Clinical characteristics and outcome of acromegaly induced by ectopic secretion of Growth Hormone-Releasing Hormone (GHRH): A French nationwide series of 21 cases

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 6, 2012, Pages 2093-2104

  Garby, Laetitia ^a,b   Caron, Philippe ^e   Claustrat, Francine ^b   Chanson, Philippe ^f,g,h   Tabarin, Antoine ⁱ   Rohmer, Vincent ^j   Arnault, Gwenaëlle ^k   Bonnet, Fabrice ^l   Chabre, Olivier ^m   Christin Maitre, Sophie ⁿ   Du Boullay, Hélène ^o   Murat, Arnaud ^p   Nakib, Ihab ^q   Sadoul, Jean Louis ^r   Sassolas, Geneviéve ^b   Claustrat, Bruno ^b   Raverot, Gérald ^a,b,c   Borson Chazot, Françoise ^a,b,d  

^a UNIVERSITÉ DE LYON   (France)

^b HOSPICES CIVILS DE LYON   (France)

^c LYON NEUROSCIENCE RESEARCH CENTER   (France)

^d CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^e SERVICE DE PNEUMOLOGIE   (France)

^f UNIVERSITÉ PARIS SACLAY   (France)

^g INSERM   (France)

^h BICÊTRE HOSPITAL   (France)

ⁱ HAUT LÉVÊQUE HOSPITAL   (France)

^j ANGERS UNIVERSITY HOSPITAL   (France)

^k Service d'Endocrinologie   (France)

^l RENNES UNIVERSITY HOSPITAL   (France)

^m GRENOBLE UNIVERSITY HOSPITAL   (France)

ⁿ ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^o Service d'Endocrinologie   (France)

^p CHU de Nantes   (France)

^q Clinique Courlancy   (France)

^r UNIVERSITY HOSPITAL OF NICE   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPEPTIN; DACARBAZINE; DOXORUBICIN; FLUORODEOXYGLUCOSE F 18; FLUOROURACIL; GROWTH HORMONE RELEASING FACTOR; LONG ACTING DRUG; OCTREOTIDE; PEGVISOMANT; SOMATOMEDIN C; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; STREPTOZOCIN;

ACROMEGALY; ADOLESCENT; ADULT; AGED; APPENDIX TUMOR; ARTICLE; BRONCHUS CARCINOID; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER REGRESSION; CHEMOEMBOLIZATION; CLINICAL ARTICLE; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; ECTOPIC HORMONE PRODUCTION; ENDOSCOPIC ECHOGRAPHY; FEMALE; FOLLOW UP; FRANCE; GROWTH HORMONE BLOOD LEVEL; HUMAN; MALE; METASTASIS; OUTCOME ASSESSMENT; PANCREAS TUMOR; POPULATION RESEARCH; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SENSITIVITY ANALYSIS; THYROID SCINTISCANNING; TUMOR DIAGNOSIS; TUMOR LOCALIZATION; TUMOR VOLUME;

ACROMEGALY; ADOLESCENT; ADULT; AGED; BRONCHIAL NEOPLASMS; CARCINOID TUMOR; FEMALE; FOLLOW-UP STUDIES; FRANCE; GROWTH HORMONE-RELEASING HORMONE; GROWTH HORMONE-SECRETING PITUITARY ADENOMA; HUMANS; MALE; MIDDLE AGED; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; NEUROENDOCRINE TUMORS; PANCREATIC NEOPLASMS; PITUITARY NEOPLASMS; PROGNOSIS; REGISTRIES; TREATMENT OUTCOME;

EID: 84861997432     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-2930     Document Type: Article

References (75)

