Development of SLNs from natural lipids: Application to topical delivery of tretinoin

International Journal of Pharmaceutics

Volumn 363, Issue 1-2, 2008, Pages 132-138

  Mandawgade, Sagar D ^a   Patravale, Vandana B ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

In vitro occlusivity; Indigenous natural solid lipids; SLN based gels; Solid lipid nanoparticles (SLNs); Tretinoin

Indexed keywords

LIPID; RETINO A; RETINOIC ACID; SOLID LIPID NANOPARTICLE; STEARINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG PENETRATION; DRUG SAFETY; DRUG TOLERABILITY; EXCIPIENT COMPATIBILITY; GEL; MICROEMULSION; MORPHOLOGY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SKIN IRRITATION; SKIN PERMEABILITY; SLOW DRUG RELEASE;

ADMINISTRATION, CUTANEOUS; ANIMALS; DELAYED-ACTION PREPARATIONS; DERMATOLOGIC AGENTS; DRUG CARRIERS; DRUG COMPOUNDING; EDEMA; ERYTHEMA; GELS; LIPIDS; NANOPARTICLES; PARTICLE SIZE; PERMEABILITY; RABBITS; SKIN; SKIN ABSORPTION; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TRETINOIN; WATER LOSS, INSENSIBLE;

EID: 51649122893     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.06.028     Document Type: Article

References (19)

1. Allen J.G., and Bloxham D.P. The pharmacology and pharmacokinetics of the retinoids. Pharmacol. Ther. 40 (1989) 1-27
2. Andolsek K.M. Current therapies for the management of Acne. Am. Fam. Physician 57 (1998) 138-140
3. Aungst B.J., Nguyen N.H., and Rogers N.J. Amphiphilic vehicles improve the oral bioavailability of a poorly soluble HIV protease inhibitor at high doses. Int. J. Pharm. 156 (1997) 79-88
4. de Vringer, T., 1992. Topical preparation containing a suspension of solid lipid particles. EP 0,506,197,A1.
5. Djordjevic L., Primorac M., Stupar M., and Krajisnik D. Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug. Int. J. Pharm. 271 (2004) 11-19
6. Draize J., Woodard G., and Calvery H. Methods for the study of irritation and toxicity of substances topically applied to skin and mucous membranes. J. Pharmacol. Exp. Ther. 82 (1944) 377-390
7. Gasco M.R. Solid lipid nanospheres from warm micro-emulsions. Pharm. Technol. Eur. 9 (1997) 52-58
8. Gunstone F.D. Oils and fats: sources and constituents. The Chemistry of Oils and Fats (2005), Blackwell Publishing, UK pp. 3-13
9. Joshi M.D., and Patravale V.B. Formulation and evaluation of nanostructured lipid carrier (NLC) based gel of valdecoxib. Drug Dev. Ind. Pharm. 32 (2006) 911-918
10. Lehman P.A., John J.T., and Franz T.J. Percutaneous absorption of retinoids: influence of vehicle, light exposure and dose. J. Invest. Dermatol. 91 (1990) 56-61
11. Lucek R.W., and Colburn W.A. Clinical pharmacokinetics of the retinoids. Clin. Pharmacokinet. 10 (1985) 38-62
12. Mehnert W., and Mader K. Solid lipid nanoparticles production, characterization and applications. Adv. Drug Deliv. Rev. 47 (2001) 165-196
13. Muller R.H., Radtke M., and Wissing S.A. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev. 54 (2002) S131-S155
14. Nighland M., Yusuf M., Wisniewski S., Huddleston K., and Nyirady J. The effect of simulated solar UV irradiation on tretinoin in tretinoin gel microsphere (0.1%) and tretinoin gel (0. 025%). Cutis 77 (2006) 313-316
15. Shah K.A., Date A.A., Joshi M.D., and Patravale V.B. Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery. Int. J. Pharm. 345 (2007) 163-171
16. Verneer B.J. Skin irritation and sensitization. J. Control. Release 15 (1991) 261-265
17. Wissing S.A., Lippacher A., and Muller R.H. Investigations on the occlusive properties of solid lipid nanoparticles (SLNs). J. Cosmet. Sci. 52 (2001) 313-323
18. Yamaguchi Y., Nagasawa T., Nakamura N., Takenaga M., Mizoguchi M., Kawai S., Mizushima Y., and Igarashi R. Successful treatment of photo-damaged skin of nano-scale atRA particles using a novel transdermal delivery. J. Control. Release 104 (2005) 29-40
19. Zouboulis C.C. Retinoids-which dermatological indications will benefit in the near future?. Skin Pharmacol. Physiol. 14 (2001) 303-315