-
1
-
-
22544477523
-
Drug-associated mitochondrial toxicity and its detection
-
Amacher DE (2005) Drug-associated mitochondrial toxicity and its detection. Curr Med Chem 12:1829-1839
-
(2005)
Curr Med Chem
, vol.12
, pp. 1829-1839
-
-
Amacher, D.E.1
-
2
-
-
79958766883
-
Assessment of mitochondrial respiratory complex function in vitro and in vivo
-
Will Y (ed) Wiley, London
-
Birch-Machin MA (2008) Assessment of mitochondrial respiratory complex function in vitro and in vivo. In: Will Y (ed) Drug-induced mitochondrial dysfunction. Wiley, London, pp 383-395
-
(2008)
Drug-induced Mitochondrial Dysfunction
, pp. 383-395
-
-
Birch-Machin, M.A.1
-
3
-
-
66049157560
-
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity
-
Chen C, Krausz KW, Shah YM, Idle JR, Gonzalez FJ (2009) Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. Chem Res Toxicol 22:699-707
-
(2009)
Chem Res Toxicol
, vol.22
, pp. 699-707
-
-
Chen, C.1
Krausz, K.W.2
Shah, Y.M.3
Idle, J.R.4
Gonzalez, F.J.5
-
4
-
-
79958768263
-
-
Will Y (ed) Wiley, London
-
Ferrick D, Wu M, Swift A, Neilson A (2008) In: Will Y (ed) Drug-induced mitochondrial dysfunction. Wiley, London, pp 373-382
-
(2008)
Drug-induced Mitochondrial Dysfunction
, pp. 373-382
-
-
Ferrick, D.1
Wu, M.2
Swift, A.3
Neilson, A.4
-
5
-
-
0036007687
-
Metabolomics - The link between genotypes and phenotypes
-
Fiehn O (2002) Metabolomics - the link between genotypes and phenotypes. Plant Mol Biol 48:155-171
-
(2002)
Plant Mol Biol
, vol.48
, pp. 155-171
-
-
Fiehn, O.1
-
6
-
-
0036864788
-
The metabolic basis of arginine nutrition and pharmacotherapy
-
DOI 10.1016/S0753-3322(02)00273-1, PII S0753332202002731
-
Flynn NE, Meininger CJ, Haynes TE, Wu G (2002) The metabolic basis of arginine nutrition and pharmacotherapy. Biomed Pharmacother 56:427-438 (Pubitemid 35454030)
-
(2002)
Biomedicine and Pharmacotherapy
, vol.56
, Issue.9
, pp. 427-438
-
-
Flynn, N.E.1
Meininger, C.J.2
Haynes, T.E.3
Wu, G.4
-
7
-
-
0026732710
-
Mammalian skeletal muscle fibers distinguished by contents of phosphocreatine, ATP, and Pi
-
Kushmerick MJ, Moerland TS, Wiseman RW (1992) Mammalian skeletal muscle fibers distinguished by contents of phosphocreatine, ATP, and Pi. Proc Natl Acad Sci USA 89:7521-7525
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 7521-7525
-
-
Kushmerick, M.J.1
Moerland, T.S.2
Wiseman, R.W.3
-
8
-
-
0038236741
-
Alpha-synuclein aggregation: A link between mitochondrial defects and Parkinson's disease?
-
Lee SJ (2003) Alpha-synuclein aggregation: a link between mitochondrial defects and Parkinson's disease? Antioxid Redox Signal 5:337-348
-
(2003)
Antioxid Redox Signal
, vol.5
, pp. 337-348
-
-
Lee, S.J.1
-
9
-
-
0032231623
-
Epidemiology of A3243G, the mutation for mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes: Prevalence of the mutation in an adult population
-
DOI 10.1086/301959
-
Majamaa K, Moilanen JS, Uimonen S, Remes AM, Salmela PI, Karppa M, Majamaa-Voltti KA, Rusanen H, Sorri M, Peuhkurinen KJ, Hassinen IE (1998) Epidemiology of A3243G, the mutation for mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes: prevalence of the mutation in an adult population. Am J Hum Genet 63:447-454 (Pubitemid 30418626)
-
(1998)
American Journal of Human Genetics
, vol.63
, Issue.2
, pp. 447-454
-
-
Majamaa, K.1
Moilanen, J.S.2
Uimonen, S.3
Remes, A.M.4
Salmela, P.I.5
Karppa, M.6
Majamaa-Voltti, K.A.M.7
Rusanen, H.8
Sorri, M.9
Peuhkurinen, K.J.10
Hassinen, I.E.11
-
10
-
-
1342310587
-
Use of Metabonomics to Identify Impaired Fatty Acid Metabolism as the Mechanism of a Drug-Induced Toxicity
-
DOI 10.1021/tx034123j
-
Mortishire-Smith RJ, Skiles GL, Lawrence JW, Spence S, Nicholls AW, Johnson BA, Nicholson JK (2004) Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity. Chem Res Toxicol 17:165-173 (Pubitemid 38252496)
