly: A meta-analysis
    • A rigorous analysis of cabergoline in the treatment of acromegaly
    • Sandret L, Maison P, Chanson P. Place of cabergoline in acromegaly: a meta-analysis. J Clin Endocrinol Metab 2011;96:1327-35 . A rigorous analysis of cabergoline in the treatment of acromegaly.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1327-1335
    • Sandret, L.1    Maison, P.2    Chanson, P.3
  • 116
    • 33845974147 scopus 로고    scopus 로고
    • Valvular heart disease and the use of dopamine agonists for Parkinson's disease
    • Zanettini R, Antonini A, Gatto G, et al. Valvular heart disease and the use of dopamine agonists for Parkinson's disease. N Engl J Med 2007;356:39-46
    • (2007) N Engl J Med , vol.356 , pp. 39-46
    • Zanettini, R.1    Antonini, A.2    Gatto, G.3
  • 117
    • 84883403996 scopus 로고    scopus 로고
    • Safety of long-term treatment with cabergoline on cardiac valve disease in patients with prolactinomas
    • Auriemma RS, Pivonello R, Perone Y, et al. Safety of long-term treatment with cabergoline on cardiac valve disease in patients with prolactinomas. Eur J Endocrinol 2013;169:359-66
    • (2013) Eur J Endocrinol , vol.169 , pp. 359-366
    • Auriemma, R.S.1    Pivonello, R.2    Perone, Y.3
  • 118
    • 84866175011 scopus 로고    scopus 로고
    • No evidence of a detrimental effect of cabergoline therapy on cardiac valves in patients with acromegaly
    • Maione L, Garcia C, Bouchachi A, et al. No evidence of a detrimental effect of cabergoline therapy on cardiac valves in patients with acromegaly. J Clin Endocrinol Metab 2012;97:E1714-19
    • (2012) J Clin Endocrinol Metab , vol.97
    • Maione, L.1    Garcia, C.2    Bouchachi, A.3
  • 119
    • 84880303531 scopus 로고    scopus 로고
    • The role of combination medical therapy in acromegaly: Hope for the nonresponsive patient
    • Fleseriu M. The role of combination medical therapy in acromegaly: hope for the nonresponsive patient. Curr Opin Endocrinol Diabetes Obes 2013;20:321-9
    • (2013) Curr Opin Endocrinol Diabetes Obes , vol.20 , pp. 321-329
    • Fleseriu, M.1
  • 120
    • 70449713587 scopus 로고    scopus 로고
    • Clinical effectiveness and costeffectiveness of pegvisomant for the treatment of acromegaly: A systematic review and economic evaluation
    • Moore DJ, Adi Y, Connock MJ, Bayliss S. Clinical effectiveness and costeffectiveness of pegvisomant for the treatment of acromegaly: a systematic review and economic evaluation. BMC Endocr Disord 2009;9:20
    • (2009) BMC Endocr Disord , vol.9 , pp. 20
    • Moore, D.J.1    Adi, Y.2    Connock, M.J.3    Bayliss, S.4
  • 121
    • 84859550807 scopus 로고    scopus 로고
    • Effective combination treatment with cabergoline and low-dose pegvisomant in active acromegaly: A Prospective Clinical Trial
    • Higham CE, Atkinson a B, Aylwin S, et al. Effective combination treatment with cabergoline and low-dose pegvisomant in active acromegaly: a Prospective Clinical Trial. J Clin Endocrinol Metab 2012;97:1187-93
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1187-1193
    • Higham, C.E.1    Atkinson, A.B.2    Aylwin, S.3
  • 122
    • 33750079272 scopus 로고    scopus 로고
    • The cost of medical care for the acromegalic patient
    • Knutzen R, Ezzat S. The cost of medical care for the acromegalic patient. Neuroendocrinology 2006;83:139-44
    • (2006) Neuroendocrinology , vol.83 , pp. 139-144
    • Knutzen, R.1    Ezzat, S.2
  • 123
    • 0034985604 scopus 로고    scopus 로고
    • Longitudinal assessment of economic burden and clinical outcomes in acromegaly
    • Wilson LS, Shin JL, Ezzat S. Longitudinal assessment of economic burden and clinical outcomes in acromegaly. Endocr Pract 2001;7:170-80
    • (2001) Endocr Pract , vol.7 , pp. 170-180
