Developmental Onset of bilirubin-induced neurotoxicity involves toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice

Journal of Biological Chemistry

Volumn 289, Issue 8, 2014, Pages 4699-4709

  Yueh, Mei Fei ^a   Chen, Shujuan ^a   Nguyen, Nghia ^a   Tukey, Robert H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPERBILIRUBINEMIA; INNATE IMMUNITY; NEONATAL MOUSE; NEUROINFLAMMATION; NEUROTOXICITY; SERUM BILIRUBIN; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTORS;

MAMMALS; SIGNALING;

TOXICITY;

BILIRUBIN; GLUCURONOSYLTRANSFERASE 1A1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILIRUBIN BLOOD LEVEL; BILIRUBIN INDUCED NEUROTOXICITY; BRAIN CELL; CELL ACTIVATION; CELLULAR STRESS RESPONSE; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE; GENE EXPRESSION; GLIA CELL; GLIOSIS; HYPERBILIRUBINEMIA; IMMUNOHISTOCHEMISTRY; KERNICTERUS; MICROGLIA; MOUSE; NEUROTOXICITY; NEWBORN; NEWBORN DEATH; NONHUMAN; ONSET AGE; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SEIZURE; SIGNAL TRANSDUCTION; TLR2 GENE; UGT1A1 GENE; UPREGULATION;

BRAIN; GLIA; NEUROINFLAMMATION; OXIDATIVE STRESS; TOLL-LIKE RECEPTORS (TLR); UDP-GLUCURONOSYLTRANSFERASE;

ANIMALS; APOPTOSIS; BILIRUBIN; CALCIUM-BINDING PROTEINS; CYCLOOXYGENASE 2; FLUORESCENT ANTIBODY TECHNIQUE; GENE DELETION; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCURONOSYLTRANSFERASE; HUMANS; HYPERBILIRUBINEMIA; INFLAMMATION MEDIATORS; KERNICTERUS; MICE; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; NADPH OXIDASE; NEUROGLIA; NEUROTOXICITY SYNDROMES; NF-KAPPA B; OXIDATION-REDUCTION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TOLL-LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84896698025     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.518613     Document Type: Article

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