-
1
-
-
0014038168
-
Digitalis in the treatment of hypertension. A preliminary report
-
Abarquez RF Jr (1967). Digitalis in the treatment of hypertension. A preliminary report. Acta Med Philipp 3, 161-170.
-
(1967)
Acta Med Philipp
, vol.3
, pp. 161-170
-
-
Abarquez Jr., R.F.1
-
2
-
-
0027400475
-
In vivo assessment of the inotropic and toxic effects of oxidized ouabain
-
Arad M, Shotan A, Heller M, Rabinowitz B & Uretzki G (1993). In vivo assessment of the inotropic and toxic effects of oxidized ouabain. Basic Res Cardiol 88, 42-51.
-
(1993)
Basic Res Cardiol
, vol.88
, pp. 42-51
-
-
Arad, M.1
Shotan, A.2
Heller, M.3
Rabinowitz, B.4
Uretzki, G.5
-
4
-
-
0023395490
-
+-ATPase: on the number of the ATP sites of the functional unit
-
+-ATPase: on the number of the ATP sites of the functional unit. J Bioenerg Biomembr 19, 359-374.
-
(1987)
J Bioenerg Biomembr
, vol.19
, pp. 359-374
-
-
Askari, A.1
-
5
-
-
63849168850
-
Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets
-
Bagrov AY, Shapiro JI & Fedorova OV (2009). Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets. Pharmacol Rev 61, 9-38.
-
(2009)
Pharmacol Rev
, vol.61
, pp. 9-38
-
-
Bagrov, A.Y.1
Shapiro, J.I.2
Fedorova, O.V.3
-
8
-
-
84863633664
-
+-ATPase activity in skeletal muscle cells
-
+-ATPase activity in skeletal muscle cells. J Biol Chem 287, 23451-23463.
-
(2012)
J Biol Chem
, vol.287
, pp. 23451-23463
-
-
Benziane, B.1
Bjornholm, M.2
Pirkmajer, S.3
Austin, R.L.4
Kotova, O.5
Viollet, B.6
Zierath, J.R.7
Chibalin, A.V.8
-
9
-
-
0031758268
-
Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function
-
Blanco G & Mercer RW (1998). Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function. Am J Physiol Renal Physiol 275, F633-F650.
-
(1998)
Am J Physiol Renal Physiol
, vol.275
-
-
Blanco, G.1
Mercer, R.W.2
-
10
-
-
0017684120
-
Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis
-
Blaustein MP (1977). Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. Am J Physiol Cell Physiol 232, C165-C173.
-
(1977)
Am J Physiol Cell Physiol
, vol.232
-
-
Blaustein, M.P.1
-
13
-
-
0031852360
-
The cellular mechanism of action of cardiotonic steroids: a new hypothesis
-
Blaustein MP, Juhaszova M & Golovina VA (1998). The cellular mechanism of action of cardiotonic steroids: a new hypothesis. Clin and Exp Hypertens 20, 691-703.
-
(1998)
Clin and Exp Hypertens
, vol.20
, pp. 691-703
-
-
Blaustein, M.P.1
Juhaszova, M.2
Golovina, V.A.3
-
14
-
-
84863116727
-
How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension
-
Blaustein MP, Leenen FH, Chen L, Golovina VA, Hamlyn JM, Pallone TL, Van Huysse JW, Zhang J & Wier WG (2012). How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. Am J Physiol Heart Circ Physiol 302, H1031-H1049.
-
(2012)
Am J Physiol Heart Circ Physiol
, vol.302
-
-
Blaustein, M.P.1
Leenen, F.H.2
Chen, L.3
Golovina, V.A.4
Hamlyn, J.M.5
Pallone, T.L.6
Van Huysse, J.W.7
Zhang, J.8
Wier, W.G.9
-
16
-
-
0017854563
-
Light-scattering studies on bile acid salts I: Pattern of self-association of sodium cholate, sodium glycocholate, and sodium taurocholate in aqueous electrolyte solutions
-
Chang Y & Cardinal JR (1978). Light-scattering studies on bile acid salts I: Pattern of self-association of sodium cholate, sodium glycocholate, and sodium taurocholate in aqueous electrolyte solutions. J Pharm Sci 67, 174-181.
-
(1978)
J Pharm Sci
, vol.67
, pp. 174-181
-
-
Chang, Y.1
Cardinal, J.R.2
-
20
-
-
79960382104
-
Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology
-
DeWire SM & Violin JD (2011). Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology. Circ Res 109, 205-216.
-
(2011)
Circ Res
, vol.109
, pp. 205-216
-
-
DeWire, S.M.1
Violin, J.D.2
-
21
-
-
0031051347
-
The effect of digoxin on mortality and morbidity in patients with heart failure
-
Digitalis Investigative Group
-
Digitalis Investigative Group (1997). The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 336, 525-533.
-
(1997)
N Engl J Med
, vol.336
, pp. 525-533
-
-
-
22
-
-
0035831504
-
Thermal denaturation of the Na,K-ATPase provides evidence for α-α oligomeric interaction and γ subunit association with the C-terminal domain
-
Donnet C, Arystarkhova E & Sweadner KJ (2001). Thermal denaturation of the Na, K-ATPase provides evidence for α-α oligomeric interaction and γ subunit association with the C-terminal domain. J Biol Chem 276, 7357-7365.
-
(2001)
J Biol Chem
, vol.276
, pp. 7357-7365
-
-
Donnet, C.1
Arystarkhova, E.2
Sweadner, K.J.3
-
23
-
-
0347362780
-
The α2 isoform of Na,K-ATPase mediates ouabain-induced cardiac inotropy in mice
-
Dostanic I, Lorenz JN, Schultz Jel J, Grupp IL, Neumann JC, Wani MA & Lingrel JB (2003). The α2 isoform of Na, K-ATPase mediates ouabain-induced cardiac inotropy in mice. J Biol Chem 278, 53026-53034.