1. Faglia G, Arosio M, Bazzoni N 1992 Ectopic acromegaly. Endocrinol Metab Clin North Am 21:575-595
2. Losa M, Schopohl J, von Werder K 1993 Ectopic secretion of growth hormone-releasing hormone in man. J Endocrinol Invest 16:69-81 (Pubitemid 23096272)
3. Sano T, Asa SL, Kovacs K 1988 Growth hormone-releasing hormone-producing tumors: clinical, biochemical, and morphological manifestations. Endocr Rev 9:357-373
4. Guillemin R, Brazeau P, Böhlen P, Esch F, Ling N, Wehrenberg WB 1982 Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science 5:218:585-587 (Pubitemid 12003047)
5. Rivier J, Spiess J, Thorner M, Vale W 1982 Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature 300:276-278 (Pubitemid 13234739)
6. Spiess J, Rivier J, Thorner M, Vale W 1982 Sequence analysis of a growth hormone releasing factor from a human pancreatic islet tumor. Biochemistry 23:21:6037-6040 (Pubitemid 13141608)
7. Esch FS, Böhlen P, Ling NC, Brazeau PE, Wehrenberg WB, Thorner MO, Cronin MJ, Guillemin R 1982 Characterization of a 40 residue peptide from a human pancreatic tumor with growth hormone releasing activity. Biochem Biophys Res Commun 109:152-158 (Pubitemid 13072680)
8. Sassolas G, Chayvialle JA, Partensky C, Berger G, Trouillas J, Berger F, Claustrat B, Cohen R, Girod C, Guillemin R 1983 [Acromegaly, clinical expression of the production of growth hormone releasing factor in pancreatic tumors]. Ann Endocrinol (Paris) 44:347-354 (French)
9. Thorner MO, Perryman RL, Cronin MJ, Rogol AD, Draznin M, Johanson A, Vale W, Horvath E, Kovacs K 1982 Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. J Clin Invest 70:965-977 (Pubitemid 13254920)
10. Ling N, Esch F, Böhlen P, Brazeau P, Wehrenberg WB, Guillemin R 1984 Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor. Proc Natl Acad Sci USA 81:4302-4306 (Pubitemid 14052432)
11. Gudbjartsson T, Agnarsson BA, Palsson PS, Johannesson A 2011 Acromegaly caused by ectopic growth hormone-releasing hormone production from a bronchial carcinoid tumor. Thorac Cardiovasc Surg 59:184-185
12. Weiss DE, Vogel H, Lopes MB, Chang SD, Katznelson L 2011 Ectopic acromegaly due to a pancreatic neuroendocrine tumor producing growth hormone-releasing hormone. Endocr Pract 17:79-84
13. Verrua E, Ronchi CL, Ferrante E, Ferrari DI, Bergamaschi S, Ferrero S, Zatelli MC, Branca V, Spada A, Beck-Peccoz P, Lania AG 2010 Acromegaly secondary to an incidentally discovered growth-hormone-releasing hormone secreting bronchial carcinoid tumour associated to a pituitary incidentaloma. Pituitary 13:289-292
14. Butler PW, Cochran CS, Merino MJ, Nguyen DM, Schrump DS, Gorden P 9 April 2010 Ectopic growth hormone-releasing hormone secretion by a bronchial carcinoid tumor: clinical experience following tumor resection and long-acting octreotide therapy. Pituitary 10.1007/s11102-010-0226-7
15. Colak Ozbey N, Kapran Y, Bozbora A, Erbil Y, Tascioglu C, Asa SL 2009 Ectopic growth hormone-releasing hormone secretion by a neuroendocrine tumor causing acromegaly: long-term follow-up results. Endocr Pathol 20:127-132
16. van Hoek M, Hofland LJ, de Rijke YB, van Nederveen FH, de Krijger RR, van Koetsveld PM, Lamberts SW, van der Lely AJ, de Herder WW, Feelders RA 2009 Effects of somatostatin analogs on a growth hormone-releasing hormone secreting bronchial carcinoid, in vivo and in vitro studies. J Clin Endocrinol Metab 94:428-433
17. de Jager CM, de Heide LJ, van den Berg G, Wolthuis A, van Schelven WD 2007 Acromegaly caused by a growth hormone-releasing hormone secreting carcinoid tumour of the lung: the effect of octreotide treatment. Neth J Med 65:263-266 (Pubitemid 47232742)
