메뉴 건너뛰기




Volumn 40, Issue 4, 2014, Pages 513-522

Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies

Author keywords

Fibroblasts; Immune inhibitory ligands; Immune system; Immunotherapy; Pancreatic cancer; Review; T regulatory cells; Th1; Th2; Vaccination

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GALECTIN; GEMCITABINE; IMMUNOMODULATING AGENT; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2 RECEPTOR ALPHA; IPILIMUMAB; MESOTHELIN; REACTIVE OXYGEN METABOLITE; TICILIMUMAB; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELL VACCINE; VASCULOTROPIN;

EID: 84896702241     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2013.11.005     Document Type: Review
Times cited : (152)

References (103)
  • 1
    • 79952232216 scopus 로고    scopus 로고
    • Global cancer statistics
    • Jemal A., et al. Global cancer statistics. CA Cancer J Clin 2011, 61(2):69-90.
    • (2011) CA Cancer J Clin , vol.61 , Issue.2 , pp. 69-90
    • Jemal, A.1
  • 2
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • Mantovani A., et al. Cancer-related inflammation. Nature 2008, 454(7203):436-444.
    • (2008) Nature , vol.454 , Issue.7203 , pp. 436-444
    • Mantovani, A.1
  • 3
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 2005, 5(4):263-274.
    • (2005) Nat Rev Cancer , vol.5 , Issue.4 , pp. 263-274
    • Zou, W.1
  • 4
    • 65549112641 scopus 로고    scopus 로고
    • Dynamic behavior and function of Foxp3+ regulatory T cells in tumor bearing host
    • Qin F.X. Dynamic behavior and function of Foxp3+ regulatory T cells in tumor bearing host. Cell Mol Immunol 2009, 6(1):3-13.
    • (2009) Cell Mol Immunol , vol.6 , Issue.1 , pp. 3-13
    • Qin, F.X.1
  • 5
    • 84872132293 scopus 로고    scopus 로고
    • Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer
    • Pedroza-Gonzalez A., et al. Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer. Hepatology 2012, 57(1):183-194.
    • (2012) Hepatology , vol.57 , Issue.1 , pp. 183-194
    • Pedroza-Gonzalez, A.1
  • 6
    • 33750630223 scopus 로고    scopus 로고
    • Clinical roles of increased populations of Foxp3+CD4 T cells in peripheral blood from advanced pancreatic cancer patients
    • Ikemoto T., et al. Clinical roles of increased populations of Foxp3+CD4 T cells in peripheral blood from advanced pancreatic cancer patients. Pancreas 2006, 33(4):386-390.
    • (2006) Pancreas , vol.33 , Issue.4 , pp. 386-390
    • Ikemoto, T.1
  • 7
    • 33749317518 scopus 로고    scopus 로고
    • Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions
    • Hiraoka N., et al. Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res 2006, 12(18):5423-5434.
    • (2006) Clin Cancer Res , vol.12 , Issue.18 , pp. 5423-5434
    • Hiraoka, N.1
  • 8
    • 84859108137 scopus 로고    scopus 로고
    • Circulating CD4+CD25+ regulatory T cells in patients with pancreatic cancer
    • Yamamoto T., et al. Circulating CD4+CD25+ regulatory T cells in patients with pancreatic cancer. Pancreas 2012, 41(3):409-415.
    • (2012) Pancreas , vol.41 , Issue.3 , pp. 409-415
    • Yamamoto, T.1
  • 9
    • 77955549860 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity
    • Ostrand-Rosenberg S. Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity. Cancer Immunol Immunother 2010, 59(10):1593-1600.
    • (2010) Cancer Immunol Immunother , vol.59 , Issue.10 , pp. 1593-1600
    • Ostrand-Rosenberg, S.1
  • 10
    • 68249113734 scopus 로고    scopus 로고
    • Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma
    • Zhao F., et al. Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma. Immunology 2009, 128(1):141-149.
    • (2009) Immunology , vol.128 , Issue.1 , pp. 141-149
    • Zhao, F.1
  • 11
    • 80054102628 scopus 로고    scopus 로고
    • Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13
    • Gabitass R.F., et al. Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13. Cancer Immunol Immunother 2011, 60(10):1419-1430.
