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Volumn 142, Issue 1-2, 1998, Pages 1-14

At the cutting edge. G protein abnormalities in pituitary adenomas

Author keywords

G proteins; Gsp; Phosphodiesterase; Pituitary adenomas

Indexed keywords

CYCLIC AMP; GROWTH HORMONE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; PHOSPHODIESTERASE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 0032566155     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(98)00116-6     Document Type: Article
Times cited : (44)

References (97)
  • 1
    • 0027202237 scopus 로고
    • Clinical and biochemical characteristics of acromegalic patients harboring gsp-positive and gsp-negative pituitary tumors
    • Adams E.F., Brockmeier S., Friedmann E., Roth M., Buchfelder M., Fahlbusch R. Clinical and biochemical characteristics of acromegalic patients harboring gsp-positive and gsp-negative pituitary tumors. Neurosurgery. 33:1993;198-203.
    • (1993) Neurosurgery , vol.33 , pp. 198-203
    • Adams, E.F.1    Brockmeier, S.2    Friedmann, E.3    Roth, M.4    Buchfelder, M.5    Fahlbusch, R.6
  • 5
    • 0030656476 scopus 로고    scopus 로고
    • Immunodetection of G proteins in human pituitary adenomas; Evidence for a low expression of proteins of the Gi subfamily
    • Ballarè E., Mantovani S., Bassetti M., Lania A., Spada A. Immunodetection of G proteins in human pituitary adenomas; evidence for a low expression of proteins of the Gi subfamily. Eur. J. Endocrinol. 137:1997;482-489.
    • (1997) Eur. J. Endocrinol. , vol.137 , pp. 482-489
    • Ballarè, E.1    Mantovani, S.2    Bassetti, M.3    Lania, A.4    Spada, A.5
  • 7
    • 0029017174 scopus 로고
    • The cyclic adenosine 3′, 5′ monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas
    • Bertherat J., Chanson P., Montminy M. The cyclic adenosine 3′, 5′ monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. Mol. Endocrinol. 9:1995;777-783.
    • (1995) Mol. Endocrinol. , vol.9 , pp. 777-783
    • Bertherat, J.1    Chanson, P.2    Montminy, M.3
  • 8
    • 1842413392 scopus 로고
    • Growth hormone releasing factor stimulates cell proliferation of somatotrophs in vitro
    • Billestrup N., Swanson L.W., Vale W. Growth hormone releasing factor stimulates cell proliferation of somatotrophs in vitro. Proc. Natl. Acad. Sci. USA. 83:1986;6854-6857.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 6854-6857
    • Billestrup, N.1    Swanson, L.W.2    Vale, W.3
  • 9
    • 0025010979 scopus 로고
    • The GTPase superfamily: A conserved switch for diverse cell functions
    • Bourne H.R., Sanders D.A., McCormick F. The GTPase superfamily: a conserved switch for diverse cell functions. Nature. 348:1990;125-132.
    • (1990) Nature , vol.348 , pp. 125-132
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 11
    • 0026062347 scopus 로고
    • Pituitary hyperplasia and gigantism in mice caused by a cholera toxin transgene
    • Burton F.H., Hasel K.W., Bloom F.E., Sutcliffe J.G. Pituitary hyperplasia and gigantism in mice caused by a cholera toxin transgene. Nature. 350:1991;74-77.
    • (1991) Nature , vol.350 , pp. 74-77
    • Burton, F.H.1    Hasel, K.W.2    Bloom, F.E.3    Sutcliffe, J.G.4
  • 13
    • 0025914568 scopus 로고
    • Function of homeodomain protein GHF1 in pituitary cell proliferation
    • Castrillo J.L., Theill L.E., Karin M. Function of homeodomain protein GHF1 in pituitary cell proliferation. Science. 253:1991;197-199.
    • (1991) Science , vol.253 , pp. 197-199
    • Castrillo, J.L.1    Theill, L.E.2    Karin, M.3
  • 15
    • 0025277540 scopus 로고
    • Autoregulation of pit 1 gene expression mediated by two cis-active promoter elements
    • Chen R., Ingraham H.A., Treacy M.N., Albert V.R., Wilson L., Rosenfeld M.G. Autoregulation of pit 1 gene expression mediated by two cis-active promoter elements. Nature. 346:1990;583-586.