18. Sugihara H, Shibasaki T, Tatsuguchi A, Okajima F, Wakita S, Nakajima Y, Tanimura K, Tamura H, Ishii S, Kamegai J, Akasu H, Kitagawa W, Shimizu K, Nakamura Y, Uchida E, Tajiri T, Naito Z, Katakami H, Oikawa S 2007 A non-acromegalic case of multiple endocrine neoplasia type 1 accompanied by a growth hormone-releasing hormone-producing pancreatic tumor. J Endocrinol Invest 30:421-427 (Pubitemid 47098238)
19. Vieira Neto L, Taboada GF, Corrêa LL, Polo J, Nascimento AF, Chimelli L, Rumilla K, Gadelha MR 2007 Acromegaly secondary to growth hormone-releasing hormone secreted by an incidentally discovered pheochromocytoma. Endocr Pathol 18:46-52 (Pubitemid 47345622)
20. Biermasz NR, Smit JW, Pereira AM, Frölich M, Romijn JA, Roelfsema F 2007 Acromegaly caused by growth hormone-releasing hormone- producing tumors: long-term observational studies in three patients. Pituitary 10:237-249 (Pubitemid 350055035)
21. Fainstein Day P, Frohman L, Garcia Rivello H, Reubi JC, Sevlever G, Glerean M, Fernandez Gianotti T, Pietrani M, Rabadan A, Racioppi S, Bidlingmaier M 2007 Ectopic growth hormone-releasing hormone secretion by a metastatic bronchial carcinoid tumor: a case with a non hypophysial intracranial tumor that shrank during long acting octreotide treatment. Pituitary 10:311-319 (Pubitemid 350055045)
22. Nasr C, Mason A, Mayberg M, Staugaitis SM, Asa SL 2006 Acromegaly and somatotroph hyperplasia with adenomatous transformation due to pituitary metastasis of a growth hormone-releasing hormone-secreting pulmonary endocrine carcinoma. J Clin Endocrinol Metab 91:4776-4780 (Pubitemid 44917306)
23. Zatelli MC, Maffei P, Piccin D, Martini C, Rea F, Rubello D, Margutti A, Culler MD, Sicolo N, degli Uberti EC 2005 Somatostatin analogs in vitro effects in a growth hormone-releasing hormone-secreting bronchial carcinoid. J Clin Endocrinol Metab 90:2104-2109 (Pubitemid 40586246)
24. Athanassiadi K, Exarchos D, Tsagarakis S, Bellenis I 2004 Acromegaly caused by ectopic growth hormone-releasing hormone secretion by a carcinoid bronchial tumor: a rare entity. J Thorac Cardiovasc Surg 128:631-632 (Pubitemid 39278405)
25. Agha, Farrell L, Downey P, Keeling P, Leen E, Sreenan S 2004 Acromegaly secondary to growth hormone releasing hormone secretion. Ir J Med Sci 173:215-216
26. Osella G, Orlandi F, Caraci P, Ventura M, Deandreis D, Papotti M, Bongiovanni M, Angeli A, Terzolo M 2003 Acromegaly due to ectopic secretion of GHRH by bronchial carcinoid in a patient with empty sella. J Endocrinol Invest 26:163-169 (Pubitemid 36503065)
27. Altstadt TJ, Azzarelli B, Bevering C, Edmondson J, Nelson PB 2002 Acromegaly caused by a growth hormone-releasing hormone-secreting carcinoid tumor: case report. Neurosurgery 50:1356-1359;discussion 1360
28. Furrer J, Hättenschwiler A, Komminoth P, Pfammatter T, Wiesli P 2001 Carcinoid syndrome, acromegaly, and hypoglycemia due to an insulin-secreting neuroendocrine tumor of the liver. J Clin Endocrinol Metab 86:2227-2230 (Pubitemid 32472944)
29. Othman NH, Ezzat S, Kovacs K, Horvath E, Poulin E, Smyth HS, Asa SL 2001 Growth hormone-releasing hormone (GHRH) and GHRHreceptor (GHRH-R) isoform expression in ectopic acromegaly. Clin Endocrinol (Oxf) 55:135-140 (Pubitemid 34204310)
30. Van den Bruel A, Fevery J, Van Dorpe J, Hofland L, Bouillon R 1999 Hormonal and volumetric long term control of a growth hormone-releasing hormone-producing carcinoid tumor. J Clin Endocrinol Metab 84:3162-3169 (Pubitemid 30646938)
