Digoxin prevents ouabain and high salt intake-induced hypertension in rats with sinoaortic denervation

Hypertension

Volumn 34, Issue 4 II, 1999, Pages 733-738

  Huang, Bing S ^a   Kudlac, Marian ^a   Kumarathasan, Raj ^a   Leenen, Frans H H ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

Baroreflex; Denervation, sinoaortic; Digoxin; Fab; Nerve activity, sympathetic, renal; Ouabain; Sodium intake; Stress, air

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); DIGOXIN; IMMUNOGLOBULIN F(AB) FRAGMENT; OUABAIN;

ADRENERGIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE THERAPY; ARTICLE; CAROTID SINUS DENERVATION; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME INHIBITION; HEART RATE; HYPERTENSION; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSORECEPTOR; PRIORITY JOURNAL; RAT; SALT INTAKE; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032709861     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.34.4.733     Document Type: Article

References (23)

1. Leenen FHH, Harmsen E, Yu H, Ou C. Effects of dietary sodium on central and peripheral ouabain-like activity in spontaneously hypertensive rats. Am J Physiol. 1993;264:H2051-H2055.
2. Leenen FHH, Harmsen E, Yu H. Dietary sodium and central vs. peripheral ouabain-like activity in Dahl salt-sensitive vs. salt-resistant rats. Am J Physiol. 1994;267:H1916-H1920.
3. Huang BS, Leenen FHH. Brain "ouabain" mediates the sympathoexcitatory and hypertensive effects of high sodium intake in Dahl salt-sensitive rats. Circ Res. 1994;74:586-595.
4. Huang BS, Leenen FHH. Blockade of brain "ouabain" prevents sympatho-excitatory and pressor responses to high sodium in spontaneously hypertensive rats. Am J Physiol. 1996;271:H103-H108.
5. Huang BS, Leenen FHH. Brain 'ouabain' and desensitization of arterial baroreflex by high sodium in Dahl salt-sensitive rats. Hypertension. 1995;25:372-376.
6. Huang BS, Leenen FHH. Brain 'ouabain,' sodium, and arterial baroreflex in spontaneously hypertensive rats. Hypertension. 1995;25:814-817.
7. Huang BS, Leenen FHH. Dietary Na and baroreflex modulation of blood pressure and RSNA in normotensive vs. spontaneously hypertensive rats. Am J Physiol. 1994;266:H496-H502.
8. Osborn JW, Provo BJ. Salt-dependent hypertension in the sinoaortic-denervated rats. Hypertension. 1992;19:658-662.
9. Howe PRC, Rogeras PF, Minson JB. Dietary sodium loading elevated blood pressure in baroreceptor denervated rats. J Auton Nerv Syst. 1990; 29:151-156.
10. Huang BS, Huang X, Harmsen E, Leenen FHH. Chronic central versus peripheral ouabain, blood pressure, and sympathetic activity in rats. Hypertension. 1994;23(pt 2):1087-1090.
11. Yuan CM, Manunta P, Hamlyn JM, Chen S, Bohen E, Yeun J, Haddy FJ, Pamnani MB. Long-term ouabain administration produces hypertension in rats. Hypertension. 1993;22:178-187.
12. Manunta P, Rogowski AC, Hamilton BP, Hamlyn JM. Ouabain-induced hypertension in the rats: relationships among plasma and tissue ouabain and blood pressure. J Hypertens. 1994;12:549-560.
13. Abreu GR, Futuro Neto HA, Cabral AM, Vasquez EC. Ouabain produces diverse excitatory effects on afferent baroreceptor nerve activity in SHR and WKY animals. Clin Exp Hypertens. 1998;20:85-94.
14. Manunta P, Tyzack J, Hamilton BP, Hamlyn JM. Augmentation and antagonism of ouabain-induced hypertension. Hypertens. 1993;22:432. Abstract.
15. Mancia G, Seravalle G, Giannattasio C, Bossi M, Preti L, Cattaneo BM, Grassi G. Reflex cardiovascular control in congestive heart failure. Am J Cardiol. 1992;69:17G-22G.
16. Razin M, Borosh M, Weinstock M. Rabbits with genetic impairment in baroreflex sensitivity show abnormal renal hemodynamics and proximal tubular sodium reabsorption in response to a saline infusion. J Hypertens. 1993;11:799-804.
17. Newton GE, Tong JH, Schofield AM, Baines AD, Floras AD, Parker JD. Digoxin reduces cardiac sympathetic activity in severe congestive heart failure. J Am Coll Cardiol. 1996;28:155-161.
18. Rich S, Seidlitz M, Dodin E, Osimani D, Judd D, Genthner D, McLaughin V, Francis G. The short-term effects of digoxin in patients with right ventricular dysfunction from pulmonary hypertension. Chest. 1998;114:787-792.
19. Leenen FHH, Huang BS, Yu H, Yuan B. Brain "ouabain" mediates sympathetic hyperactivity in congestive heart failure. Circ Res. 1995;77: 993-1000.
20. Head GA, McCarty R. Vagal and sympathetic components of the heart rate range and gain of the baroreceptor-heart rate reflex in conscious rats. J Auton Nerv Syst. 1987;21:203-213.
21. Jobert PH. Are all cardiac glycosides pharmacodynamically similar? Eur J Clin Pharmacol. 1990;39:317-320.
22. Ito S, Koren G, Harper PA. Handling of digoxin and ouabain by renal tubular cells (LLC-PK1). J Pharmacol Exp Ther. 1992;261:109-113.
23. Finotti P. Palatini P. Canrenone as a partial agonist at the digitalis receptor site of sodium-potassium-activated adenosine triphosphatase. J Pharmacol Exp Ther. 1981;217:784-791.