    • (1990) Nature , vol.346 , pp. 583-586
    • Chen, R.1    Ingraham, H.A.2    Treacy, M.N.3    Albert, V.R.4    Wilson, L.5    Rosenfeld, M.G.6
  • 16
    • 0028153118 scopus 로고
    • Ion channels and signal transduction in the regulation of growth hormone secretion
    • Chen C., Vincent J.D., Clarke I.J. Ion channels and signal transduction in the regulation of growth hormone secretion. Trends Endocrinol. Metab. 5:1994;227-233.
    • (1994) Trends Endocrinol. Metab. , vol.5 , pp. 227-233
    • Chen, C.1    Vincent, J.D.2    Clarke, I.J.3
  • 17
    • 0031032953 scopus 로고    scopus 로고
    • Intracellular calcium ion in response to somatostatin in cells from human somatotroph adenomas
    • Chen Z.P., Xu S.U., Lightman S.L., Hall L., Levy A. Intracellular calcium ion in response to somatostatin in cells from human somatotroph adenomas. Clin. Endocrinol. (Oxford). 46:1997;45-53.
    • (1997) Clin. Endocrinol. (Oxford) , vol.46 , pp. 45-53
    • Chen, Z.P.1    Xu, S.U.2    Lightman, S.L.3    Hall, L.4    Levy, A.5
  • 19
    • 0025285138 scopus 로고
    • A new constitutively activating mutation of the Gs protein α subunit-gsp oncogene is found in human pituitary tumours
    • Clementi E., Malgaretti N., Meldolesi J., Taramelli R. A new constitutively activating mutation of the Gs protein α subunit-gsp oncogene is found in human pituitary tumours. Oncogene. 5:1990;1059-1061.
    • (1990) Oncogene , vol.5 , pp. 1059-1061
    • Clementi, E.1    Malgaretti, N.2    Meldolesi, J.3    Taramelli, R.4
  • 20
    • 0029009878 scopus 로고
    • Recent progress in understanding the hormonal regulation of phosphodiesterases
    • Conti M., Nemoz G., Sette C., Vicini E. Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocr. Rev. 16:1995;370-389.
    • (1995) Endocr. Rev. , vol.16 , pp. 370-389
    • Conti, M.1    Nemoz, G.2    Sette, C.3    Vicini, E.4
  • 21
    • 0027716596 scopus 로고
    • Inhibition by cAMP of Ras-dependent activation of Raf
    • Cook S.J., McCormick F. Inhibition by cAMP of Ras-dependent activation of Raf. Science. 262:1993;1069-1072.
    • (1993) Science , vol.262 , pp. 1069-1072
    • Cook, S.J.1    McCormick, F.2
  • 22
    • 0019858493 scopus 로고
    • The 7315α pituiatry tumor is refractory to dopaminergic inhibition of prolactin release but contains dopamine receptors
    • Cronin M.J., Valdenegro C.A., Perkins S.N., MacLeod R.M. The 7315α pituiatry tumor is refractory to dopaminergic inhibition of prolactin release but contains dopamine receptors. Endocrinology. 109:1981;2160-2166.
    • (1981) Endocrinology , vol.109 , pp. 2160-2166
    • Cronin, M.J.1    Valdenegro, C.A.2    Perkins, S.N.3    MacLeod, R.M.4
  • 23
    • 0029664322 scopus 로고    scopus 로고
    • Constitutive activation of the Gsα protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas
    • Derwahl M., Hamacher C., Russo D., Broecker M., Manole D., Schatz H., Kopp P., Filetti S. Constitutive activation of the Gsα protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas. J. Clin. Endocrinol. Metab. 81:1996;1898-1904.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 1898-1904
    • Derwahl, M.1    Hamacher, C.2    Russo, D.3    Broecker, M.4    Manole, D.5    Schatz, H.6    Kopp, P.7    Filetti, S.8
  • 24
    • 0029011084 scopus 로고
    • G protein-coupled receptor systems involved in cell growth and oncogenesis
    • Dhanasekaran N., Heasley L.E., Johnson G.L. G protein-coupled receptor systems involved in cell growth and oncogenesis. Endocr. Rev. 16:1995;259-270.