-
(2003)
J Biol Chem
, vol.278
, pp. 53026-53034
-
-
Dostanic, I.1
Lorenz, J.N.2
Schultz Jel, J.3
Grupp, I.L.4
Neumann, J.C.5
Wani, M.A.6
Lingrel, J.B.7
-
25
-
-
33645422490
-
The physiological role of the α1 and α2 isoforms of the Na,K-ATPase and biological significance of their cardiac glycoside binding site
-
Dostanic-Larson I, Lorenz JN, Van Huysse JW, Neumann JC, Moseley AE & Lingrel JB (2006). The physiological role of the α1 and α2 isoforms of the Na, K-ATPase and biological significance of their cardiac glycoside binding site. Am J Physiol Regul Integr Comp Physiol 290, R524-R528.
-
(2006)
Am J Physiol Regul Integr Comp Physiol
, vol.290
-
-
Dostanic-Larson, I.1
Lorenz, J.N.2
Van Huysse, J.W.3
Neumann, J.C.4
Moseley, A.E.5
Lingrel, J.B.6
-
26
-
-
27644466627
-
The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation
-
Dostanic-Larson I, Van Huysse JW, Lorenz JN & Lingrel JB (2005). The highly conserved cardiac glycoside binding site of Na, K-ATPase plays a role in blood pressure regulation. Proc Natl Acad Sci U S A 102, 15845-15850.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 15845-15850
-
-
Dostanic-Larson, I.1
Van Huysse, J.W.2
Lorenz, J.N.3
Lingrel, J.B.4
-
27
-
-
0037022951
-
1 sodium pump, marinobufagenin, is a novel mediator of sodium chloride-dependent hypertension
-
1 sodium pump, marinobufagenin, is a novel mediator of sodium chloride-dependent hypertension. Circulation 105, 1122-1127.
-
(2002)
Circulation
, vol.105
, pp. 1122-1127
-
-
Fedorova, O.V.1
Talan, M.I.2
Agalakova, N.I.3
Lakatta, E.G.4
Bagrov, A.Y.5
-
29
-
-
0031872223
-
Role of the ouabain-like factor and Na-K pump in rat and human genetic hypertension
-
Ferrandi M, Manunta P, Rivera R, Bianchi G & Ferrari P (1998). Role of the ouabain-like factor and Na-K pump in rat and human genetic hypertension. Clin Exp Hypertens 20, 629-639.
-
(1998)
Clin Exp Hypertens
, vol.20
, pp. 629-639
-
-
Ferrandi, M.1
Manunta, P.2
Rivera, R.3
Bianchi, G.4
Ferrari, P.5
-
30
-
-
78049232372
-
Rostafuroxin: An ouabain-inhibitor counteracting specific forms of hypertension
-
Ferrari P (2010). Rostafuroxin: An ouabain-inhibitor counteracting specific forms of hypertension. Biochim Biophys Acta 1802, 1254-1258.
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 1254-1258
-
-
Ferrari, P.1
-
31
-
-
7844239580
-
PST2238: A new antihypertensive compound that antagonizes the long-term pressor effect of ouabain
-
Ferrari P, Torielli L, Ferrandi M, Padoani G, Duzzi L, Florio M, Conti F, Melloni P, Vesci L, Corsico N & Bianchi G (1998). PST2238: A new antihypertensive compound that antagonizes the long-term pressor effect of ouabain. J Pharmacol Exp Ther 285, 83-94.
-
(1998)
J Pharmacol Exp Ther
, vol.285
, pp. 83-94
-
-
Ferrari, P.1
Torielli, L.2
Ferrandi, M.3
Padoani, G.4
Duzzi, L.5
Florio, M.6
Conti, F.7
Melloni, P.8
Vesci, L.9
Corsico, N.10
Bianchi, G.11
-
32
-
-
0004208435
-
-
Reinhold Publishing Corp., New York.
-
Fieser LF & Fieser M (1959). Steroids. Reinhold Publishing Corp., New York.
-
(1959)
Steroids
-
-
Fieser, L.F.1
Fieser, M.2
-
33
-
-
0027121326
-
Epstein-Barr virus-transformed B lymphocytes produce low molecular mass molecules with autocrine growth factor and competence factor activity
-
Garzelli C, Bazzichi A, Dayah AM, Manunta M, Incaprera M & Falcone G (1992). Epstein-Barr virus-transformed B lymphocytes produce low molecular mass molecules with autocrine growth factor and competence factor activity. FEMS Microbiol Lett 79, 449-454.
-
(1992)
FEMS Microbiol Lett
, vol.79
, pp. 449-454
-
-
Garzelli, C.1
Bazzichi, A.2
Dayah, A.M.3
Manunta, M.4
Incaprera, M.5
Falcone, G.6
-
34
-
-
84878285091
-
Lack of evidence of increased mortality among patients with atrial fibrillation taking digoxin: findings from post hoc propensity-matched analysis of the AFFIRM trial
-
Gheorghiade M, Fonarow GC, van Veldhuisen DJ, Cleland JG, Butler J, Epstein AE, Patel K, Aban IB, Aronow WS, Anker SD & Ahmed A (2013). Lack of evidence of increased mortality among patients with atrial fibrillation taking digoxin: findings from post hoc propensity-matched analysis of the AFFIRM trial. Eur Heart J 34, 1489-1497.