    • (2011) Cancer Immunol Immunother , vol.60 , Issue.10 , pp. 1419-1430
    • Gabitass, R.F.1
  • 12
    • 84862128998 scopus 로고    scopus 로고
    • Differentiation and gene expression profile of tumor-associated macrophages
    • Schmieder A., et al. Differentiation and gene expression profile of tumor-associated macrophages. Semin Cancer Biol 2012, 22(4):289-297.
    • (2012) Semin Cancer Biol , vol.22 , Issue.4 , pp. 289-297
    • Schmieder, A.1
  • 13
    • 67349168435 scopus 로고    scopus 로고
    • Role of macrophages in tumour progression
    • Siveen K.S., Kuttan G. Role of macrophages in tumour progression. Immunol Lett 2009, 123(2):97-102.
    • (2009) Immunol Lett , vol.123 , Issue.2 , pp. 97-102
    • Siveen, K.S.1    Kuttan, G.2
  • 14
    • 2642547301 scopus 로고    scopus 로고
    • Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma
    • Esposito I., et al. Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. J Clin Pathol 2004, 57(6):630-636.
    • (2004) J Clin Pathol , vol.57 , Issue.6 , pp. 630-636
    • Esposito, I.1
  • 15
    • 79954600458 scopus 로고    scopus 로고
    • Significance of M2-polarized tumor-associated macrophage in pancreatic cancer
    • Kurahara H., et al. Significance of M2-polarized tumor-associated macrophage in pancreatic cancer. J Surg Res 2011, 167(2):e211-e219.
    • (2011) J Surg Res , vol.167 , Issue.2
    • Kurahara, H.1
  • 16
    • 27544506907 scopus 로고    scopus 로고
    • High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients
    • Schmitz-Winnenthal F.H., et al. High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients. Cancer Res 2005, 65(21):10079-10087.
    • (2005) Cancer Res , vol.65 , Issue.21 , pp. 10079-10087
    • Schmitz-Winnenthal, F.H.1
  • 17
    • 1842505346 scopus 로고    scopus 로고
    • CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma
    • Fukunaga A., et al. CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma. Pancreas 2004, 28(1):e26-e31.
    • (2004) Pancreas , vol.28 , Issue.1
    • Fukunaga, A.1
  • 18
    • 58749091119 scopus 로고    scopus 로고
    • Carcinoembryonic antigen-specific but not antiviral CD4 T cell immunity is impaired in pancreatic carcinoma patients
    • Tassi E., et al. Carcinoembryonic antigen-specific but not antiviral CD4 T cell immunity is impaired in pancreatic carcinoma patients. J Immunol 2008, 181(9):6595-6603.
    • (2008) J Immunol , vol.181 , Issue.9 , pp. 6595-6603
    • Tassi, E.1
  • 19
    • 0032770957 scopus 로고    scopus 로고
    • Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients
    • Bellone G., et al. Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients. Am J Pathol 1999, 155(2):537-547.
    • (1999) Am J Pathol , vol.155 , Issue.2 , pp. 537-547
    • Bellone, G.1
  • 20
    • 84858289306 scopus 로고    scopus 로고
    • Circulating myeloid dendritic cells as prognostic factors in patients with pancreatic cancer who have undergone surgical resection
    • Yamamoto T., et al. Circulating myeloid dendritic cells as prognostic factors in patients with pancreatic cancer who have undergone surgical resection. J Surg Res 2012, 173(2):299-308.
    • (2012) J Surg Res , vol.173 , Issue.2 , pp. 299-308
    • Yamamoto, T.1
  • 21
    • 78149425157 scopus 로고    scopus 로고
    • Semi mature blood dendritic cells exist in patients with ductal pancreatic adenocarcinoma owing to inflammatory factors released from the tumor
    • Tjomsland V., et al. Semi mature blood dendritic cells exist in patients with ductal pancreatic adenocarcinoma owing to inflammatory factors released from the tumor. PLoS One 2010, 5(10):e13441.