    • (1995) Endocr. Rev. , vol.16 , pp. 259-270
    • Dhanasekaran, N.1    Heasley, L.E.2    Johnson, G.L.3
  • 26
    • 0030020680 scopus 로고    scopus 로고
    • Structure of the thyrotrophin-releasing hormone receptor in human pituitary adenomas
    • Faccenda E., Melmed S., Bevan J.S., Eidne K.A. Structure of the thyrotrophin-releasing hormone receptor in human pituitary adenomas. Clin. Endocrinol. (Oxford). 44:1996;341-347.
    • (1996) Clin. Endocrinol. (Oxford) , vol.44 , pp. 341-347
    • Faccenda, E.1    Melmed, S.2    Bevan, J.S.3    Eidne, K.A.4
  • 27
    • 0029164908 scopus 로고
    • Differential effects of cAMP on the MAP kinase cascade; Evidence for a cAMP-insensitive step that can bypass Raf-1
    • Faure M., Bourne H.R. Differential effects of cAMP on the MAP kinase cascade; evidence for a cAMP-insensitive step that can bypass Raf-1. Mol. Biol. Cell. 6:1995;1025-1035.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 1025-1035
    • Faure, M.1    Bourne, H.R.2
  • 28
    • 0028216328 scopus 로고
    • Guanine-nucleotide exchange factors: A family of positive regulators of ras and related GTPases
    • Feig L.A. Guanine-nucleotide exchange factors: a family of positive regulators of ras and related GTPases. Curr. Opin. Cell. Biol. 6:1994;204-211.
    • (1994) Curr. Opin. Cell. Biol. , vol.6 , pp. 204-211
    • Feig, L.A.1
  • 30
    • 0028141937 scopus 로고
    • Genomic effects of the putative oncogene Gαs: Chronic transcriptional activation of c-fos protooncogene in endocrine cells
    • Gaiddon C., Boutillier A.L., Monnier D., Mercken L., Loeffler J.P. Genomic effects of the putative oncogene Gαs: chronic transcriptional activation of c-fos protooncogene in endocrine cells. J. Biol. Chem. 36:1994;22663-22671.
    • (1994) J. Biol. Chem. , vol.36 , pp. 22663-22671
    • Gaiddon, C.1    Boutillier, A.L.2    Monnier, D.3    Mercken, L.4    Loeffler, J.P.5
  • 31
    • 0028982711 scopus 로고
    • Transcriptional effects in GH3 cells of Gsα mutants associated with human pituitary tumors: Stimulation of adenosine 3′,5′-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A
    • Gaiddon C., Mercken L., Bancroft C., Loeffler J.P. Transcriptional effects in GH3 cells of Gsα mutants associated with human pituitary tumors: stimulation of adenosine 3′,5′-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A. Endocrinology. 136:1995;4331-4338.
    • (1995) Endocrinology , vol.136 , pp. 4331-4338
    • Gaiddon, C.1    Mercken, L.2    Bancroft, C.3    Loeffler, J.P.4
  • 32
    • 0025971854 scopus 로고
    • Genetic mapping of the Gs-α subunit gene (GNAS1) to the distal long arm of chromosome 20 using a polymorphism detected by denaturing gradient gel electrophoresis
    • Gejman P.V., Weinstein L.S., Martinez M., Spiegel A.M., Cao Q., Hseih W.T., Hoehe M.R., Gershon E.S. Genetic mapping of the Gs-α subunit gene (GNAS1) to the distal long arm of chromosome 20 using a polymorphism detected by denaturing gradient gel electrophoresis. Genomics. 9:1991;782-783.
    • (1991) Genomics , vol.9 , pp. 782-783
    • Gejman, P.V.1    Weinstein, L.S.2    Martinez, M.3    Spiegel, A.M.4    Cao, Q.5    Hseih, W.T.6    Hoehe, M.R.7    Gershon, E.S.8
  • 34
    • 0026640629 scopus 로고
    • MAP kinase is constitutively activated in gip2 and Src transformed Rat-1α fibroblasts
    • Gupta S.K., Gallego C., Johnson G.L., Heasley L.E. MAP kinase is constitutively activated in gip2 and Src transformed Rat-1α fibroblasts. J. Biol. Chem. 267:1992;7987-7990.
