Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis

European Journal of Pharmacology

Volumn 616, Issue 1-3, 2009, Pages 287-292

  Hu, Shilian ^a   Yin, Shi ^a   Jiang, Xiaodong ^a   Huang, Dabing ^a   Shen, Gan ^a  

^a Anhui Institute of Geology   (China)

Author keywords

Alcoholic liver injury; Apoptosis; Inflammation; Melatonin; Oxidative stress

Indexed keywords

AMINOTRANSFERASE; CYTOKINE; MELATONIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL LIVER CIRRHOSIS; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; KUPFFER CELL; LIPID PEROXIDATION; LIVER PROTECTION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ALCOHOLS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; CYTOKINES; GENE EXPRESSION REGULATION; INFLAMMATION; LIPID PEROXIDATION; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; MELATONIN; MICE; OXIDATIVE STRESS;

EID: 67749093260     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.06.044     Document Type: Article

References (27)

1. Albano E. Alcohol, oxidative stress and free radical damage. Proc. Nutr. Soc. 65 (2006) 278-290
2. Arteel G.E. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 124 (2003) 778-790
3. Arteel G.E. Alcohol-induced oxidative stress in the liver: in vivo measurements. Methods Mol. Biol. 447 (2008) 185-197
4. Calvo J.R., Reiter R.J., Garcia J.J., Ortiz G.G., Tan D.X., and Karbownik M. Characterization of the protective effects of melatonin and related indoles against alpha-naphthylisothiocyanate-induced liver injury in rats. J. Cell. Biochem. 80 (2001) 461-470
5. Cuzzocrea S., and Reiter R.J. Pharmacological actions of melatonin in acute and chronic inflammation. Curr. Top. Med. Chem. 2 (2002) 153-165
6. Dey A., and Cederbaum A.I. Alcohol and oxidative liver injury. Hepatology 43 (2006) S63-S74
7. Garcia-Ruiz C., Colell A., Morales A., Kaplowitz N., and Fernandez-Checa J.C. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol. Pharmacol. 48 (1995) 825-834
8. Hoek J.B., and Pastorino J.G. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 27 (2002) 63-68
9. Horiguchi N., Wang L., Mukhopadhyay P., Park O., Jeong W.I., Lafdil F., Osei-Hyiaman D., Moh A., Fu X.Y., Pacher P., Kunos G., and Gao B. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 134 (2008) 1148-1158
10. Ji C., Deng Q., and Kaplowitz N. Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology 40 (2004) 442-451
11. Khanal T., Choi J.H., Hwang Y.P., and Jeong H.G. Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanol-induced hepatotoxicity in mice. Food Chem. Toxicol. 47 (2009) 530-535
12. Korkmaz A., Reiter R.J., Topal T., Manchester L.C., Oter S., and Tan D.X. Melatonin: an established antioxidant worthy of use in clinical trials. Mol. Med. 15 (2009) 43-50
13. Nagy L.E. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp. Biol. Med. (Maywood) 228 (2003) 882-890
14. Ohta Y., Kongo M., and Kishikawa T. Preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate-induced acute liver injury in rats. J. Pineal Res. 34 (2003) 185-193
15. Ohta Y., Kongo M., Sasaki E., Nishida K., and Ishiguro I. Therapeutic effect of melatonin on carbon tetrachloride-induced acute liver injury in rats. J. Pineal Res. 28 (2000) 119-126
16. Reiter R.J., Tan D.X., Osuna C., and Gitto E. Actions of melatonin in the reduction of oxidative stress. A review. J. Biomed. Sci. 7 (2000) 444-458
17. Sozio M., and Crabb D.W. Alcohol and lipid metabolism. Am. J. Physiol. Endocrinol. Metab. 295 (2008) E10-E16
18. Subramanian P., Mirunalini S., Pandi-Perumal S.R., Trakht I., and Cardinali D.P. Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats. Eur. J. Pharmacol. 571 (2007) 116-119
19. Sun R., Park O., Horiguchi N., Kulkarni S., Jeong W.I., Sun H.Y., Radaeva S., and Gao B. STAT1 contributes to dsRNA inhibition of liver regeneration after partial hepatectomy in mice. Hepatology 44 (2006) 955-966
20. Tan D.X., Manchester L.C., Terron M.P., Flores L.J., and Reiter R.J. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?. J. Pineal Res. 42 (2007) 28-42
21. Uesugi T., Froh M., Arteel G.E., Bradford B.U., Wheeler M.D., Gabele E., Isayama F., and Thurman R.G. Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice. J. Immunol. 168 (2002) 2963-2969
22. Vidali M., Stewart S.F., and Albano E. Interplay between oxidative stress and immunity in the progression of alcohol-mediated liver injury. Trends Mol. Med. 14 (2008) 63-71
23. Wang H., Wei W., Shen Y.X., Dong C., Zhang L.L., Wang N.P., Yue L., and Xu S.Y. Protective effect of melatonin against liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide. World J. Gastroenterol. 10 (2004) 2690-2696
24. Wang H., Wei W., Wang N.P., Gui S.Y., Wu L., Sun W.Y., and Xu S.Y. Melatonin ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress. Life Sci. 77 (2005) 1902-1915
25. Wang H., Wei W., Zhang S.Y., Shen Y.X., Wang N.P., Yue L., and Xu S.Y. Melatonin-selenium nanoparticles protects liver against immunological injury induced by bacillus Calmette-Guerin and lipopolysaccharide. Acta Pharm. Sin. 26 (2005) 745-752
26. Williams R. Global challenges in liver disease. Hepatology 44 (2006) 521-526
27. Yin M., Wheeler M.D., Kono H., Bradford B.U., Gallucci R.M., Luster M.I., and Thurman R.G. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology 117 (1999) 942-952