Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits

Nature

Volumn 431, Issue 7005, 2004, Pages 184-187

  True, Heather L ^a,b   Bedin, Ilana ^a   Lindquist, Susan L ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; MOLECULAR STRUCTURE; PROTEINS; YEAST;

GENETIC VARIATION; PHENOTYPES; PROGENY; TRANSLATION;

GENES;

BIOLOGY;

ARTICLE; CONTROLLED STUDY; EPIGENETICS; EVOLUTIONARY ADAPTATION; FUNGAL GENETICS; GENETIC ASSOCIATION; GENETIC REASSORTMENT; GENETIC REGULATION; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; MOLECULAR GENETICS; NONHUMAN; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; PROGENY; RNA TRANSLATION; STOP CODON; SURVIVAL; TRANSLATION REGULATION; YEAST;

CELL DIVISION; CODON, NONSENSE; CROSSES, GENETIC; EVOLUTION; GENE EXPRESSION REGULATION, FUNGAL; GENOTYPE; MODELS, GENETIC; PHENOTYPE; PRIONS; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; VARIATION (GENETICS);

EID: 4544235083     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02885     Document Type: Article

References (30)

1. Agrawal, A. A. Phenotypic plasticity in the interactions and evolution of species. Science 294, 321-326 (2001).
2. Behera, N. & Nanjundiah, V. Phenotypic plasticity can potentiate rapid evolutionary change. J. Theor. Biol. 226, 177-184 (2004).
3. Pigliucci, M. & Murren, C. J. Perspective: Genetic assimilation and a possible evolutionary paradox: can macroevolution sometimes be so fast as to pass us by? Evolution Int. J. Org. Evolution 57, 1455-1464 (2003).
4. True, H. L. & Lindquist, S. L. A yeast prion provides a mechanism for genetic variation and phenotypic diversity. Nature 407, 477-483 (2000).
5. Uptain, S. M. & Lindquist, S. Prions as protein-based genetic elements. Annu. Rev. Microbiol. 56, 703-741 (2002).
6. Michelitsch, M. D. & Weissman, J. S. A census of glutamine/ asparagine-rich regions: implications for their conserved function and the prediction of novel prions. Proc. Natl Acad. Sci. USA 97, 11910-11915 (2000).
7. Harrison, P. M. & Gerstein, M. A method to assess compositional bias in biological sequences and its application to prion-like glutamine/asparagine- rich domains in eukaryotic proteomes. Genome Biol. 4, R40 (2003).
8. Harrison, P. et al. A small reservoir of disabled ORFs in the yeast genome and its implications for the dynamics of proteome evolution. J. Mol. Biol. 316, 409-419 (2002).
9. Namy, O., Duchateau-Nguyen, G. & Rousset, J. P. Translational readthrough of the PDE2 stop codon modulates cAMP levels in Saccharomyces cerevisiae. Mol. Microbial. 43, 641-652 (2002).
10. Namy, O. et al. Identification of stop codon readthrough genes in Saccharomyces cerevisiae. Nucleic Acids Res. 31, 2289-2296 (2003).
11. Sherman, M. Y. & Goldberg, A. L. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron 29, 15-32 (2001).
12. Ter-Avanesyan, M. D. et al. Deletion analysis of the SUP35 gene of the yeast Saccharomyces cerevisiae reveals two non-overlapping functional regions in the encoded protein. Mol. Microbiol. 7, 683-692 (1993).
13. Liu, J. J. & Lindquist, S. Oligopeptide-repeat expansions modulate 'protein-only' inheritance in yeast. Nature 400, 573-576 (1999).
14. Sondheimer, N. & Lindquist, S. Rnq1: an epigenetic modifier of protein function in yeast. Mol. Cell 5, 163-172 (2000).
15. Chernoff, Y. O., Newnam, G. P. & Liebman, S. W. The translational function of nucleotide C1054 in the small subunit rRNA is conserved throughout evolution: genetic evidence in yeast. Proc. Natl Acad. Sci. USA 93, 2517-2522 (1996).
16. Bradley, M. E., Bagriantsev, S., Vishveshwara, N. & Liebman, S. W. Guanidine reduces stop codon read-through caused by missense mutations in SUP35 or SUP45. Yeast 20, 625-632 (2003).
17. Leeds, P., Peltz, S. W., Jacobson, A. & Culbertson, M. R. The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes Dev. 5, 2303-2314 (1991).
18. Frischmeyer, P. A. et al. An mRNA surveillance mechanism that eliminates transcripts lacking termination codons. Science 295, 2258-2261 (2002).
19. DePace, A. H., Santoso, A., Hillner, P. & Weissman, J. S. A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion. Cell 93, 1241-1252 (1998).
20. Firoozan, M., Grant, C. M., Duarte, J. A. & Tuite, M. F. Quantitation of readthrough of termination codons in yeast using a novel gene fusion assay. Yeast 7, 173-183 (1991).
21. -] mutations in Saccharomyces cerevisiae. Genet. Res. 37, 173-182 (1981).
22. Eaglestone, S. S., Cox, B. S. & Tuite, M. F. Translation termination efficiency can be regulated in Saccharomyces cerevisiac environmental stress through a prion-mediated mechanism. EMBO J. 18, 1974-1981 (1999).
23. Chernoff, Y. O. et al. Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein. Mol. Microbiol. 35, 865-876 (2000).
24. Kushnirov, V. V., Koehneva-Pervukhova, N. V., Chechenova, M. B., Frolova, N. S. & Ter-Avanesyan, M. D. Prion properties of the Sup35 protein of yeast Pichia methanolica. EMBO J. 19, 324-331 (2000).
25. +] "prions" that are crosstransmissible and susceptible beyond a species barrier through a quasi-prion state. Mol. Cell 7, 1121-1130 (2001).
26. Santoso, A., Chien, P., Osherovich, L. Z. & Weissman, J. S. Molecular basis of a yeast prion species barrier. Cell 100, 277-288 (2000).
27. +]. Evolution 57, 1498-1512 (2003).
28. Rutherford, S. L. & Lindquist, S. Hsp90 as a capacitor for morphological evolution. Nature 396, 336-342 (1998).
29. Queitsch, C., Sangster, T. A. & Lindquist, S. Hsp90 as a capacitor of phenotypic variation. Nature 417, 618-624 (2002).
30. Guthrie, C. & Fink, G. (eds) Guide to Yeast Genetics and Molecular Biology (Academic Press, San Diego, 1991).