    • (2010) PLoS One , vol.5 , Issue.10
    • Tjomsland, V.1
  • 22
    • 33847684243 scopus 로고    scopus 로고
    • Loss of expression of antigen-presenting molecules in human pancreatic cancer and pancreatic cancer cell lines
    • Pandha H., et al. Loss of expression of antigen-presenting molecules in human pancreatic cancer and pancreatic cancer cell lines. Clin Exp Immunol 2007, 148(1):127-135.
    • (2007) Clin Exp Immunol , vol.148 , Issue.1 , pp. 127-135
    • Pandha, H.1
  • 23
    • 0026652536 scopus 로고
    • Natural killer cell activity in patients with adenocarcinoma in the upper gastrointestinal tract
    • Aparicio-Pages M.N., et al. Natural killer cell activity in patients with adenocarcinoma in the upper gastrointestinal tract. J Clin Lab Immunol 1991, 35(1):27-32.
    • (1991) J Clin Lab Immunol , vol.35 , Issue.1 , pp. 27-32
    • Aparicio-Pages, M.N.1
  • 24
    • 79960333930 scopus 로고    scopus 로고
    • Clinical significance of the immunostimulatory MHC class I chain-related molecule A and NKG2D receptor on NK cells in pancreatic cancer
    • Duan X., et al. Clinical significance of the immunostimulatory MHC class I chain-related molecule A and NKG2D receptor on NK cells in pancreatic cancer. Med Oncol 2011, 28(2):466-474.
    • (2011) Med Oncol , vol.28 , Issue.2 , pp. 466-474
    • Duan, X.1
  • 25
    • 84866681005 scopus 로고    scopus 로고
    • Effect of pemetrexed on innate immune killer cells and adaptive immune T cells in subjects with adenocarcinoma of the pancreas
    • Davis M., et al. Effect of pemetrexed on innate immune killer cells and adaptive immune T cells in subjects with adenocarcinoma of the pancreas. J Immunother 2012, 35(8):629-640.
    • (2012) J Immunother , vol.35 , Issue.8 , pp. 629-640
    • Davis, M.1
  • 26
    • 33847385431 scopus 로고    scopus 로고
    • Costimulation, coinhibition and cancer
    • Inman B.A., et al. Costimulation, coinhibition and cancer. Curr Cancer Drug Targets 2007, 7(1):15-30.
    • (2007) Curr Cancer Drug Targets , vol.7 , Issue.1 , pp. 15-30
    • Inman, B.A.1
  • 27
    • 49649093382 scopus 로고    scopus 로고
    • B7-H1 up-regulated expression in human pancreatic carcinoma tissue associates with tumor progression
    • Geng L., et al. B7-H1 up-regulated expression in human pancreatic carcinoma tissue associates with tumor progression. J Cancer Res Clin Oncol 2008, 134(9):1021-1027.
    • (2008) J Cancer Res Clin Oncol , vol.134 , Issue.9 , pp. 1021-1027
    • Geng, L.1
  • 28
    • 34247532726 scopus 로고    scopus 로고
    • Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    • Nomi T., et al. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res 2007, 13(7):2151-2157.
    • (2007) Clin Cancer Res , vol.13 , Issue.7 , pp. 2151-2157
    • Nomi, T.1
  • 29
    • 79952033624 scopus 로고    scopus 로고
    • The CD40-CD154 interaction would correlate with proliferation and immune escape in pancreatic ductal adenocarcinoma
    • Shoji Y., et al. The CD40-CD154 interaction would correlate with proliferation and immune escape in pancreatic ductal adenocarcinoma. J Surg Oncol 2011, 103(3):230-238.
    • (2011) J Surg Oncol , vol.103 , Issue.3 , pp. 230-238
    • Shoji, Y.1
  • 30
    • 74549182599 scopus 로고    scopus 로고
    • Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer
    • Loos M., et al. Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer. BMC Cancer 2009, 9:463.
    • (2009) BMC Cancer , vol.9 , pp. 463
    • Loos, M.1
  • 31
    • 70449534753 scopus 로고    scopus 로고
    • Clinical importance of B7-H3 expression in human pancreatic cancer
    • Yamato I., et al. Clinical importance of B7-H3 expression in human pancreatic cancer. Br J Cancer 2009, 101(10):1709-1716.
