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Volumn 83, Issue , 2014, Pages 1-14

Aggregate culture: A more accurate predictor of microcystin toxicity for risk assessment

Author keywords

Aggregate; Cell culture model; Cyanotoxins; Microcystins; OATP1B1; OATP1B3

Indexed keywords

MICROCYSTIN; ORGANIC ANION TRANSPORTER F; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; REACTIVE OXYGEN METABOLITE; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; ORGANIC ANION TRANSPORTER; SLCO1B1 PROTEIN, HUMAN; SLCO1B3 PROTEIN, HUMAN;

EID: 84896523910     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2014.02.017     Document Type: Article
Times cited : (10)

References (46)
  • 1
    • 17444419342 scopus 로고    scopus 로고
    • Molecular mechanisms of reduced glutathione transport: Role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
    • N. Ballatori, C.L. Hammond, J.B. Cunningham, S.M. Krance, and R. Marchan Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins Toxicol. Appl. Pharmacol. 204 2005 238 255
    • (2005) Toxicol. Appl. Pharmacol. , vol.204 , pp. 238-255
    • Ballatori, N.1    Hammond, C.L.2    Cunningham, J.B.3    Krance, S.M.4    Marchan, R.5
  • 2
    • 77955095954 scopus 로고    scopus 로고
    • Fluorescence-based assays for the assessment of drug interaction with the human transporters OATP1B1 and OATP1B3
    • D. Bednarczyk Fluorescence-based assays for the assessment of drug interaction with the human transporters OATP1B1 and OATP1B3 Anal. Biochem. 405 2010 50 58
    • (2010) Anal. Biochem. , vol.405 , pp. 50-58
    • Bednarczyk, D.1
  • 3
    • 24044450575 scopus 로고    scopus 로고
    • High crustacean toxicity of microcystin congeners does not correlate with high protein phosphatase inhibitory activity
    • J.F. Blom, and F. Juttner High crustacean toxicity of microcystin congeners does not correlate with high protein phosphatase inhibitory activity Toxicon 46 2005 465 470
    • (2005) Toxicon , vol.46 , pp. 465-470
    • Blom, J.F.1    Juttner, F.2
  • 4
    • 29244445465 scopus 로고    scopus 로고
    • Microcystin-LR induced cellular effects in mammalian and fish primary hepatocyte cultures and cell lines: A comparative study
    • D.A. Boaru, N. Dragos, and K. Schirmer Microcystin-LR induced cellular effects in mammalian and fish primary hepatocyte cultures and cell lines: a comparative study Toxicology 218 2006 134 148
    • (2006) Toxicology , vol.218 , pp. 134-148
    • Boaru, D.A.1    Dragos, N.2    Schirmer, K.3
  • 5
    • 1342328049 scopus 로고    scopus 로고
    • Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured rat hepatocytes
    • N. Bouaicha, and I. Maatouk Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured rat hepatocytes Toxicol. Lett. 148 2004 53 63
    • (2004) Toxicol. Lett. , vol.148 , pp. 53-63
    • Bouaicha, N.1    Maatouk, I.2
  • 6
    • 75349086483 scopus 로고    scopus 로고
    • Molecular mechanisms of microcystin toxicity in animal cells
    • A. Campos, and V. Vasconcelos Molecular mechanisms of microcystin toxicity in animal cells Int. J. Mol. Sci. 11 2010 268 287
    • (2010) Int. J. Mol. Sci. , vol.11 , pp. 268-287
    • Campos, A.1    Vasconcelos, V.2
  • 7
    • 64549117445 scopus 로고    scopus 로고
    • Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes
    • T.T. Chang, and M. Hughes-Fulford Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes Tissue Eng. A 15 2009 559 567
    • (2009) Tissue Eng. A , vol.15 , pp. 559-567
    • Chang, T.T.1    Hughes-Fulford, M.2
  • 8
    • 0034006893 scopus 로고    scopus 로고
    • Study on the cytotoxicity of microcystin-LR on cultured cells
    • M.W. Chong, K.D. Gu, P.K. Lam, M. Yang, and W.F. Fong Study on the cytotoxicity of microcystin-LR on cultured cells Chemosphere 41 2000 143 147
    • (2000) Chemosphere , vol.41 , pp. 143-147
    • Chong, M.W.1    Gu, K.D.2    Lam, P.K.3    Yang, M.4    Fong, W.F.5
  • 9
    • 0032124844 scopus 로고    scopus 로고
    • The toxicology of microcystins
    • R.M. Dawson The toxicology of microcystins Toxicon 36 1998 953 962
    • (1998) Toxicon , vol.36 , pp. 953-962
    • Dawson, R.M.1
  • 11
    • 14644403686 scopus 로고    scopus 로고
    • Guidance values for microcystins in water and cyanobacterial supplement products (blue-green algal supplements): A reasonable or misguided approach?
