Overcoming multidrug resistance in 2D and 3D culture models by controlled drug chitosan-graft poly(caprolactone)-based nanoparticles

Journal of Pharmaceutical Sciences

Volumn 103, Issue 4, 2014, Pages 1064-1074

  Shi, Wei Bin ^a   Le, Van Minh ^a,b   Gu, Chun Hua ^b   Zheng, Yuan Hong ^b   Lang, Mei Dong ^b   Lu, Yan Hua ^b   Liu, Jian Wen ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

3D cultures; 5 fluorouracil; chitosan; drug delivery; in vitro models; multidrug resistance; nanoparticles

Indexed keywords

CHITOSAN; CHITOSAN POLYCAPROLACTONE COPOLYMER; COLLAGEN GEL; FLUOROURACIL; NANOPARTICLE; POLYCAPROLACTONE; RHODAMINE 123; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRAIN HCT116; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; LIGHT SCATTERING; MTT ASSAY; MULTIDRUG RESISTANCE; TRANSMISSION ELECTRON MICROSCOPY; TUMOR MICROENVIRONMENT;

3D CULTURES; 5-FLUOROURACIL; CHITOSAN; DRUG DELIVERY; IN VITRO MODELS; MULTIDRUG RESISTANCE; NANOPARTICLES;

ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; HUMANS; NANOPARTICLES; NEOPLASMS; POLYESTERS;

EID: 84896396134     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23860     Document Type: Article

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