Structure-activity relationships for the hypertensinogenic activity of ouabain: Role of the sugar and lactone ring

Hypertension

Volumn 37, Issue 2 II, 2001, Pages 472-477

  Manunta, Paolo ^a,b   Hamilton, Bruce P ^a   Hamlyn, John M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Analogs and derivatives; Blood pressure; Glycosides; Sodium pump

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) INHIBITOR; OUABAGENIN; OUABAIN; RHAMNOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONFORMATION; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; HYPERTENSION; IMMUNOASSAY; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0035090156     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.37.2.472     Document Type: Conference Paper

References (30)

1. Physiology and pharmacology of endogenous digitalis-like factors
2. Endogenous ouabain, sodium balance and blood pressure: A review and a hypothesis
3. The role of humoral agents in volume expanded hypertension
4. Sodium ions, calcium ions, blood pressure regulation and hypertension
5. Dahl's hypothesis that a saluretic substance may be responsible for a sustained rise in arterial pressure: Its possible role in essential hypertension
6. Effects of digoxin on responsiveness to the pressor actions of angiotensin and norepinephrine in man
7. Digitalis in the treatment of hypertension, a preliminary report
8. Long-term ouabain administration produces hypertension in rats
9. Ouabain-induced hypertension in the rat: Relationships among circulating and tissue ouabain and blood pressure
10. Chronic central versus peripheral ouabain, blood pressure, and sympathetic activity in rats
11. Chronic sodium-potassium-ATPase inhibition with ouabain impairs renal haemodynamics and pressure natriuresis in the rat
12. Comparative study of the effects of ouabain and digoxin on blood pressure of rats
13. Chronic hypertension induced by ouabain but not digoxin in the rat: Antihypertensive effect of digoxin and digitoxin
14. Tissue localization of active Na. K-ATPase isoenzymes by determination of their profile of inhibition with ouabain, digoxin, digitoxigenin and LND 796, a new aminosteroid cardiotonic
15. The lead structure in cardiac glycosides is 5β 14β-androstane-3β 14-diol
16. Smooth muscle hypertrophy and arterial remodelling in deoxycorticosterone-acetate-salt hypertension
17. Measurement of blood pressure in rats
18. Development of an immunoassay for endogenous digitalis factor
19. +-activated ATPase from ox brain
20. Cardiac active principles
21. Ouabain or g-strophanthin
22. Different effects of in vivo ouabain and digoxin on renal artery function and blood pressure in the rat
23. Secretion of a lactone-hydrogenated ouabain-like effector of sodium, potassium-adenosine triphosphatase activity by adrenal cells
24. Endogenous ouabain in primary aldosteronism and essential hypertension: Relationship with plasma renin, aldosterone and blood pressure levels
25. Centrally-induced vasopressor responses to sodium-potassium adenosine triphosphatase inhibitor, ouabain, may be mediated via angiotensin II in the anteroventral third ventricle in the brain
26. The vasopressor response to centrally administered ouabain
27. Role of electrolytes and digitalis-like activity in hypertension: Effects of digitoxin, sodium, potassium, magnesium on blood pressure
28. Digoxin prevents ouabain and high salt intake-induced hypertension in rats with sinoaortic denervation
29. +-transporting ATPase from human and guinea pig cardiac muscle through the use of digitalis derivatives as analytical probes