메뉴 건너뛰기




Volumn 37, Issue 12, 2014, Pages 1624-1633

Aloin protects against chronic alcoholic liver injury via attenuating lipid accumulation, oxidative stress and inflammation in mice

Author keywords

Aloin; Chronic alcoholic liver injury; Hepatoprotection; Inflammation; Lipid accumulation; Oxidative stress

Indexed keywords

ALLOIN; ANTIOXIDANT; BIOLOGICAL MARKER; CYTOKINE; EMODIN;

EID: 84896551756     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-014-0370-0     Document Type: Article
Times cited : (42)

References (46)
  • 1
    • 33845927120 scopus 로고    scopus 로고
    • Alcohol, oxidative stress and free radical damage
    • 1:CAS:528:DC%2BD28XhtFWlu7zL 16923312
    • Albano, E. 2006. Alcohol, oxidative stress and free radical damage. Proceedings of the Nutrition Society 65: 278-290.
    • (2006) Proceedings of the Nutrition Society , vol.65 , pp. 278-290
    • Albano, E.1
  • 2
    • 39749090649 scopus 로고    scopus 로고
    • Oxidative mechanisms in the pathogenesis of alcoholic liver disease
    • 1:CAS:528:DC%2BD1cXivVynu74%3D 18045675
    • Albano, E. 2008. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Molecular Aspects of Medicine 29: 9-16.
    • (2008) Molecular Aspects of Medicine , vol.29 , pp. 9-16
    • Albano, E.1
  • 3
    • 84866097840 scopus 로고    scopus 로고
    • Cytokines in alcoholic liver disease
    • 1:CAS:528:DC%2BC38XivVSisrs%3D 22367091
    • An, L., X. Wang, and A.I. Cederbaum. 2012. Cytokines in alcoholic liver disease. Archives of Toxicology 86: 1337-1348.
    • (2012) Archives of Toxicology , vol.86 , pp. 1337-1348
    • An, L.1    Wang, X.2    Cederbaum, A.I.3
  • 4
    • 82155168001 scopus 로고    scopus 로고
    • In vitro antimicrobial and antioxidant activities of anthrone and chromone from the latex of Aloe harlana reynolds
    • 1:CAS:528:DC%2BC3MXhsV2mt7jJ 21452374
    • Asamenew, G., D. Bisrat, A. Mazumder, and K. Asres. 2011. In vitro antimicrobial and antioxidant activities of anthrone and chromone from the latex of Aloe harlana reynolds. Phytotherapy Research: PTR 25: 1756-1760.
    • (2011) Phytotherapy Research: PTR , vol.25 , pp. 1756-1760
    • Asamenew, G.1    Bisrat, D.2    Mazumder, A.3    Asres, K.4
  • 5
    • 0030714659 scopus 로고    scopus 로고
    • Cytotoxicity of a low molecular weight fraction from Aloe vera (Aloe barbadensis Miller) gel
    • 1:CAS:528:DyaK2sXnsVWgsr4%3D 9403965
    • Avila, H., J. Rivero, F. Herrera, and G. Fraile. 1997. Cytotoxicity of a low molecular weight fraction from Aloe vera (Aloe barbadensis Miller) gel. Toxicon 35: 1423-1430.
    • (1997) Toxicon , vol.35 , pp. 1423-1430
    • Avila, H.1    Rivero, J.2    Herrera, F.3    Fraile, G.4
  • 6
    • 0141569111 scopus 로고    scopus 로고
    • Radical-scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats
    • 14522430
    • Beppu, H., T. Koike, K. Shimpo, T. Chihara, M. Hoshino, C. Ida, and H. Kuzuya. 2003. Radical-scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats. Journal of Ethnopharmacology 89: 37-45.
    • (2003) Journal of Ethnopharmacology , vol.89 , pp. 37-45
    • Beppu, H.1    Koike, T.2    Shimpo, K.3    Chihara, T.4    Hoshino, M.5    Ida, C.6    Kuzuya, H.7
  • 8
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • 1:CAS:528:DyaE28XksVehtrY%3D 942051
    • Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72: 248-254.
    • (1976) Analytical Biochemistry , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 10
    • 0030575939 scopus 로고    scopus 로고
    • Acceleration of the alcohol oxidation rate in rats with aloin, a quinone derivative of Aloe
    • 1:CAS:528:DyaK28Xms1Gks7o%3D 8937458
    • Chung, J.H., J.C. Cheong, J.Y. Lee, H.K. Roh, and Y.N. Cha. 1996. Acceleration of the alcohol oxidation rate in rats with aloin, a quinone derivative of Aloe. Biochemical Pharmacology 52: 1461-1468.
