Newborn pig skin as model membrane in in vitro drug permeation studies: A technical note

AAPS PharmSciTech

Volumn 8, Issue 4, 2007, Pages

  Cilurzo, Francesco ^a   Minghetti, Paola ^a   Sinico, Chiara ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Benzoxazinones; Human epidermis; In vitro skin permeation experiment; Newborn pig skin

Indexed keywords

BENZOXAZINONE DERIVATIVE; PROPRANOLOL; BENZOXAZINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DIFFUSION; DRUG PENETRATION; DRUG STRUCTURE; EPIDERMIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; NEWBORN; NONHUMAN; PHYSICAL CHEMISTRY; RANDOMIZATION; SCREENING TEST; SKIN PERMEABILITY; SUBCUTANEOUS FAT; SWINE; ANIMAL; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DIFFUSION CHAMBER; DRUG SCREENING; EVALUATION; INSTRUMENTATION; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; PERMEABILITY; REPRODUCIBILITY; SKIN; STRUCTURE ACTIVITY RELATION; TISSUE CULTURE TECHNIQUE;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANIMALS, NEWBORN; BENZOXAZINES; DIFFUSION; DIFFUSION CHAMBERS, CULTURE; DRUG EVALUATION, PRECLINICAL; HUMANS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PERMEABILITY; REPRODUCIBILITY OF RESULTS; SKIN; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; TISSUE CULTURE TECHNIQUES;

EID: 36849043019     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt0804094     Document Type: Article

References (12)

1. Hammond SA, Tsonis C, Sellins K, et al. Transcutaneous immunization of domestic animals: opportunities and challenges. Adv Drug Deliv Rev. 2000;43:45-55.
2. Priborsky J, Takayama K, Nagai T, Waitzova D, Elis J. Evaluation of in vitro and in situ transdermal absorption of drugs in pig and rat skin. Chem Pharm Bull (Tokyo). 1987;35:4915-4920.
3. Songkro S, Purwo Y, Becket G, Rades T. Investigation of newborn pig skin as an in vitro animal model for transdermal drug delivery. STP Pharma Sci. 2003;13:133-139.
4. Songkro S, Rades T, Becket G. The effects of p-menthane monoterpenes and related compounds on the percutaneous absorption of propranolol hydrochloride across newborn pig skin. I. In vitro skin permeation and retention studies. STP Pharma Sci. 2003;13: 349-357.
5. Songkro S, Becket G, Rades T. The effects of p-menthane monoterpenes and related compounds on the percutaneous absorption of propranolol hydrochloride across newborn pig skin. II. Infrared spectroscopic and thermal analysis investigations. STP Pharma Sci. 2003;13:397-404.
6. Songkro S, Becket G, Rades T. The effects of p-menthane monoterpenes and related compounds on the percutaneous absorption of propranolol hydrochloride across newborn pig skin: III. Correlation between penetration enhancing activity and physicochemical properties of terpenes determined by principal components analysis. J Drug Deliv Sci Tech. 2004;14:223-228.
7. Baroli B, Lopez-Quintela MA, Delgado-Charro MB, Fadda AM, Blanco-Mendez J. Microemulsions for topical delivery of 8-methoxsalen. J Control Release. 2000;69:209-218.
8. Sinico C, Manconi M, Peppi M, Lai F, Valenti D, Fadda AM. Liposomes as carriers for dermal delivery of tretinoin: in vitro evaluation of drug permeation and vesicle-skin interaction. J Control Release. 2005;103:123-136.
9. Minghetti P, Casiraghi A, Cilurzo F, et al. Solvation enthalpies as descriptors of structure - in vitro percutaneous permeation of benzoxazinones regioisomers. Farmaco. 2000;55:563-568.
10. Schreiber S, Mahmouda A, Vuiaa, A, et al. Reconstructed epidermis versus human and animal skin in skin absorption studies. Toxicol In Vitro. 2005;19:813-825.
11. Dick IP, Scott RC. Pig ear skin as an in vitro model for human skin permeability. J Pharm Pharmacol. 1992;44:640-645.
12. Vallet V, Cruz C, Josse D, Bazire A, Lallement G, Boudry I. In vitro percutaneous penetration of organophosphorus compounds using full-thickness and split-thickness pig and human skin. Toxicol In Vitro. 2007;21:1182-1190.