The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells

Cancer Research

Volumn 66, Issue 2, 2006, Pages 1033-1039

  Grantab, Rama ^a   Sivananthan, Shankar ^a   Tannock, Ian F ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; ALPHA E CATENIN; ANTINEOPLASTIC AGENT; DOXORUBICIN; FLUOROURACIL; METHOTREXATE; PACLITAXEL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ARTIFICIAL MEMBRANE; CANCER SURVIVAL; CELL ADHESION; CELL DENSITY; CELL GROWTH; COLON CARCINOMA; CONTROLLED STUDY; DRUG PENETRATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE DIAGNOSIS; TEFLON SUPPORT MEMBRANE;

ANTINEOPLASTIC AGENTS; CARCINOMA; CELL ADHESION; CELL COMMUNICATION; CELL SURVIVAL; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; HUMANS; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 31544444415     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-3077     Document Type: Article

References (30)

1. Jain RK. Vascular and interstitial barriers to delivery of therapeutic agents in tumors. Cancer Metastasis Rev 1990;9:253-66.
2. Jain RK. Transport of molecules, particles, and cells in solid tumors. Annu Rev Biomed Eng 1999;1:241-63.
3. Tannock IF. Tumor physiology and drug resistance. Cancer Metastasis Rev 2001;20:123-32.
4. Cole SPC, Tannock IF. The Basic Science of Oncology. 4th ed. New York (NY): McGraw-Hill Companies, Inc.; 2005. p. 376-99.
5. Sutherland RM, Eddy HA, Bareham B, Reich K, Vanantwerp D. Resistance to Adriamycin in multicellular spheroids. Int J Radiat Oncol Biol Phys 1979;5:1225-30.
6. West GW, Weichselbaum R, Little JB. Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy. Cancer Res 1980; 40:3665-8.
7. Nederman T, Carlsson J. Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids. Cancer Chemother Pharmacol 1984;13:131-5.
8. Sutherland RM. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 1988;240:177-84.
9. Durand RE. Distribution and activity of antineoplastic drugs in a tumor model. J Natl Cancer Inst 1989;81: 1623-52.
10. Hicks KO, Ohms SJ, van Zijl PL, Denny WA, Hunter PJ, Wilson WR. An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours. Br J Cancer 1997;76:894-903.
11. Wilson WR, Hicks KO. Measurement of extravascular drug diffusion in multicellular layers. Br J Cancer 1999; 79:1623-6.
12. Tannock IF, Lee CM, Tunggal JK, Cowan DS, Egorin MJ. Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy. Clin Cancer Res 2002;8:878-84.
13. Hicks KO, Fleming Y, Sum BG, Koch CJ, Wilson WR. Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model. Int J Radiat Oncol Biol Phys 1998;42:641-9.
14. Phillips RM, Loadman PM, Cronin BP. Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours. Br J Cancer 1998;77:2112-9.
15. Tunggal JK, Cowan DS, Shaikh H, Tannock IF. Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors. Clin Cancer Res 1999;5:1583-6.
16. Kyle AH, Minchinton AI. Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model. Cancer Chemother Pharmacol 1999;43:213-20.
17. Kyle AH, Huxham LA, Chiam AS, Sim DH, Minchinton AI. Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture. Cancer Res 2004;64:6304-9.
18. Tunggal JK, Melo T, Ballinger JR, Tannock IF. The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers. Int J Cancer 2000;86:101-7.
19. Cowan DS, Tannock IF. Factors that influence the penetration of methotrexate through solid tissue. Int J Cancer 2001;91:120-5.
20. Au JL, Jang SH, Wientjes MG. Clinical aspects of drug delivery to tumors. J Control Release 2002;78:81-95.
21. Kuh HJ, Jang SH, Wientjes MG, Weaver JR, Au JL. Determinants of paclitaxel penetration and accumulation in human solid tumor. J Pharmacol Exp Ther 1999; 290:871-80.
22. Jang SH, Wientjes MG, Au JL. Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule. J Pharmacol Exp Ther 2001;296:1035-42.
23. Vermeulen SJ, Mollet F, Teugels E, et al. The αE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. Oncogene 1999;18: 905-15.
24. Oda T, Kanai Y, Shimoyama Y, Nagafuchi A, Tsukita S, Hirohashi S. Cloning of the human α-catenin cDNA and its aberrant mRNA in a human cancer cell line. Biochem Biophys Res Commun 1993;193:897-904.
25. Vanpoucke G, Nollet F, Tejpar S, Cassiman JJ, van Roy F. The human αE-catenin gene CTNNA1: mutational analysis and rare occurrence of a truncated splice variant. Biochim Biophys Acta 2002;1574:262-8.
26. Gottesman MM. Mechanisms of cancer drug resistance. Annu Rev Med 2002;53:615-27.
27. Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol 2005;205:275-92.
28. St. Croix B, Rak JW, Kapitain S, Sheehan C, Graham CH, Kerbel RS. Reversal by hyalurodinase of adhesion dependent multicellular drug resistance in mammary carcinoma cells. J Natl Cancer Inst 1996; 88:1285-96.
29. Sherman-Baust CA, Weeraratna AT, Rangel LB, et al. Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells. Cancer Cell 2003;3: 377-86.
30. Netti PA, Berk DA, Swartz MA, Grodzinsky AJ, Jain RK. Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Res 2000;60: 2497-503.