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Volumn 294, Issue 2-3, 2012, Pages 61-79

The toxicological mode of action and the safety of synthetic amorphous silica-A nanostructured material

Author keywords

Mode of action; Nano object; Nanoparticle; Nanosilica; Nanostructured; Synthetic amorphous silica

Indexed keywords

CELL MEMBRANE MARKER; COSMETIC; CYTOKINE; HYDROGEN; LIPID; NANOMATERIAL; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; SYNTHETIC SILICON DIOXIDE; UNCLASSIFIED DRUG;

EID: 84858998451     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.02.001     Document Type: Review
Times cited : (258)

References (123)
  • 4
    • 34547728156 scopus 로고    scopus 로고
    • Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months
    • Arts J.H., Muijser H., Duistermaat E., Junker K., Kuper C.F. Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months. Food Chem. Toxicol. 2007, 45:1856-1867.
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 1856-1867
    • Arts, J.H.1    Muijser, H.2    Duistermaat, E.3    Junker, K.4    Kuper, C.F.5
  • 5
    • 49249083598 scopus 로고    scopus 로고
    • Preexposure to amorphous silica particles attenuates but also enhances allergic reactions in trimellitic anhydride sensitized Brown Norway rats
    • Arts J.H., Schijf M.A., Kuper C.F. Preexposure to amorphous silica particles attenuates but also enhances allergic reactions in trimellitic anhydride sensitized Brown Norway rats. Inhal. Toxicol. 2008, 20:935-948.
    • (2008) Inhal. Toxicol. , vol.20 , pp. 935-948
    • Arts, J.H.1    Schijf, M.A.2    Kuper, C.F.3
  • 7
    • 84993812777 scopus 로고    scopus 로고
    • Safety assessment of silica and related cosmetic ingredients. Washington, DC, USA, Cosmetic Ingredient Review. Unpublished Report by the Cosmetic Ingredient Review
    • Becker, L.C., Bergfeld, W.F., Belsito, D.V., Hill, R.A., Klaassen, C.D., Liebler, D.C., Marks Jr., J.G., Shank, R.C., Slaga, T.J., Snyder, P.W., 2009. Safety assessment of silica and related cosmetic ingredients. Washington, DC, USA, Cosmetic Ingredient Review. Unpublished Report by the Cosmetic Ingredient Review, pp. 1-81.
    • (2009) , pp. 1-81
    • Becker, L.C.1    Bergfeld, W.F.2    Belsito, D.V.3    Hill, R.A.4    Klaassen, C.D.5    Liebler, D.C.6    Marks Jr, J.G.7    Shank, R.C.8    Slaga, T.J.9    Snyder, P.W.10
  • 8
    • 84873070795 scopus 로고    scopus 로고
    • Wahrnehmung der Nanotechnologie in internetgestützten Diskussionen-Ergebnisse einer Onlinediskursanalyse zu Risiken und Chancen von Nanotechnologie und Nanoprodukten
    • Bundesinstitut für Risikobewertung, Berlin, ISBN 3-938163-57-7, ISSN 1614-3795 (in German).
    • Böl, G.F., Epp, A., Hertel, R. (Eds.), 2010. Wahrnehmung der Nanotechnologie in internetgestützten Diskussionen-Ergebnisse einer Onlinediskursanalyse zu Risiken und Chancen von Nanotechnologie und Nanoprodukten. Bundesinstitut für Risikobewertung, Berlin, ISBN 3-938163-57-7, ISSN 1614-3795 (in German).
    • (2010)
    • Böl, G.F.1    Epp, A.2    Hertel, R.3
  • 9
    • 1942484815 scopus 로고    scopus 로고
    • Inhaled particles and lung cancer. Part B: paradigms and risk assessment
    • Borm P.J.A., Schins R., Albrecht C. Inhaled particles and lung cancer. Part B: paradigms and risk assessment. Int. J. Cancer 2004, 110:3-14.
    • (2004) Int. J. Cancer , vol.110 , pp. 3-14
    • Borm, P.J.A.1    Schins, R.2    Albrecht, C.3
  • 11
    • 33144477406 scopus 로고    scopus 로고
    • Research strategies for safety evaluation of nanomaterials. Part V: role of dissolution in biological fate and effects of nanoscale particles
    • Borm P., Klaessig F.C., Landry T.D., Moudgil B., Pauluhn J., Thomas K., Trottier R., Wood S. Research strategies for safety evaluation of nanomaterials. Part V: role of dissolution in biological fate and effects of nanoscale particles. Toxicol. Sci. 2006, 90:23-32.
    • (2006) Toxicol. Sci. , vol.90 , pp. 23-32
    • Borm, P.1    Klaessig, F.C.2    Landry, T.D.3    Moudgil, B.4    Pauluhn, J.5    Thomas, K.6    Trottier, R.7    Wood, S.8
  • 12
    • 84859003379 scopus 로고    scopus 로고
    • Nanosilica? Clarifications are necessary!
    • (Early Online)
    • Bosch A., Maier M., Morfeld P. Nanosilica? Clarifications are necessary!. Nanotoxicology 2011, 1-3. (Early Online).
    • (2011) Nanotoxicology , pp. 1-3
    • Bosch, A.1    Maier, M.2    Morfeld, P.3
  • 13
    • 84858997496 scopus 로고    scopus 로고
    • Best Available Techniques Reference Document. Integrated Pollution Prevention and Control. Reference Document on Best Available Techniques for the Manufacture of Large Volume Inorganic Chemicals-Solids and Others industry
    • BREF, Chapter 5: Synthetic Amorphous Silica. European Commission, August 2007.
    • BREF, 2007. Best Available Techniques Reference Document. Integrated Pollution Prevention and Control. Reference Document on Best Available Techniques for the Manufacture of Large Volume Inorganic Chemicals-Solids and Others industry. Chapter 5: Synthetic Amorphous Silica. European Commission, August 2007.