    • (1992) J. Biol. Chem. , vol.267 , pp. 7987-7990
    • Gupta, S.K.1    Gallego, C.2    Johnson, G.L.3    Heasley, L.E.4
  • 35
    • 0030902708 scopus 로고    scopus 로고
    • GH3 expressing constitutively active Gs alpha (Q227L) show enhanced hormone secretion and proliferation
    • Ham J., Ivan M., Wynford-Thomas D., Scanlon M.F. GH3 expressing constitutively active Gs alpha (Q227L) show enhanced hormone secretion and proliferation. Mol. Cell. Endocrinol. 127:1997;41-47.
    • (1997) Mol. Cell. Endocrinol. , vol.127 , pp. 41-47
    • Ham, J.1    Ivan, M.2    Wynford-Thomas, D.3    Scanlon, M.F.4
  • 39
    • 0027519698 scopus 로고
    • Analysis of the Gsα gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-directed sequencing method using paraffin-embedded tissues
    • Hosoi E., Yokogoshi Y., Hosoi E., Horie H., Sano T., Yamada S., Saito S. Analysis of the Gsα gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-directed sequencing method using paraffin-embedded tissues. Acta Endocrinol. 129:1993;301-306.
    • (1993) Acta Endocrinol. , vol.129 , pp. 301-306
    • Hosoi, E.1    Yokogoshi, Y.2    Hosoi, E.3    Horie, H.4    Sano, T.5    Yamada, S.6    Saito, S.7
  • 40
    • 0029830014 scopus 로고    scopus 로고
    • RGS10 is a selective activator of Gαi GTPase activity
    • Hunt T.W., Fields T.A., Casey P.J., Peralta E.G. RGS10 is a selective activator of Gαi GTPase activity. Nature. 383:1996;175-177.
    • (1996) Nature , vol.383 , pp. 175-177
    • Hunt, T.W.1    Fields, T.A.2    Casey, P.J.3    Peralta, E.G.4
  • 41
    • 0027956207 scopus 로고
    • Rapid GDP release from Gsα in patients with gain and loss of endocrine function
    • Iiri T., Herzmark P., Nakamoto J.M., Van Dop C., Bourne H.R. Rapid GDP release from Gsα in patients with gain and loss of endocrine function. Nature. 371:1994;164-168.
    • (1994) Nature , vol.371 , pp. 164-168
    • Iiri, T.1    Herzmark, P.2    Nakamoto, J.M.3    Van Dop, C.4    Bourne, H.R.5
  • 42
    • 0027973467 scopus 로고
    • Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of gαi2
    • Ikezu T., Okamoto T., Murayama Y., Homma Y., Ogata E., Nishimoto I. Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of gαi2. J. Biol. Chem. 269:1994;31955-31961.
    • (1994) J. Biol. Chem. , vol.269 , pp. 31955-31961
    • Ikezu, T.1    Okamoto, T.2    Murayama, Y.3    Homma, Y.4    Ogata, E.5    Nishimoto, I.6
  • 43
    • 0030667246 scopus 로고    scopus 로고
    • Absence of mutations in exon 3 of the GnRH receptor in human gonadotroph adenomas
    • Kaye P.V., Hapgood J., Millar R.P. Absence of mutations in exon 3 of the GnRH receptor in human gonadotroph adenomas. Clin. Endocrinol. 47:1997;546-554.
    • (1997) Clin. Endocrinol. , vol.47 , pp. 546-554
    • Kaye, P.V.1    Hapgood, J.2    Millar, R.P.3
  • 44
    • 0024404145 scopus 로고
    • GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumors
    • Landis C., Masters S.B., Spada A., Pace A.M., Bourne H.R., Vallar L. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumors. Nature. 340:1989;692-696.