    • Wilson, L.S.1    Shin, J.L.2    Ezzat, S.3
  • 125
    • 84877725293 scopus 로고    scopus 로고
    • Pharmacoeconomic aspects of the treatment of pituitary gland tumours
    • Sowinski J, Sawicka N, Piatek K, Zybek A. Pharmacoeconomic aspects of the treatment of pituitary gland tumours. Contemp Oncol 2013;17:137-43
    • (2013) Contemp Oncol , vol.17 , pp. 137-143
    • Sowinski, J.1    Sawicka, N.2    Piatek, K.3    Zybek, A.4
  • 127
    • 84860799680 scopus 로고    scopus 로고
    • Decision-tree model for health economic comparison of two long-acting somatostatin receptor ligand devices in france germany and the UK
    • Marty R, Roze S, Kurth H. Decision-tree model for health economic comparison of two long-acting somatostatin receptor ligand devices in France, Germany, and the UK. Med Devices (Auckl) 2012;5:39-44
    • (2012) Med Devices (Auckl) , vol.5 , pp. 39-44
    • Marty, R.1    Roze, S.2    Kurth, H.3
  • 128
    • 84865844655 scopus 로고    scopus 로고
    • Comparative effectiveness review of treatment options for pituitary microadenomas in acromegaly
    • Marko NF, LaSota E, Hamrahian AH, Weil RJ. Comparative effectiveness review of treatment options for pituitary microadenomas in acromegaly. J Neurosurg 2012;117:522-38
    • (2012) J Neurosurg , vol.117 , pp. 522-538
    • Marko, N.F.1    Lasota, E.2    Hamrahian, A.H.3    Weil, R.J.4
  • 129
    • 84896712613 scopus 로고    scopus 로고
    • Novartis Corporate publications [Internet]
    • Novartis Corporate publications [Internet]
  • 130
    • 84896699450 scopus 로고    scopus 로고
    • IPSEN Group Website Publications [Internet]
    • IPSEN Group Website Publications [Internet]
  • 131
    • 84896731746 scopus 로고    scopus 로고
    • Pfizer Financial Reports [Internet]
    • Pfizer Financial Reports [Internet]
  • 132
    • 15744397552 scopus 로고    scopus 로고
    • Cost-of-illness study in acromegalic patients in Italy
    • Didoni G, Grottol S, Gasco V, et al. Cost-of-illness study in acromegalic patients in Italy. J Endocrinol Invest 2004;27:1034-9
    • (2004) J Endocrinol Invest , vol.27 , pp. 1034-1039
    • Didoni, G.1    Grottol, S.2    Gasco, V.3
  • 133
    • 63149159296 scopus 로고    scopus 로고
    • Octreotide LAR vs surgery in newly diagnosed patients with acromegaly: A randomized, open-label, multicentre study
    • Colao A, Cappabianca P, Caron P, et al. Octreotide LAR vs. surgery in newly diagnosed patients with acromegaly: a randomized, open-label, multicentre study. Clin Endocrinol (Oxf) 2009;70:757-68
    • (2009) Clin Endocrinol (Oxf) , vol.70 , pp. 757-768
    • Colao, A.1    Cappabianca, P.2    Caron, P.3
  • 134
    • 34347380169 scopus 로고    scopus 로고
    • A prospective, multicentre study to investigate the efficacy, safety and tolerability of octreotide LAR (longacting repeatable octreotide) in the primary therapy of patients with acromegaly
    • Mercado M, Borges F, Bouterfa H, et al. A prospective, multicentre study to investigate the efficacy, safety and tolerability of octreotide LAR (longacting repeatable octreotide) in the primary therapy of patients with acromegaly. Clin Endocrinol (Oxf) 2007;66:859-68
    • (2007) Clin Endocrinol (Oxf) , vol.66 , pp. 859-868
    • Mercado, M.1    Borges, F.2    Bouterfa, H.3
  • 136
    • 84878762635 scopus 로고    scopus 로고
    • Acromegalic patients lost to follow-up: A pilot study
    • A very interesting study analyzing reasons for patients lost to follow-up with an interventional part leading those patients back to therapy
    • Kasuki L, Marques NV, Nuez MJ, et al. Acromegalic patients lost to follow-up: a pilot study. Pituitary 2013;16:245-50 . A very interesting study analyzing reasons for patients lost to follow-up with an interventional part leading those patients back to therapy.