    • D. Dietrich, and S. Hoeger Guidance values for microcystins in water and cyanobacterial supplement products (blue-green algal supplements): a reasonable or misguided approach? Toxicol. Appl. Pharmacol. 203 2005 273 289
    • (2005) Toxicol. Appl. Pharmacol. , vol.203 , pp. 273-289
    • Dietrich, D.1    Hoeger, S.2
  • 12
    • 77952549883 scopus 로고    scopus 로고
    • The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: A comparison of primary human hepatocytes and OATP-transfected HEK293 cells
    • A. Fischer, S.J. Hoeger, K. Stemmer, D.J. Feurstein, D. Knobeloch, A. Nussler, and D.R. Dietrich The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells Toxicol. Appl. Pharmacol. 245 2010 9 20
    • (2010) Toxicol. Appl. Pharmacol. , vol.245 , pp. 9-20
    • Fischer, A.1    Hoeger, S.J.2    Stemmer, K.3    Feurstein, D.J.4    Knobeloch, D.5    Nussler, A.6    Dietrich, D.R.7
  • 14
    • 1642559254 scopus 로고    scopus 로고
    • Microcystin-LR and okadaic acid-induced cellular effects: A dualistic response
    • M.M. Gehringer Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response FEBS Lett. 557 2004 1 8
    • (2004) FEBS Lett. , vol.557 , pp. 1-8
    • Gehringer, M.M.1
  • 15
    • 77953403463 scopus 로고    scopus 로고
    • Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3
    • C. Gui, A. Obaidat, R. Chaguturu, and B. Hagenbuch Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3 Curr. Chem. Genom. 4 2010 1 8
    • (2010) Curr. Chem. Genom. , vol.4 , pp. 1-8
    • Gui, C.1    Obaidat, A.2    Chaguturu, R.3    Hagenbuch, B.4
  • 16
    • 2942572700 scopus 로고    scopus 로고
    • Measuring reactive species and oxidative damage in vivo and in cell culture: How should you do it and what do the results mean?
    • B. Halliwell, and M. Whiteman Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br. J. Pharmacol. 142 2004 231 255
    • (2004) Br. J. Pharmacol. , vol.142 , pp. 231-255
    • Halliwell, B.1    Whiteman, M.2
  • 17
    • 34547169521 scopus 로고    scopus 로고
    • Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines
    • C. Hilgendorf, G. Ahlin, A. Seithel, P. Artursson, A.L. Ungell, and J. Karlsson Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines Drug. Metab. Dispos. 35 2007 1333 1340
    • (2007) Drug. Metab. Dispos. , vol.35 , pp. 1333-1340
    • Hilgendorf, C.1    Ahlin, G.2    Seithel, A.3    Artursson, P.4    Ungell, A.L.5    Karlsson, J.6
  • 18
    • 0142107445 scopus 로고    scopus 로고
    • Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucronate or sulfate
    • L. Homolya, A. Varadi, and B. Srakadi Multidrug resistance-associated proteins: export pumps for conjugates with glutathione, glucronate or sulfate Biofactors 17 2003 103 114
    • (2003) Biofactors , vol.17 , pp. 103-114
    • Homolya, L.1    Varadi, A.2    Srakadi, B.3
  • 19
    • 0024333577 scopus 로고
    • Toxicity of microcystin LR, a cyclic heptapeptide hepatotoxin from Microcystis aeruginosa, to rats and mice
    • S.B. Hooser, V.R. Beasley, R.A. Lovell, W.W. Carmichael, and W.M. Haschek Toxicity of microcystin LR, a cyclic heptapeptide hepatotoxin from Microcystis aeruginosa, to rats and mice Vet. Pathol. 26 1989 246 252
    • (1989) Vet. Pathol. , vol.26 , pp. 246-252
    • Hooser, S.B.1    Beasley, V.R.2    Lovell, R.A.3    Carmichael, W.W.4    Haschek, W.M.5
  • 20
    • 0026195015 scopus 로고
    • Actin filament alterations in rat hepatocytes induced in vivo and in vitro by microcystin-LR, a hepatotoxin from the blue-green alga, Microcystis aeruginosa
