Genistein modulates oxidative stress in breast cancer cell lines according to ERa/ERβ ratio: Effects on mitochondrial functionality, sirtuins, uncoupling protein 2 and antioxidant enzymes

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 9, 2013, Pages 2045-2051

  Nadal Serrano, Mercedes ^a   Pons, Daniel Gabriel ^a   Sastre Serra, Jorge ^a   Blanquer Rossellò, Madel Mar ^a   Roca, Pilar ^a   Oliver, Jordi ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

Breast cancer; ERa ER ratio; Genistein; Mitochondria; Oxidative stress

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GA BINDING PROTEIN; GENISTEIN; MANGANESE SUPEROXIDE DISMUTASE; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PRESENILIN 2; SIRTUIN 1; SIRTUIN 3; UNCOUPLING PROTEIN 2;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRION; OXIDATIVE STRESS; UPREGULATION;

2′,7′-DICHLOROFLUORESCEIN DIACETATE; 4-HNE; 4-HYDROXY-2-NONENAL; BREAST CANCER; CAT; CATALASE; DCFDA; ERΑ; ERΑ/ERΒ RATIO; ERΒ; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GEN; GENISTEIN; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MNSOD; NAO; NONYL ACRIDINE ORANGE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXPHOS; REACTIVE OXYGEN SPECIES; ROS; SIRT; SIRTUIN; TETRAMETHYLRHODAMINE METHYL ESTER; TMRM; UCP; UNCOUPLING PROTEIN; ΔΨM;

ANTIOXIDANTS; BREAST NEOPLASMS; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CELL LINE, TUMOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENISTEIN; HUMANS; ION CHANNELS; MCF-7 CELLS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIRTUINS;

EID: 84880882868     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2013.07.002     Document Type: Article

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