    • (2013) Pituitary , vol.16 , pp. 245-250
    • Kasuki, L.1    Marques, N.V.2    Nuez, M.J.3
  • 137
    • 79955093923 scopus 로고    scopus 로고
    • Pathogenesis of pituitary tumors
    • Melmed S. Pathogenesis of pituitary tumors. Nat Rev Endocrinol 2011;7:257-66
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 257-266
    • Melmed, S.1
  • 138
    • 11244276992 scopus 로고    scopus 로고
    • The E2F family: Specific functions and overlapping interests
    • Attwooll C, Lazzerini Denchi E, Helin K. The E2F family: specific functions and overlapping interests. EMBO J 2004;23:4709-16
    • (2004) EMBO J , vol.23 , pp. 4709-4716
    • Attwooll, C.1    Lazzerini Denchi, E.2    Helin, K.3
  • 139
    • 0141864375 scopus 로고    scopus 로고
    • Genetics of pituitary tumors: Focus on G-protein mutations
    • Lania A, Mantovani G, Spada A. Genetics of pituitary tumors: focus on G-protein mutations. Exp Biol Med (Maywood) 2003;228:1004-17
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 1004-1017
    • Lania, A.1    Mantovani, G.2    Spada, A.3
  • 140
    • 0032566155 scopus 로고    scopus 로고
    • Ballarè E. G protein abnormalities in pituitary adenomas
    • Spada A, Lania A, Ballarè E. G protein abnormalities in pituitary adenomas. Mol Cell Endocrinol 1998;142:1-14
    • (1998) Mol Cell Endocrinol , vol.142 , pp. 1-14
    • Spada, A.1    Lania, A.2
  • 141
    • 78049432058 scopus 로고    scopus 로고
    • Growth hormone-secreting adenomas: Pathology and cell biology
    • Lopes MB. Growth hormone-secreting adenomas: pathology and cell biology. Neurosurg Focus 2010;29:E2
    • (2010) Neurosurg Focus , vol.29
    • Lopes, M.B.1
  • 142
    • 85047689866 scopus 로고    scopus 로고
    • Telomeres, stem cells, senescence, and cancer
    • Sharpless NE, DePinho RA. Telomeres, stem cells, senescence, and cancer. J Clin Invest 2004;113:160-8
    • (2004) J Clin Invest , vol.113 , pp. 160-168
    • Sharpless, N.E.1    Depinho, R.A.2
  • 143
    • 0037013154 scopus 로고    scopus 로고
    • A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
    • Schmitt CA, Fridman JS, Yang M, et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 2002;109:335-46
    • (2002) Cell , vol.109 , pp. 335-346
    • Schmitt, C.A.1    Fridman, J.S.2    Yang, M.3
  • 144
    • 23244452684 scopus 로고    scopus 로고
    • Suppressing cancer: The importance of being senescent
    • Campisi J. Suppressing cancer: the importance of being senescent. Science 2005;309:886-7
    • (2005) Science , vol.309 , pp. 886-887
    • Campisi, J.1
  • 145
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3
  • 146
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • Bartkova J, Rezaei N, Liontos M, et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006;444:633-7
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1    Rezaei, N.2    Liontos, M.3
  • 147
    • 34249668278 scopus 로고    scopus 로고
    • Pituitary tumor-transforming gene: Physiology and implications for tumorigenesis
    • Vlotides G, Eigler T, Melmed S. Pituitary tumor-transforming gene: physiology and implications for tumorigenesis. Endocr Rev 2007;28:165-86
    • (2007) Endocr Rev , vol.28 , pp. 165-186
    • Vlotides, G.1    Eigler, T.2    Melmed, S.3
  • 148
    • 0025168454 scopus 로고
    • Distribution of somatostatin receptors in normal and tumor tissue
    • Reubi JC, Kvols L, Krenning E, Lamberts SW. Distribution of somatostatin receptors in normal and tumor tissue. Metabolism 1990;39:78-81
    • (1990) Metabolism , vol.39 , pp. 78-81
    • Reubi, J.C.1    Kvols, L.2    Krenning, E.3    Lamberts, S.W.4
  • 150
    • 26944493862 scopus 로고    scopus 로고
    • Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
    • Brown RJ, Adams JJ, Pelekanos RA, et al. Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol 2005;12:814-21
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 814-821
    • Brown, R.J.1    Adams, J.J.2    Pelekanos, R.A.3
  • 151
    • 0027179365 scopus 로고
    • Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase
    • Argetsinger LS, Campbell GS, Yang X, et al. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 1993;74:237-44