    • (2007)
  • 16
    • 33947360667 scopus 로고    scopus 로고
    • In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line
    • Chang J.S., Chang K.L., Hwang D.F., Kong Z.L. In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line. Environ. Sci. Technol. 2007, 41:2064-2068.
    • (2007) Environ. Sci. Technol. , vol.41 , pp. 2064-2068
    • Chang, J.S.1    Chang, K.L.2    Hwang, D.F.3    Kong, Z.L.4
  • 18
    • 14644430952 scopus 로고    scopus 로고
    • Comparing study of the effect of nanosized silicon dioxide and microsized silicon dioxide on fibrogenesis in rats
    • Chen Y., Chen J., Dong J., Jin Y. Comparing study of the effect of nanosized silicon dioxide and microsized silicon dioxide on fibrogenesis in rats. Toxicol. Ind. Health 2004, 20:21-27.
    • (2004) Toxicol. Ind. Health , vol.20 , pp. 21-27
    • Chen, Y.1    Chen, J.2    Dong, J.3    Jin, Y.4
  • 20
    • 36148954259 scopus 로고    scopus 로고
    • Inflammatory mediators induced by intratracheal instillation of ultrafine amorphous silica particles
    • Cho W.S., Choi M., Han B.S., Cho M., Oh J., Park K., Kim S.J., Kim S.H., Jeong J. Inflammatory mediators induced by intratracheal instillation of ultrafine amorphous silica particles. Toxicol. Lett. 2007, 175:24-33.
    • (2007) Toxicol. Lett. , vol.175 , pp. 24-33
    • Cho, W.S.1    Choi, M.2    Han, B.S.3    Cho, M.4    Oh, J.5    Park, K.6    Kim, S.J.7    Kim, S.H.8    Jeong, J.9
  • 21
    • 67650229580 scopus 로고    scopus 로고
    • The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
    • Cho M., Cho W.S., Choi M., Kim S.J., Han B.S., Kim S.H., Kim H.O., Sheen Y.Y., Jeong J. The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles. Toxicol. Lett. 2009, 189:177-183.
    • (2009) Toxicol. Lett. , vol.189 , pp. 177-183
    • Cho, M.1    Cho, W.S.2    Choi, M.3    Kim, S.J.4    Han, B.S.5    Kim, S.H.6    Kim, H.O.7    Sheen, Y.Y.8    Jeong, J.9
  • 23
    • 34147144905 scopus 로고    scopus 로고
    • The effects of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells
    • Chung T.H., Wu S.H., Yao M., Lu C.W., Lin Y.S., Hung Y., Mou C.Y., Chen Y.C., Huang D.M. The effects of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells. Biomat. 2007, 28:2959-2966.
    • (2007) Biomat. , vol.28 , pp. 2959-2966
    • Chung, T.H.1    Wu, S.H.2    Yao, M.3    Lu, C.W.4    Lin, Y.S.5    Hung, Y.6    Mou, C.Y.7    Chen, Y.C.8    Huang, D.M.9
  • 24
    • 79551622114 scopus 로고    scopus 로고
    • The phagocytosis and toxicity of amorphous silica
    • Costantini L.M., Gilberti R.M., Knecht D.A. The phagocytosis and toxicity of amorphous silica. PLoS ONE 2011, 6:e14647. 10.1371/journal.pone.0014647.
    • (2011) PLoS ONE , vol.6
    • Costantini, L.M.1    Gilberti, R.M.2    Knecht, D.A.3
  • 26
    • 0014808377 scopus 로고
    • The stability of amorphous colloidal silica
    • Depasse J., Watillon A. The stability of amorphous colloidal silica. J. Colloid Interface Sci. 1970, 33:430-438.
    • (1970) J. Colloid Interface Sci. , vol.33 , pp. 430-438
    • Depasse, J.1    Watillon, A.2
  • 27
    • 38849165400 scopus 로고    scopus 로고
    • Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region
    • Donaldson K., Borm P.J.A., Oberdörster G., Pinkerton K.E., Stone V., Tran C.L. Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region. Inhal. Toxicol. 2008, 20:53-62.
    • (2008) Inhal. Toxicol. , vol.20 , pp. 53-62
    • Donaldson, K.1    Borm, P.J.A.2    Oberdörster, G.3    Pinkerton, K.E.4    Stone, V.5    Tran, C.L.6
  • 28
    • 79955561944 scopus 로고    scopus 로고
    • Toxicity of amorphous silica nanoparticles on eukaryotic cell model is determined by particle agglomeration and serum protein adsorption effects
    • Drescher D., Orts-Gil G., Laibe G., Natte K., Veh R.W., österle W., Kneipp J. Toxicity of amorphous silica nanoparticles on eukaryotic cell model is determined by particle agglomeration and serum protein adsorption effects. Anal. Bioanal. Chem. 2011, 400:1367-1373.
    • (2011) Anal. Bioanal. Chem. , vol.400 , pp. 1367-1373
    • Drescher, D.1    Orts-Gil, G.2    Laibe, G.3    Natte, K.4    Veh, R.W.5    österle, W.6    Kneipp, J.7
  • 30
    • 84859007787 scopus 로고    scopus 로고
    • ECETOC, European Centre for Ecotoxicology and Toxicology of Chemicals. Synthetic Amorphous Silica (CAS No. 7631-86-9). JACC No. 51. Brussels
    • ECETOC, 2006. European Centre for Ecotoxicology and Toxicology of Chemicals. Synthetic Amorphous Silica (CAS No. 7631-86-9). JACC No. 51. Brussels, 237 pp.
    • (2006) , pp. 237
  • 31
    • 80054700190 scopus 로고    scopus 로고
    • Scientific opinion of the panel on food additives and nutrient sources added to food on calcium silicate, silicon dioxide and silicic acid gel added for nutritional purposes to food supplements following a request from the European Commission
    • EFSA (European Food Safety Authority)
    • EFSA (European Food Safety Authority) Scientific opinion of the panel on food additives and nutrient sources added to food on calcium silicate, silicon dioxide and silicic acid gel added for nutritional purposes to food supplements following a request from the European Commission. EFSA J. 2009, 1132:1-24.