    • (2009) Br J Cancer , vol.101 , Issue.10 , pp. 1709-1716
    • Yamato, I.1
  • 32
    • 34548590227 scopus 로고    scopus 로고
    • Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer
    • Hinz S., et al. Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer. Cancer Res 2007, 67(17):8344-8350.
    • (2007) Cancer Res , vol.67 , Issue.17 , pp. 8344-8350
    • Hinz, S.1
  • 33
    • 0035486830 scopus 로고    scopus 로고
    • TGF-beta1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion
    • Teraoka H., et al. TGF-beta1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion. Int J Oncol 2001, 19(4):709-715.
    • (2001) Int J Oncol , vol.19 , Issue.4 , pp. 709-715
    • Teraoka, H.1
  • 34
    • 34347400681 scopus 로고    scopus 로고
    • TGF-beta1 down-regulates ICAM-1 expression and enhances liver metastasis of pancreatic cancer
    • Sawada T., et al. TGF-beta1 down-regulates ICAM-1 expression and enhances liver metastasis of pancreatic cancer. Adv Med Sci 2006, 51:60-65.
    • (2006) Adv Med Sci , vol.51 , pp. 60-65
    • Sawada, T.1
  • 35
    • 33644586895 scopus 로고    scopus 로고
    • Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival
    • Bellone G., et al. Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival. Cancer Immunol Immunother 2006, 55(6):684-698.
    • (2006) Cancer Immunol Immunother , vol.55 , Issue.6 , pp. 684-698
    • Bellone, G.1
  • 36
    • 33646893538 scopus 로고    scopus 로고
    • The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells
    • Fallarino F., et al. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol 2006, 176(11):6752-6761.
    • (2006) J Immunol , vol.176 , Issue.11 , pp. 6752-6761
    • Fallarino, F.1
  • 37
    • 43049103779 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection
    • [discussion 854-6]
    • Witkiewicz A., et al. Expression of indoleamine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection. J Am Coll Surg 2008, 206(5):849-854. [discussion 854-6].
    • (2008) J Am Coll Surg , vol.206 , Issue.5 , pp. 849-854
    • Witkiewicz, A.1
  • 38
    • 77956156950 scopus 로고    scopus 로고
    • Multiple functional targets of the immunoregulatory activity of galectin-1: control of immune cell trafficking, dendritic cell physiology, and T-cell fate
    • Cooper D., et al. Multiple functional targets of the immunoregulatory activity of galectin-1: control of immune cell trafficking, dendritic cell physiology, and T-cell fate. Methods Enzymol 2010, 480:199-244.
    • (2010) Methods Enzymol , vol.480 , pp. 199-244
    • Cooper, D.1
  • 39
    • 77958581453 scopus 로고    scopus 로고
    • Identification of up- and down-regulated proteins in gemcitabine-resistant pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry
    • Kuramitsu Y., et al. Identification of up- and down-regulated proteins in gemcitabine-resistant pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry. Anticancer Res 2010, 30(9):3367-3372.
    • (2010) Anticancer Res , vol.30 , Issue.9 , pp. 3367-3372
    • Kuramitsu, Y.1
  • 40
    • 41149157015 scopus 로고    scopus 로고
    • Proteomic analysis to identify biomarker proteins in pancreatic ductal adenocarcinoma
    • Chung J.C., et al. Proteomic analysis to identify biomarker proteins in pancreatic ductal adenocarcinoma. ANZ J Surg 2008, 78(4):245-251.
    • (2008) ANZ J Surg , vol.78 , Issue.4 , pp. 245-251
    • Chung, J.C.1
  • 41
    • 22144475491 scopus 로고    scopus 로고
    • Galectin-1 is an inductor of pancreatic stellate cell activation
    • Fitzner B., et al. Galectin-1 is an inductor of pancreatic stellate cell activation. Cell Signal 2005, 17(10):1240-1247.
    • (2005) Cell Signal , vol.17 , Issue.10 , pp. 1240-1247
    • Fitzner, B.1
  • 42
    • 84856960944 scopus 로고    scopus 로고
    • High expression of galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer
    • Tang D., et al. High expression of galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer. Int J Cancer 2012, 130(10):2337-2348.