-
(2013)
Eur Heart J
, vol.34
, pp. 1489-1497
-
-
Gheorghiade, M.1
Fonarow, G.C.2
van Veldhuisen, D.J.3
Cleland, J.G.4
Butler, J.5
Epstein, A.E.6
Patel, K.7
Aban, I.B.8
Aronow, W.S.9
Anker, S.D.10
Ahmed, A.11
-
35
-
-
0016436430
-
Cholesterol in aqueous solution: hydrophobicity and self-association
-
Gilbert DB, Tanford C & Reynolds JA (1975). Cholesterol in aqueous solution: hydrophobicity and self-association. Biochemistry (Mosc) 14, 444-448.
-
(1975)
Biochemistry (Mosc)
, vol.14
, pp. 444-448
-
-
Gilbert, D.B.1
Tanford, C.2
Reynolds, J.A.3
-
36
-
-
0019936906
-
Dihydroouabain is an antagonist of ouabain inotropic action
-
Godfraind T, Ghysel-Burton J & De Pover A (1982). Dihydroouabain is an antagonist of ouabain inotropic action. Nature 299, 824-826.
-
(1982)
Nature
, vol.299
, pp. 824-826
-
-
Godfraind, T.1
Ghysel-Burton, J.2
De Pover, A.3
-
38
-
-
0026637052
-
Elevated concentrations of endogenous ouabain in patients with congestive heart failure
-
Gottlieb SS, Rogowski AC, Weinberg M, Krichten CM, Hamilton BP & Hamlyn JM (1992). Elevated concentrations of endogenous ouabain in patients with congestive heart failure. Circulation 86, 420-425.
-
(1992)
Circulation
, vol.86
, pp. 420-425
-
-
Gottlieb, S.S.1
Rogowski, A.C.2
Weinberg, M.3
Krichten, C.M.4
Hamilton, B.P.5
Hamlyn, J.M.6
-
39
-
-
0003410475
-
Self-association of cholesterol in aqueous solution
-
Haberland ME & Reynolds JA (1973). Self-association of cholesterol in aqueous solution. Proc Natl Acad Sci U S A 70, 2313-2316.
-
(1973)
Proc Natl Acad Sci U S A
, vol.70
, pp. 2313-2316
-
-
Haberland, M.E.1
Reynolds, J.A.2
-
40
-
-
0022370787
-
+-pump ATPase in human erythrocytes. Radiation target size analyses
-
+-pump ATPase in human erythrocytes. Radiation target size analyses. J Biol Chem 260, 14016-14019.
-
(1985)
J Biol Chem
, vol.260
, pp. 14016-14019
-
-
Hah, J.1
Goldinger, J.M.2
Jung, C.Y.3
-
41
-
-
0025821399
-
Identification and characterization of a ouabain-like compound from human plasma
-
Hamlyn JM, Blaustein MP, Bova S, DuCharme DW, Harris DW, Mandel F, Mathews WR & Ludens JH (1991). Identification and characterization of a ouabain-like compound from human plasma. Proc Natl Acad Sci U S A 88, 6259-6263.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 6259-6263
-
-
Hamlyn, J.M.1
Blaustein, M.P.2
Bova, S.3
DuCharme, D.W.4
Harris, D.W.5
Mandel, F.6
Mathews, W.R.7
Ludens, J.H.8
-
42
-
-
42049103503
-
Activating effects of low dose cardiotonic steroids on dog kidney Na,K-ATPase activity: role of endogenous inhibition
-
ed. Glynn I & Ellory C - The Company of Biologists, Cambridge.
-
Hamlyn JM, Cohen N, Zyren J & Blaustein MP (1985). Activating effects of low dose cardiotonic steroids on dog kidney Na, K-ATPase activity: role of endogenous inhibition. In The Sodium Pump, ed. Glynn I & Ellory C, pp. 667-673. The Company of Biologists, Cambridge.
-
(1985)
The Sodium Pump
, pp. 667-673
-
-
Hamlyn, J.M.1
Cohen, N.2
Zyren, J.3
Blaustein, M.P.4
-
43
-
-
0029880847
-
Endogenous ouabain, sodium balance and blood pressure: a review and a hypothesis
-
Hamlyn JM, Hamilton BP & Manunta P (1996). Endogenous ouabain, sodium balance and blood pressure: a review and a hypothesis. J Hypertens 14, 151-167.
-
(1996)
J Hypertens
, vol.14
, pp. 151-167
-
-
Hamlyn, J.M.1
Hamilton, B.P.2
Manunta, P.3
-
44
-
-
0020334656
-
+)ATPase associated with essential hypertension
-
+)ATPase associated with essential hypertension. Nature 300, 650-652.
-
(1982)
Nature
, vol.300
, pp. 650-652
-
-
Hamlyn, J.M.1
Ringel, R.2
Schaeffer, J.3
Levinson, P.D.4
Hamilton, B.P.5
Kowarski, A.A.6
Blaustein, M.P.7
-
45
-
-
0016801029
-
Covalent labeling of the digitalis-binding component of plasma membranes
-
Hegyvary C (1975). Covalent labeling of the digitalis-binding component of plasma membranes. Mol Pharmacol 11, 588-594.
-
(1975)
Mol Pharmacol
, vol.11
, pp. 588-594
-
-
Hegyvary, C.1
-
47
-
-
0019823527
-
Stimulation of monovalent cation active transport by low concentrations of cardiac glycosides. Role of catecholamines
-
Hougen TJ, Spicer N & Smith TW (1981). Stimulation of monovalent cation active transport by low concentrations of cardiac glycosides. Role of catecholamines. J Clin Invest 68, 1207-1214.
-
(1981)
J Clin Invest
, vol.68
, pp. 1207-1214
-
-
Hougen, T.J.1
Spicer, N.2
Smith, T.W.3
-
48
-
-
0032709861
-
Digoxin prevents ouabain and high salt intake-induced hypertension in rats with sinoaortic denervation
-
Huang BS, Kudlac M, Kumarathasan R & Leenen FH (1999). Digoxin prevents ouabain and high salt intake-induced hypertension in rats with sinoaortic denervation. Hypertension 34, 733-738.