    • (2009) EFSA J. , vol.1132 , pp. 1-24
  • 32
    • 70349394917 scopus 로고    scopus 로고
    • Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B
    • Eom H.J., Choi J. Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B. Toxicol. In Vitro 2009, 23:1326-1332.
    • (2009) Toxicol. In Vitro , vol.23 , pp. 1326-1332
    • Eom, H.J.1    Choi, J.2
  • 33
    • 84859007788 scopus 로고    scopus 로고
    • EPA, U.S. Environmental Protection Agency. Screening-Level Hazard Characterization of Silane, Dichlorodimethyl-, Reaction Product with Silica (CASRN 68611-44-9), June 2011.
    • EPA, 2011. U.S. Environmental Protection Agency. Screening-Level Hazard Characterization of Silane, Dichlorodimethyl-, Reaction Product with Silica (CASRN 68611-44-9), June 2011.
    • (2011)
  • 35
    • 84859007789 scopus 로고
    • FDA, Food and Drug Research Laboratories, Inc. Teratologic Evaluation of FDA 71-48 (Syloid; silica aerogel). Reports prepared under DEW Contract No. FDA 71-260. Maspeth NW,
    • FDA, 1973. Food and Drug Research Laboratories, Inc. Teratologic Evaluation of FDA 71-48 (Syloid; silica aerogel). Reports prepared under DEW Contract No. FDA 71-260. Maspeth NW, 56 pp.
    • (1973) , pp. 56
  • 39
    • 33845686331 scopus 로고    scopus 로고
    • Studies of robustness of industrial aciniform aggregates and agglomerates-carbon black and amorphous silica: a review amplified by new data
    • Gray C.A., Muranko H. Studies of robustness of industrial aciniform aggregates and agglomerates-carbon black and amorphous silica: a review amplified by new data. J. Occupational Environ. Med. 2006, 48:1279-1290.
    • (2006) J. Occupational Environ. Med. , vol.48 , pp. 1279-1290
    • Gray, C.A.1    Muranko, H.2
  • 41
  • 43
    • 49649100580 scopus 로고    scopus 로고
    • The biocompatibility of mesoporous silicates
    • Hudson S., Padera R.F., Langer R., Kohane D.S. The biocompatibility of mesoporous silicates. Biomaterials 2008, 29(30):4045-4055.
    • (2008) Biomaterials , vol.29 , Issue.30 , pp. 4045-4055
    • Hudson, S.1    Padera, R.F.2    Langer, R.3    Kohane, D.S.4
  • 44
    • 84859009819 scopus 로고    scopus 로고
    • IARC, International Agency on the Research of Cancer. Working Group on the Evaluation of Carcinogenic Risks to Humans. Silica, some silicates, coal dust and para-aramid fibrils
    • IARC, 1997. International Agency on the Research of Cancer. Working Group on the Evaluation of Carcinogenic Risks to Humans. Silica, some silicates, coal dust and para-aramid fibrils, vol. 68, 1-475.
    • (1997) , vol.68 , pp. 1-475
  • 45
    • 0004615552 scopus 로고    scopus 로고
    • The International Organisation for Standardisation. Nanotechnologies-Terminology and definitions for nano-objects-Nanoparticle, nanofibre and nanoplate
    • ISO/TS 27687 (will be revised as ISO/TS 80004-2).ISO
    • ISO, 2008. The International Organisation for Standardisation. Nanotechnologies-Terminology and definitions for nano-objects-Nanoparticle, nanofibre and nanoplate. ISO/TS 27687 (will be revised as ISO/TS 80004-2).
    • (2008)
  • 46
    • 84859006353 scopus 로고    scopus 로고
    • ISO, The International Organisation for Standardisation. Nanotechnologies-Vocabulary-Part 1: Core Terms. ISO/TS 80004-1.
    • ISO, 2010. The International Organisation for Standardisation. Nanotechnologies-Vocabulary-Part 1: Core Terms. ISO/TS 80004-1.
    • (2010)
  • 47
    • 79957641978 scopus 로고    scopus 로고
    • Effect of surface charge on nano-sized silica particles-induced liver injury
    • Isoda K., Hasezaki T., Kondoh M., Tsutsumi Y., Yagi K. Effect of surface charge on nano-sized silica particles-induced liver injury. Pharmazie 2011, 66:278-281.
    • (2011) Pharmazie , vol.66 , pp. 278-281
    • Isoda, K.1    Hasezaki, T.2    Kondoh, M.3    Tsutsumi, Y.4    Yagi, K.5
  • 48
    • 79957466363 scopus 로고    scopus 로고
    • Toxicity of oxide nanoparticles to the green algae Chlorella sp.
    • Ji J., Long Z., Lin D. Toxicity of oxide nanoparticles to the green algae Chlorella sp. Chem. Eng. J. 2011, 170:525-530.
    • (2011) Chem. Eng. J. , vol.170 , pp. 525-530
    • Ji, J.1    Long, Z.2    Lin, D.3
  • 49
    • 63249132825 scopus 로고    scopus 로고
    • Bacterial toxicity comparison between nano- and micro-sized oxide particles
    • Jiang W., Mashayekhi H., Xing B. Bacterial toxicity comparison between nano- and micro-sized oxide particles. Environ. Pollut. 2009, 157:1619-1625.
    • (2009) Environ. Pollut. , vol.157 , pp. 1619-1625
    • Jiang, W.1    Mashayekhi, H.2    Xing, B.3
  • 51
    • 28744445635 scopus 로고    scopus 로고
    • Acute pulmonary toxicity caused by exposure to colloidal silica: particle size dependent pathological changes in mice
    • Kaewamatawong T., Kawamura N., Okajima M., Sawada M., Morita T., Shimada A. Acute pulmonary toxicity caused by exposure to colloidal silica: particle size dependent pathological changes in mice. Toxicol. Pathol. 2005, 33:743-749.