    • (2012) Int J Cancer , vol.130 , Issue.10 , pp. 2337-2348
    • Tang, D.1
  • 43
    • 84864549889 scopus 로고    scopus 로고
    • Stromal galectin-1 expression is associated with long-term survival in resectable pancreatic ductal adenocarcinoma
    • Chen R., et al. Stromal galectin-1 expression is associated with long-term survival in resectable pancreatic ductal adenocarcinoma. Cancer Biol Ther 2012, 13(10):899-907.
    • (2012) Cancer Biol Ther , vol.13 , Issue.10 , pp. 899-907
    • Chen, R.1
  • 44
    • 77956409684 scopus 로고    scopus 로고
    • Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells
    • Dardalhon V., et al. Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. J Immunol 2010, 185(3):1383-1392.
    • (2010) J Immunol , vol.185 , Issue.3 , pp. 1383-1392
    • Dardalhon, V.1
  • 45
    • 52049118288 scopus 로고    scopus 로고
    • Tumor-associated galectin-3 modulates the function of tumor-reactive T cells
    • Peng W., et al. Tumor-associated galectin-3 modulates the function of tumor-reactive T cells. Cancer Res 2008, 68(17):7228-7236.
    • (2008) Cancer Res , vol.68 , Issue.17 , pp. 7228-7236
    • Peng, W.1
  • 46
    • 84864344525 scopus 로고    scopus 로고
    • The expressions and clinical significances of tissue and serum galectin-3 in pancreatic carcinoma
    • Xie L., et al. The expressions and clinical significances of tissue and serum galectin-3 in pancreatic carcinoma. J Cancer Res Clin Oncol 2012, 138(6):1035-1043.
    • (2012) J Cancer Res Clin Oncol , vol.138 , Issue.6 , pp. 1035-1043
    • Xie, L.1
  • 47
    • 84865016312 scopus 로고    scopus 로고
    • Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling
    • Song S., et al. Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling. PLoS One 2012, 7(8):e42699.
    • (2012) PLoS One , vol.7 , Issue.8
    • Song, S.1
  • 48
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner
    • Erez N., et al. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 2010, 17(2):135-147.
    • (2010) Cancer Cell , vol.17 , Issue.2 , pp. 135-147
    • Erez, N.1
  • 49
    • 78149298209 scopus 로고    scopus 로고
    • Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha
    • Kraman M., et al. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science 2010, 330(6005):827-830.
    • (2010) Science , vol.330 , Issue.6005 , pp. 827-830
    • Kraman, M.1
  • 50
    • 84863285103 scopus 로고    scopus 로고
    • Expression of fibroblast activation protein in human pancreatic adenocarcinoma and its clinicopathological significance
    • Shi M., et al. Expression of fibroblast activation protein in human pancreatic adenocarcinoma and its clinicopathological significance. World J Gastroenterol 2012, 18(8):840-846.
    • (2012) World J Gastroenterol , vol.18 , Issue.8 , pp. 840-846
    • Shi, M.1
  • 51
    • 78650743475 scopus 로고    scopus 로고
    • Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras
    • Weden S., et al. Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras. Int J Cancer 2011, 128(5):1120-1128.
    • (2011) Int J Cancer , vol.128 , Issue.5 , pp. 1120-1128
    • Weden, S.1
  • 52
    • 79958244310 scopus 로고    scopus 로고
    • Targeting mutated K-ras in pancreatic adenocarcinoma using an adjuvant vaccine
    • Abou-Alfa G.K., et al. Targeting mutated K-ras in pancreatic adenocarcinoma using an adjuvant vaccine. Am J Clin Oncol 2011, 34(3):321-325.
    • (2011) Am J Clin Oncol , vol.34 , Issue.3 , pp. 321-325
    • Abou-Alfa, G.K.1
  • 53
    • 84896739165 scopus 로고    scopus 로고
    • A randomized, placebo controlled, double blind, multicenter phase 2 adjuvant trial of the efficacy, immunogeneicity, and safety of GI-4000 plus Gem vs Gem alone in patients with resected pancreas cancer with activating Ras mutations/survival and immunology analysis of the R1 Subgroup
    • [abstr #e14501]
    • Muscarella P., et al. A randomized, placebo controlled, double blind, multicenter phase 2 adjuvant trial of the efficacy, immunogeneicity, and safety of GI-4000 plus Gem vs Gem alone in patients with resected pancreas cancer with activating Ras mutations/survival and immunology analysis of the R1 Subgroup. J Clin Oncol 2012, 30(Suppl.). [abstr #e14501].