-
(1999)
Hypertension
, vol.34
, pp. 733-738
-
-
Huang, B.S.1
Kudlac, M.2
Kumarathasan, R.3
Leenen, F.H.4
-
49
-
-
9144275007
-
2+ exchanger type-1 in vascular smooth muscle
-
2+ exchanger type-1 in vascular smooth muscle. Nat Med 10, 1193-1199.
-
(2004)
Nat Med
, vol.10
, pp. 1193-1199
-
-
Iwamoto, T.1
Kita, S.2
Zhang, J.3
Blaustein, M.P.4
Arai, Y.5
Yoshida, S.6
Wakimoto, K.7
Komuro, I.8
Katsuragi, T.9
-
50
-
-
84863290583
-
Normal pregnancy: mechanisms underlying the paradox of a ouabain-resistant state with elevated endogenous ouabain, suppressed arterial sodium calcium exchange, and low blood pressure
-
Jacobs BE, Liu Y, Pulina MV, Golovina VA & Hamlyn JM (2012). Normal pregnancy: mechanisms underlying the paradox of a ouabain-resistant state with elevated endogenous ouabain, suppressed arterial sodium calcium exchange, and low blood pressure. Am J Physiol Heart Circ Physiol 302, H1317-H1329.
-
(2012)
Am J Physiol Heart Circ Physiol
, vol.302
-
-
Jacobs, B.E.1
Liu, Y.2
Pulina, M.V.3
Golovina, V.A.4
Hamlyn, J.M.5
-
51
-
-
0031442209
-
+ pump α subunit isoforms in plasmalemma. Physiological implications
-
+ pump α subunit isoforms in plasmalemma. Physiological implications. Ann N Y Acad Sci 834, 524-536.
-
(1997)
Ann N Y Acad Sci
, vol.834
, pp. 524-536
-
-
Juhaszova, M.1
Blaustein, M.P.2
-
52
-
-
13044270999
-
On the structure of endogenous ouabain
-
Kawamura A, Guo J, Itagaki Y, Bell C, Wang Y, Haupert GT Jr, Magil S, Gallagher RT, Berova N & Nakanishi K (1999). On the structure of endogenous ouabain. Proc Natl Acad Sci U S A 96, 6654-6659.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 6654-6659
-
-
Kawamura, A.1
Guo, J.2
Itagaki, Y.3
Bell, C.4
Wang, Y.5
Haupert Jr., G.T.6
Magil, S.7
Gallagher, R.T.8
Berova, N.9
Nakanishi, K.10
-
53
-
-
84857497773
-
Biased signalling and allosteric machines: new vistas and challenges for drug discovery
-
Kenakin TP (2012). Biased signalling and allosteric machines: new vistas and challenges for drug discovery. Br J Pharmacol 165, 1659-1669.
-
(2012)
Br J Pharmacol
, vol.165
, pp. 1659-1669
-
-
Kenakin, T.P.1
-
54
-
-
0034979097
-
Pressor and vascular effects of cardiac glycosides
-
Kirch W (2001). Pressor and vascular effects of cardiac glycosides. Eur J Clin Invest 31 (Suppl. 2), 5-9.
-
(2001)
Eur J Clin Invest
, vol.31
, Issue.SUPPL. 2
, pp. 5-9
-
-
Kirch, W.1
-
55
-
-
0027991609
-
Ouabain is secreted by bovine adrenocortical cells
-
Laredo J, Hamilton BP & Hamlyn JM (1994). Ouabain is secreted by bovine adrenocortical cells. Endocrinology 135, 794-797.
-
(1994)
Endocrinology
, vol.135
, pp. 794-797
-
-
Laredo, J.1
Hamilton, B.P.2
Hamlyn, J.M.3
-
56
-
-
0031017359
-
Angiotensin II stimulates secretion of endogenous ouabain from bovine adrenocortical cells via angiotensin type 2 receptors
-
Laredo J, Shah JR, Lu ZR, Hamilton BP & Hamlyn JM (1997). Angiotensin II stimulates secretion of endogenous ouabain from bovine adrenocortical cells via angiotensin type 2 receptors. Hypertension 29, 401-407.
-
(1997)
Hypertension
, vol.29
, pp. 401-407
-
-
Laredo, J.1
Shah, J.R.2
Lu, Z.R.3
Hamilton, B.P.4
Hamlyn, J.M.5
-
57
-
-
4344644553
-
Oligomerization of the Na,K-ATPase in cell membranes
-
Laughery M, Todd M & Kaplan JH (2004). Oligomerization of the Na, K-ATPase in cell membranes. J Biol Chem 279, 36339-36348.
-
(2004)
J Biol Chem
, vol.279
, pp. 36339-36348
-
-
Laughery, M.1
Todd, M.2
Kaplan, J.H.3
-
58
-
-
0344884599
-
A study of the sodium- and potassium-activated adenosinetriphosphatase activity of heart microsomal fraction
-
Lee KS & Yu DH (1963). A study of the sodium- and potassium-activated adenosinetriphosphatase activity of heart microsomal fraction. Biochem Pharmacol 12, 1253-1264.
-
(1963)
Biochem Pharmacol
, vol.12
, pp. 1253-1264
-
-
Lee, K.S.1
Yu, D.H.2
-
59
-
-
33748366036
-
2+ sensor
-
2+ sensor. Proc Natl Acad Sci U S A 103, 13232-13237.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 13232-13237
-
-
Lee, M.Y.1
Song, H.2
Nakai, J.3
Ohkura, M.4
Kotlikoff, M.I.5
Kinsey, S.P.6
Golovina, V.A.7
Blaustein, M.P.8
-
61
-
-
77951883450
-
The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na,K-ATPase
-
Lingrel JB (2010). The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na, K-ATPase. Annu Rev Physiol 72, 395-412.