    • (1996) Biochemical Pharmacology , vol.52 , pp. 1461-1468
    • Chung, J.H.1    Cheong, J.C.2    Lee, J.Y.3    Roh, H.K.4    Cha, Y.N.5
  • 11
    • 0023706894 scopus 로고
    • Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production
    • 1:CAS:528:DyaL1cXmtV2ns7s%3D
    • Ding, A.H., C.F. Nathan, and D.J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. Journal of Immunology 141: 2407-2412.
    • (1988) Journal of Immunology , vol.141 , pp. 2407-2412
    • Ding, A.H.1    Nathan, C.F.2    Stuehr, D.J.3
  • 14
    • 84861101379 scopus 로고    scopus 로고
    • In vivo and in vitro studies on the antioxidant activity of aloin compared to doxorubicin in rats
    • 1:CAS:528:DC%2BC38Xks1yqtro%3D
    • Esmat, A.Y., M.M. Said, G.M. Hamdy, A.A. Soliman, and S.A. Khalil. 2012. In vivo and in vitro studies on the antioxidant activity of aloin compared to doxorubicin in rats. Drug Development Research 73: 154-165.
    • (2012) Drug Development Research , vol.73 , pp. 154-165
    • Esmat, A.Y.1    Said, M.M.2    Hamdy, G.M.3    Soliman, A.A.4    Khalil, S.A.5
  • 15
    • 32544451466 scopus 로고    scopus 로고
    • Cytotoxicity of a natural anthraquinone (aloin) against human breast cancer cell lines with and without erbB-2-topoisomerase II alpha coamplification
    • 1:CAS:528:DC%2BD28XkvVSnt7g%3D 16357514
    • Esmat, A.Y., C. Tomasetto, and M.C. Rio. 2006. Cytotoxicity of a natural anthraquinone (aloin) against human breast cancer cell lines with and without erbB-2-topoisomerase II alpha coamplification. Cancer Biology and Therapy 5: 97-103.
    • (2006) Cancer Biology and Therapy , vol.5 , pp. 97-103
    • Esmat, A.Y.1    Tomasetto, C.2    Rio, M.C.3
  • 16
    • 61349161828 scopus 로고    scopus 로고
    • Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis
    • 1:CAS:528:DC%2BD1MXisVOhtro%3D 2675276 19251117
    • Forsyth, C.B., A. Farhadia, S.M. Jakate, Y.M. Tang, M. Shaikh, and A. Keshavarzian. 2009. Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis. Alcohol 43: 163-172.
    • (2009) Alcohol , vol.43 , pp. 163-172
    • Forsyth, C.B.1    Farhadia, A.2    Jakate, S.M.3    Tang, Y.M.4    Shaikh, M.5    Keshavarzian, A.6
  • 17
    • 0023222638 scopus 로고
    • Barbaloin in aloe species
    • 1:CAS:528:DyaL2sXlsFWhur8%3D 17269040
    • Groom, Q.J., and T. Reynolds. 1987. Barbaloin in aloe species. Planta Medica 53: 345-348.
    • (1987) Planta Medica , vol.53 , pp. 345-348
    • Groom, Q.J.1    Reynolds, T.2
  • 18
    • 67749093260 scopus 로고    scopus 로고
    • Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis
    • 1:CAS:528:DC%2BD1MXptlansbk%3D 19576882
    • Hu, S., S. Yin, X. Jiang, D. Huang, and G. Shen. 2009. Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis. European Journal of Pharmacology 616: 287-292.
    • (2009) European Journal of Pharmacology , vol.616 , pp. 287-292
    • Hu, S.1    Yin, S.2    Jiang, X.3    Huang, D.4    Shen, G.5
  • 19
    • 62749162644 scopus 로고    scopus 로고
    • Cinnamon extract protects against acute alcohol-induced liver steatosis in mice
    • 1:CAS:528:DC%2BD1MXjsFKitbo%3D 19126670
    • Kanuri, G., S. Weber, V. Volynets, A. Spruss, S.C. Bischoff, and I. Bergheim. 2009. Cinnamon extract protects against acute alcohol-induced liver steatosis in mice. The Journal of nutrition 139: 482-487.