    • (1989) Nature , vol.340 , pp. 692-696
    • Landis, C.1    Masters, S.B.2    Spada, A.3    Pace, A.M.4    Bourne, H.R.5    Vallar, L.6
  • 46
    • 0031754596 scopus 로고    scopus 로고
    • Constitutively active Gsα is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas
    • Lania A., Persani L., Ballarè E., Mantovani S., Losa M., Spada A. Constitutively active Gsα is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas. J. Clin. Endocrinol. Metab. 83:1998;1624-1628.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 1624-1628
    • Lania, A.1    Persani, L.2    Ballarè, E.3    Mantovani, S.4    Losa, M.5    Spada, A.6
  • 47
    • 0026499881 scopus 로고
    • Thyroid expression of an A2 adenosine receptor transgene induces thyroid hyperplasia and hyperthyroidism
    • Ledent C., Dumont J.E., Vassart G., Parmentier M. Thyroid expression of an A2 adenosine receptor transgene induces thyroid hyperplasia and hyperthyroidism. EMBO J. 11:1992;537-542.
    • (1992) EMBO J. , vol.11 , pp. 537-542
    • Ledent, C.1    Dumont, J.E.2    Vassart, G.3    Parmentier, M.4
  • 48
    • 0027236844 scopus 로고
    • Molecular basis of the little mouse phenotype and implications for cell type-specific growth
    • Lin S., Lin C., Gukovsky I., Lusis A., Sawchenko P., Rosenfeld M.G. Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature. 364:1993;208-213.
    • (1993) Nature , vol.364 , pp. 208-213
    • Lin, S.1    Lin, C.2    Gukovsky, I.3    Lusis, A.4    Sawchenko, P.5    Rosenfeld, M.G.6
  • 50
    • 0028157931 scopus 로고
    • Constitutively active stimulatory G protein as in β cells of transgenic mice causes counteregulation of the increased adenosine 3′53-monophosphate and insulin secretion
    • Ma Y.H., Landis C.A., Tchao N., Wang J., Rodd G., Hanapan D., Bourne H.R., Grodsky G.M. Constitutively active stimulatory G protein as in β cells of transgenic mice causes counteregulation of the increased adenosine 3′53-monophosphate and insulin secretion. Endocrinology. 134:1994;42-47.
    • (1994) Endocrinology , vol.134 , pp. 42-47
    • Ma, Y.H.1    Landis, C.A.2    Tchao, N.3    Wang, J.4    Rodd, G.5    Hanapan, D.6    Bourne, H.R.7    Grodsky, G.M.8
  • 51
    • 0025965495 scopus 로고
    • Activation of the cyclic AMP cascade as an oncogenic mechanism: The thyroid example
    • Maenhaut C., Roger P.P., Reuse S., Dumont J.E. Activation of the cyclic AMP cascade as an oncogenic mechanism: the thyroid example. Biochimie. 73:1991;29-36.
    • (1991) Biochimie , vol.73 , pp. 29-36
    • Maenhaut, C.1    Roger, P.P.2    Reuse, S.3    Dumont, J.E.4
  • 52
    • 0028152333 scopus 로고
    • MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
    • Marshall C.J. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr. Opin. Gen. Develop. 4:1994;82-89.
    • (1994) Curr. Opin. Gen. Develop. , vol.4 , pp. 82-89
    • Marshall, C.J.1
  • 55
    • 0028116687 scopus 로고
    • Expression of mutationally activated Gαs stimulates growth and differentiation of thyroid FRTL 5 cells
    • Muca C., Vallar L. Expression of mutationally activated Gαs stimulates growth and differentiation of thyroid FRTL 5 cells. Oncogene. 9:1994;3647-3653.
    • (1994) Oncogene , vol.9 , pp. 3647-3653
    • Muca, C.1    Vallar, L.2
  • 56
    • 0029166561 scopus 로고
    • Activation of cyclic nucleotide phosphodiesterase in FRTL-5 thyroid cells expressing a constitutively active Gsα
    • Nemoz G., Sette C., Hess M., Muca C., Vallar L., Conti M. Activation of cyclic nucleotide phosphodiesterase in FRTL-5 thyroid cells expressing a constitutively active Gsα Mol. Endocrinol. 9:1995;1279-1287.