-
(2010)
Annu Rev Physiol
, vol.72
, pp. 395-412
-
-
Lingrel, J.B.1
-
63
-
-
0027460750
-
2+-release channels: a possible role in cardiac inotropy
-
2+-release channels: a possible role in cardiac inotropy. Br J Pharmacol 108, 1043-1050.
-
(1993)
Br J Pharmacol
, vol.108
, pp. 1043-1050
-
-
McGarry, S.J.1
Williams, A.J.2
-
64
-
-
0035090156
-
Structure-activity relationships for the hypertensinogenic activity of ouabain: role of the sugar and lactone ring
-
Manunta P, Hamilton BP & Hamlyn JM (2001). Structure-activity relationships for the hypertensinogenic activity of ouabain: role of the sugar and lactone ring. Hypertension 37, 472-477.
-
(2001)
Hypertension
, vol.37
, pp. 472-477
-
-
Manunta, P.1
Hamilton, B.P.2
Hamlyn, J.M.3
-
65
-
-
0033799448
-
Chronic hypertension induced by ouabain but not digoxin in the rat: antihypertensive effect of digoxin and digitoxin
-
Manunta P, Hamilton J, Rogowski AC, Hamilton BP & Hamlyn JM (2000). Chronic hypertension induced by ouabain but not digoxin in the rat: antihypertensive effect of digoxin and digitoxin. Hypertens Res 23 (Suppl.), S77-85.
-
(2000)
Hypertens Res
, vol.23
, Issue.SUPPL.
-
-
Manunta, P.1
Hamilton, J.2
Rogowski, A.C.3
Hamilton, B.P.4
Hamlyn, J.M.5
-
66
-
-
78651315741
-
Endogenous ouabain and the renin-angiotensin-aldosterone system: distinct effects on Na handling and blood pressure in human hypertension
-
Manunta P, Hamlyn JM, Simonini M, Messaggio E, Lanzani C, Bracale M, Argiolas G, Casamassima N, Brioni E, Glorioso N & Bianchi G (2011). Endogenous ouabain and the renin-angiotensin-aldosterone system: distinct effects on Na handling and blood pressure in human hypertension. J Hypertens 29, 349-356.
-
(2011)
J Hypertens
, vol.29
, pp. 349-356
-
-
Manunta, P.1
Hamlyn, J.M.2
Simonini, M.3
Messaggio, E.4
Lanzani, C.5
Bracale, M.6
Argiolas, G.7
Casamassima, N.8
Brioni, E.9
Glorioso, N.10
Bianchi, G.11
-
68
-
-
0034637552
-
+-ATPase, nor do the sites coexist in native enzyme
-
+-ATPase, nor do the sites coexist in native enzyme. J Biol Chem 275, 24512-24517.
-
(2000)
J Biol Chem
, vol.275
, pp. 24512-24517
-
-
Martin, D.W.1
Sachs, J.R.2
-
70
-
-
77951673270
-
Ouabain attenuates cardiotoxicity induced by other cardiac steroids
-
Nesher M, Shpolansky U, Viola N, Dvela M, Buzaglo N, Ben-Ami HC, Rosen H & Lichtstein D (2010). Ouabain attenuates cardiotoxicity induced by other cardiac steroids. Br J Pharmacol 160, 346-354.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 346-354
-
-
Nesher, M.1
Shpolansky, U.2
Viola, N.3
Dvela, M.4
Buzaglo, N.5
Ben-Ami, H.C.6
Rosen, H.7
Lichtstein, D.8
-
71
-
-
1342308416
-
Ouabain increases sarcoplasmic reticulum calcium release in cardiac myocytes
-
Nishio M, Ruch SW, Kelly JE, Aistrup GL, Sheehan K & Wasserstrom JA (2004). Ouabain increases sarcoplasmic reticulum calcium release in cardiac myocytes. J Pharmacol Exp Ther 308, 1181-1190.
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 1181-1190
-
-
Nishio, M.1
Ruch, S.W.2
Kelly, J.E.3
Aistrup, G.L.4
Sheehan, K.5
Wasserstrom, J.A.6
-
72
-
-
0026351118
-
Synthesis and structural characterization of a cardioactive biotinylated digoxin analogue
-
Nutikka A, Pang H, Soldin S & Lingwood C (1991). Synthesis and structural characterization of a cardioactive biotinylated digoxin analogue. Clin Biochem 24, 469-473.
-
(1991)
Clin Biochem
, vol.24
, pp. 469-473
-
-
Nutikka, A.1
Pang, H.2
Soldin, S.3
Lingwood, C.4
-
73
-
-
0028334076
-
Ouabain binding kinetics of the rat alpha two and alpha three isoforms of the sodium-potassium adenosine triphosphate
-
O'Brien WJ, Lingrel JB & Wallick ET (1994). Ouabain binding kinetics of the rat alpha two and alpha three isoforms of the sodium-potassium adenosine triphosphate. Arch Biochem Biophys 310, 32-39.
-
(1994)
Arch Biochem Biophys
, vol.310
, pp. 32-39
-
-
O'Brien, W.J.1
Lingrel, J.B.2
Wallick, E.T.3
-
74
-
-
34047150549
-
Kinetic characterization of Na,K-ATPase inhibition by Eosin
-
Ogan JT, Reifenberger MS, Milanick MA & Gatto C (2007). Kinetic characterization of Na, K-ATPase inhibition by Eosin. Blood Cells Mol Dis 38, 229-237.
