Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo

Neurobiology of Disease

Volumn 55, Issue , 2013, Pages 64-75

  Vaccaro, Alexandra ^a,b,c   Patten, Shunmoogum A ^b,c   Aggad, Dina ^a,b,c   Julien, Carl ^a,b,c   Maios, Claudia ^b   Kabashi, Edor ^b,d   Drapeau, Pierre ^b,c   Parker, J Alex ^a,b,c  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITY OF MONTREAL   (Canada)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

ALS; C. elegans; ER stress; Genetic models; Neurodegeneration; Small molecules; TDP 43; Zebrafish

Indexed keywords

GUANABENZ; METHYLENE BLUE; PHENAZINE; SALUBRINAL; TAR DNA BINDING PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CAENORHABDITIS ELEGANS; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; HUMAN; HYPERTENSION; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARALYSIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FOLDING;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CINNAMATES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; ESCAPE REACTION; GREEN FLUORESCENT PROTEINS; GUANABENZ; HUMANS; MICROINJECTIONS; MOVEMENT DISORDERS; MUTATION; NEURONS; NEUROTOXICITY SYNDROMES; PHENAZINES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; THIOUREA; TIME FACTORS; TOUCH; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84877075803     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.03.015     Document Type: Article

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