Electrophysiological and metabolic effects of CHF5074 in the hippocampus: Protection against in vitro ischemia

Pharmacological Research

Volumn 81, Issue , 2014, Pages 83-90

  Mango, D ^a   Barbato, G ^b,c   Piccirilli, S ^c   Panico, M B ^a   Feligioni, M ^b   Schepisi, C ^a,d   Graziani, M ^d   Porrini, V ^e   Benarese, M ^e   Lanzillotta, A ^e   Pizzi, M ^e,f   Pieraccini, S ^g   Sironi, M ^g   Blandini, F ^h   Nicoletti, F ^d   Mercuri, N B ^a,c   Imbimbo, B P ⁱ   Nistico R ^a,d  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e UNIVERSITY OF BRESCIA   (Italy)

^f IRCCS SAN CAMILLO HOSPITAL   (Italy)

^g UNIVERSITY OF MILAN   (Italy)

^h C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

ⁱ Research and Development Department   (Italy)

Author keywords

ASICs; CHF5074; Electrophysiology; Hippocampus; Neuroprotection

Indexed keywords

1 [3',4' DICHLORO 2 FLUORO(1,1' BIPHENYL) 4 YL]CYCLOPROPANECARBOXYLIC ACID; ACETIC ACID; ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1A; ALANINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CASPASE 3; CHF 5074; LACTIC ACID; N METHYL DEXTRO ASPARTIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG; 1-(3',4'-DICHLORO-2-FLUORO(1,1'-BIPHENYL)-4-YL)CYCLOPROPANECARBOXYLIC ACID; ACETIC ACID DERIVATIVE; ASPARTIC ACID; CYCLOPROPANE DERIVATIVE; FLURBIPROFEN; N-ACETYLASPARTATE; NEUROPROTECTIVE AGENT;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EMBRYO; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; IC 50; IN VITRO STUDY; MALE; METABOLIC ACIDOSIS; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; ELECTROPHYSIOLOGY; ISCHEMIA; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULARIZATION; WISTAR RAT;

ACETATES; ALANINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPARTIC ACID; CELLS, CULTURED; CYCLOPROPANES; ELECTROPHYSIOLOGICAL PHENOMENA; FLURBIPROFEN; HIPPOCAMPUS; IN VITRO TECHNIQUES; ISCHEMIA; LACTIC ACID; MALE; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS; RATS, WISTAR;

EID: 84896354023     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.02.010     Document Type: Article

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