-
(2007)
Blood Cells Mol Dis
, vol.38
, pp. 229-237
-
-
Ogan, J.T.1
Reifenberger, M.S.2
Milanick, M.A.3
Gatto, C.4
-
76
-
-
0015691863
-
Dog red blood cells. Adjustment of salt and water content in vitro
-
Parker JC (1973). Dog red blood cells. Adjustment of salt and water content in vitro. J Gen Physiol 62, 147-156.
-
(1973)
J Gen Physiol
, vol.62
, pp. 147-156
-
-
Parker, J.C.1
-
77
-
-
0035143633
-
Endogenous ouabain and hemodynamic and left ventricular geometric patterns in essential hypertension
-
Pierdomenico SD, Bucci A, Manunta P, Rivera R, Ferrandi M, Hamlyn JM, Lapenna D, Cuccurullo F & Mezzetti A (2001). Endogenous ouabain and hemodynamic and left ventricular geometric patterns in essential hypertension. Am J Hypertens 14, 44-50.
-
(2001)
Am J Hypertens
, vol.14
, pp. 44-50
-
-
Pierdomenico, S.D.1
Bucci, A.2
Manunta, P.3
Rivera, R.4
Ferrandi, M.5
Hamlyn, J.M.6
Lapenna, D.7
Cuccurullo, F.8
Mezzetti, A.9
-
78
-
-
36049049738
-
2+ entry in purinergically stimulated aorta smooth muscle cells
-
2+ entry in purinergically stimulated aorta smooth muscle cells. Circ Res 101, 1030-1038.
-
(2007)
Circ Res
, vol.101
, pp. 1030-1038
-
-
Poburko, D.1
Liao, C.H.2
Lemos, V.S.3
Lin, E.4
Maruyama, Y.5
Cole, W.C.6
van Breemen, C.7
-
80
-
-
73549122116
-
2+ transporters in arterial smooth muscle from ouabain-induced hypertensive rats
-
2+ transporters in arterial smooth muscle from ouabain-induced hypertensive rats. Am J Physiol Heart Circ Physiol 298, H263-H274.
-
(2010)
Am J Physiol Heart Circ Physiol
, vol.298
-
-
Pulina, M.V.1
Zulian, A.2
Berra-Romani, R.3
Beskina, O.4
Mazzocco-Spezzia, A.5
Baryshnikov, S.G.6
Papparella, I.7
Hamlyn, J.M.8
Blaustein, M.P.9
Golovina, V.A.10
-
82
-
-
0030950682
-
17β-(3-furyl)-5β-Androstane-3β,14β,17α-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action
-
Quadri L, Bianchi G, Cerri A, Fedrizzi G, Ferrari P, Gobbini M, Melloni P, Sputore S & Torri M (1997). 17β-(3-furyl)-5β-Androstane-3β, 14β, 17α-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action. J Med Chem 40, 1561-1564.
-
(1997)
J Med Chem
, vol.40
, pp. 1561-1564
-
-
Quadri, L.1
Bianchi, G.2
Cerri, A.3
Fedrizzi, G.4
Ferrari, P.5
Gobbini, M.6
Melloni, P.7
Sputore, S.8
Torri, M.9
-
83
-
-
77952624088
-
Sympathetic nerves and endothelium influence the vasoconstrictor effect of low concentrations of ouabain in pressurized small arteries
-
Raina H, Zhang Q, Rhee AY, Pallone TL & Wier WG (2010). Sympathetic nerves and endothelium influence the vasoconstrictor effect of low concentrations of ouabain in pressurized small arteries. Am J Physiol Heart Circ Physiol 298, H2093-H2101.
-
(2010)
Am J Physiol Heart Circ Physiol
, vol.298
-
-
Raina, H.1
Zhang, Q.2
Rhee, A.Y.3
Pallone, T.L.4
Wier, W.G.5
-
84
-
-
0037206368
-
Sex-based differences in the effect of digoxin for the treatment of heart failure
-
Rathore SS, Wang Y & Krumholz HM (2002). Sex-based differences in the effect of digoxin for the treatment of heart failure. N Engl J Med 347, 1403-1411.
-
(2002)
N Engl J Med
, vol.347
, pp. 1403-1411
-
-
Rathore, S.S.1
Wang, Y.2
Krumholz, H.M.3
-
85
-
-
0010712161
-
Influence of cardioactive principles on pump ATPase
-
ed. Wilbrandt W & Lindgren P - Pergamon Press, Oxford, UK.
-
Repke K (1963). Influence of cardioactive principles on pump ATPase. In Proceedings of the First International Pharmacological Meeting, ed. Wilbrandt W & Lindgren P, pp. 65-73. Pergamon Press, Oxford, UK.
-
(1963)
Proceedings of the First International Pharmacological Meeting
, pp. 65-73
-
-
Repke, K.1
-
86
-
-
0028788618
-
Immunoreactive endogenous ouabain in primary aldosteronism and essential hypertension: relationship with plasma renin, aldosterone and blood pressure levels
-
Rossi G, Manunta P, Hamlyn JM, Pavan E, De Toni R, Semplicini A & Pessina AC (1995). Immunoreactive endogenous ouabain in primary aldosteronism and essential hypertension: relationship with plasma renin, aldosterone and blood pressure levels. J Hypertens 13, 1181-1191.
-
(1995)
J Hypertens
, vol.13
, pp. 1181-1191
-
-
Rossi, G.1
Manunta, P.2
Hamlyn, J.M.3
Pavan, E.4
De Toni, R.5
Semplicini, A.6
Pessina, A.C.7
-
87
-
-
84960988768
-
[Cardiac glycosides as inhibitors of active potassium and sodium transport by erythrocyte membrane]
-
Schatzmann HJ (1953). [Cardiac glycosides as inhibitors of active potassium and sodium transport by erythrocyte membrane]. Helv Physiol Pharmacol Acta 11, 346-354.