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Muscarella, P.1
  • 54
    • 84896729459 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT00300950&Search=Search.
  • 55
    • 0037211750 scopus 로고    scopus 로고
    • Circulating anti-MUC1 IgG antibodies as a favorable prognostic factor for pancreatic cancer
    • Hamanaka Y., et al. Circulating anti-MUC1 IgG antibodies as a favorable prognostic factor for pancreatic cancer. Int J Cancer 2003, 103(1):97-100.
    • (2003) Int J Cancer , vol.103 , Issue.1 , pp. 97-100
    • Hamanaka, Y.1
  • 56
    • 84896706581 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT00088660&Search=Search.
  • 57
    • 84896739440 scopus 로고    scopus 로고
    • [homepage on the Internet]. Identifier: UMIN000005248. Available from:
    • [homepage on the Internet]. Identifier: UMIN000005248. Available from: https://www.upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=history&action=list&type=summary&recptno=R000006238&language=E.
  • 58
    • 84896733209 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=+NCT01417000&Search=Search.
  • 59
    • 84896716222 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT00655785&Search=Search.
  • 60
    • 84896738083 scopus 로고    scopus 로고
    • [homepage on the Internet]. Identifier: UMIN000001664. Available from:
    • [homepage on the Internet]. Identifier: UMIN000001664. Available from: https://www.upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000002006&language=E.
  • 61
    • 33845247353 scopus 로고    scopus 로고
    • Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study
    • Bernhardt S.L., et al. Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study. Br J Cancer 2006, 95(11):1474-1482.
    • (2006) Br J Cancer , vol.95 , Issue.11 , pp. 1474-1482
    • Bernhardt, S.L.1
  • 62
    • 68649104725 scopus 로고    scopus 로고
    • A randomized phase III study of gemcitabine (G) versus GV1001 in sequential combination with G in patients with unresectable and metastatic pancreatic cancer (PC)
    • [abstr 4601]
    • Buanes T., et al. A randomized phase III study of gemcitabine (G) versus GV1001 in sequential combination with G in patients with unresectable and metastatic pancreatic cancer (PC). ASCO Annu Conf 2009, 27(15s). [abstr 4601].
    • (2009) ASCO Annu Conf , vol.27 , Issue.15 S
    • Buanes, T.1
  • 63
    • 84896704400 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT01526473&Search=Search.
  • 64
    • 0035152718 scopus 로고    scopus 로고
    • Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation
    • Jaffee E.M., et al. Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J Clin Oncol 2001, 19(1):145-156.
    • (2001) J Clin Oncol , vol.19 , Issue.1 , pp. 145-156
    • Jaffee, E.M.1
  • 65
    • 79151486551 scopus 로고    scopus 로고
    • A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A phase II trial of safety, efficacy, and immune activation
    • Lutz E., et al. A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A phase II trial of safety, efficacy, and immune activation. Ann Surg 2011, 253(2):328-335.
    • (2011) Ann Surg , vol.253 , Issue.2 , pp. 328-335
    • Lutz, E.1
  • 66
    • 84896698553 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT00305760&Search=Search.
  • 67
    • 84896716067 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT00389610&Search=Search.
  • 68
    • 84896735498 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT00727441&Search=Search.
  • 69
    • 84896722540 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT01595321&Search=Search.
  • 70
    • 68149088312 scopus 로고    scopus 로고
    • A phase I/II study of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumors
    • Lepisto A.J., et al. A phase I/II study of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumors. Cancer Ther 2008, 6(B):955-964.
    • (2008) Cancer Ther , vol.6 , Issue.B , pp. 955-964
    • Lepisto, A.J.1
  • 71
    • 84860521660 scopus 로고    scopus 로고
    • Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4 and CD8 T cells in melanoma patients
    • Van Nuffel A.M., et al. Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4 and CD8 T cells in melanoma patients. Mol Ther 2012, 20(5):1063-1074.