    • S.B. Hooser, V.R. Beasley, L.L. Waite, M.S. Kuhlenschmidt, W.W. Carmichael, and W.M. Haschek Actin filament alterations in rat hepatocytes induced in vivo and in vitro by microcystin-LR, a hepatotoxin from the blue-green alga, Microcystis aeruginosa Vet. Pathol. 28 1991 259 266
    • (1991) Vet. Pathol. , vol.28 , pp. 259-266
    • Hooser, S.B.1    Beasley, V.R.2    Waite, L.L.3    Kuhlenschmidt, M.S.4    Carmichael, W.W.5    Haschek, W.M.6
  • 21
    • 77950441751 scopus 로고    scopus 로고
    • Mitochondrial toxicity of microcystin-LR on cultured cells: Application to the analysis of contaminated water samples
    • G. Jasionek, A. Zhdanov, J. Davenport, L. Blaha, and D.B. Papkovsky Mitochondrial toxicity of microcystin-LR on cultured cells: application to the analysis of contaminated water samples Environ. Sci. Technol. 44 2010 2535 2541
    • (2010) Environ. Sci. Technol. , vol.44 , pp. 2535-2541
    • Jasionek, G.1    Zhdanov, A.2    Davenport, J.3    Blaha, L.4    Papkovsky, D.B.5
  • 22
    • 80355138148 scopus 로고    scopus 로고
    • Experimental approaches to tissue engineering
    • A. Khademhosseini Experimental approaches to tissue engineering J. Vis. Exp.: JoVE 2007 272
    • (2007) J. Vis. Exp.: JoVE , pp. 272
    • Khademhosseini, A.1
  • 24
    • 34447545755 scopus 로고    scopus 로고
    • Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3
    • M. Komatsu, T. Furukawa, R. Ikeda, S. Takumi, Q. Nong, K. Aoyama, S. Akiyama, D. Keppler, and T. Takeuchi Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3 Toxicol. Sci. 97 2007 407 416
    • (2007) Toxicol. Sci. , vol.97 , pp. 407-416
    • Komatsu, M.1    Furukawa, T.2    Ikeda, R.3    Takumi, S.4    Nong, Q.5    Aoyama, K.6    Akiyama, S.7    Keppler, D.8    Takeuchi, T.9
  • 25
    • 33644919674 scopus 로고    scopus 로고
    • Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line
    • M. Le Vee, E. Jigorel, D. Glaise, P. Gripon, C. Guguen-Guillouzo, and O. Fardel Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line Eur. J. Pharm. Sci. 28 2006 109 117
    • (2006) Eur. J. Pharm. Sci. , vol.28 , pp. 109-117
    • Le Vee, M.1    Jigorel, E.2    Glaise, D.3    Gripon, P.4    Guguen-Guillouzo, C.5    Fardel, O.6
  • 26
    • 59249106851 scopus 로고    scopus 로고
    • Survival advantages of multicellular spheroids vs. Monolayers of HepG2 cells in vitro
    • C.L. Li, T. Tian, K.J. Nan, N. Zhao, Y.H. Guo, J. Cui, J. Wang, and W.G. Zhang Survival advantages of multicellular spheroids vs. monolayers of HepG2 cells in vitro Oncol. Rep. 20 2008 1465 1471
    • (2008) Oncol. Rep. , vol.20 , pp. 1465-1471
    • Li, C.L.1    Tian, T.2    Nan, K.J.3    Zhao, N.4    Guo, Y.H.5    Cui, J.6    Wang, J.7    Zhang, W.G.8
  • 27
    • 79960992399 scopus 로고    scopus 로고
    • Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by alpha4 protein in HEK293 cells
    • T. Li, P. Huang, J. Liang, W. Fu, Z. Guo, and L. Xu Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by alpha4 protein in HEK293 cells Int. J. Biol. Sci. 7 2011 740 752
    • (2011) Int. J. Biol. Sci. , vol.7 , pp. 740-752
    • Li, T.1    Huang, P.2    Liang, J.3    Fu, W.4    Guo, Z.5    Xu, L.6
  • 28
    • 84863063428 scopus 로고    scopus 로고
    • Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells
    • J. Liang, T. Li, Y.L. Zhang, Z.L. Guo, and L.H. Xu Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells J. Zhejiang Univ. Sci. B 12 2011 951 960