31. Drange MR, Melmed S 1998 Long-acting lanreotide induces clinical and biochemical remission of acromegaly caused by disseminated growth hormone-releasing hormone-secreting carcinoid. J Clin Endocrinol Metab 83:3104-3109 (Pubitemid 28500942)
32. Jansson JO, Svensson J, Bengtsson BA, Frohman LA, Ahlman H, Wängberg B 1998 Acromegaly and Cushing's syndrome due to ectopic production of GHRH and ACTH by a thymic carcinoid tumour: in vitro responses to GHRH and GHRP-6. Clin Endocrinol (Oxf) 48:243-250 (Pubitemid 28091058)
33. Krassowski J, Zgliczyñski W, Jeske W, Zgliczyñski S 1999 Comment of long-acting lanreotide inducing clinical and biochemical remission of acromegaly caused by disseminated GHRH secreting carcinoid. J Clin Endocrinol Metab 84:1761-1762 (Pubitemid 30644292)
34. Platts JK, Child DF, Meadows P, Harvey JN 1997 Ectopic acromegaly. Postgrad Med J 73:349-351 (Pubitemid 27303021)
35. Sanno N, Teramoto A, Osamura RY, Genka S, Katakami H, Jin L, Lloyd RV, Kovacs K 1997 A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly. J Clin Endocrinol Metab 82:2731-2737 (Pubitemid 27337902)
36. Liu SW, van de Velde CJ, Heslinga JM, Kievit J, Roelfsema F 1996 Acromegaly caused by growth hormone-relating hormone in a patient with multiple endocrine neoplasia type I. Jpn J Clin Oncol 26:49-52 (Pubitemid 126469266)
37. Lefebvre S, De Paepe L, Abs R, Rahier J, Selvais P, Maiter D 1995 Subcutaneous octreotide treatment of a growth hormone-releasing hormone-secreting bronchial carcinoid: superiority of continuous versus intermittent administration to control hormonal secretion. Eur J Endocrinol 133:320-324
38. Bertherat J, Turpin G, Rauch C, Li JY, Epelbaum J, Sassolas G, Schaison G 1994 Presence of somatostatin receptors negatively coupled to adenylate cyclase in ectopic growth hormone-releasing hormone- and α-subunit-secreting tumors from acromegalic patients responsive to octreotide. J Clin Endocrinol Metab 79:1457-1464
39. Ezzat S, Asa SL, Stefaneanu L, Whittom R, Smyth HS, Horvath E, Kovacs K, Frohman LA 1994 Somatotroph hyperplasia without pituitary adenoma associated with a long standing growth hormone- releasing hormone-producing bronchial carcinoid. J Clin Endocrinol Metab 78:555-560 (Pubitemid 24083291)
40. Saito H, Sano T, Yamasaki R, Mitsuhashi S, Hosoi E, Saito S 1993 Demonstration of biological activity of a growth hormone-releasing hormone-like substance produced by a pheochromocytoma. Acta Endocrinol 129:246-250 (Pubitemid 23295687)
41. Price DE, Absalom SR, Davidson K, Bolia A, Bell PR, Howlett TA 1992 A case of multiple endocrine neoplasia: hyperparathyroidism, insulinoma, GRF-oma, hypercalcitoninaemia and intractable peptic ulceration. Clin Endocrinol (Oxf) 37:187-188
42. Glikson M, Gil-Ad I, Galun E, Dresner R, Zilberman S, Halperin Y, Okon E, Laron Z, Rubinow A 1991 Acromegaly due to ectopic growth hormone-releasing hormone secretion by a bronchial carcinoid tumour. Dynamic hormonal responses to various stimuli. Acta Endocrinol 125:366-371
43. Harris PE, Bouloux PM, Wass JA, Besser GM 1990 Successful treatment by chemotherapy for acromegaly associated with ectopic growth hormone releasing hormone secretion from a carcinoid tumour. Clin Endocrinol (Oxf) 32:315-321 (Pubitemid 20063564)
44. Popoviæ V, Miciæ D, Damjanoviæ S, Petakov M, Manojloviæ D, Miæiæ J 1990 Discordance between growth hormone responses after growth hormone-releasing hormone (GHRH) and insulin hypoglycemia in ectopic GHRH syndrome. Endocrinol Exp 24:167-173 (Pubitemid 20162042)
45. Moller DE, Moses AC, Jones K, Thorner MO, Vance ML 1989 Octreotide suppresses both growth hormone (GH) and GH-releasing hormone (GHRH) in acromegaly due to ectopic GHRH secretion. J Clin Endocrinol Metab 68:499-504 (Pubitemid 19052899)