    • (2005) Toxicol. Pathol. , vol.33 , pp. 743-749
    • Kaewamatawong, T.1    Kawamura, N.2    Okajima, M.3    Sawada, M.4    Morita, T.5    Shimada, A.6
  • 52
    • 33845756686 scopus 로고    scopus 로고
    • Acute and subacute pulmonary toxicity of low dose of ultrafine colloidal silica particles in mice after intratracheal instillation
    • Kaewamatawong T., Shimada A., Okajima M., Inoue H., Morita T., Inoue K., Takano H. Acute and subacute pulmonary toxicity of low dose of ultrafine colloidal silica particles in mice after intratracheal instillation. Toxicol. Pathol. 2006, 34:958-965.
    • (2006) Toxicol. Pathol. , vol.34 , pp. 958-965
    • Kaewamatawong, T.1    Shimada, A.2    Okajima, M.3    Inoue, H.4    Morita, T.5    Inoue, K.6    Takano, H.7
  • 53
    • 58149186811 scopus 로고    scopus 로고
    • Nanoparticulate-induced toxicity and related mechanism in vitro and in vivo
    • Kim H.W., Ahn E.K., Jee B.K., Yoon H.K., Lee K.H., Lim Y. Nanoparticulate-induced toxicity and related mechanism in vitro and in vivo. J. Nanopart. Res. 2009, 11:55-65.
    • (2009) J. Nanopart. Res. , vol.11 , pp. 55-65
    • Kim, H.W.1    Ahn, E.K.2    Jee, B.K.3    Yoon, H.K.4    Lee, K.H.5    Lim, Y.6
  • 54
    • 79951701991 scopus 로고    scopus 로고
    • Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by silica nanomaterials in human neuronal cell line
    • Kim Y.J., Yu M., Park H.O., Yang S.I. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by silica nanomaterials in human neuronal cell line. Mol. Cell Toxicol. 2010, 6:337-344.
    • (2010) Mol. Cell Toxicol. , vol.6 , pp. 337-344
    • Kim, Y.J.1    Yu, M.2    Park, H.O.3    Yang, S.I.4
  • 55
    • 0031080387 scopus 로고    scopus 로고
    • A systematic approach for evaluating the quality of experimental and ecotoxicological data
    • Klimisch H.J., Andreae E., Tillmann U. A systematic approach for evaluating the quality of experimental and ecotoxicological data. Reg. Tox. Pharm. 1997, 25:1-5.
    • (1997) Reg. Tox. Pharm. , vol.25 , pp. 1-5
    • Klimisch, H.J.1    Andreae, E.2    Tillmann, U.3
  • 56
    • 80051501190 scopus 로고    scopus 로고
    • Relationship of pulmonary toxicity and carcinogenicity of fine and ultrafine granular dusts in a rat bioassay
    • Kolling A., Ernst H., Rittinghausen S., Heinrich U. Relationship of pulmonary toxicity and carcinogenicity of fine and ultrafine granular dusts in a rat bioassay. Inhal. Toxicol. 2011, 23:544-554.
    • (2011) Inhal. Toxicol. , vol.23 , pp. 544-554
    • Kolling, A.1    Ernst, H.2    Rittinghausen, S.3    Heinrich, U.4
  • 58
    • 77957177396 scopus 로고
    • The pulmonary response and clearance of Ludox colloidal silica after a 4-week inhalation exposure in rats
    • Lee K.P., Kelly D.P. The pulmonary response and clearance of Ludox colloidal silica after a 4-week inhalation exposure in rats. Fundam. Appl. Toxicol. 1992, 19:399-410.
    • (1992) Fundam. Appl. Toxicol. , vol.19 , pp. 399-410
    • Lee, K.P.1    Kelly, D.P.2
  • 59
    • 67349169994 scopus 로고    scopus 로고
    • Genotoxicity and ecotoxicity assays using the freshwater crustacean Daphnia Magna and the larva of the aquatic midge Chironomus riparius to screen the ecological risks of nanoparticle exposure
    • Lee S.W., Kim S.M., Choi J. Genotoxicity and ecotoxicity assays using the freshwater crustacean Daphnia Magna and the larva of the aquatic midge Chironomus riparius to screen the ecological risks of nanoparticle exposure. Environ. Tax. Pharm. 2009, 28:86-91.
    • (2009) Environ. Tax. Pharm. , vol.28 , pp. 86-91
    • Lee, S.W.1    Kim, S.M.2    Choi, J.3
  • 60
    • 0028129977 scopus 로고
    • Characterization and toxicological behavior of synthetic amorphous hydrophobic silica
    • Lewinson J., Mayr W., Wagner H. Characterization and toxicological behavior of synthetic amorphous hydrophobic silica. Regul. Toxicol. Pharmacol. 1994, 20(1):37-57.
    • (1994) Regul. Toxicol. Pharmacol. , vol.20 , Issue.1 , pp. 37-57
    • Lewinson, J.1    Mayr, W.2    Wagner, H.3
  • 61
    • 34250217766 scopus 로고    scopus 로고
    • Exposure of engineered nanoparticles to human lung epithelial cells: influence of chemical composition and catalytic activity on oxidative stress
    • Limbach L.K., Wick P., Manser P., Grass R.N., Bruinink A., Stark W.J. Exposure of engineered nanoparticles to human lung epithelial cells: influence of chemical composition and catalytic activity on oxidative stress. Environ. Sci. Technol. 2007, 41:4158-4163.
    • (2007) Environ. Sci. Technol. , vol.41 , pp. 4158-4163
    • Limbach, L.K.1    Wick, P.2    Manser, P.3    Grass, R.N.4    Bruinink, A.5    Stark, W.J.6
  • 62
    • 33845218637 scopus 로고    scopus 로고
    • In vitro toxicity of silica nanoparticles in human lung cancer cells
    • Lin W., Huang Y.W., Zhou X.D., Ma Y. In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol. Appl. Pharmacol. 2006, 217:252-259.