    • (1993) Cell , vol.74 , pp. 237-244
    • Argetsinger, L.S.1    Campbell, G.S.2    Yang, X.3
  • 152
    • 20144380439 scopus 로고    scopus 로고
    • SOCS2 negatively regulates growth hormone action in vitro and in vivo
    • Greenhalgh CJ, Rico-Bautista E, Lorentzon M, et al. SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest 2005;115:397-406
    • (2005) J Clin Invest , vol.115 , pp. 397-406
    • Greenhalgh, C.J.1    Rico-Bautista, E.2    Lorentzon, M.3
  • 153
    • 44649148404 scopus 로고    scopus 로고
    • An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
    • Rowlinson SW, Yoshizato H, Barclay JL, et al. An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway. Nat Cell Biol 2008;10:740-7
    • (2008) Nat Cell Biol , vol.10 , pp. 740-747
    • Rowlinson, S.W.1    Yoshizato, H.2    Barclay, J.L.3
  • 155
    • 68549139637 scopus 로고    scopus 로고
    • Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors
    • Dworakowska D, Wlodek E, Leontiou CA, et al. Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors. Endocr Relat Cancer 2009;16:1329-38
    • (2009) Endocr Relat Cancer , vol.16 , pp. 1329-1338
    • Dworakowska, D.1    Wlodek, E.2    Leontiou, C.A.3
  • 156
    • 84856216099 scopus 로고    scopus 로고
    • Targeting Raf/MEK/ERK pathway in pituitary adenomas
    • Suojun Z, Feng W, Dongsheng G, Ting L. Targeting Raf/MEK/ERK pathway in pituitary adenomas. Eur J Cancer 2012;48:389-95
    • (2012) Eur J Cancer , vol.48 , pp. 389-395
    • Suojun, Z.1    Feng, W.2    Dongsheng, G.3    Ting, L.4
  • 157
    • 0036111856 scopus 로고    scopus 로고
    • SOM230: A novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile
    • Bruns C, Lewis I, Briner U, et al. SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile. Eur J Endocrinol 2002;146:707-16
    • (2002) Eur J Endocrinol , vol.146 , pp. 707-716
    • Bruns, C.1    Lewis, I.2    Briner, U.3
  • 158
    • 77954484928 scopus 로고    scopus 로고
    • Pasireotide (SOM230) demonstrates efficacy and safety in patients with acromegaly: A randomized, multicenter, phase II trial
    • Petersenn S, Schopohl J, Barkan A, et al. Pasireotide (SOM230) demonstrates efficacy and safety in patients with acromegaly: a randomized, multicenter, phase II trial. J Clin Endocrinol Metab 2010;95:2781-9
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2781-2789
    • Petersenn, S.1    Schopohl, J.2    Barkan, A.3
  • 159
    • 84862091799 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of a single dose of pasireotide long-acting release in healthy volunteers: A singlecenter phase i study
    • Dietrich H, Hu K, Ruffin M, et al. Safety, tolerability, and pharmacokinetics of a single dose of pasireotide long-acting release in healthy volunteers: a singlecenter phase I study. Eur J Endocrinol 2012;166:821-8
    • (2012) Eur J Endocrinol , vol.166 , pp. 821-828
    • Dietrich, H.1    Hu, K.2    Ruffin, M.3
  • 160
    • 84862084544 scopus 로고    scopus 로고
    • A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers
    • Golor G, Hu K, Ruffin M, et al. A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers. Drug Des Devel Ther 2012;6:71-9
    • (2012) Drug des Devel Ther , vol.6 , pp. 71-79
    • Golor, G.1    Hu, K.2    Ruffin, M.3
  • 161
    • 84881316265 scopus 로고    scopus 로고
    • Hyperglycemia associated with pasireotide: Results from a mechanistic study in healthy volunteers
    • Henry RR, Ciaraldi TP, Armstrong D, et al. Hyperglycemia associated with pasireotide: results from a mechanistic study in healthy volunteers. J Clin Endocrinol Metab 2013;98:3446-53
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 3446-3453
    • Henry, R.R.1    Ciaraldi, T.P.2    Armstrong, D.3
  • 162
    • 83455162028 scopus 로고    scopus 로고
    • Mechanism and management of hyperglycemia associated with pasireotide: Results from studies in healthy volunteers
    • Henry RR, Mudaliar S, Wetli-Hermosillo K, et al. Mechanism and management of hyperglycemia associated with pasireotide: results from studies in healthy volunteers. Endocr Abstr 2011;260:P260
    • (2011) Endocr Abstr , vol.260
    • Henry, R.R.1    Mudaliar, S.2    Wetli-Hermosillo, K.3