    • (2012) Mol Ther , vol.20 , Issue.5 , pp. 1063-1074
    • Van Nuffel, A.M.1
  • 72
    • 5144226237 scopus 로고    scopus 로고
    • Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes
    • Rosenberg S.A., Dudley M.E. Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes. Proc Natl Acad Sci USA 2004, 101(Suppl. 2):14639-14645.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.SUPPL. 2 , pp. 14639-14645
    • Rosenberg, S.A.1    Dudley, M.E.2
  • 73
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • Morgan R.A., et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 2006, 314(5796):126-129.
    • (2006) Science , vol.314 , Issue.5796 , pp. 126-129
    • Morgan, R.A.1
  • 74
    • 70149114880 scopus 로고    scopus 로고
    • Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
    • Johnson L.A., et al. Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood 2009, 114(3):535-546.
    • (2009) Blood , vol.114 , Issue.3 , pp. 535-546
    • Johnson, L.A.1
  • 75
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
    • Kochenderfer J.N., et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood 2012, 119(12):2709-2720.
    • (2012) Blood , vol.119 , Issue.12 , pp. 2709-2720
    • Kochenderfer, J.N.1
  • 76
    • 78650969008 scopus 로고    scopus 로고
    • Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells
    • Lamers C.H., et al. Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells. Blood 2011, 117(1):72-82.
    • (2011) Blood , vol.117 , Issue.1 , pp. 72-82
    • Lamers, C.H.1
  • 77
    • 84877669593 scopus 로고    scopus 로고
    • The basic principles of chimeric antigen receptor design
    • Sadelain M., Brentjens R., Riviere I. The basic principles of chimeric antigen receptor design. Cancer Discov 2013, 3(4):388-398.
    • (2013) Cancer Discov , vol.3 , Issue.4 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2    Riviere, I.3
  • 78
    • 84866653054 scopus 로고    scopus 로고
    • T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice
    • [p. 1095-107.e2]
    • Chmielewski M., et al. T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice. Gastroenterology 2012, 143(4). [p. 1095-107.e2].
    • (2012) Gastroenterology , vol.143 , Issue.4
    • Chmielewski, M.1
  • 79
    • 40549097760 scopus 로고    scopus 로고
    • Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes
    • Kondo H., et al. Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes. Anticancer Res 2008, 28(1B):379-387.
    • (2008) Anticancer Res , vol.28 , Issue.1 B , pp. 379-387
    • Kondo, H.1
  • 80
    • 49849084482 scopus 로고    scopus 로고
    • Adoptive immunotherapy for pancreatic cancer: cytotoxic T lymphocytes stimulated by the MUC1-expressing human pancreatic cancer cell line YPK-1
    • Kawaoka T., et al. Adoptive immunotherapy for pancreatic cancer: cytotoxic T lymphocytes stimulated by the MUC1-expressing human pancreatic cancer cell line YPK-1. Oncol Rep 2008, 20(1):155-163.
    • (2008) Oncol Rep , vol.20 , Issue.1 , pp. 155-163
    • Kawaoka, T.1
  • 81
    • 84896731719 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/show/NCT01723306?term=pancreatic+cancer%2C+tcr&rank=4.
  • 82
    • 84896721478 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT01583686&Search=Search.
  • 83
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C., et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011, 364(26):2517-2526.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1
  • 84
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi F.S., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010, 363(8):711-723.
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1
  • 85
    • 77958050577 scopus 로고    scopus 로고
    • Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
    • Royal R.E., et al. Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother 2010, 33(8):828-833.
    • (2010) J Immunother , vol.33 , Issue.8 , pp. 828-833
    • Royal, R.E.1
  • 86
    • 84896738298 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://clinicaltrials.gov/ct2/results?term=NCT00836407+Search=Search.
  • 87
    • 84896740558 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT00556023+&Search=Search.
  • 88
    • 84896697935 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT01473940&Search=Search.
  • 89
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer J.R., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012, 366(26):2455-2465.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1
  • 90
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O., et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013, 369(2):134-144.
