Overexpression of platelet-type 12-lipoxygenase promotes tumor cell survival by enhancing αvβ3 and αvβ3 integrin expression

Cancer Research

Volumn 63, Issue 14, 2003, Pages 4258-4267

  Pidgeon, Graham P ^a   Tang, Keqin ^a   Cai, Yin Long ^a   Piasentin, Evano ^b   Honn, Kenneth V ^a,b,c  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; ALPHA5 INTEGRIN; ARACHIDONATE 12 LIPOXYGENASE; BAICALEIN; BETA3 INTEGRIN; BETA5 INTEGRIN; HYDROXYICOSATETRAENOIC ACID; HYDROXYOCTADECADIENOIC ACID; LIPOXYGENASE INHIBITOR; N BENZYL N HYDROXY 5 PHENYLPENTAMIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL ADHESION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; WESTERN BLOTTING;

12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; APOPTOSIS; ARACHIDONATE 12-LIPOXYGENASE; BLOOD PLATELETS; CARCINOMA, SQUAMOUS CELL; CELL MEMBRANE; CELL SURVIVAL; FLOW CYTOMETRY; HUMANS; INTEGRIN ALPHAVBETA3; INTEGRINS; MALE; PROSTATIC NEOPLASMS; RECEPTORS, VITRONECTIN; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0043175177     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Funk, C. D. Molecular biology in the eicosanoid field. Prog. Nucleic Acid Res. Mol. Biol., 45: 67-98, 1993.
2. Funk, C. D., Furci, L., and Fitzgerald, G. A. Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase. Proc. Natl. Acad. Sci. USA, 87: 5638-5642, 1990.
3. Yoshimoto, T., Suzuki, H., Yamamoto, S., Takai, T., Yokoyama, C., and Tanabe, T. Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes. Proc. Natl. Acad. Sci. USA, 87: 2142-2146, 1990.
4. Natarajan, R., Esworthy, R., Bai, W., Gu, J. L., Wilczynski, S., and Nadler, J. L. Increase 12-lipoxygenase expression in breast cancer cells and tissues. Regulation by epidermal growth factor. J. Clin. Endocrinol. Metab., 82: 1790-1798, 1997.
5. Kamitani, H., Geller, M., and Eling, T. The possible involvement of 15-lipoxygenase/leukocyte type 12-lipoxygenase in colorectal carcinogenesis. Adv. Exp. Med. Biol., 469: 593-598, 1991.
6. Nie, D., Hillman, G. G., Geddes, T., Tang, K., Pierson, C., Grignon, D. D. J., and Honn, K. V. Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth. Cancer Res., 58: 4047-4051, 1998.
7. Timar, J., Rasa, E., Honn, K. V., and Hagmann, W. 12-Lipoxygenase expression in human melanoma cell lines. Adv. Exp. Med. Biol., 469: 617-622, 1999.
8. Ding, X. Z., Kuszynski, C. A., El-Metwally, T. H., and Adrian, T. E. Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells. Biochem. Biophys. Res. Commun., 266: 392-399, 1999.
9. Nappez, C., Liagre, B., and Beneytout, J. L. Changes in lipoxygenase activities in human erythroleukemia (HEL) cells during diosgenin-induced differentiation. Cancer Lett., 96: 133-140, 1995.
10. Pidgeon, G. P., Kandouz, M., Meram, A., and Honn, K. V. Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Cancer Res., 62: 2721-2727, 2002.
11. Woodhouse, E. C., Chuaqui, R. F., and Liotta, L. A. General mechanism of metastasis. Cancer (Phila.), 80: 1529-1537, 1997.
12. Giancotti, F. G., and Ruoslahti, E. Integrin signalling. Science (Wash. DC), 285: 1028-1032, 1999.
13. Bissell, M. J., Weaver, V. M., Lelievre, S. A., Wang, F., Petersen, O. W., and Schmeicel, K. L. Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Res., 59 (Suppl.): 1757s-1763s, discussion 1763s-1764s, 1999.
14. Clarke, E. A., and Brugge, J. S. Integrins and signal transduction pathways: the road taken. Science (Wash. DC), 268: 233-239, 1995.
15. Howe, A., Aplin, A. E., Alahari, S. K., and Juliano, R. L. Integrin signaling and cell growth control. Curr. Opin. Cell Biol., 10: 220-231, 1998.
16. Gilmore, A. P., and Burridge, K. Molecular mechanisms for focal adhesion assembly through regulation of protein-protein interactions. Structure, 4: 647-651, 1996.
17. 1 integrins on fibroblasts. Nature (Lond.), 383: 438-440, 1996.
18. Sheetz, M. P., Felsenfeld, D. P., and Galbraith, C. G. Cell migration: regulation of force on extracellular-matrix-integrin complexes. Trends Cell Biol., 8: 51-54. 1998.
19. 1 suppresses apoptosis triggered by serum starvation but not phorbol ester in MCF-7 breast cancer cells that overexpress protein kinase C-α Int. J. Oncol., 18: 195-201, 2001.
20. 5 are expressed by endothelium of high risk neuroblastoma, and their inhibition is associated with increased endogenous ceramide. Cancer Res., 60: 712-721, 2000.