  • 163
    • 84874313212 scopus 로고    scopus 로고
    • Management of hyperglycaemia in Cushing's disease: Experts' proposals on the use of pasireotide
    • Reznik Y, Bertherat J, Borson-Chazot F, et al. Management of hyperglycaemia in Cushing's disease: experts' proposals on the use of pasireotide. Diabetes Metab 2013;39:34-41
    • (2013) Diabetes Metab , vol.39 , pp. 34-41
    • Reznik, Y.1    Bertherat, J.2    Borson-Chazot, F.3
  • 164
    • 84872807767 scopus 로고    scopus 로고
    • Pasireotide LAR is significantly more effective than octreotide LAR at inducing biochemical control in patients with acromegaly: Results of a 12-month randomized, double-blind, multicenter, phase III study
    • OC1.1
    • Colao A, Bronstein MD, Freda PU, et al. Pasireotide LAR is significantly more effective than octreotide LAR at inducing biochemical control in patients with acromegaly: results of a 12-month randomized, double-blind, multicenter, phase III study. Endocr Abstr 2012;29:OC1.1
    • (2012) Endocr Abstr , vol.29
    • Colao, A.1    Bronstein, M.D.2    Freda, P.U.3
  • 165
    • 17844406157 scopus 로고    scopus 로고
    • Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: A target for drug delivery
    • Cano-Cebrian MJ, Zornoza T, Granero L, Polache A. Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: a target for drug delivery. Curr Drug Deliv 2005;2:9-22
    • (2005) Curr Drug Deliv , vol.2 , pp. 9-22
    • Cano-Cebrian, M.J.1    Zornoza, T.2    Granero, L.3    Polache, A.4
  • 166
    • 84863580229 scopus 로고    scopus 로고
    • OR14,80 OctreolinTM, a safe oral alternative for parenteral octreotide treatment
    • Tuvia S, Salama P, Weinstein I, et al. OR14,80 OctreolinTM, a safe oral alternative for parenteral octreotide treatment. Growth Horm IGF Res 2010;20:S35-6
    • (2010) Growth Horm IGF Res , vol.20
    • Tuvia, S.1    Salama, P.2    Weinstein, I.3
  • 167
    • 84863588864 scopus 로고    scopus 로고
    • Oral octreotide absorption in human subjects: Comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression
    • Tuvia S, Atsmon J, Teichman SL, et al. Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression. J Clin Endocrinol Metab 2012;97:1-8
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1-8
    • Tuvia, S.1    Atsmon, J.2    Teichman, S.L.3
  • 168
    • 10244235366 scopus 로고    scopus 로고
    • PTR-3173 (somatoprim), a novel somatostatin analog with affinity for somatostatin receptors 2, 4 and 5 is a potent inhibitor of human GH secretion
    • Shimon I, Rubinek T, Hadani M, Alhadef N. PTR-3173 (somatoprim), a novel somatostatin analog with affinity for somatostatin receptors 2, 4 and 5 is a potent inhibitor of human GH secretion. J Endocrinol Invest 2004;27:721-7
    • (2004) J Endocrinol Invest , vol.27 , pp. 721-727
    • Shimon, I.1    Rubinek, T.2    Hadani, M.3    Alhadef, N.4
  • 169
    • 84856094615 scopus 로고    scopus 로고
    • DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours
    • Plockinger U, Hoffmann U, Geese M, et al. DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours. Eur J Endocrinol 2012;166:223-34
    • (2012) Eur J Endocrinol , vol.166 , pp. 223-234
    • Plockinger, U.1    Hoffmann, U.2    Geese, M.3
  • 170
    • 17744364678 scopus 로고    scopus 로고
    • Novel long-acting somatostatin analog with endocrine selectivity: Potent suppression of growth hormone but not of insulin
    • Afargan M, Janson ET, Gelerman G, et al. Novel long-acting somatostatin analog with endocrine selectivity: potent suppression of growth hormone but not of insulin. Endocrinology 2001;142:477-86
    • (2001) Endocrinology , vol.142 , pp. 477-486
    • Afargan, M.1    Janson, E.T.2    Gelerman, G.3
  • 171
    • 79953171104 scopus 로고    scopus 로고
    • Oral delivery of octreotide acetate in Intravail- improves uptake, half-life, and bioavailability over subcutaneous administration in male Swiss webster mice
    • Maggio ET, Grasso P. Oral delivery of octreotide acetate in Intravail- improves uptake, half-life, and bioavailability over subcutaneous administration in male Swiss webster mice. Regul Pept 2011;167:233-8