    • (2006) Toxicol. Appl. Pharmacol. , vol.217 , pp. 252-259
    • Lin, W.1    Huang, Y.W.2    Zhou, X.D.3    Ma, Y.4
  • 64
    • 0030581759 scopus 로고    scopus 로고
    • Micronucleus formation in V79 cells treated with respirable silica dispersed in medium and in simulated pulmonary surfactant
    • Liu X., Keane M.J., Zhong B.Z., Ong T., Wallace W.E. Micronucleus formation in V79 cells treated with respirable silica dispersed in medium and in simulated pulmonary surfactant. Mut. Res. 1996, 361:89-94.
    • (1996) Mut. Res. , vol.361 , pp. 89-94
    • Liu, X.1    Keane, M.J.2    Zhong, B.Z.3    Ong, T.4    Wallace, W.E.5
  • 65
    • 67650338048 scopus 로고    scopus 로고
    • Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles
    • Lu F., Wu S.H., Hung Y., Mou C.Y. Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles. Small 2009, 5:1408-1413.
    • (2009) Small , vol.5 , pp. 1408-1413
    • Lu, F.1    Wu, S.H.2    Hung, Y.3    Mou, C.Y.4
  • 67
    • 33845696200 scopus 로고    scopus 로고
    • Does lung surfactant promote disaggregation of nanostructured titanium dioxide?
    • Maier M., Hannebauer B., Holldorff H., Albers P. Does lung surfactant promote disaggregation of nanostructured titanium dioxide?. J. Occupational Environ. Med. 2006, 48:1314-1320.
    • (2006) J. Occupational Environ. Med. , vol.48 , pp. 1314-1320
    • Maier, M.1    Hannebauer, B.2    Holldorff, H.3    Albers, P.4
  • 68
    • 0030981092 scopus 로고    scopus 로고
    • Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer
    • McLaughlin J.K., Chow W.H., Levy L.S. Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer. J. Toxicol. Environ. Health 1997, 50:553-566.
    • (1997) J. Toxicol. Environ. Health , vol.50 , pp. 553-566
    • McLaughlin, J.K.1    Chow, W.H.2    Levy, L.S.3
  • 69
    • 79952578038 scopus 로고    scopus 로고
    • Mode of Action Frameworks in Toxicity Testing and Chemical Risk Assessment
    • Ph.D. Thesis. Institute for Risk Assessment Sciences (IRAS), Utrecht University, the Netherlands. ISBN: 978-90-393-51505.
    • Meek, M.E., 2009. Mode of Action Frameworks in Toxicity Testing and Chemical Risk Assessment. Ph.D. Thesis. Institute for Risk Assessment Sciences (IRAS), Utrecht University, the Netherlands. ISBN: 978-90-393-51505.
    • (2009)
    • Meek, M.E.1
  • 71
    • 31644438928 scopus 로고    scopus 로고
    • Dose-response and threshold analysis of tumor prevalence after intratracheal instillation of six types of low- and high-surface-area particles in a chronic rat experiment
    • Morfeld P., Albrecht C., Drommer W., Borm P.J.A. Dose-response and threshold analysis of tumor prevalence after intratracheal instillation of six types of low- and high-surface-area particles in a chronic rat experiment. Inhal. Toxicol. 2006, 18:215-225.
    • (2006) Inhal. Toxicol. , vol.18 , pp. 215-225
    • Morfeld, P.1    Albrecht, C.2    Drommer, W.3    Borm, P.J.A.4
  • 72
    • 0034583372 scopus 로고    scopus 로고
    • Control of morphology in synthesizing mesoporous silica
    • Mou C.Y., Lin H.P. Control of morphology in synthesizing mesoporous silica. Pure Appl. Chem. 2000, 72(1-2):137-146.
    • (2000) Pure Appl. Chem. , vol.72 , Issue.1-2 , pp. 137-146
    • Mou, C.Y.1    Lin, H.P.2
  • 75
    • 0014019296 scopus 로고
    • Physicochemical properties of silica in relation to its toxicity
    • Nash T., Allison A.C., Harington J.S. Physicochemical properties of silica in relation to its toxicity. Nature 1966, 211:259-261.
    • (1966) Nature , vol.211 , pp. 259-261
    • Nash, T.1    Allison, A.C.2    Harington, J.S.3
  • 76
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • Nel A., Xia T., Mädler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311(5761):622-627.
    • (2006) Science , vol.311 , Issue.5761 , pp. 622-627
    • Nel, A.1    Xia, T.2    Mädler, L.3    Li, N.4
  • 79
    • 35348852487 scopus 로고    scopus 로고
    • Occurrence, behaviour and effects of nanoparticles in the environment
    • Nowack B., Bucheli T.D. Occurrence, behaviour and effects of nanoparticles in the environment. Environ. Poll. 2007, 150:5-22.
    • (2007) Environ. Poll. , vol.150 , pp. 5-22
    • Nowack, B.1    Bucheli, T.D.2
  • 80
    • 84873069232 scopus 로고    scopus 로고
    • OECD, Organisation for Economic Co-operation and Development. SIDS Dossier on Synthetic Amorphous Silica and Silicates. October 2004.
    • OECD, 2004. Organisation for Economic Co-operation and Development. SIDS Dossier on Synthetic Amorphous Silica and Silicates. October 2004.
  • 81
    • 84859006126 scopus 로고    scopus 로고
    • Chapter 3: Data Evaluation. Guidance for Determining the Quality of Data for the SIDS Dossier: Reliability, Relevance and Adequacy
    • OECD, Organisation for Economic Co-operation and Development. Manual for Investigation of HPV Chemicals.
    • OECD, 2005. Organisation for Economic Co-operation and Development. Manual for Investigation of HPV Chemicals. Chapter 3: Data Evaluation. Guidance for Determining the Quality of Data for the SIDS Dossier: Reliability, Relevance and Adequacy.