    • (2009) The Journal of Nutrition , vol.139 , pp. 482-487
    • Kanuri, G.1    Weber, S.2    Volynets, V.3    Spruss, A.4    Bischoff, S.C.5    Bergheim, I.6
  • 20
    • 0030176375 scopus 로고    scopus 로고
    • Metabolism of aloin-The influence of nutrition
    • 1:CAS:528:DyaK28Xks1Sisrs%3D 8818052
    • Koch, A. 1996. Metabolism of aloin-The influence of nutrition. Journal of Pharmaceutical and Biomedical Analysis 14: 1335-1338.
    • (1996) Journal of Pharmaceutical and Biomedical Analysis , vol.14 , pp. 1335-1338
    • Koch, A.1
  • 21
    • 67349255858 scopus 로고    scopus 로고
    • Signalling pathways in alcohol-induced liver inflammation
    • 1:CAS:528:DC%2BD1MXlslWms7g%3D 3342816 19398236
    • Mandrekar, P., and G. Szabo. 2009. Signalling pathways in alcohol-induced liver inflammation. Journal of Hepatology 50: 1258-1266.
    • (2009) Journal of Hepatology , vol.50 , pp. 1258-1266
    • Mandrekar, P.1    Szabo, G.2
  • 22
    • 0028670876 scopus 로고
    • Mutant mice, Cu, Zn superoxide dismutase, and motor neuron degeneration
    • 1:CAS:528:DyaK2MXisVGls7w%3D 7985031
    • Mccord, J.M. 1994. Mutant mice, Cu, Zn superoxide dismutase, and motor neuron degeneration. Science 266: 1586-1587.
    • (1994) Science , vol.266 , pp. 1586-1587
    • McCord, J.M.1
  • 23
    • 0141625009 scopus 로고    scopus 로고
    • Recent insights into the role of the innate immune system in the development of alcoholic liver disease
    • 1:CAS:528:DC%2BD3sXntlaksbY%3D 12968059
    • Nagy, L.E. 2003. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Experimental Biology and Medicine 228: 882-890.
    • (2003) Experimental Biology and Medicine , vol.228 , pp. 882-890
    • Nagy, L.E.1
  • 24
    • 79957629091 scopus 로고    scopus 로고
    • Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice
    • 1:CAS:528:DC%2BC3MXmvFWitro%3D 21457746
    • Noh, J.R., Y.H. Kim, G.T. Gang, J.H. Hwang, H.S. Lee, S.Y. Ly, W.K. Oh, K.S. Song, and C.H. Lee. 2011. Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice. Food and Chemical Toxicology 49: 1537-1543.
    • (2011) Food and Chemical Toxicology , vol.49 , pp. 1537-1543
    • Noh, J.R.1    Kim, Y.H.2    Gang, G.T.3    Hwang, J.H.4    Lee, H.S.5    Ly, S.Y.6    Oh, W.K.7    Song, K.S.8    Lee, C.H.9
  • 26
    • 77954052476 scopus 로고    scopus 로고
    • Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models
    • 1:CAS:528:DC%2BD1MXkvFegsbk%3D 2788160 20016696
    • Park, M.Y., H.J. Kwon, and M.K. Sung. 2009a. Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models. Nutrition Research and Practice 3: 9-14.
    • (2009) Nutrition Research and Practice , vol.3 , pp. 9-14
    • Park, M.Y.1    Kwon, H.J.2    Sung, M.K.3
  • 27
    • 67149097678 scopus 로고    scopus 로고
    • Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages
    • 1:CAS:528:DC%2BD1MXlsFChur4%3D 19352036
    • Park, M.Y., H.J. Kwon, and M.K. Sung. 2009b. Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Bioscience, Biotechnology, and Biochemistry 73: 828-832.
    • (2009) Bioscience, Biotechnology, and Biochemistry , vol.73 , pp. 828-832
    • Park, M.Y.1    Kwon, H.J.2    Sung, M.K.3
  • 28
    • 79952446275 scopus 로고    scopus 로고
    • Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model
    • 1:CAS:528:DC%2BC3MXjsFensrY%3D 21277867
    • Park, M.Y., H.J. Kwon, and M.K. Sung. 2011. Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model. Life Sciences 88: 486-492.
    • (2011) Life Sciences , vol.88 , pp. 486-492
    • Park, M.Y.1    Kwon, H.J.2    Sung, M.K.3
  • 29
    • 84862731331 scopus 로고    scopus 로고
    • Barbaloin: A concise report of its pharmacological and analytical aspects
    • 1:CAS:528:DC%2BC38Xht1agsLnN 3609230 23569857
    • Patel, D.K., K. Patel, and V. Tahilyani. 2012. Barbaloin: A concise report of its pharmacological and analytical aspects. Asian Pacific Journal of Tropical Biomedicine 2: 835-838.