    • (2011) Regul Pept , vol.167 , pp. 233-238
    • Maggio, E.T.1    Grasso, P.2
  • 172
    • 84871393397 scopus 로고    scopus 로고
    • A subcutaneous octreotide hydrogel implant for the treatment of acromegaly
    • Gadelha MR, Chieffo C, Bai SA, et al. A subcutaneous octreotide hydrogel implant for the treatment of acromegaly. Endocr Pract 2012;18:870-81
    • (2012) Endocr Pract , vol.18 , pp. 870-881
    • Gadelha, M.R.1    Chieffo, C.2    Bai, S.A.3
  • 173
    • 84885194977 scopus 로고    scopus 로고
    • Efficacy and safety of an octreotide implant in the treatment of patients with acromegaly
    • Chieffo C, Cook D, Xiang Q, Frohman LA. Efficacy and safety of an octreotide implant in the treatment of patients with acromegaly. J Clin Endocrinol Metab 2013;98:4047-54
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 4047-4054
    • Chieffo, C.1    Cook, D.2    Xiang, Q.3    Frohman, L.A.4
  • 174
    • 33744988373 scopus 로고    scopus 로고
    • BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, vs universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide
    • Jaquet P, Gunz G, Saveanu A, et al. BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, vs universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide. J Endocrinol Invest 2005;28:21-7
    • (2005) J Endocrinol Invest , vol.28 , pp. 21-27
    • Jaquet, P.1    Gunz, G.2    Saveanu, A.3
  • 175
    • 82155172862 scopus 로고    scopus 로고
    • Somatostatin-dopamine chimeras: A novel approach to treatment of neuroendocrine tumors
    • Culler MD. Somatostatin-dopamine chimeras: a novel approach to treatment of neuroendocrine tumors. Horm Metab Res 2011;43:854-7
    • (2011) Horm Metab Res , vol.43 , pp. 854-857
    • Culler, M.D.1
  • 176
    • 22744440925 scopus 로고    scopus 로고
    • Efficacy of chimeric molecules directed towards multiple somatostatin and dopamine receptors on inhibition of GH and prolactin secretion from GH-secreting pituitary adenomas classified as partially responsive to somatostatin analog therapy
    • Jaquet P, Gunz G, Saveanu A, et al. Efficacy of chimeric molecules directed towards multiple somatostatin and dopamine receptors on inhibition of GH and prolactin secretion from GH-secreting pituitary adenomas classified as partially responsive to somatostatin analog therapy. Eur J Endocrinol 2005;153:135-41
    • (2005) Eur J Endocrinol , vol.153 , pp. 135-141
    • Jaquet, P.1    Gunz, G.2    Saveanu, A.3
  • 177
    • 84865303875 scopus 로고    scopus 로고
    • Somatostatin analogs and chimeric somatostatin-dopamine molecules differentially regulate human growth hormone and prolactin gene expression and secretion in vitro
    • Gruszka A, Culler MD, Melmed S. Somatostatin analogs and chimeric somatostatin-dopamine molecules differentially regulate human growth hormone and prolactin gene expression and secretion in vitro. Mol Cell Endocrinol 2012;362:104-9
    • (2012) Mol Cell Endocrinol , vol.362 , pp. 104-109
    • Gruszka, A.1    Culler, M.D.2    Melmed, S.3
  • 178
    • 33646347639 scopus 로고    scopus 로고
    • A GH receptor antisense oligonucleotide inhibits hepatic GH receptor expression, IGF-I production and body weight gain in normal mice
    • Tachas G, Lofthouse S, Wraight CJ, et al. A GH receptor antisense oligonucleotide inhibits hepatic GH receptor expression, IGF-I production and body weight gain in normal mice. J Endocrinol 2006;189:147-54
    • (2006) J Endocrinol , vol.189 , pp. 147-154
    • Tachas, G.1    Lofthouse, S.2    Wraight, C.J.3
  • 179
    • 0023605735 scopus 로고
    • Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl- imidazo[5,1-d] 1,2,35-tetrazin-4(3H)-one (CCRG 81045 M & B 39831) a novel drug with potential as an alternative to dacarbazine
    • Stevens MF, Hickman JA, Langdon SP, et al. Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]- 1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine. Cancer Res 1987;47:5846-52
    • (1987) Cancer Res , vol.47 , pp. 5846-5852
    • Stevens, M.F.1    Hickman, J.A.2    Langdon, S.P.3
  • 180
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens A-C, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005;352:997-1003
