Studies with a growth hormone antagonist and dual-fluorescent confocal microscopy demonstrate that the full-length human growth hormone receptor, but not the truncated isoform, is very rapidly internalized independent of Jak2-Stat5 signaling

Journal of Biological Chemistry

Volumn 274, Issue 21, 1999, Pages 14791-14798

  Maamra, Mabrouka ^a   Finidori, Joelle ^b   Von Laue, Sigward ^a   Simon, Sylvie ^a   Justice, Sue ^a   Webster, Jonathan ^a   Dower, Steven ^a   Ross, Richard ^a,c  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b INSERM   (France)

^c NORTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE RECEPTOR;

ARTICLE; CONFORMATIONAL TRANSITION; HUMAN; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR DENSITY; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TRANSPORT KINETICS;

GOLGI APPARATUS; HUMAN GROWTH HORMONE; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; PROTEIN ISOFORMS; RECEPTORS, SOMATOTROPIN;

EID: 0033591392     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.21.14791     Document Type: Article

References (28)

1. Finidori, J., and Kelly, P. A. (1995) J. Endocrinol. 147, 11-23
2. Ross, R. J. M., Esposito, N., Shen, X. Y., Von Laue, S., Chew, S. L., Dobson, P., Postel-Vinay, M., and Finidori, J. (1997) Mol. Endocrinol. 11, 265-273
3. Dastot, F., Sobrier, F., Duquesnoy, P., Duriez, B., Goosens, M., and Amselem, S. (1996) Proc. Natl. Acad. Sci. U. S. A. 98, 10723-10728
4. Htun, H., Barsony, J., Renyi, I., Gould, D. L., and Hager, G. L. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 4845-4850
5. Amit, T., Bergman, T., Dastot, F., Youdim, M. B. H., Amselem, S., and Hochberg, Z. (1997) J. Clin. Endocrinol. Metab. 82, 3813-3817
6. Ayling, R. M., Ross, R. J. M., Towner, P., Von Laue, S., Finidori, J., Moutoussamy, S., Buchanan, C. R., Clayton, P. E., and Norman, M. (1997) Nat. Genet. 16, 13-14
7. Iida, K., Takahashi, Y., Kaji, H., Nose, O., Okimura, Y., Abe, H., and Chihara, K. (1998) J. Clin. Endocrinol. Metab. 83, 531-537
8. Ilondo, M. M., Smal, J., De Meyts, P., and Courtoy, P. J. (1991) Endocrinology 128, 1597-3729
9. Govers, R., Kerkhof, P. V., Schwartz, A. L., and Strous, G. J. (1997) EMBO J. 16, 4851-4858
10. Allevato, G., Billestrup, N., Goujon, L., Galsgaard, E. D., Noratedt, G., Postel-Vinay, M.-C., Kelly, P. A., and Nielson, J. H. (1995) J. Biol. Chem. 270, 17210-17214
11. Govers, R., Van Kerkhof, P., Schwartz, A. L., and Strous, G. J. (1998) J. Biol. Chem. 273, 16426-16433
12. Silva, C. M., Weber, M. J., and Thorner, M. O. (1993) Endocrinology 132, 101-108
13. Mellado, M., Rodriguez-Frade, J. M., Kremer, L., von Kobbe, C., de Ana, A. M., Merida, I., and Martinez-A., C. (1997) J. Biol. Chem. 272, 9189-9196
14. Fuh, G., Cunningham, B. C., Fukunaga, R., Nagata, S., Goeddel, D. V., and Wells, J. A. (1992) Science 256, 1677-1680
15. Harding, P. A., Wang, X., Okada, S., Chen, W. Y., Wan, W., and Kopchick, J. J. (1996) J. Biol. Chem. 271, 6708-6712
16. van der Lely, A. J., Lamberts, S. W. J., Barkan, A., Pandya, N., Besser, G. M., Trainer, P. J., Bonert, V., Melmed, S., Clemmons, D. R., Rose, R., Vance, M. L., Thorner, M. O., Zib, K. A., Davis, R. J., Bennett, W. F., and Scarlett, J. A. (1998) Program and Abstracts: The Endocrine Society 1998, p. 57, Abstr. OR4-1
17. Thorner, M. O., Scarlett, J. A., Zib, K. A., Straume, M., and Bennett, W. F. (1998) Program and Abstracts: The Endocrine Society 1998, p. 57, Abstr. OR4-2
18. Lowman, H. B., and Wells, J. A. (1993) J. Mol. Biol. 234, 564-578
19. Leung, K., Waters, M. J., Markus, I., Baumbach, W. R., and Ho, K. K. Y. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 11381-11386
20. Wang, Y., and Wood, W. I. (1995) Mol. Endocrinol. 9, 303-311
21. Presley, J. F., Cole, N. B., Schroer, T. A., Hirschberg, K., Zaal, K. J. M., and Lippincott-Schwartz, J. (1997) Nature 389, 81-85
22. Htun, H., Barsony, J., Renyi, I., Gould, D. L., and Hager, G. L. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 4845-4850
23. Tarasova, N. I., Stauber, R. H., Choi, J. K., Hudson, E. A., Czerwinski, G., Miller, J. L., Pavlakis, G. N., Michejda, C. J., and Wank, S. A. (1998) J. Biol. Chem. 272, 14817-14824
24. Kallal, L., Gagnon, A. W., Penn, R. B., and Benovic, J. L. (1998) J. Biol. Chem. 273, 322-328
25. Sotiropoulos, A., Moutoussamy, S., Renaudie, F., Clauss, M., Kayser, C., Gouilleux, F., Kelly, P. A., and Finidori, J. (1996) Mol. Endocrinol. 10, 998-1009
26. Goujon, L., Allevato, G., Simonin, G., Paquereau, L., Le Cam, A., Clark, J., Nielsen, J. H., Djiane, J., Postel-Vinay, M., Edery, M., and Kelly, P. A. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 957-961
27. Wojcik, J., Berg, M. A., Esposito, N., Geffner, M. E., Sakati, N., Reiter, E. O., Dower, S. K., Francke, U., Postel-Vinay, M., and Finidori, J. (1998) J. Clin. Endocrinol. Metab. 83, 4481-4489
28. Barak, L. S., Ferguson, S. S. G., Zhang, J., Martenson, C., Meyer, T., and Caron, M. G. (1997) Mol. Pharmacol. 51, 177-184