Dose dependence of intratumoral perivascular distribution of monoclonal antibodies

Journal of Pharmaceutical Sciences

Volumn 101, Issue 2, 2012, Pages 860-867

  Rhoden, John J ^a   Wittrup, Karl Dane ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cancer; Carcinoembryonic antigen; Drug transport; Macromolecular drug delivery; Mathematical models; Microdistribution; Preclinical pharmacokinetics; Protein delivery; Transport barriers; Tumor penetration

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY SM3E; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ARTICLE; BLOOD VESSEL PERMEABILITY; DOSE RESPONSE; DRUG DISTRIBUTION; DRUG EXTRAVASATION; ENDOCYTOSIS; HUMAN; HUMAN CELL; IMAGE ANALYSIS; LIMIT OF QUANTITATION; MATHEMATICAL MODEL; MICROSCOPY; MOUSE; NONHUMAN; TUMOR BLOOD FLOW; TUMOR CELL;

EID: 84455205619     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22801     Document Type: Article

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