-
(2004)
Chemical Research in Toxicology
, vol.17
, Issue.2
, pp. 165-173
-
-
Mortishire-Smith, R.J.1
Skiles, G.L.2
Lawrence, J.W.3
Spence, S.4
Nicholls, A.W.5
Johnson, B.A.6
Nicholson, J.K.7
-
12
-
-
0030819144
-
Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy
-
Neubauer S, Horn M, Cramer M, Harre K, Newell JB, Peters W, Pabst T, Ertl G, Hahn D, Ingwall JS, Kochsiek K (1997) Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation 96:2190-2196 (Pubitemid 27425822)
-
(1997)
Circulation
, vol.96
, Issue.7
, pp. 2190-2196
-
-
Neubauer, S.1
Horn, M.2
Cramer, M.3
Harre, K.4
Newell, J.B.5
Pabst, T.6
Ertl, G.7
Hahn, D.8
Ingwall, J.S.9
Kochsiek, K.10
-
13
-
-
0036463681
-
Metabonomics: A platform for studying drug toxicity and gene function
-
DOI 10.1038/nrd728
-
Nicholson JK, Connelly J, Lindon JC, Holmes E (2002) Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov 1:153-161 (Pubitemid 41646523)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.2
, pp. 153-161
-
-
Nicholson, J.K.1
Connelly, J.2
Lindon, J.C.3
Holmes, E.4
-
15
-
-
0028434775
-
WET, a T1- and B1-insensitive water-suppression method for in vivo localized 1H NMR spectroscopy
-
Ogg RJ, Kingsley PB, Taylor JS (1994) WET, a T1- and B1-insensitive water-suppression method for in vivo localized 1H NMR spectroscopy. J Magn Reson B 104:1-10
-
(1994)
J Magn Reson B
, vol.104
, pp. 1-10
-
-
Ogg, R.J.1
Kingsley, P.B.2
Taylor, J.S.3
-
16
-
-
0037022352
-
Cytochrome c release from mitochondria proceeds by a two-step process
-
DOI 10.1073/pnas.241655498
-
Ott M, Robertson JD, Gogvadze V, Zhivotovsky B, Orrenius S (2002) Cytochrome c release from mitochondrial proceeds by a two-step process. Proc Natl Acad Sci USA 99:1259-1263 (Pubitemid 34136480)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.3
, pp. 1259-1263
-
-
Ott, M.1
Robertson, J.D.2
Gogvadze, V.3
Zhivotovsky, B.4
Orrenius, S.5
-
17
-
-
34547599329
-
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
-
DOI 10.1126/science.1143780
-
Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG (2007) Sirtuin 2 inhibitors rescue alpha-synuclein- mediated toxicity in models of Parkinson's disease. Science 317:516-519 (Pubitemid 47196116)
-
(2007)
Science
, vol.317
, Issue.5837
, pp. 516-519
-
-
Outeiro, T.F.1
Kontopoulos, E.2
Altmann, S.M.3
Kufareva, I.4
Strathearn, K.E.5
Amore, A.M.6
Volk, C.B.7
Maxwell, M.M.8
Rochet, J.-C.9
McLean, P.J.10
Young, A.B.11
Abagyan, R.12
Feany, M.B.13
Hyman, B.T.14
Kazantsev, A.G.15
-
19
-
-
20544466649
-
Metabonomics in toxicology: A review
-
Robertson DG (2005) Metabonomics in toxicology: a review. Toxicol Sci 85:809-822
-
(2005)
Toxicol Sci
, vol.85
, pp. 809-822
-
-
Robertson, D.G.1
-
20
-
-
78650533229
-
High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio
-
Ross JM, Oberg J, Brene S, Coppotelli G, Terzioglu M, Pernold K, Goiny M, Sitnikov R, Kehr J, Trifunovic A, Larsson NG, Hoffer BJ, Olson L (2010) High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio. Proc Natl Acad Sci USA 107:20087-20092
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 20087-20092
-
-
Ross, J.M.1
Oberg, J.2
Brene, S.3
Coppotelli, G.4
Terzioglu, M.5
Pernold, K.6
Goiny, M.7
Sitnikov, R.8
Kehr, J.9
Trifunovic, A.10
Larsson, N.G.11
Hoffer, B.J.12
Olson, L.13
-
21
-
-
0024390719
-
Mitochondrial complex I deficiency in Parkinson's disease
-
Schapira AH, Cooper JM, Dexter D, Jenner P, Clark JB, Marsden CD (1989) Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1:1269 (Pubitemid 19140359)
-
(1989)
Lancet
, vol.1
, Issue.8649
, pp. 1269
-
-
Schapira, A.H.V.1
Cooper, J.M.2
Dexter, D.3
Jenner, P.4
Clark, J.B.5
Marsden, C.D.6
-
22
-
-
0037306564
-
Creatine deficiency syndromes
-
Schulze A (2003) Creatine deficiency syndromes. Mol Cell Biochem 244:143-150
-