    • (1995) Mol. Endocrinol. , vol.9 , pp. 1279-1287
    • Nemoz, G.1    Sette, C.2    Hess, M.3    Muca, C.4    Vallar, L.5    Conti, M.6
  • 59
    • 0025826856 scopus 로고
    • A mutant α-subunit of Gip2 induces neoplastic transformationin RAT-1 cells
    • Pace A.M., Wong Y.H., Bourne H.R. A mutant α-subunit of Gip2 induces neoplastic transformationin RAT-1 cells. Proc. Natl. Acad. Sci. USA. 88:1991;7031-7035.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7031-7035
    • Pace, A.M.1    Wong, Y.H.2    Bourne, H.R.3
  • 62
    • 0025323257 scopus 로고
    • Mutation in the gene encoding the stimulatory G protein of the adenylate cyclase in Albright's hereditary osteodystrophy
    • Patten J.L., Johns D.R., Valle D., Eil C., Gruppuso P.A., Steele G., Smallwood P.M., Levine M.A. Mutation in the gene encoding the stimulatory G protein of the adenylate cyclase in Albright's hereditary osteodystrophy. New Engl. J. Med. 322:1990;1412-1419.
    • (1990) New Engl. J. Med. , vol.322 , pp. 1412-1419
    • Patten, J.L.1    Johns, D.R.2    Valle, D.3    Eil, C.4    Gruppuso, P.A.5    Steele, G.6    Smallwood, P.M.7    Levine, M.A.8
  • 63
    • 0027368204 scopus 로고
    • No evidence for oncogenic mutations in guanine-nucleotide binding proteins of human adrenocortical neoplasms
    • Reincke M., Karl M., Travis W., Chrousos G.P. No evidence for oncogenic mutations in guanine-nucleotide binding proteins of human adrenocortical neoplasms. J. Clin. Endocrinol. Metab. 77:1993;1419-1422.
    • (1993) J. Clin. Endocrinol. Metab. , vol.77 , pp. 1419-1422
    • Reincke, M.1    Karl, M.2    Travis, W.3    Chrousos, G.P.4
  • 64
    • 0029114410 scopus 로고
    • Molecular biology of somatostatin receptors
    • Reisine T., Bell G.I. Molecular biology of somatostatin receptors. Endocr. Rev. 16:1995;427-442.
    • (1995) Endocr. Rev. , vol.16 , pp. 427-442
    • Reisine, T.1    Bell, G.I.2
  • 67
    • 0028172104 scopus 로고
    • A novel Gs α mutant in a patient with Albright's hereditary osteodystophy uncouples cell surface receptors from adenylyl cyclase
    • Schwindinger W.F., Miric A., Zimmerman D., Levine M.A. A novel Gs α mutant in a patient with Albright's hereditary osteodystophy uncouples cell surface receptors from adenylyl cyclase. J. Biol. Chem. 269:1994;25387-25391.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25387-25391
    • Schwindinger, W.F.1    Miric, A.2    Zimmerman, D.3    Levine, M.A.4
  • 68
    • 0026694168 scopus 로고
    • Identification of a mutation in the gene encoding the α subunit of the stimulatory G-protein of adenylyl cyclase in McCune-Albright syndrome
    • Schwindinger W.F., Francomano C.A., Levine M.A. Identification of a mutation in the gene encoding the α subunit of the stimulatory G-protein of adenylyl cyclase in McCune-Albright syndrome. Proc. Natl. Acad. Sci. USA. 89:1992;5152-5156.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5152-5156
    • Schwindinger, W.F.1    Francomano, C.A.2    Levine, M.A.3
  • 69
    • 0029093559 scopus 로고
    • G protein-coupled receptor structure and function: The impact of disease-causing mutations
    • R.V. Thakker. London: Bailliere Tindall
    • Shenker A. G protein-coupled receptor structure and function: the impact of disease-causing mutations. Thakker R.V. Bailliere's Clininical Endocrinology and Metabolism. 9(3):1995;427-451 Bailliere Tindall, London.