46. Melmed S, Ziel FH, Braunstein GD, Downs T, Frohman LA 1988 Medical management of acromegaly due to ectopic production of growth hormone-releasing hormone by a carcinoid tumor. J Clin Endocrinol Metab 67:395-399
47. Yamasaki R, Saito H, Sano T, Kameyama K, Yoshimoto K, Hosoi E, Matsumura M, Harada K, Saito S 1988 Ectopic growth hormone-releasing hormone (GHRH) syndrome in a case with multiple endocrine neoplasia type I. Endocrinol Jpn 35:97-109 (Pubitemid 19003885)
48. Southgate HJ, Archbold GP, el-Sayed ME, Wright J, Marks V 1988 Ectopic release of GHRH and ACTH from an adenoid cystic carcinoma resulting in acromegaly and complicated by pituitary infarction. Postgrad Med J 64:145-148 (Pubitemid 18068766)
49. Ramsay JA, Kovacs K, Asa SL, Pike MJ, Thorner MO 1988 Reversible sellar enlargement due to growth hormone-releasing hormone production by pancreatic endocrine tumors in a acromegalic patient with multiple endocrine neoplasia type I syndrome. Cancer 62:445-450
50. Garcia-Luna PP, Leal-Cerro A, Montero C, Scheithauer BW, Campanario A, Dieguez C, Astorga R, Kovacs K 1987 A rare cause of acromegaly: ectopic production of growth hormone-releasing factor by a bronchial carcinoid tumor. Surg Neurol 27:563-568 (Pubitemid 17073863)
51. Carroll DG, Delahunt JW, Teague CA, Cooke RR, Adams EF, Christofides ND, Bloom SR, Terenghi G, Polak JM 1987 Resolution of acromegaly after removal of a bronchial carcinoid shown to secrete growth hormone releasing factor. Aust N Z J Med 17:63-67 (Pubitemid 17109124)
52. Adams EF, Skrabal F, Carroll D, Loizou M, White MC, Biggins JA, Mashiter K 1987 Ectopic corticotrophin-releasing-factor and growth hormone releasing factor secretion: diagnosis using human pituitary cell culture. Horm Res 25:80-87 (Pubitemid 17034065)
53. Boizel R, Halimi S, Labat F, Cohen R, Bachelot I 1987 Acromegaly due to a growth hormone-releasing hormone-secreting bronchial carcinoid tumor: further information on the abnormal responsiveness of the somatotroph cells and their recovery after successful treatment. J Clin Endocrinol Metab 64:304-308 (Pubitemid 17001063)
54. Barkan AL, Shenker Y, Grekin RJ, Vale WW, Lloyd RV, Beals TF 1986 Acromegaly due to ectopic growth hormone (GH)-releasing hormone (GHRH) production: dynamic studies of GH and ectopic GHRH secretion. J Clin Endocrinol Metab 63:1057-1064 (Pubitemid 17173037)
55. Roth KA, Wilson DM, Eberwine J, Dorin RI, Kovacs K, Bensch KG, Hoffman AR 1986 Acromegaly and pheochromocytoma: a multiple endocrine syndrome caused by a plurihormonal adrenal medullary tumor. J Clin Endocrinol Metab 63:1421-1426 (Pubitemid 17206442)
56. Saeger W, Schulte HM, Klöppel G 1986 Morphology of a GHRH producing pancreatic islet cell tumour causing acromegaly. Virchows Arch A Pathol Anat Histopathol 409:547-554 (Pubitemid 16090135)
57. Wilson DM, Ceda GP, Bostwick DG, Webber RJ, Minkoff JR, Pont A, Hintz RL, Bensch KG, Kraemer FB, Rosenfeld RG 1984 Acromegaly and Zollinger-Ellison syndrome secondary to an islet cell tumor: characterization and quantification of plasma and tumor human growth hormone-releasing factor. J Clin Endocrinol Metab 59:1002-1005 (Pubitemid 14020707)
58. Berger G, Trouillas J, Bloch B, Sassolas G, Berger F, Partensky C, Chayvialle JA, Brazeau P, Claustrat B, Lesbros F 1984 Multihormonal carcinoid tumor of the pancreas. Secreting growth hormone-releasing factor as a cause of acromegaly. Cancer 54:2097-2108 (Pubitemid 15210792)