-
(1953)
Helv Physiol Pharmacol Acta
, vol.11
, pp. 346-354
-
-
Schatzmann, H.J.1
-
88
-
-
0031985698
-
Bovine adrenals contain, in addition to ouabain, a second inhibitor of the sodium pump
-
Schneider R, Wray V, Nimtz M, Lehmann WD, Kirch U, Antolovic R & Schoner W (1998). Bovine adrenals contain, in addition to ouabain, a second inhibitor of the sodium pump. J Biol Chem 273, 784-792.
-
(1998)
J Biol Chem
, vol.273
, pp. 784-792
-
-
Schneider, R.1
Wray, V.2
Nimtz, M.3
Lehmann, W.D.4
Kirch, U.5
Antolovic, R.6
Schoner, W.7
-
89
-
-
34547733409
-
Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth
-
Schoner W & Scheiner-Bobis G (2007). Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth. Am J Physiol Cell Physiol 293, C509-C536.
-
(2007)
Am J Physiol Cell Physiol
, vol.293
-
-
Schoner, W.1
Scheiner-Bobis, G.2
-
90
-
-
0003518480
-
-
John Wiley & Sons, New York.
-
Segel E (1975). Enzyme Kinetics. John Wiley & Sons, New York.
-
(1975)
Enzyme Kinetics
-
-
Segel, E.1
-
91
-
-
0024893183
-
Two-dimensional crystalline arrays of Na,K-ATPase with new subunit interactions induced by cobalt-tetrammine-ATP
-
Skriver E, Maunsbach AB, Hebert H, Scheiner-Bobis G & Schoner W (1989). Two-dimensional crystalline arrays of Na, K-ATPase with new subunit interactions induced by cobalt-tetrammine-ATP. J Ultrastruct Mol Struct Res 102, 189-195.
-
(1989)
J Ultrastruct Mol Struct Res
, vol.102
, pp. 189-195
-
-
Skriver, E.1
Maunsbach, A.B.2
Hebert, H.3
Scheiner-Bobis, G.4
Schoner, W.5
-
92
-
-
4243512741
-
Basic mechanisms of cardiac glycoside action
-
ed. Smith TW - Grune & Stratton, Orlando.
-
Smith TW (1986a). Basic mechanisms of cardiac glycoside action. In Digitalis Glycosides, ed. Smith TW, pp. 5-27. Grune & Stratton, Orlando.
-
(1986)
Digitalis Glycosides
, pp. 5-27
-
-
Smith, T.W.1
-
93
-
-
84896715622
-
Serum and plasma cardiac glycoside concentrations: clinical use and misuse
-
ed. Smith TW - Grune & Stratton, Orlando.
-
Smith TW (1986b). Serum and plasma cardiac glycoside concentrations: clinical use and misuse. In Digitalis Glycosides, ed. Smith TW, pp. 153-167. Grune & Stratton, Orlando.
-
(1986)
Digitalis Glycosides
, pp. 153-167
-
-
Smith, T.W.1
-
96
-
-
0142120501
-
Circulating endogenous digitalis-like factor(s) (EDLF) in man is derived from the adrenals and its secretion is ACTH-dependent
-
Sophocleous A, Elmatzoglou I & Souvatzoglou A (2003). Circulating endogenous digitalis-like factor(s) (EDLF) in man is derived from the adrenals and its secretion is ACTH-dependent. J Endocrinol Invest 26, 668-674.
-
(2003)
J Endocrinol Invest
, vol.26
, pp. 668-674
-
-
Sophocleous, A.1
Elmatzoglou, I.2
Souvatzoglou, A.3
-
97
-
-
78651354653
-
Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin
-
Staessen JA, Thijs L, Stolarz-Skrzypek K, Bacchieri A, Barton J, Espositi ED, de Leeuw PW, Dluzniewski M, Glorioso N, Januszewicz A, Manunta P, Milyagin V, Nikitin Y, Soucek M, Lanzani C, Citterio L, Timio M, Tykarski A, Ferrari P, Valentini G, Kawecka-Jaszcz K & Bianchi G (2011). Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin. Trials 12, 13.
-
(2011)
Trials
, vol.12
, pp. 13
-
-
Staessen, J.A.1
Thijs, L.2
Stolarz-Skrzypek, K.3
Bacchieri, A.4
Barton, J.5
Espositi, E.D.6
de Leeuw, P.W.7
Dluzniewski, M.8
Glorioso, N.9
Januszewicz, A.10
Manunta, P.11
Milyagin, V.12
Nikitin, Y.13
Soucek, M.14
Lanzani, C.15
Citterio, L.16
Timio, M.17
Tykarski, A.18
Ferrari, P.19
Valentini, G.20
Kawecka-Jaszcz, K.21
Bianchi, G.22
more..
-
98
-
-
0014466925
-
Dimers and trimers of α-tocopherol: metabolic and synthetic studies
-
Strauch BS, Fales HM, Pittman RC & Avigan J (1969). Dimers and trimers of α-tocopherol: metabolic and synthetic studies. J Nutr 97, 194-202.
-
(1969)
J Nutr
, vol.97
, pp. 194-202
-
-
Strauch, B.S.1
Fales, H.M.2
Pittman, R.C.3
Avigan, J.4
-
100
-
-
13044307872
-
+-pump inhibitor from bovine adrenal glands
-
ed. Bamberg E & Schoner W - Steinkopf, Darmstadt.
-
+-pump inhibitor from bovine adrenal glands. In The Sodium Pump: Structure, Mechanism, Hormonal Control and its Role in Disease, ed. Bamberg E & Schoner W, pp. 763-766. Steinkopf, Darmstadt.