    • (2011) J. Zhejiang Univ. Sci. B , vol.12 , pp. 951-960
    • Liang, J.1    Li, T.2    Zhang, Y.L.3    Guo, Z.L.4    Xu, L.H.5
  • 29
    • 33751186142 scopus 로고    scopus 로고
    • Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver
    • A. Libra, C. Fernetti, V. Lorusso, M. Visigalli, P.L. Anelli, F. Staud, C. Tiribelli, and L. Pascolo Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver J. Pharmacol. Exp. Ther. 319 2006 809 817
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 809-817
    • Libra, A.1    Fernetti, C.2    Lorusso, V.3    Visigalli, M.4    Anelli, P.L.5    Staud, F.6    Tiribelli, C.7    Pascolo, L.8
  • 30
    • 79958812771 scopus 로고    scopus 로고
    • Three-dimensional spheroid cultures of A549 and HepG2 cells exhibit different lipopolysaccharide (LPS) receptor expression and LPS-induced cytokine response compared with monolayer cultures
    • J. Liu, W. Abate, J. Xu, D. Corry, B. Kaul, and S.K. Jackson Three-dimensional spheroid cultures of A549 and HepG2 cells exhibit different lipopolysaccharide (LPS) receptor expression and LPS-induced cytokine response compared with monolayer cultures Innate Immun. 17 2011 245 255
    • (2011) Innate Immun. , vol.17 , pp. 245-255
    • Liu, J.1    Abate, W.2    Xu, J.3    Corry, D.4    Kaul, B.5    Jackson, S.K.6
  • 31
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25 2001 402 408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 32
    • 42149136754 scopus 로고    scopus 로고
    • Characterization of organic anion transporting polypeptide 1b2-null mice: Essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR
    • H. Lu, S. Choudhuri, K. Ogura, I.L. Csanaky, X. Lei, X. Cheng, P.Z. Song, and C.D. Klaassen Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR Toxicol. Sci. 103 2008 35 45
    • (2008) Toxicol. Sci. , vol.103 , pp. 35-45
    • Lu, H.1    Choudhuri, S.2    Ogura, K.3    Csanaky, I.L.4    Lei, X.5    Cheng, X.6    Song, P.Z.7    Klaassen, C.D.8
  • 33
    • 84869756255 scopus 로고    scopus 로고
    • Peptide nanofiber hydrogel induces formation of bile canaliculi structures in three-dimensional hepatic cell culture
    • M.M. Malinen, H. Palokangas, M. Yliperttula, and A. Urtti Peptide nanofiber hydrogel induces formation of bile canaliculi structures in three-dimensional hepatic cell culture Tissue Eng. A 18 2012 2418 2425
    • (2012) Tissue Eng. A , vol.18 , pp. 2418-2425
    • Malinen, M.M.1    Palokangas, H.2    Yliperttula, M.3    Urtti, A.4
  • 34
    • 45549099814 scopus 로고    scopus 로고
    • Cyanotoxins: Sampling, sample processing and toxin uptake
    • J.A. Meriluoto, and L.E. Spoof Cyanotoxins: sampling, sample processing and toxin uptake Adv. Exp. Med. Biol. 619 2008 483 499
    • (2008) Adv. Exp. Med. Biol. , vol.619 , pp. 483-499
    • Meriluoto, J.A.1    Spoof, L.E.2
  • 36
    • 33847411960 scopus 로고    scopus 로고
    • Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells
    • N.R. Monks, S. Liu, Y. Xu, H. Yu, A.S. Bendelow, and J.A. Moscow Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells Mol. Cancer Ther. 6 2007 587 598
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 587-598
    • Monks, N.R.1    Liu, S.2    Xu, Y.3    Yu, H.4    Bendelow, A.S.5    Moscow, J.A.6
  • 37
    • 77957340057 scopus 로고    scopus 로고
    • Addressing the design of in vitro models for the investigation of microcystins: The essential role of transporter-mediated uptake