21. 3-mediated activation of apoptosis. Exp. Cell Res., 251: 33-45, 1999.
22. Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P. H., and Downward, J. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J., 16: 2783-2793, 1997.
23. Wu, C., Keightley, S. Y., Leung-Hagesteijn, C., Radeva, G., Coppolino, M., Goicoechea, S., McDonald, J. A., and Dedhar, S. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J. Biol. Chem., 273: 528-536, 1998.
24. Uhm, J. H., Dooley, N. P., Kyritsis, A. P., Rao, J. S., and Gladson, C. L. Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death. Clin. Cancer Res., 5: 1587-1594, 1999.
25. Pouliot, N., Connolly, L. M., Moritz, R. L., Simpson, R. J., and Burgess, A. W. Colon cancer cells adhesion and spreading on autocrine laminin-10 is mediated by multiple integrin receptors and modulated by EGF receptor stimulation. Exp. Cell Res., 261: 360-371, 2000.
26. 3 activation by non-steroidal anti-inflammatory drugs. FEBS Lett., 446: 318-322, 1999.
27. 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis. Nat. Med., 7: 1041-1047, 2000.
28. 3 integrins on endothelial cells. Int. J. Cancer. 54: 102-111, 1993.
29. 3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells. Thromb. Haemostasis, 85: 1037-1042, 2001.
30. Patricia, M. K., Kim, J. A., Harper, C. M., Shih, P. T., Berliner, J. A., Natarajan, R., Nadler, J. L., and Hedrick, C. C. Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells. Arterioscler. Thromb. Vasc. Biol., 19: 2615-2622, 1999.
31. Tang, K., Finley, R. L., Jr., Nie, D., and Honn, K. V. Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening. Biochemistry, 39: 3185-3191, 2000.
32. Tang, D. G., Chen, Y. Q., and Honn, K. V. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Proc. Natl. Acad., Sci. USA, 93: 5241-5246, 1996.
33. Rice, R. L., Tang, D. G., Haddad, M., Honn, K. V., and Taylor, J. D. 12(S)-Hydroxyeicosatetraenoic acid increases the actin microfilament content in B16a melanoma cells: a protein kinase-dependent process. Int. J. Cancer. 77: 271-278, 1998.
34. Timar, J., Raso, E., Dome, B., Li, L., Grignon, D., Nie, D., Honn, K. V., and Hagmann, W. Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential. Int. J. Cancer. 87: 37-43, 2000.
35. Ruoslahti, E. Stretching is good for a cell. Science (Wash. DC), 276: 1345-1346, 1997.
36. 3 integrin, NF-κB. osteoprotegerin endothelial cell survival pathway. Potential role in angiogenesis. Trends Cardiovasc. Med., 12: 83-88, 2002.
37. 3 promotes M21 melanoma growth in human skin by regulating rumor cell survival. Cancer Res., 59: 2724-2730, 1999.
38. 3 Integrin engagement modulates cell adhesion, proliferafion, and protease secretion in human lymphoid tumor cells. Exp. Hematol., 8: 993-1003, 2001.
39. 3 integrin cell-surface expression protects A431 cells from epidermal growth factor-induced apoptosis. Int. J. Cancer. 87: 360-367, 2000.
40. Freyer, A. M., Johnson, S. R., and Hall, I. P. Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol., 25: 569-576, 2001.
41. 1 integrin interaction enhances survival and proliferation and modulates steroidogenesis of ovine granulosa cells. J. Endocrinol., 172: 45-59, 2002.
42. 5 subunit, in HT29 colon carcinoma cells, suppresses apoptosis triggered by serum deprivation. Exp. Cell Res., 224: 208-213, 1996.
43. Pignatelli, M., Cardillo, M. R., Hanby, A., and Stamp, G. W. Integrins and their accessory adhesion molecules in mammary carcinomas: loss of polarization in poorly differentiated tumors. Hum. Pathol., 23: 1159-1166, 1992.
44. Hoyt, D. G., Rusnak, J. M., Mannix, R. J., Modzelewski, R. A., Johnson, C. S., and Lazo, J. S. Integrin activation suppresses etoposide-induced DNA strand breakage in cultured murine tumor-derived endothelial cells. Cancer Res., 56: 4146-4149, 1996.
45. 3 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc. Natl. Acad. Sci. USA, 92: 6161-6165, 1995.
46. 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J. Cell Biol., 134: 1323-1332, 1994.
47. v by protein kinase C activator 12(S)-HETE. J. Cell Sci., 108: 2629-2644, 1995.
48. Tang, D. G., and Honn, K. V. Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and deletion of GSH: role of 12-lipoxygenase in regulating tumor cell survival. J. Cell. Physiol., 172: 155-170, 1997.