VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death

Journal of Biological Chemistry

Volumn 284, Issue 18, 2009, Pages 12384-12398

  Gitcho, Michael A ^a   Strider, Jeffrey ^a   Carter, Deborah ^a   Taylor Reinwald, Lisa ^a   Forman, Mark S ^a   Goate, Alison M ^a,b   Cairns, Nigel J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; AUTOSOMAL DOMINANTS; CELL VIABILITY; CYTOSOL; DNA-BINDING PROTEIN; ENDOPLASMIC RETICULUM STRESS; INCLUSION BODIES; INTRACELLULAR TRAFFICKING; NEURODEGENERATION; PROTEASOME; UBIQUITIN;

CELL DEATH; INCLUSIONS;

CELL CULTURE;

MUTANT PROTEIN; PROTEASOME; TAR DNA BINDING PROTEIN; UBIQUITIN C; VALOSIN CONTAINING PROTEIN; ADENOSINE TRIPHOSPHATASE; CDC48 PROTEIN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; PROTEIN TDP-43;

AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BRAIN ATROPHY; BRAIN NERVE CELL; CELL CULTURE; CELL DEATH; CELL LOSS; CELL NUCLEUS; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; FRONTAL LOBE; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; GLIOSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INCLUSION BODY MYOSITIS; INTRACELLULAR TRANSPORT; NERVE DEGENERATION; PAGET BONE DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TEMPORAL LOBE; BIOLOGICAL MODEL; CELL SURVIVAL; CYTOPLASM; DEMENTIA; ENDOPLASMIC RETICULUM; FEMALE; GENETICS; MALE; METABOLISM; MIDDLE AGED; MUTATION; PATHOLOGY; PROTEIN TRANSPORT; TUMOR CELL LINE; UBIQUITINATION;

ADENOSINE TRIPHOSPHATASES; APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; CYTOPLASM; DEMENTIA; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MUTATION; PROTEIN TRANSPORT; UBIQUITINATION;

EID: 66449134941     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900992200     Document Type: Article

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