    • (1995) Bailliere's Clininical Endocrinology and Metabolism 9(3) , pp. 427-451
    • Shenker, A.1
  • 70
    • 0031158860 scopus 로고    scopus 로고
    • Genetic basis of endocrine disease: Pituitary tumor pathogenesis
    • Shimon I., Melmed S. Genetic basis of endocrine disease: Pituitary tumor pathogenesis. J. Clin. Endocrinol. Metab. 82:1997;1675-1681.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1675-1681
    • Shimon, I.1    Melmed, S.2
  • 71
    • 0025695763 scopus 로고
    • Clinical, biochemical and morphological correlates in patients bearing growth hormone secreting tumors with or without constitutively active adenylyl cyclase
    • Spada A., Arosio M., Bochicchio D., Bazzoni N., Vallar L., Bassetti M., Faglia G. Clinical, biochemical and morphological correlates in patients bearing growth hormone secreting tumors with or without constitutively active adenylyl cyclase. J. Clin. Endocrinol. Metab. 71:1990;1421-1426.
    • (1990) J. Clin. Endocrinol. Metab. , vol.71 , pp. 1421-1426
    • Spada, A.1    Arosio, M.2    Bochicchio, D.3    Bazzoni, N.4    Vallar, L.5    Bassetti, M.6    Faglia, G.7
  • 74
    • 0026712286 scopus 로고
    • Receptor-effector coupling by G proteins: Implications for normal and abnormal signal trasduction
    • Spiegel A.M., Shenker A., Weinstein L.S. Receptor-effector coupling by G proteins: implications for normal and abnormal signal trasduction. Endocr. Rev. 13:1992;536-565.
    • (1992) Endocr. Rev. , vol.13 , pp. 536-565
    • Spiegel, A.M.1    Shenker, A.2    Weinstein, L.S.3
  • 75
    • 0029941917 scopus 로고    scopus 로고
    • Mutations in G proteins and G protein-coupled receptors in endocrine disease
    • Spiegel A.M. Mutations in G proteins and G protein-coupled receptors in endocrine disease. J. Clin. Endocrinol. Metab. 81:1996;2434-2442.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 2434-2442
    • Spiegel, A.M.1
  • 76
    • 0025853062 scopus 로고
    • Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant
    • Struthers R.S., Vale W.W., Arias C., Sawchenko P.E., Montminy M.R. Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature. 350:1991;622-624.
    • (1991) Nature , vol.350 , pp. 622-624
    • Struthers, R.S.1    Vale, W.W.2    Arias, C.3    Sawchenko, P.E.4    Montminy, M.R.5
  • 80
    • 0023522307 scopus 로고
    • Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas
    • Vallar L., Spada A., Giannattasio G. Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature. 330:1987;566-567.
    • (1987) Nature , vol.330 , pp. 566-567
    • Vallar, L.1    Spada, A.2    Giannattasio, G.3
  • 81
    • 0024596455 scopus 로고
    • Mechanisms of signal transduction at the D2 receptor
    • Vallar L., Meldolesi J. Mechanisms of signal transduction at the D2 receptor. Trends Pharmacol. Sci. 10:1989;74-77.
    • (1989) Trends Pharmacol. Sci. , vol.10 , pp. 74-77
    • Vallar, L.1    Meldolesi, J.2
  • 83
    • 0029882954 scopus 로고    scopus 로고
    • Characteristics of gsp-positive growth hormone secreting pituitary tumors in Korean acromegalic patients
    • Yang I., Park S., Ryu M., Woo J., Kim S., Kim J., Kim K., Choi Y. Characteristics of gsp-positive growth hormone secreting pituitary tumors in Korean acromegalic patients. Eur. J. Endocrinol. 134:1996;720-726.
    • (1996) Eur. J. Endocrinol. , vol.134 , pp. 720-726
    • Yang, I.1    Park, S.2    Ryu, M.3    Woo, J.4    Kim, S.5    Kim, J.6    Kim, K.7    Choi, Y.8
  • 84
    • 0027325891 scopus 로고
    • Rare mutations of the Gsα asubunit gene in human endocrine tumours
    • Yoshimoto K., Iwahana H., Fukuda A., Sano T., Itakura M. Rare mutations of the Gsα asubunit gene in human endocrine tumours. Cancer. 72:1993;1386-1393.