(2003)
Mol Cell Biochem
, vol.244
, pp. 143-150
-
-
Schulze, A.1
-
23
-
-
0037309446
-
Lack of creatine in muscle and brain in an adult with GAMT deficiency
-
DOI 10.1002/ana.10455
-
Schulze A, Bachert P, Schlemmer H, Harting I, Polster T, Salomons GS, Verhoeven NM, Jakobs C, Fowler B, Hoffmann GF, Mayatepek E (2003) Lack of creatine in muscle and brain in an adult with GAMT deficiency. Ann Neurol 53:248-251 (Pubitemid 36164008)
-
(2003)
Annals of Neurology
, vol.53
, Issue.2
, pp. 248-251
-
-
Schulze, A.1
Bachert, P.2
Schlemmer, H.3
Harting, I.4
Polster, T.5
Salomons, G.S.6
Verhoeven, N.M.7
Jakobs, C.8
Fowler, B.9
Hoffmann, G.F.10
Mayatepek, E.11
-
24
-
-
76549086505
-
A plasma signature of human mitochondrial disease revealed through metabolic profiling of spend media from cultured muscle cells
-
Shaham D, Slate NG, Goldberger O, Xu Q, Ramanathan A, Souza AL, Clish CB, Sims KB, Mootha VK (2010) A plasma signature of human mitochondrial disease revealed through metabolic profiling of spend media from cultured muscle cells. Proc Nat Acad Sci USA 107:1571-1575
-
(2010)
Proc Nat Acad Sci USA
, vol.107
, pp. 1571-1575
-
-
Shaham, D.1
Slate, N.G.2
Goldberger, O.3
Xu, Q.4
Ramanathan, A.5
Souza, A.L.6
Clish, C.B.7
Sims, K.B.8
Mootha, V.K.9
-
25
-
-
0004155427
-
-
W.H. Freeman and Company, New York
-
Stryer L (1995) Biochemistry. W.H. Freeman and Company, New York
-
(1995)
Biochemistry
-
-
Stryer, L.1
-
26
-
-
62749187786
-
Characterization of hepatic mitochondrial injury induced by fatty acid oxidation inhibitors
-
Vickers AE (2009) Characterization of hepatic mitochondrial injury induced by fatty acid oxidation inhibitors. Toxicol Pathol 37:78-88
-
(2009)
Toxicol Pathol
, vol.37
, pp. 78-88
-
-
Vickers, A.E.1
-
28
-
-
33745700438
-
Targeted profiling: Quantitative analysis of 1H NMR metabolomics data
-
Weljie AM, Newton J, Mercier P, Carlson E, Slupsky CM (2006) Targeted profiling: quantitative analysis of 1H NMR metabolomics data. Anal Chem 78:4430-4442
-
(2006)
Anal Chem
, vol.78
, pp. 4430-4442
-
-
Weljie, A.M.1
Newton, J.2
Mercier, P.3
Carlson, E.4
Slupsky, C.M.5
-
29
-
-
41049096359
-
Quantitative metabolomics using NMR
-
Wishart DS (2008) Quantitative metabolomics using NMR. Trends Anal Chem 27:228-237
-
(2008)
Trends Anal Chem
, vol.27
, pp. 228-237
-
-
Wishart, D.S.1
-
30
-
-
33750202111
-
Quantification and identification of components in solution mixtures from 1D proton NMR spectra using singular value decomposition
-
DOI 10.1021/ac0606857
-
Xu Q, Sachs JR, Wang TC, Schaefer WH (2006) Quantification and identification of components in solution mixtures from 1D proton NMR spectra using singular value decomposition. Anal Chem 78:7175-7185 (Pubitemid 44607560)
-
(2006)
Analytical Chemistry
, vol.78
, Issue.20
, pp. 7175-7185
-
-
Xu, Q.1
Sachs, J.R.2
Wang, T.-C.3
Schaefer, W.H.4
-
31
-
-
51449105863
-
Integrated pathway analysis of rat urine metabolic profiles and kidney transcriptomic profiles to elucidate the systems toxicology of model nephrotoxicants
-
Xu EY, Perlina A, Vu H, Troth SP, Brennan RJ, Aslamkhan AG, Xu Q (2008) Integrated pathway analysis of rat urine metabolic profiles and kidney transcriptomic profiles to elucidate the systems toxicology of model nephrotoxicants. Chem Res Toxicol 21:1548-1561
-
(2008)
Chem Res Toxicol
, vol.21
, pp. 1548-1561
-
-
Xu, E.Y.1
Perlina, A.2
Vu, H.3
Troth, S.P.4
Brennan, R.J.5
Aslamkhan, A.G.6
Xu, Q.7
-
32
-
-
58449117420
-
Metabolomics in pharmaceutical research and development: Metabolites, mechanisms and pathways
-
Xu EY, Schaefer WH, Xu Q (2009) Metabolomics in pharmaceutical research and development: metabolites, mechanisms and pathways. Curr Opin Drug Discov Devel 12:40-52
-
(2009)
Curr Opin Drug Discov Devel
, vol.12
, pp. 40-52
-
-
Xu, E.Y.1
Schaefer, W.H.2
Xu, Q.3
|