    • (2005)
  • 82
    • 34548625886 scopus 로고    scopus 로고
    • Silicon nanoparticles: application in cell biology and medicine
    • O'Farrell N., Houtton A., Horrocks B.R. Silicon nanoparticles: application in cell biology and medicine. Int. J. Nanomed. 2006, 1:451-472.
    • (2006) Int. J. Nanomed. , vol.1 , pp. 451-472
    • O'Farrell, N.1    Houtton, A.2    Horrocks, B.R.3
  • 83
    • 18844406983 scopus 로고    scopus 로고
    • Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implication for pulmoary fibrosis
    • O'Reilly K.M.A., Phipps R.P., Thatcher T.H., Graf B.A., van Kirk J., Sime P.J. Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implication for pulmoary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol. 2005, 288:L1010-L1016.
    • (2005) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.288
    • O'Reilly, K.M.A.1    Phipps, R.P.2    Thatcher, T.H.3    Graf, B.A.4    van Kirk, J.5    Sime, P.J.6
  • 84
    • 62549089641 scopus 로고    scopus 로고
    • Syndecan-1 mediates the coupling of positively charged submicrometer amorphous silica particles with actin filaments across the alveolar epithelial cell membrane
    • Orr G., Panther D.J., Cassens K.J., Phillips J.L., Tarasevich B.J., Pounds J.G. Syndecan-1 mediates the coupling of positively charged submicrometer amorphous silica particles with actin filaments across the alveolar epithelial cell membrane. Toxicol. Appl. Pharmacol. 2009, 236:210-220.
    • (2009) Toxicol. Appl. Pharmacol. , vol.236 , pp. 210-220
    • Orr, G.1    Panther, D.J.2    Cassens, K.J.3    Phillips, J.L.4    Tarasevich, B.J.5    Pounds, J.G.6
  • 85
    • 79957826519 scopus 로고    scopus 로고
    • DNA damaging effects of nanoparticles in breast cancer cells
    • Abstracts of the 2007 Annual Meeting of the American Association for Cancer Research (As cited by Barnes et al., 2008).
    • Pacheco, S.E., Mashayekhi, H., Jiang, W., Xing, B., Arcaro, K.F., 2007. DNA damaging effects of nanoparticles in breast cancer cells. Abstracts of the 2007 Annual Meeting of the American Association for Cancer Research (As cited by Barnes et al., 2008).
    • (2007)
    • Pacheco, S.E.1    Mashayekhi, H.2    Jiang, W.3    Xing, B.4    Arcaro, K.F.5
  • 86
    • 0024987978 scopus 로고
    • Surface and bulk infrared modes of crystalline and amorphorous silica particles: a study of the relation of surface structure to cytotoxicity of respirable silica
    • Pandurangi R.S., Seehra M.S., Razzaboni B.L., Bolsaitis P. Surface and bulk infrared modes of crystalline and amorphorous silica particles: a study of the relation of surface structure to cytotoxicity of respirable silica. Environ. Health Perspect. 1990, 86:327-336.
    • (1990) Environ. Health Perspect. , vol.86 , pp. 327-336
    • Pandurangi, R.S.1    Seehra, M.S.2    Razzaboni, B.L.3    Bolsaitis, P.4
  • 87
    • 57649243749 scopus 로고    scopus 로고
    • Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro
    • Park E.J., Park K. Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol. Lett. 2009, 184:18-25.
    • (2009) Toxicol. Lett. , vol.184 , pp. 18-25
    • Park, E.J.1    Park, K.2
  • 90
    • 3543004104 scopus 로고    scopus 로고
    • Effects of nano-scaled particles on endothelial cell function in vitro: studies on viability, proliferation, and inflammation
    • Peters K., Unger R.E., Kirkpatrick C.J., Gatti A.M., Monari E. Effects of nano-scaled particles on endothelial cell function in vitro: studies on viability, proliferation, and inflammation. J. Mater. Sci. Mater. Med. 2004, 15:321-325.
    • (2004) J. Mater. Sci. Mater. Med. , vol.15 , pp. 321-325
    • Peters, K.1    Unger, R.E.2    Kirkpatrick, C.J.3    Gatti, A.M.4    Monari, E.5
  • 92
    • 63349100925 scopus 로고    scopus 로고
    • 2 nanoparticles from nanocomposites
    • 2 nanoparticles from nanocomposites. Polymer Degrad. Stab. 2009, 94:873-876.
    • (2009) Polymer Degrad. Stab. , vol.94 , pp. 873-876
    • Reijnders, L.1
  • 94
    • 4143104578 scopus 로고    scopus 로고
    • Dissolution kinetics of synthetic amorphous silica in biological-like media and its theoretical description
    • Roelofs F., Vogelsberger W. Dissolution kinetics of synthetic amorphous silica in biological-like media and its theoretical description. J. Phys. Chem. B 2004, 108:11308-11316.
    • (2004) J. Phys. Chem. B , vol.108 , pp. 11308-11316
    • Roelofs, F.1    Vogelsberger, W.2
  • 95
    • 34347234840 scopus 로고    scopus 로고
    • Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles
    • Sayes C.M., Reed K.I., Warheit D.B. Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol. Sci. 2007, 97:163-180.
    • (2007) Toxicol. Sci. , vol.97 , pp. 163-180
    • Sayes, C.M.1    Reed, K.I.2    Warheit, D.B.3
  • 96
    • 77149148098 scopus 로고    scopus 로고
    • Changing the dose metric for inhalation toxicity studies: short-term study in rats with engineered aerosolized amorphous silica nanoparticles
    • Sayes C.M., Reed K.L., Glover K.P., Swain K.A., Ostraat M.L., Donner E.M., Warheit D.B. Changing the dose metric for inhalation toxicity studies: short-term study in rats with engineered aerosolized amorphous silica nanoparticles. Inhal. Toxicol. 2010, 22:348-354.
