Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity

Free Radical Biology and Medicine

Volumn 68, Issue , 2014, Pages 80-86

  Jang, Jun Ho ^a,b,c   Bruse, Shannon ^c   Liu, Yushi ^c   Duffy, Veronica ^c   Zhang, Chunyu ^c   Oyamada, Nathaniel ^c   Randell, Scott ^d   Matsumoto, Akiko ^e   Thompson, David C ^e   Lin, Yong ^c   Vasiliou, Vasilis ^e   Tesfaigzi, Yohannes ^c   Nyunoya, Toru ^a,b,c  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b NEW MEXICO VA HEALTH CARE SYSTEM   (United States)

^c LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Airway epithelial cells; ALDH3A1; Chronic obstructive pulmonary disease; Cigarette smoke; Cytotoxicity; DNA damage; FANCD2; Free radicals; Reactive aldehydes

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 3A1; AROMATIC HYDROCARBON RECEPTOR; CIGARETTE SMOKE; CIGARETTE SMOKE EXTRACT; FANCONI ANEMIA GROUP D2 PROTEIN; GAMMA HISTONE H2AX; HISTONE H2AX; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUCOSA; CELL IMMORTALIZATION; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVITY; FETUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM;

AIRWAY EPITHELIAL CELLS; ALDH3A1; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; CIGARETTE SMOKE; CYTOTOXICITY; DNA DAMAGE; FANCD2; FREE RADICALS; REACTIVE ALDEHYDES;

ALDEHYDE DEHYDROGENASE; ALDEHYDES; APOPTOSIS; BRONCHI; CELL SURVIVAL; CELLS, CULTURED; DNA DAMAGE; EPITHELIAL CELLS; HUMANS; RNA, SMALL INTERFERING; SMOKING;

EID: 84896515925     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.11.028     Document Type: Article

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