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 134-144
    • Hamid, O.1
  • 91
    • 84868291942 scopus 로고    scopus 로고
    • Anti-PD-1 (BMS-936558, MDX-1106) in patients with advanced solid tumors: clinical activity, safety, and a potential biomarker for response
    • Topalian S.L., Brahmer J.R., Hodi F.S. Anti-PD-1 (BMS-936558, MDX-1106) in patients with advanced solid tumors: clinical activity, safety, and a potential biomarker for response. ASCO Annu Conf 2012, 30(15s):144s.
    • (2012) ASCO Annu Conf , vol.30 , Issue.15 s
    • Topalian, S.L.1    Brahmer, J.R.2    Hodi, F.S.3
  • 92
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian S.L., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012, 366(26):2443-2454.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1
  • 93
    • 77954716038 scopus 로고    scopus 로고
    • Clinical significance of B7-H1 and B7-1 expressions in pancreatic carcinoma
    • Wang L., et al. Clinical significance of B7-H1 and B7-1 expressions in pancreatic carcinoma. World J Surg 2010, 34(5):1059-1065.
    • (2010) World J Surg , vol.34 , Issue.5 , pp. 1059-1065
    • Wang, L.1
  • 94
    • 84896712784 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/results?term=NCT01313416&Search=Search.
  • 95
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok J.D., et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013, 369(2):122-133.
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 122-133
    • Wolchok, J.D.1
  • 96
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty G.L., et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 2011, 331(6024):1612-1616.
    • (2011) Science , vol.331 , Issue.6024 , pp. 1612-1616
    • Beatty, G.L.1
  • 97
    • 84896720750 scopus 로고    scopus 로고
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from:
    • ClinicalTrials.gov [homepage on the Internet]. Identifier: Available from: http://www.clinicaltrials.gov/ct2/show/NCT01456585?term=CP-870%2C893&rank=2.
  • 98
    • 30144444279 scopus 로고    scopus 로고
    • Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
    • Dannull J., et al. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest 2005, 115(12):3623-3633.
    • (2005) J Clin Invest , vol.115 , Issue.12 , pp. 3623-3633
    • Dannull, J.1
  • 99
    • 42649136634 scopus 로고    scopus 로고
    • Transient T cell depletion causes regression of melanoma metastases
    • Rasku M.A., et al. Transient T cell depletion causes regression of melanoma metastases. J Transl Med 2008, 6:12.
    • (2008) J Transl Med , vol.6 , pp. 12
    • Rasku, M.A.1
  • 100
    • 27444435581 scopus 로고    scopus 로고
    • Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma
    • Attia P., et al. Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma. J Immunother 2005, 28(6):582-592.
    • (2005) J Immunother , vol.28 , Issue.6 , pp. 582-592
    • Attia, P.1
  • 101
    • 70350496784 scopus 로고    scopus 로고
    • Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells
    • Rech A.J., Vonderheide R.H. Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells. Ann NY Acad Sci 2009, 1174:99-106.
    • (2009) Ann NY Acad Sci , vol.1174 , pp. 99-106
    • Rech, A.J.1    Vonderheide, R.H.2
  • 102
    • 77953134540 scopus 로고    scopus 로고
    • Metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory T lymphocytes and inhibiting tumor angiogenesis
    • Chen C.A., et al. Metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory T lymphocytes and inhibiting tumor angiogenesis. Mol Ther 2010, 18(6):1233-1243.
    • (2010) Mol Ther , vol.18 , Issue.6 , pp. 1233-1243
    • Chen, C.A.1
  • 103
    • 70350434889 scopus 로고    scopus 로고
    • Effective depletion of regulatory T cells allows the recruitment of mesothelin-specific CD8 T cells to the antitumor immune response against a mesothelin-expressing mouse pancreatic adenocarcinoma
    • Leao I.C., et al. Effective depletion of regulatory T cells allows the recruitment of mesothelin-specific CD8 T cells to the antitumor immune response against a mesothelin-expressing mouse pancreatic adenocarcinoma. Clin Transl Sci 2008, 1(3):228-239.
    • (2008) Clin Transl Sci , vol.1 , Issue.3 , pp. 228-239
    • Leao, I.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.