    • (2010) Inhal. Toxicol. , vol.22 , pp. 348-354
    • Sayes, C.M.1    Reed, K.L.2    Glover, K.P.3    Swain, K.A.4    Ostraat, M.L.5    Donner, E.M.6    Warheit, D.B.7
  • 98
    • 84873062897 scopus 로고    scopus 로고
    • Nanoparticle Induced Inflammatory Signaling in the Lung
    • Mechanism of Aerosil200 Particulate Induced Inflammatoy Gene Expression in Alveolar Epithelial Cells. VDM Verlag Dr. Müller. ISBN 978-3-639-21552-6.
    • Singal, M., 2010. Nanoparticle Induced Inflammatory Signaling in the Lung. Mechanism of Aerosil200 Particulate Induced Inflammatoy Gene Expression in Alveolar Epithelial Cells. VDM Verlag Dr. Müller. ISBN 978-3-639-21552-6.
    • (2010)
    • Singal, M.1
  • 99
    • 21044451701 scopus 로고    scopus 로고
    • Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells
    • Singal M., Finkelstein J. Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells. Exp. Lung Res. 2005, 31:581-597.
    • (2005) Exp. Lung Res. , vol.31 , pp. 581-597
    • Singal, M.1    Finkelstein, J.2
  • 100
    • 58149465609 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells
    • Slowing I.I., Wu C.W., Vivero-Escoto J.L., Lin V.S. Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells. Small 2009, 5:57-62.
    • (2009) Small , vol.5 , pp. 57-62
    • Slowing, I.I.1    Wu, C.W.2    Vivero-Escoto, J.L.3    Lin, V.S.4
  • 101
    • 79958015214 scopus 로고    scopus 로고
    • Exocytosis of mesoporous silica nanoparticles from mammalian cells: from asymmetric cell-to-cell transfer to protein harvesting
    • Slowing I., Vivero-Escoto J.L., Zhao Y., Kandel K., Peeraphaldit C., Trewyn B.G., Lin V.S. Exocytosis of mesoporous silica nanoparticles from mammalian cells: from asymmetric cell-to-cell transfer to protein harvesting. Small 2011, 7:1526-1532.
    • (2011) Small , vol.7 , pp. 1526-1532
    • Slowing, I.1    Vivero-Escoto, J.L.2    Zhao, Y.3    Kandel, K.4    Peeraphaldit, C.5    Trewyn, B.G.6    Lin, V.S.7
  • 102
    • 58149251011 scopus 로고    scopus 로고
    • Effect of micro/nano silica particle feeding for mice
    • So S.J., Jang I.S., Han C.S. Effect of micro/nano silica particle feeding for mice. J. Nanosci. Nanotechnol. 2008, 8:5367-5371.
    • (2008) J. Nanosci. Nanotechnol. , vol.8 , pp. 5367-5371
    • So, S.J.1    Jang, I.S.2    Han, C.S.3
  • 103
    • 84859006348 scopus 로고    scopus 로고
    • Particle analysis of pyrogenic (fumed) silicas at technical concentrations and under technical handling conditions
    • Techn. Univ. Dresden, Inst. f. Verfahrenstechn. (20 January 2001 as cited by OECD (2004)).
    • Stintz, M., 2001. Particle analysis of pyrogenic (fumed) silicas at technical concentrations and under technical handling conditions. Techn. Univ. Dresden, Inst. f. Verfahrenstechn. (20 January 2001 as cited by OECD (2004)).
    • (2001)
    • Stintz, M.1
  • 104
    • 20444406055 scopus 로고
    • Controlled growth of monodisperse silica spheres in the micron size range
    • Stöber W., Fink W., Bohn E. Controlled growth of monodisperse silica spheres in the micron size range. J. Colloid Interface Sci. 1968, 26:62-69.
    • (1968) J. Colloid Interface Sci. , vol.26 , pp. 62-69
    • Stöber, W.1    Fink, W.2    Bohn, E.3
  • 105
    • 84873066887 scopus 로고    scopus 로고
    • A simple pulmonary retention model for inhaled soluble particles of limited biological residence time
    • Report by CIIT, Research Triangle Park, USA and Fraunhofer-Institut, Hannover, Germany. 30 June 2000. Study sponsored by CEFIC/ASASP, Brussels, Belgium.
    • Stöber, W., Wong, B., Koch, W., Windt, H., 2000. A simple pulmonary retention model for inhaled soluble particles of limited biological residence time. Report by CIIT, Research Triangle Park, USA and Fraunhofer-Institut, Hannover, Germany. 30 June 2000. Study sponsored by CEFIC/ASASP, Brussels, Belgium.
    • (2000)
    • Stöber, W.1    Wong, B.2    Koch, W.3    Windt, H.4
  • 106
    • 0023790254 scopus 로고
    • Oral ingestion of Syloid to mice and rats and its chronic toxicity and carcinogenicity
    • Takizawa Y., Hirasawa F., Noritomi E., Aida M., Tsunoda H., Uesugi S. Oral ingestion of Syloid to mice and rats and its chronic toxicity and carcinogenicity. Acta Med. Biol. 1988, 36:27-56.
    • (1988) Acta Med. Biol. , vol.36 , pp. 27-56
    • Takizawa, Y.1    Hirasawa, F.2    Noritomi, E.3    Aida, M.4    Tsunoda, H.5    Uesugi, S.6
  • 107
    • 33846500915 scopus 로고    scopus 로고
    • Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments
    • Teeguarden J.G., Hinderliter P.M., Orr G., Thrall B.D., Pounds J.G. Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments. Toxicol. Sci. 2007, 95:300-312.
    • (2007) Toxicol. Sci. , vol.95 , pp. 300-312
    • Teeguarden, J.G.1    Hinderliter, P.M.2    Orr, G.3    Thrall, B.D.4    Pounds, J.G.5
  • 108
    • 67349116785 scopus 로고    scopus 로고
    • Are rat results from intratracheal instillation of 19 granular dusts a reliable basis for predicting cancer risk?
    • Valberg P.A., Bruch J., McCunney R.J. Are rat results from intratracheal instillation of 19 granular dusts a reliable basis for predicting cancer risk?. Regul. Toxicol. Pharmacol. 2009, 54:72-83.
