Application of a novel ultra-low elution volume 96-well solid-phase extraction method to the LC/MS/MS determination of simvastatin and simvastatin acid in human plasma

Journal of Pharmaceutical and Biomedical Analysis

Volumn 38, Issue 3, 2005, Pages 521-527

  Yang, Amy Y ^a   Sun, Li ^a   Musson, Donald G ^a   Zhao, Jamie J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Elution plate; Human plasma; LC MS MS; Simvastatin; Simvastatin acid; SPE

Indexed keywords

ACETONITRILE; AMMONIUM ACETATE; DRUG METABOLITE; METHANOL; SIMVASTATIN; SIMVASTATIN ACID; SOLVENT; UNCLASSIFIED DRUG; WATER;

ANALYTICAL EQUIPMENT; ARTICLE; BLOOD ANALYSIS; COST CONTROL; DILUTION; ELUTION; EVAPORATION; HUMAN; INTERMETHOD COMPARISON; LABORATORY TEST; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETER; PRIORITY JOURNAL; RELIABILITY; REPRODUCIBILITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME;

CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; SIMVASTATIN;

EID: 19544373327     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.01.016     Document Type: Article

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