    • (2012) Asian Pacific Journal of Tropical Biomedicine , vol.2 , pp. 835-838
    • Patel, D.K.1    Patel, K.2    Tahilyani, V.3
  • 30
    • 84869466985 scopus 로고    scopus 로고
    • Amelioration of alcohol-induced hepatotoxicity by the administration of ethanolic extract of Sida cordifolia Linn
    • 1:CAS:528:DC%2BC38Xhs1yms73J 22289614
    • Rejitha, S., P. Prathibha, and M. Indira. 2012. Amelioration of alcohol-induced hepatotoxicity by the administration of ethanolic extract of Sida cordifolia Linn. The British Journal of Nutrition 108: 1256-1263.
    • (2012) The British Journal of Nutrition , vol.108 , pp. 1256-1263
    • Rejitha, S.1    Prathibha, P.2    Indira, M.3
  • 31
    • 0034847310 scopus 로고    scopus 로고
    • Alcoholic liver disease: New insights into mechanisms and preventative strategies
    • 1:CAS:528:DC%2BD3MXmt1ynsbg%3D 11530336
    • Stewart, S., D. Jones, and C.P. Day. 2001. Alcoholic liver disease: New insights into mechanisms and preventative strategies. Trends in Molecular Medicine 7: 408-413.
    • (2001) Trends in Molecular Medicine , vol.7 , pp. 408-413
    • Stewart, S.1    Jones, D.2    Day, C.P.3
  • 32
    • 0037082350 scopus 로고    scopus 로고
    • Role of malondialdehyde-acetaldehyde adducts in liver injury
    • 1:CAS:528:DC%2BD38XhtF2jt7w%3D 11841919
    • Tuma, D.J. 2002. Role of malondialdehyde-acetaldehyde adducts in liver injury. Free Radical Biology and Medicine 32: 303-308.
    • (2002) Free Radical Biology and Medicine , vol.32 , pp. 303-308
    • Tuma, D.J.1
  • 33
    • 0029031035 scopus 로고
    • Geographical variation in the major compounds of Aloe ferox leaf exudate
    • 7617769
    • Van Wyk, B.E., M.C. Van Rheede Van Oudtshoorn, and G.F. Smith. 1995. Geographical variation in the major compounds of Aloe ferox leaf exudate. Planta Medica 61: 250-253.
    • (1995) Planta Medica , vol.61 , pp. 250-253
    • Van Wyk, B.E.1    Van Rheede Van Oudtshoorn, M.C.2    Smith, G.F.3
  • 34
    • 68949165996 scopus 로고    scopus 로고
    • Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease
    • 1:CAS:528:DC%2BD1MXhtVKrtr3L 19489076
    • Wang, Y., G. Millonig, J. Nair, E. Patsenker, F. Stickel, S. Mueller, H. Bartsch, and H.K. Seitz. 2009. Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. Hepatology 50: 453-461.
    • (2009) Hepatology , vol.50 , pp. 453-461
    • Wang, Y.1    Millonig, G.2    Nair, J.3    Patsenker, E.4    Stickel, F.5    Mueller, S.6    Bartsch, H.7    Seitz, H.K.8
  • 36
    • 36849031867 scopus 로고    scopus 로고
    • Combined effects of vitamin C, vitamin E, and sodium selenate supplementation on absolute ethanol-induced injury in various organs of rats
    • 1:CAS:528:DC%2BD2sXhsVSnsbvF 18066967
    • Yanardag, R., O. Ozsoy-Sacan, S. Ozdil, and S. Bolkent. 2007. Combined effects of vitamin C, vitamin E, and sodium selenate supplementation on absolute ethanol-induced injury in various organs of rats. International Journal of Toxicology 26: 513-523.
    • (2007) International Journal of Toxicology , vol.26 , pp. 513-523
    • Yanardag, R.1    Ozsoy-Sacan, O.2    Ozdil, S.3    Bolkent, S.4
  • 37
    • 85012986851 scopus 로고    scopus 로고
    • Protective effects of crude aloe polysaccharides and aloin on mice with acute liver injury induced by alcohol
    • 1:CAS:528:DC%2BC38XhvVent7fJ
    • Ye, Q., H.Y. Wang, and H. Qian. 2012. Protective effects of crude aloe polysaccharides and aloin on mice with acute liver injury induced by alcohol. Science and Technology of Food Industry 33: 355-358.