    • (2009) Regul. Toxicol. Pharmacol. , vol.54 , pp. 72-83
    • Valberg, P.A.1    Bruch, J.2    McCunney, R.J.3
  • 109
    • 52649158738 scopus 로고    scopus 로고
    • Ecotoxicity of silica nanoparticles to the green alga pseudokirchnerie/la subcapitata: importance of surface area
    • van Hoecke K., De Schamphelaere K.A.C., Van der Meeren P., Lucas S., Janssen C.R. Ecotoxicity of silica nanoparticles to the green alga pseudokirchnerie/la subcapitata: importance of surface area. Environ. Tox. Chem. 2008, 27:1948-1957.
    • (2008) Environ. Tox. Chem. , vol.27 , pp. 1948-1957
    • van Hoecke, K.1    De Schamphelaere, K.A.C.2    Van der Meeren, P.3    Lucas, S.4    Janssen, C.R.5
  • 111
    • 84859007783 scopus 로고    scopus 로고
    • Some results of dissolution experiments carried out with different kinds of amorphous silica
    • CEFIC/ASASP Report 1999 as cited in OECD (2004).
    • Vogelsberger, W., 1999. Some results of dissolution experiments carried out with different kinds of amorphous silica. CEFIC/ASASP Report 1999 as cited in OECD (2004).
    • (1999)
    • Vogelsberger, W.1
  • 112
    • 0016163083 scopus 로고
    • Passage of particles through the wall of the gastrointestinal tract
    • Volkheimer G. Passage of particles through the wall of the gastrointestinal tract. Environ. Health Perspect. 1974, 9:215-225.
    • (1974) Environ. Health Perspect. , vol.9 , pp. 215-225
    • Volkheimer, G.1
  • 113
    • 76749155561 scopus 로고
    • Four-week inhalation toxicity study with Ludox colloidal silica in rats: pulmonary cellular responses
    • Warheit D.B., Carakostas M.C., Kelly D.P., Hartsky M.A. Four-week inhalation toxicity study with Ludox colloidal silica in rats: pulmonary cellular responses. Fundam. Appl. Toxicol. 1991, 16:590-601.
    • (1991) Fundam. Appl. Toxicol. , vol.16 , pp. 590-601
    • Warheit, D.B.1    Carakostas, M.C.2    Kelly, D.P.3    Hartsky, M.A.4
  • 114
    • 0029587450 scopus 로고
    • Differential pulmonary responses in rats inhaling crystalline, colloidal or amorphous silica dusts
    • Warheit D.B., McHugh T.A., Hartsky M.A. Differential pulmonary responses in rats inhaling crystalline, colloidal or amorphous silica dusts. Scand. J. Work Environ. Health 1995, 21(Suppl. 2):19-21.
    • (1995) Scand. J. Work Environ. Health , vol.21 , Issue.SUPPL. 2 , pp. 19-21
    • Warheit, D.B.1    McHugh, T.A.2    Hartsky, M.A.3
  • 115
    • 75949122702 scopus 로고    scopus 로고
    • Effects of silica nanoparticles on growth and photosynthetic pigmaent contents of Scenedesmus obliquus
    • Wei C., Zhang Y., Guo J., Han B., Yang X., Yuan J. Effects of silica nanoparticles on growth and photosynthetic pigmaent contents of Scenedesmus obliquus. J. Environ. Sci. 2010, 22:155-160.
    • (2010) J. Environ. Sci. , vol.22 , pp. 155-160
    • Wei, C.1    Zhang, Y.2    Guo, J.3    Han, B.4    Yang, X.5    Yuan, J.6
  • 117
    • 58149475510 scopus 로고    scopus 로고
    • Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition
    • Yang H., Liu C., Yang D., Zhang H., Xi Z. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J. Appl. Toxicol. 2009, 29:69-78.
    • (2009) J. Appl. Toxicol. , vol.29 , pp. 69-78
    • Yang, H.1    Liu, C.2    Yang, D.3    Zhang, H.4    Xi, Z.5
  • 118
    • 65249177368 scopus 로고    scopus 로고
    • Interactions of humic acid with nanosized inorganic oxides
    • Yang K., Lin D., Xing B. Interactions of humic acid with nanosized inorganic oxides. Langmuir 2009, 25:3571-3576.
    • (2009) Langmuir , vol.25 , pp. 3571-3576
    • Yang, K.1    Lin, D.2    Xing, B.3
  • 120
    • 77951621268 scopus 로고    scopus 로고
    • In vitro toxicity of silica nanoparticles in myocardial cells
    • Ye Y., Liu J., Chen M., Sun L., Lan M. In vitro toxicity of silica nanoparticles in myocardial cells. Environ. Toxicol. Pharmacol. 2010, 29:131-137.
    • (2010) Environ. Toxicol. Pharmacol. , vol.29 , pp. 131-137
    • Ye, Y.1    Liu, J.2    Chen, M.3    Sun, L.4    Lan, M.5
  • 121
    • 77649179574 scopus 로고    scopus 로고
    • 2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line
    • 2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line. Toxicol. In Vitro 2010, 24:751-758.
    • (2010) Toxicol. In Vitro , vol.24 , pp. 751-758
    • Ye, Y.1    Liu, J.2    Xu, J.3    Sun, L.4    Chem, M.5    Lan, M.6
  • 123
    • 0030727386 scopus 로고    scopus 로고
    • Detection of mineral-dust-induced DNA damage in two mammalian cell lines using the alkaline single cell gel comet assay
    • Zhong B.Z., Whong W.Z., Ong T.M. Detection of mineral-dust-induced DNA damage in two mammalian cell lines using the alkaline single cell gel comet assay. Mutat. Res. 1997, 393:181-187.
    • (1997) Mutat. Res. , vol.393 , pp. 181-187
    • Zhong, B.Z.1    Whong, W.Z.2    Ong, T.M.3


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