N-acetylaspartate to total creatine ratio in the hippocampal CA1 sector after transient cerebral ischemia in gerbils: Influence of neuronal elements, reactive gliosis, and tissue atrophy

Journal of Cerebral Blood Flow and Metabolism

Volumn 23, Issue 6, 2003, Pages 700-708

  Konaka, Kuni ^a   Ueda, Hirokazu ^a   Li, Ji Yao ^a   Matsumoto, Masayasu ^a   Sakoda, Saburo ^a   Yanagihara, Takehiko ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cerebral ischemia; Gerbil; Gliosis; Hippocampus; N acetylaspartate total creatine ratio

Indexed keywords

CREATINE; CREATINE PHOSPHATE; N ACETYLASPARTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN ATROPHY; BRAIN ISCHEMIA; CELL DENSITY; CONTROLLED STUDY; GERBIL; GLIOSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; REPERFUSION; STATISTICAL ANALYSIS;

EID: 0038458827     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000071888.63724.56     Document Type: Article

References (43)

1. Arai H, Passonneau JV, Lust WD (1986) Energy metabolism in delayed neuronal death of CA1 neurons of the hippocampus following transient ischemia in the gerbil. Metab Brain Dis 1:263-278
2. Bhakoo KK, Pearce D (2000) In vitro expression of N-acetyl aspartate by oligodendrocytes: implications for proton magnetic resonance spectroscopy signal in vivo. J Neurochem 74:254-262
3. Bonnekoh P, Barbier A, Oschlies U, Hossmann KA (1990) Selective vulnerability in the gerbil hippocampus: morphological changes after 5-min ischemia and long survival times. Acta Neuropathol 80:18-25
4. Brand A, Richter-Landsberg C, Leibfritz D (1993) Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 15:289-298
5. Burlina AP, Ferrari V, Facci L, Skaper SD, Burlina AB (1997) Mast cells contain large quantities of secretagogue-sensitive N-acetylaspartate. J Neurochem 69:1314-1317
6. Cendes F, Stanley JA, Dubeau F, Andermann F, Arnold DL (1997) Proton magnetic resonance spectroscopic imaging for discrimination of absence and complex partial seizures. Ann Neurol 41:74-81
7. Davies SEC, Newcombe J, Williams SR, McDonald WI, Clark JB (1995) High resolution proton NMR spectroscopy of multiple sclerosis lesions. J Neurochem 64:742-748
8. Duijin JH, Matson GB, Maudsley AA, Hugg JW, Weiner MW (1992) Human brain infarction: proton MR spectroscopy. Radiology 183:711-718
9. Erecinska M, Silver IA (1989) ATP and brain function. J Cereb Blood Flow Metab 9:2-19
10. Fawcett JW, Asher RA (1999) The glial scar and central nervous system repair. Brain Res Bull 49:377-391
11. Gehrmann J, Bonnekoh P, Miyazawa T, Hossmann KA, Kreutzberg GW (1992) Immunocytochemical study of an early microglial activation in ischemia. J Cereb Blood Flow Metab 12:257-269
12. Hatakeyama T, Matsumoto M, Brengman JM, Yanagihara T (1988) Immunohistochemical investigation of ischemic and postischemic damage after bilateral carotid occlusion in gerbils. Stroke 19:1526-1534
13. 1H magnetic resonance spectroscopy in rats. Neurosurgery 38:121-130
14. Jenkins BG, Klivenyi P, Kustermann E, Andreassen OA, Ferrante RJ, Rosen BR, Beal MF (2000) Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice. J Neurochem 74:2108-2119
15. Johansen FF, Jorgensen MB, Diemer NH (1983) Resistance of hippocampal CA1 interneurons to 20 min of transient cerebral ischemia in the rat. Acta Neuropathol 61:135-140
16. Kirino T (1993) Presynaptic terminals in hippocampal gliosis following transient ischemia in the Mongolian gerbil. Prog Brain Res 96:261-270
17. Koller KJ, Zaczek R, Coyle JT (1984) N-acetyl-aspartyl-glutamate: regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method. J Neurochem 43:1136-1142
18. Konaka K, Ueda H, Li JY, Matsumoto M, Yanagihara T (2002) N-acetyl aspartate to total creatine ratio after transient cerebral ischemia in gerbils: influence of reactive gliosis and tissue atrophy [abstract]. Ann Neurol 52(Suppl 1):S61
19. Kondo Y, Ogawa N, Asanuma M, Ota Z, Mori A (1995) Regional differences in late-onset iron deposition, ferritin, transferrin, astrocyte proliferation, and microglial activation after transient forebrain ischemia in rat brain. J Cereb Blood Flow Metab 15:216-226