59. Thorner MO, Frohman LA, Leong DA, Thominet J, Downs T, Hellmann P, Chitwood J, Vaughan JM, Vale W 1984 Extrahypothalamic growth-hormone-releasing factor (GRF) secretion is a rare cause of acromegaly: plasma GRF levels in 177 acromegalic patients. J Clin Endocrinol Metab 59:846-849 (Pubitemid 14020682)
60. Growth Hormone Research Society; Pituitary Society 2004 Biochemical assessment and long-term monitoring in patients with acromegaly: statement from a joint consensus conference of the Growth Hormone Research Society and the Pituitary Society. J Clin Endocrinol Metab 89:3099-3102
61. Caron P, Guittard J, Trouillas J, Salvador M, Bayard F 1992 [Acromegaly and bronchial carcinoid tumor. Apropos of a case]. Ann Endocrinol (Paris). 53:158-161 (French)
62. Girard P, Cohen R, Sassolas G, Harthe C, Cabrera P, Boissel JP 1987 Pharmacokinetics of human growth hormone releasing factor (hGRF-44 NH2) in normal men after intravenous administration of a large range of doses. Eur J Clin Pharmacol 32:507-513 (Pubitemid 17096198)
63. Solcia E, Klöppel G, Sobin LH 2000 Histological typing of endocrine tumors. WHO international histological classification of tumours. 2nd ed. Geneva: World Health Organization
64. Travis WD, Brambilla E, Müller-Hemerlinck HK 2004 Classification of tumours. Pathology and genetics of tumours of the lung, pleura, thymus and heart. Geneva: World Health Organization IARC Press
65. Trouillas J, Labat-Moleur F, Sturm N, Kujas M, Heymann MF, Figarella-Branger D, Patey M, Mazucca M, Decullier E, Vergès B, Chabre O, Calender A 2008 Pituitary tumors and hyperplasia in multiple endocrine neoplasia type 1 syndrome (MEN1): a case-control study in a series of 77 patients versus 2509 non-MEN1 patients. Am J Surg Pathol 32:534-543 (Pubitemid 351458295)
66. Asa SL, Kovacs K, Thorner MO, Leong DA, Rivier J, Vale W 1985 Immunohistological localization of growth hormone-releasing hormone in human tumors. J Clin Endocrinol Metab 60:423-427 (Pubitemid 15133839)
67. Bostwick DG, Quan R, Hoffman AR, Webber RJ, Chang JK, Bensch KG 1984 Growth-hormone-releasing factor immunoreactivity in human endocrine tumors. Am J Pathol 117:167-170 (Pubitemid 15209029)
68. Christofides ND, Stephanou A, Suzuki H, Yiangou Y, Bloom SR 1984 Distribution of immunoreactive growth hormone-releasing hormone in the human brain and intestine and its production by tumors. J Clin Endocrinol Metab 59:747-751 (Pubitemid 14012501)
69. Dayal Y, Lin HD, Tallberg K, Reichlin S, DeLellis RA, Wolfe HJ 1986 Immunocytochemical demonstration of growth hormone-releasing factor in gastrointestinal and pancreatic endocrine tumors. Am J Clin Pathol 85:13-20 (Pubitemid 16166034)
70. 18F-FDG PET. J Nucl Med 51:704-712
71. Tan EH, Tan CH 2011 Imaging of gastroenteropancreatic neuroendocrine tumors. World J Clin Oncol 2:28-43
72. Scarpa A, Mantovani W, Capelli P, Beghelli S, Boninsegna L, Bettini R, Panzuto F, Pederzoli P, delle Fave G, Falconi M 2010 Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patients. Mod Pathol 23:824-833
73. Oberg K, Jelic S; ESMO Guidelines Working Group 2009 Neuroendocrine bronchial and thymic tumors: ESMO clinical recommendation for diagnosis, treatment and follow-up. Ann Oncol 20(Suppl 4):147-149
74. Barkan AL, Shenker Y, Grekin RJ, Vale WW 1988 Acromegaly from ectopic growth hormone-releasing hormone secretion by a malignant carcinoid tumor. Successful treatment with long-acting somatostatin analogue SMS 201-995. Cancer 61:221-226 (Pubitemid 18056472)
75. Ch'ng JL, Anderson JV, Williams SJ, Carr DH, Bloom SR 1986 Remission of symptoms during long term treatment of metastatic pancreatic endocrine tumours with long acting somatostatin analogue. Br Med J (Clin Res Ed) 292:981-982 (Pubitemid 16137061)