    • (1993) Cancer , vol.72 , pp. 1386-1393
    • Yoshimoto, K.1    Iwahana, H.2    Fukuda, A.3    Sano, T.4    Itakura, M.5
  • 85
    • 0030769810 scopus 로고    scopus 로고
    • A novel mutation adjacent to the switch III domain of Gs alpha in a patient with pseudohypoparathyroidism
    • Warner D.R., Gejman P.V., Collins R.M., Weinstein L.S. A novel mutation adjacent to the switch III domain of Gs alpha in a patient with pseudohypoparathyroidism. Mol. Endocrinol. 11:1997;1718-1727.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1718-1727
    • Warner, D.R.1    Gejman, P.V.2    Collins, R.M.3    Weinstein, L.S.4
  • 86
    • 0029808079 scopus 로고    scopus 로고
    • RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunit
    • Watson N., Linder M.E., Druey K.M., Kehrl J.H., Blumer K.J. RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunit. Nature. 383:1996;172-175.
    • (1996) Nature , vol.383 , pp. 172-175
    • Watson, N.1    Linder, M.E.2    Druey, K.M.3    Kehrl, J.H.4    Blumer, K.J.5
  • 88
    • 0030249276 scopus 로고    scopus 로고
    • Glomerular-specific imprinting of the mouse Gsα gene; How does this related to hormone resistance in Albright hereditary osteodystrophy?
    • Williamson C.M., Schofield J., Dutton E.R., Seymour A., Beechey C.V., Edwards Y.H., Peters J. Glomerular-specific imprinting of the mouse Gsα gene; how does this related to hormone resistance in Albright hereditary osteodystrophy? Genomics. 36:1996;280-287.
    • (1996) Genomics , vol.36 , pp. 280-287
    • Williamson, C.M.1    Schofield, J.2    Dutton, E.R.3    Seymour, A.4    Beechey, C.V.5    Edwards, Y.H.6    Peters, J.7
  • 91
    • 0028053516 scopus 로고
    • Albright's hereditary osteodystrophy
    • Wilson L.C., Trembath R.C. Albright's hereditary osteodystrophy. J. Med. Genet. 31:1994;779-784.
    • (1994) J. Med. Genet. , vol.31 , pp. 779-784
    • Wilson, L.C.1    Trembath, R.C.2
  • 92
    • 0025804127 scopus 로고
    • Mutant α subunits of Gi2 inhibit cAMP accumulation
    • Wong Y.H., Federman A., Pace A.M. et al. Mutant α subunits of Gi2 inhibit cAMP accumulation. Nature. 351:1991;63-65.
    • (1991) Nature , vol.351 , pp. 63-65
    • Wong, Y.H.1    Federman, A.2    Pace, A.M.3
  • 93
    • 0028998475 scopus 로고
    • Mutant α subunit of Gz transforms Swiss 3T3 cells
    • Wong Y.H., Chan J.S.C., Yung L.Y., Bourne H.R. Mutant α subunit of Gz transforms Swiss 3T3 cells. Oncogene. 10:1995;1927-1933.
    • (1995) Oncogene , vol.10 , pp. 1927-1933
    • Wong, Y.H.1    Chan, J.S.C.2    Yung, L.Y.3    Bourne, H.R.4
  • 95
    • 0028338743 scopus 로고
    • Potent transforming activity of the G(13) α subunit defines a novel family of oncogenes
    • Xu N.Z., Voynoyasenetskaya T., Gutkind J.S. Potent transforming activity of the G(13) α subunit defines a novel family of oncogenes. Biochem. Biophys. Res. Commun. 201:1994;603-609.
    • (1994) Biochem. Biophys. Res. Commun. , vol.201 , pp. 603-609
    • Xu, N.Z.1    Voynoyasenetskaya, T.2    Gutkind, J.S.3
  • 96
    • 0025284399 scopus 로고
    • Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gsα
    • Zachary I., Masters S.B., Bourne H.R. Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gsα Biochem. Biophys. Res. Commun. 168:1990;1184-1193.
    • (1990) Biochem. Biophys. Res. Commun. , vol.168 , pp. 1184-1193
    • Zachary, I.1    Masters, S.B.2    Bourne, H.R.3


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