    • (2012) Science and Technology of Food Industry , vol.33 , pp. 355-358
    • Ye, Q.1    Wang, H.Y.2    Qian, H.3
  • 38
    • 12744267804 scopus 로고    scopus 로고
    • Molecular mechanisms of alcoholic fatty liver: Role of sterol regulatory element-binding proteins
    • 1:CAS:528:DC%2BD2MXmvFOitw%3D%3D 15670664
    • You, M., and D.W. Crabb. 2004a. Molecular mechanisms of alcoholic fatty liver: Role of sterol regulatory element-binding proteins. Alcohol 34: 39-43.
    • (2004) Alcohol , vol.34 , pp. 39-43
    • You, M.1    Crabb, D.W.2
  • 39
    • 3042550657 scopus 로고    scopus 로고
    • Recent advances in alcoholic liver disease II. Minireview: Molecular mechanisms of alcoholic fatty liver. American journal of physiology
    • 1:CAS:528:DC%2BD2cXlvFOhu7o%3D 15194557
    • You, M., and D.W. Crabb. 2004b. Recent advances in alcoholic liver disease II. Minireview: Molecular mechanisms of alcoholic fatty liver. American journal of physiology. Gastrointestinal and liver physiology 287: G1-G6.
    • (2004) Gastrointestinal and Liver Physiology , vol.287 , pp. 1-G6
    • You, M.1    Crabb, D.W.2
  • 40
    • 0037047284 scopus 로고    scopus 로고
    • Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)
    • 1:CAS:528:DC%2BD38XmsVKjtrY%3D 12036955
    • You, M., M. Fischer, M.A. Deeg, and D.W. Crabb. 2002. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). The Journal of biological chemistry 277: 29342-29347.
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 29342-29347
    • You, M.1    Fischer, M.2    Deeg, M.A.3    Crabb, D.W.4
  • 41
    • 9644290860 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in the action of ethanol in the liver
    • 1:CAS:528:DC%2BD2MXit1Gisg%3D%3D 15578517
    • You, M., M. Matsumoto, C.M. Pacold, W.K. Cho, and D.W. Crabb. 2004. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127: 1798-1808.
    • (2004) Gastroenterology , vol.127 , pp. 1798-1808
    • You, M.1    Matsumoto, M.2    Pacold, C.M.3    Cho, W.K.4    Crabb, D.W.5
  • 42
    • 78951474859 scopus 로고    scopus 로고
    • Hepatoprotective effect and antioxidant role of sun, sulphited-dried apricot (Prunus armeniaca L.) and its kernel against ethanol-induced oxidative stress in rats
    • 1:CAS:528:DC%2BC3MXhtlKltL4%3D
    • Yurt, B., and I. Celik. 2011. Hepatoprotective effect and antioxidant role of sun, sulphited-dried apricot (Prunus armeniaca L.) and its kernel against ethanol-induced oxidative stress in rats. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 49: 508-513.
    • (2011) Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association , vol.49 , pp. 508-513
    • Yurt, B.1    Celik, I.2
  • 45
    • 70350302336 scopus 로고    scopus 로고
    • Effects of Puerariae radix extract on the increasing intestinal permeability in rat with alcohol-induced liver injury
    • 19735712
    • Zhang, R.R., Y.Y. Hu, J.Y. Yuan, and D.Z. Wu. 2009. Effects of Puerariae radix extract on the increasing intestinal permeability in rat with alcohol-induced liver injury. Journal of Ethnopharmacology 126: 207-214.
    • (2009) Journal of Ethnopharmacology , vol.126 , pp. 207-214
    • Zhang, R.R.1    Hu, Y.Y.2    Yuan, J.Y.3    Wu, D.Z.4
  • 46
    • 43749090001 scopus 로고    scopus 로고
    • Protective effect of bicyclol on acute alcohol-induced liver injury in mice
    • 1:CAS:528:DC%2BD1cXmsVGmtb0%3D 18371952
    • Zhao, J., H. Chen, and Y. Li. 2008. Protective effect of bicyclol on acute alcohol-induced liver injury in mice. European Journal of Pharmacology 586: 322-331.
    • (2008) European Journal of Pharmacology , vol.586 , pp. 322-331
    • Zhao, J.1    Chen, H.2    Li, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.