-
(1994)
The Sodium Pump: Structure, Mechanism, Hormonal Control and its Role in Disease
, pp. 763-766
-
-
Tamura, M.1
Konishi, F.2
Sakakibara, M.3
Inagami, T.4
-
101
-
-
0035046029
-
The oligomeric nature of Na/K-transport ATPase
-
Taniguchi K, Kaya S, Abe K & Mardh S (2001). The oligomeric nature of Na/K-transport ATPase. J Biochem 129, 335-342.
-
(2001)
J Biochem
, vol.129
, pp. 335-342
-
-
Taniguchi, K.1
Kaya, S.2
Abe, K.3
Mardh, S.4
-
102
-
-
62849089258
-
Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain
-
Tripodi G, Citterio L, Kouznetsova T, Lanzani C, Florio M, Modica R, Messaggio E, Hamlyn JM, Zagato L, Bianchi G, Staessen JA & Manunta P (2009). Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain. Am J Hypertens 22, 357-363.
-
(2009)
Am J Hypertens
, vol.22
, pp. 357-363
-
-
Tripodi, G.1
Citterio, L.2
Kouznetsova, T.3
Lanzani, C.4
Florio, M.5
Modica, R.6
Messaggio, E.7
Hamlyn, J.M.8
Zagato, L.9
Bianchi, G.10
Staessen, J.A.11
Manunta, P.12
-
104
-
-
0021328385
-
2+] transient, membrane potential, and contraction
-
2+] transient, membrane potential, and contraction. J Gen Physiol 83, 395-415.
-
(1984)
J Gen Physiol
, vol.83
, pp. 395-415
-
-
Wier, W.G.1
Hess, P.2
-
107
-
-
0015544366
-
Structure-activity relationships of cardiotonic steroids for the inhibition of sodium- and potassium-dependent adenosine triphosphatase. I. Dissociation rate constants of various enzyme-cardiac glycoside complexes formed in the presence of magnesium and phosphate
-
Yoda A (1973). Structure-activity relationships of cardiotonic steroids for the inhibition of sodium- and potassium-dependent adenosine triphosphatase. I. Dissociation rate constants of various enzyme-cardiac glycoside complexes formed in the presence of magnesium and phosphate. Mol Pharmacol 9, 51-60.
-
(1973)
Mol Pharmacol
, vol.9
, pp. 51-60
-
-
Yoda, A.1
-
108
-
-
0016378064
-
Association and dissociation rate constants of the complexes between various cardiac monoglycosides and Na,K-ATPase
-
Yoda A (1974). Association and dissociation rate constants of the complexes between various cardiac monoglycosides and Na, K-ATPase. Ann N Y Acad Sci 242, 598-616.
-
(1974)
Ann N Y Acad Sci
, vol.242
, pp. 598-616
-
-
Yoda, A.1
-
109
-
-
0015767504
-
Structure-activity relationships of cardiotonic steroids for the inhibition of sodium- and potassium-dependent adenosine triphosphatase. II. Association rate constants of various enzyme-cardiac glycoside complexes
-
Yoda A, Yoda S & Sarrif AM (1973). Structure-activity relationships of cardiotonic steroids for the inhibition of sodium- and potassium-dependent adenosine triphosphatase. II. Association rate constants of various enzyme-cardiac glycoside complexes. Mol Pharmacol 9, 766-773.
-
(1973)
Mol Pharmacol
, vol.9
, pp. 766-773
-
-
Yoda, A.1
Yoda, S.2
Sarrif, A.M.3
-
110
-
-
0027312742
-
Long-term ouabain administration produces hypertension in rats
-
Yuan CM, Manunta P, Hamlyn JM, Chen S, Bohen E, Yeun J, Haddy FJ & Pamnani MB (1993). Long-term ouabain administration produces hypertension in rats. Hypertension 22, 178-187.
-
(1993)
Hypertension
, vol.22
, pp. 178-187
-
-
Yuan, C.M.1
Manunta, P.2
Hamlyn, J.M.3
Chen, S.4
Bohen, E.5
Yeun, J.6
Haddy, F.J.7
Pamnani, M.B.8
-
111
-
-
28244497641
-
Sodium pump α2 subunits control myogenic tone and blood pressure in mice
-
Zhang J, Lee MY, Cavalli M, Chen L, Berra-Romani R, Balke CW, Bianchi G, Ferrari P, Hamlyn JM, Iwamoto T, Lingrel JB, Matteson DR, Wier WG & Blaustein MP (2005). Sodium pump α2 subunits control myogenic tone and blood pressure in mice. J Physiol 569, 243-256.
-
(2005)
J Physiol
, vol.569
, pp. 243-256
-
-
Zhang, J.1
Lee, M.Y.2
Cavalli, M.3
Chen, L.4
Berra-Romani, R.5
Balke, C.W.6
Bianchi, G.7
Ferrari, P.8
Hamlyn, J.M.9
Iwamoto, T.10
Lingrel, J.B.11
Matteson, D.R.12
Wier, W.G.13
Blaustein, M.P.14
-
112
-
-
77951864034
-
2+ channel current, and lowers blood pressure
-
2+ channel current, and lowers blood pressure. Am J Physiol Heart Circ Physiol 298, H1472-H1483.
-
(2010)
Am J Physiol Heart Circ Physiol
, vol.298
-
-
Zhang, J.1
Ren, C.2
Chen, L.3
Navedo, M.F.4
Antos, L.K.5
Kinsey, S.P.6
Iwamoto, T.7
Philipson, K.D.8
Kotlikoff, M.I.9
Santana, L.F.10
Wier, W.G.11
Matteson, D.R.12
Blaustein, M.P.13
|