    • N.R. Monks, and J.A. Moscow Addressing the design of in vitro models for the investigation of microcystins: the essential role of transporter-mediated uptake Cell. Biol. Int. 34 2010 907 909
    • (2010) Cell. Biol. Int. , vol.34 , pp. 907-909
    • Monks, N.R.1    Moscow, J.A.2
  • 38
    • 84872269827 scopus 로고    scopus 로고
    • Organotypic cultures of HepG2 cells for in vitro toxicity studies
    • D. Mueller, A. Koetemann, and F. Noor Organotypic cultures of HepG2 cells for in vitro toxicity studies J. Bioeng. Biomed. Sci. S2 2011
    • (2011) J. Bioeng. Biomed. Sci. , vol.2 S
    • Mueller, D.1    Koetemann, A.2    Noor, F.3
  • 39
    • 80053556775 scopus 로고    scopus 로고
    • Expression of albumin and cytochrome P450 enzymes in HepG2 cells cultured with a nanotechnology-based culture plate with microfabricated scaffold
    • K. Nakamura, N. Kato, K. Aizawa, R. Mizutani, J. Yamauchi, and A. Tanoue Expression of albumin and cytochrome P450 enzymes in HepG2 cells cultured with a nanotechnology-based culture plate with microfabricated scaffold J. Toxicol. Sci. 36 2011 625 633
    • (2011) J. Toxicol. Sci. , vol.36 , pp. 625-633
    • Nakamura, K.1    Kato, N.2    Aizawa, K.3    Mizutani, R.4    Yamauchi, J.5    Tanoue, A.6
  • 41
    • 79954752177 scopus 로고    scopus 로고
    • Enhancement of drug efflux activity via MDR1 protein by spheroid culture of human hepatic cancer cells
    • A. Oshikata, T. Matsushita, and R. Ueoka Enhancement of drug efflux activity via MDR1 protein by spheroid culture of human hepatic cancer cells J. Biosci. Bioeng. 111 2011 590 593
    • (2011) J. Biosci. Bioeng. , vol.111 , pp. 590-593
    • Oshikata, A.1    Matsushita, T.2    Ueoka, R.3
  • 42
    • 27644577702 scopus 로고    scopus 로고
    • The use of the fish cell lines RTG-2 and PLHC-1 to compare the toxic effects produced by microcystins LR and RR
    • S. Pichardo, A. Jos, J.L. Zurita, M. Salguero, A.M. Camean, and G. Repetto The use of the fish cell lines RTG-2 and PLHC-1 to compare the toxic effects produced by microcystins LR and RR Toxicol. in Vitro 19 2005 865 873
    • (2005) Toxicol. in Vitro , vol.19 , pp. 865-873
    • Pichardo, S.1    Jos, A.2    Zurita, J.L.3    Salguero, M.4    Camean, A.M.5    Repetto, G.6
  • 44
    • 4944250020 scopus 로고    scopus 로고
    • Small hepatocytes in culture develop polarized transporter expression and differentiation
    • M.A. Sidler Pfandler, M. Hochli, D. Inderbitzin, P.J. Meier, and B. Stieger Small hepatocytes in culture develop polarized transporter expression and differentiation J. Cell. Sci. 117 2004 4077 4087
    • (2004) J. Cell. Sci. , vol.117 , pp. 4077-4087
    • Sidler Pfandler, M.A.1    Hochli, M.2    Inderbitzin, D.3    Meier, P.J.4    Stieger, B.5
  • 45
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034
    • J. Vandesompele, K. De Preter, F. Pattyn, B. Poppe, N. Van Roy, A. De Paepe, and F. Speleman Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome biol. 3 2002 RESEARCH0034
    • (2002) Genome Biol. , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 46
    • 2542434173 scopus 로고    scopus 로고
    • The role of reactive oxygen species in microcystin-LR-induced DNA damage
    • B. Zegura, T.T. Lah, and M. Filipic The role of reactive oxygen species in microcystin-LR-induced DNA damage Toxicology 200 2004 59 68
    • (2004) Toxicology , vol.200 , pp. 59-68
    • Zegura, B.1    Lah, T.T.2    Filipic, M.3


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