    • (2005) N Engl J Med , vol.352 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.-C.2    Gorlia, T.3
  • 181
    • 33845338456 scopus 로고    scopus 로고
    • Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: Morphological findings
    • Kovacs K, Horvath E, Syro L V, et al. Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: morphological findings. Hum Pathol 2007;38:185-9
    • (2007) Hum Pathol , vol.38 , pp. 185-189
    • Kovacs, K.1    Horvath, E.2    Syro, L.V.3
  • 182
    • 70350728390 scopus 로고    scopus 로고
    • A novel use of temozolomide in a patient with malignant prolactinoma
    • Byrne S, Karapetis C, Vrodos N. A novel use of temozolomide in a patient with malignant prolactinoma. J Clin Neurosci 2009;16:1694-6
    • (2009) J Clin Neurosci , vol.16 , pp. 1694-1696
    • Byrne, S.1    Karapetis, C.2    Vrodos, N.3
  • 183
    • 78649893043 scopus 로고    scopus 로고
    • Salvage therapy with temozolomide in patients with aggressive or metastatic pituitary adenomas: Experience in six cases
    • Losa M, Mazza E, Terreni MR, et al. Salvage therapy with temozolomide in patients with aggressive or metastatic pituitary adenomas: experience in six cases. Eur J Endocrinol 2010;163:843-51
    • (2010) Eur J Endocrinol , vol.163 , pp. 843-851
    • Losa, M.1    Mazza, E.2    Terreni, M.R.3
  • 184
    • 79951685894 scopus 로고    scopus 로고
    • Diagnosis and treatment of hyperprolactinemia: An Endocrine Society clinical practice guideline
    • Melmed S, Casanueva FF, Hoffman AR, et al. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96:273-88
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 273-288
    • Melmed, S.1    Casanueva, F.F.2    Hoffman, A.R.3
  • 185
    • 34447318059 scopus 로고    scopus 로고
    • MGMT hypermethylation: A prognostic foe, a predictive friend
    • Jacinto F V, Esteller M. MGMT hypermethylation: a prognostic foe, a predictive friend. DNA Repair (Amst) 2007;6:1155-60
    • (2007) DNA Repair (Amst) , vol.6 , pp. 1155-1160
    • Jacinto, F.V.1    Esteller, M.2
  • 186
    • 67650302290 scopus 로고    scopus 로고
    • Low O6- methylguanine-DNA methyltransferase (MGMT) expression and response to temozolomide in aggressive pituitary tumours
    • McCormack AI, McDonald KL, Gill AJ, et al. Low O6- methylguanine-DNA methyltransferase (MGMT) expression and response to temozolomide in aggressive pituitary tumours. Clin Endocrinol (Oxf) 2009;71:226-33
    • (2009) Clin Endocrinol (Oxf) , vol.71 , pp. 226-233
    • McCormack, A.I.1    McDonald, K.L.2    Gill, A.J.3
  • 187
    • 77957808859 scopus 로고    scopus 로고
    • Temozolomide treatment in aggressive pituitary tumors and pituitary carcinomas: A French multicenter experience
    • Raverot G, Sturm N, de Fraipont F, et al. Temozolomide treatment in aggressive pituitary tumors and pituitary carcinomas: a French multicenter experience. J Clin Endocrinol Metab 2010;95:4592-9
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 4592-4599
    • Raverot, G.1    Sturm, N.2    De Fraipont, F.3
  • 188
    • 33749537681 scopus 로고    scopus 로고
    • Long-term response of pituitary carcinoma to temozolomide. Report of two cases
    • Fadul CE, Kominsky AL, Meyer LP, et al. Long-term response of pituitary carcinoma to temozolomide. Report of two cases. J Neurosurg 2006;105:621-6
    • (2006) J Neurosurg , vol.105 , pp. 621-626
    • Fadul, C.E.1    Kominsky, A.L.2    Meyer, L.P.3
  • 189
    • 78049497348 scopus 로고    scopus 로고
    • Temozolomide treatment for aggressive pituitary tumors: Correlation of clinical outcome with O(6)- methylguanine methyltransferase (MGMT) promoter methylation and expression
    • Bush ZM, Longtine JA, Cunningham T, et al. Temozolomide treatment for aggressive pituitary tumors: correlation of clinical outcome with O(6)- methylguanine methyltransferase (MGMT) promoter methylation and expression. J Clin Endocrinol Metab 2010;95:E280-90
    • (2010) J Clin Endocrinol Metab , vol.95
    • Bush, Z.M.1    Longtine, J.A.2    Cunningham, T.3
  • 190
    • 79955089003 scopus 로고    scopus 로고
    • Temozolomide (Temodar-) and capecitabine (Xeloda-) treatment of an aggressive corticotroph pituitary tumor