20. Lin B, Ginsberg MD, Busto R, Dietrich WD (1998) Sequential analysis of subacute and chronic neuronal, astrocytic and microglial alterations after transient global ischemia in rats. Acta Neuropathol 95:511-523
21. Loskota WJ, Lomax P, Verity MA (1974) A stereotaxic atlas of the Mongolian gerbil brain, Ann Arbor: Ann Arbor Science, pp 650- 690
22. Macouillard-Poulletier de Gannes F, Merle M, Canioni P, Voisin PJ (1998) Metabolic and cellular characterization of immortalized human microglial cells under heat stress. Neurochem Int 33:61-73
23. Miller BL (1991) A review of chemical issues in 1H NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline. NMR Biomed 4:47-52
24. Nakano M, Ueda H, Li JY, Matsumoto M, Yanagihara T (1998) Measurement of regional N-acetylaspartate after transient global ischemia in gerbils with and without ischemic tolerance: an index of neuronal survival. Ann Neurol 44:334-340
25. Nakano M, Ueda H, Li JY, Matsumoto M, Yanagihara T (2001) A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of N-acetylaspartate in the hippocampal CA1 area after transient unilateral forebrain ischemia in gerbils. Life Sci 69:1983-1990
26. Nowak TS Jr, Fried RL, Lust WD, Passonneau JV (1985) Changes in brain energy metabolism and protein synthesis following transient bilateral ischemia in the gerbil. J Neurochem 44:487-494
27. Pontén U, Ratcheson RA, Salford LG, Siesjo BK (1973) Optimal freezing conditions for cerebral metabolites in rats. J Neurochem 21:1127-1138
28. Sager TN, Laursen H, Hansen AJ (1995) Changes in N-acetyl-aspartate content during focal and global brain ischemia of the rat. J Cereb Blood Flow Metab 15:639-646
29. Sager TN, Laursen H, Fink-Jensen A, Topp S, Stensgaard A, Hedehus M, Rosenbaum S, Valsborg JS, Hansen AJ (1999) N-Acetylaspartate distribution in rat brain striatum during acute brain ischemia. J Cereb Blood Flow Metab 19:164-172
30. Sager TN, Hansen AJ, Laursen H (2000) Correlation between N-acetylaspartate levels and histopathologic changes in cortical infarcts of mice after middle cerebral artery occlusion. J Cereb Blood Flow Metab 20:780-788
31. 4). J Histochem Cytochem 38:1683-1686
32. Sugawara T, Lewén A, Noshita N, Gasche Y, Chan PH (2002) Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats. J Neurotrauma 19:85-98
33. Tomimoto H, Yamamoto K, Homburger HA, Yanagihara T (1993) Immunoelectron microscopic investigation of creatine kinase BB-isoenzyme after cerebral ischemia in gerbils. Acta Neuropathol 86:447-455
34. Trapp BD, Bernier L, Andrews B, Colman DR (1988) Cellular and subcellular distribution of 2′,3′-cyclic nucleotide 3′-phosphodiesterase and its mRNA in the rat central nervous system. J Neurochem 51:859-868
35. Tsai G, Coyle JT (1995) N-acetylaspartate in neuropsychiatric disorders. Prog Neurobiol 46:531-540
36. Ueda H, Tagawa K, Furuya E, Matsumoto M, Yanagihara T (1999) A combined analysis of regional energy metabolism and immunohistochemical ischemic damage in the gerbil brain. J Neurochem 72:1232-1242
37. Urenjak J, Williams SR, Gadian DG, Noble M (1992) Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem 59:55-61
38. van Walderveen MAA, Barkhof F, Pouwels PJW, van Schijndel RA, Polman CH, Castelijns JA (1999) Neuronal damage in T1-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy. Ann Neurol 46:79-87
39. Whittingham TS, Douglas A, Holtzman D (1995) Creatine and nucleoside triphosphates in rat cerebral gray and white matter. Metab Brain Dis 10:347-352
40. Wiseman RW, Moerland TS, Chase PB, Stuppard R, Kushmerick MJ (1992) High-performance liquid chromatographic assays for free and phosphorylated derivatives of the creatine analogues beta-guanidopropionic acid and 1-carboxy-methyl-2-imino-imidazolidine (cyclocreatine). Anal Biochem 204:383-389
41. Yanagihara T (1990) Immunohistochemical assessment of cerebral ischemia. In: Cerebral ischemia and resuscitation (Schurr A, Rigor BM, eds), Boca Raton: CRC Press, pp 389-412
42. Yoshimine T, Morimoto K, Homburger HA, Yanagihara T (1984) Immunohistochemical localization of creatine kinase BB-isozyme and tubulin in gerbil brain. Neuroscience 12:959-969
43. Yoshimine T, Morimoto K, Brengman JM, Homburger HA, Mogami H, Yanagihara T (1985) Immunohistochemical investigation of cerebral ischemia during recirculation. J Neurosurg 63:922-928