    • Thearle MS, Freda PU, Bruce JN, et al. Temozolomide (Temodar-) and capecitabine (Xeloda-) treatment of an aggressive corticotroph pituitary tumor. Pituitary 2011;14:418-24
    • (2011) Pituitary , vol.14 , pp. 418-424
    • Thearle, M.S.1    Freda, P.U.2    Bruce, J.N.3
  • 191
    • 67649839955 scopus 로고    scopus 로고
    • Use of temozolomide in aggressive pituitary tumors: Case report
    • Mohammed S, Kovacs K, Mason W, et al. Use of temozolomide in aggressive pituitary tumors: case report. Neurosurgery 2009;64:E773-4
    • (2009) Neurosurgery , vol.64
    • Mohammed, S.1    Kovacs, K.2    Mason, W.3
  • 192
    • 70349771361 scopus 로고    scopus 로고
    • Temozolomide treatment of a pituitary carcinoma and two pituitary macroadenomas resistant to conventional therapy
    • Hagen C, Schroeder HD, Hansen S, Andersen M. Temozolomide treatment of a pituitary carcinoma and two pituitary macroadenomas resistant to conventional therapy. Eur J Endocrinol 2009;161:631-7
    • (2009) Eur J Endocrinol , vol.161 , pp. 631-637
    • Hagen, C.1    Schroeder, H.D.2    Hansen, S.3    Andersen, M.4
  • 193
    • 79959922097 scopus 로고    scopus 로고
    • Failure of temozolomide and conventional doses of pegvisomant to attain biochemical control in a severe case of acromegaly
    • Morin E, Berthelet F, Weisnagel J, et al. Failure of temozolomide and conventional doses of pegvisomant to attain biochemical control in a severe case of acromegaly. Pituitary 2012;15:97-100
    • (2012) Pituitary , vol.15 , pp. 97-100
    • Morin, E.1    Berthelet, F.2    Weisnagel, J.3
  • 194
    • 84879191836 scopus 로고    scopus 로고
    • Peptide receptor targeting in cancer: The somatostatin paradigm
    • Barbieri F, Bajetto A, Pattarozzi A, et al. Peptide receptor targeting in cancer: the somatostatin paradigm. Int J Pept 2013;2013:926295
    • (2013) Int J Pept , vol.2013 , pp. 926295
    • Barbieri, F.1    Bajetto, A.2    Pattarozzi, A.3
  • 195
    • 84881316730 scopus 로고    scopus 로고
    • Somatostatin receptors: From signaling to clinical practice
    • Theodoropoulou M, Stalla GK. Somatostatin receptors: from signaling to clinical practice. Front Neuroendocrinol 2013;34:228-52
    • (2013) Front Neuroendocrinol , vol.34 , pp. 228-252
    • Theodoropoulou, M.1    Stalla, G.K.2
  • 196
    • 84884878045 scopus 로고    scopus 로고
    • Molecular and functional properties of densely and sparsely granulated GH-producing pituitary adenomas
    • Mayr BM, Buslei R, Theodoropoulou M, et al. Molecular and functional properties of densely and sparsely granulated GH-producing pituitary adenomas. Eur J Endocrinol 2013;169(4):391-400
    • (2013) Eur J Endocrinol , vol.169 , Issue.4 , pp. 391-400
    • Mayr, B.M.1    Buslei, R.2    Theodoropoulou, M.3
  • 197
    • 84876986891 scopus 로고    scopus 로고
    • Novel pathway for somatostatin analogs in patients with acromegaly
    • Gadelha MR, Kasuki L, Korbonits M. Novel pathway for somatostatin analogs in patients with acromegaly. Trends Endocrinol Metab 2013;24:238-46
    • (2013) Trends Endocrinol Metab , vol.24 , pp. 238-246
    • Gadelha, M.R.1    Kasuki, L.2    Korbonits, M.3
  • 199
    • 84875156034 scopus 로고    scopus 로고
    • Granulation pattern, but not GSP or GHR mutation, is associated with clinical characteristics in somatostatinnaive patients with somatotroph adenomas
    • Larkin SJ, Reddy RG, Karavitaki N, et al. Granulation pattern, but not GSP or GHR mutation, is associated with clinical characteristics in somatostatinnaive patients with somatotroph adenomas. Eur J Endocrinol 2013;168(4):491-9
    • (2013) Eur J Endocrinol , vol.168 , Issue.4 , pp. 491-499
    • Larkin, S.J.1    Reddy, R.G.2    Karavitaki, N.3
  • 200
    • 0034924612 scopus 로고    scopus 로고
    • Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands
    • Reubi J, Waser B, Schaer J-C, Laissue J. Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands. Eur J Nucl Med Mol Imaging 2001;28:836-46
    • (2001) Eur J Nucl Med Mol Imaging , vol.28 , pp. 836-846
    • Reubi, J.1    Waser, B.2    Schaer, J.-C.3    Laissue, J.4


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