The effect of dietary cholesterol on macrophage accumulation in adipose tissue: Implications for systemic inflammation and atherosclerosis

Current Opinion in Lipidology

Volumn 20, Issue 1, 2009, Pages 39-44

  Subramanian, Savitha ^a   Chait, Alan ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Division of Metabolism Endocrinology and Nutrition   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CARBOHYDRATE; CHOLESTEROL; CHYLOMICRON; MONOCYTE CHEMOTACTIC PROTEIN 1;

ADIPOSE TISSUE; ARTERY WALL; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC CARDIOVASCULAR DISEASE; CHOLESTEROL DIET; CHOLESTEROL METABOLISM; CORONARY ARTERY DISEASE; CORONARY RISK; EXPERIMENTAL MODEL; FATTY LIVER; HUMAN; INFLAMMATION; LIPID DIET; LOW FAT DIET; MACROPHAGE MIGRATION; METABOLIC DISORDER; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

ADIPOSE TISSUE; ANIMALS; ATHEROSCLEROSIS; CHOLESTEROL, DIETARY; HUMANS; INFLAMMATION; LIVER; MACROPHAGES;

EID: 58849088084     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e32831bef8b     Document Type: Review

References (48)

1. Brown AJ, Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 1999; 142:1-28.
2. Krut LH, Yang JW, Schonfeld G, Ostlund RE Jr. The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells. Arterioscler Thromb Vasc Biol 1997; 17:778-785.
3. Staprans I, Pan XM, Rapp JH, Feingold KR. The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis. Mol Nutr Food Res 2005; 49:1075-1082.
4. Leonarduzzi G, Gamba P, Sottero B, et al. Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells. Free Radic Biol Med 2005; 39:1152-1161.
5. Getz GS, Reardon CA. Diet and murine atherosclerosis. Arterioscler Thromb Vasc Biol 2006; 26:242-249.
6. Vergnes L, Phan J, Strauss M, et al. Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem 2003; 278:42774-42784.
7. Wouters K, van Gorp PJ, Bieghs V, et al. Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology 2008; 48:474-486.
8. Kleemann R, Verschuren L, van Erk MJ, et al. Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis. Genome Biol 2007; 8:R200. This study showed that dietary cholesterol triggers hepatic inflammation and contributes to inflammation and worsens atherosclerosis in mice using a genomics approach.
9. Tous M, Ferre N, Rull A, et al. Dietary cholesterol and differential monocyte chemoattractant protein-1 gene expression in aorta and liver of apo E-deficient mice. Biochem Biophys Res Commun 2006; 340:1078-1084.
10. Tannock LR, O'Brien KD, Knopp RH, et al. Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects. Circulation 2005; 111:3058-3062.
11. McNamara DJ. Dietary cholesterol and atherosclerosis. Biochim Biophys Acta 2000; 1529:310-320.
12. Kromhout D, Menotti A, Bloemberg B, et al. Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study. Prev Med 1995; 24:308-315.
13. Shekelle RB, Stamler J. Dietary cholesterol and ischaemic heart disease. Lancet 1989; 1:1177-1179.
14. Shekelle RB, Shryock AM, Paul O, et al. Diet, serum cholesterol, and death from coronary heart disease. The Western Electric study. N Engl J Med 1981; 304:65-70.
15. Goff DC Jr, Shekelle RB, Katan MB, et al. Does body fatness modify the association between dietary cholesterol and risk of coronary death? Results from the Chicago Western Electric Study. Arterioscler Thromb 1992; 12:755-761.
16. Hu FB, Stampfer MJ, Manson JE, et al. Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med 1997; 337:1491 -1499.
17. Hu FB, Stampfer MJ, Rimm EB, et al. A prospective study of egg consumption and risk of cardiovascular disease in men and women. JAMA 1999; 281:1387-1394.
18. Djousse L, Gaziano JM. Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health Study. Am J Clin Nutr 2008; 87:964-969.
19. Mann Jl, Appleby PN, Key TJ, Thorogood M. Dietary determinants of ischaemic heart disease in health conscious individuals. Heart 1997; 78:450-455.
20. Shimakawa T, Sorlie P, Carpenter MA, et al. Dietary intake patterns and sociodemographic factors in the atherosclerosis risk in communities study. ARIC Study Investigators. Prev Med 1994; 23:769-780.
21. Pietinen P, Ascherio A, Korhonen P, et al. Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am J Epidemiol 1997; 145:876-887.
22. Esrey KL, Joseph L, Graver SA. Relationship between dietary intake and coronary heart disease mortality: lipid research clinics prevalence follow-up study. J Clin Epidemiol 1996; 49:211-216.
23. Posner BM, Cobb JL, Belanger AJ, et al. Dietary lipid predictors of coronary heart disease in men. The Framingham Study. Arch Intern Med 1991; 151:1181-1187.
24. Ginsberg HN, Karmally W, Siddiqui M, et al. Increases in dietary cholesterol are associated with modest increases in both LDL and HDL cholesterol in healthy young women. Arterioscler Thromb Vasc Biol 1995; 15:169-178.
25. Cesar TB, Oliveira MR, Mesquita CH, Maranhao RC. High cholesterol intake modifies chylomicron metabolism in normolipidemic young men. J Nutr 2006; 136:971-976.
26. Knopp RH, Retzlaff B, Fish B, et al. Effects of insulin resistance and obesity on lipoproteins and sensitivity to egg feeding. Arterioscler Thromb Vasc Biol 2003; 23:1437-1443.
27. Miettinen TA, Kesaniemi YA. Cholesterol absorption: regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels. Am J Clin Nutr 1989; 49:629-635.
28. Hodis HN, Crawford DW, Sevanian A. Cholesterol feeding increases plasma and aortic tissue cholesterol oxide levels in parallel: further evidence for the role of cholesterol oxidation in atherosclerosis. Atherosclerosis 1991; 89:117-126.
29. Rudel LL. Genetic factors influence the atherogenic response of lipoproteins to dietary fat and cholesterol in nonhuman primates. J Am Coll Nutr 1997; 16:306-312.
30. Faggiotto A, Ross R. Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque. Arteriosclerosis 1984; 4:341-356.
31. Hartvigsen K, Binder CJ, Hansen LF, et al. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol 2007; 27:878-885. This study demonstrated that addition of cholesterol to a regular chow diet results in extensive atherosclerosis in mice.
32. Lewis KE, Kirk EA, McDonald TO, et al. Increase in serum amyloid A evoked by dietary cholesterol is associated with increased atherosclerosis in mice. Circulation 2004; 110:540-545.
33. Cancello R, Tordjman J, Poitou C, et al. Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 2006; 55:1554-1561.
34. Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112:1796-1808.
35. Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112:1821-1830.
36. Cancello R, Henegar C, Viguerie N, et al. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 2005; 54:2277-2286.
37. Clement K, Viguerie N, Poitou C, et al. Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J 2004; 18:1657-1669.
38. Coenen KR, Gruen ML, Chait A, Hasty AH. Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue. Diabetes 2007; 56:564-573.
39. Subramanian S, Han CY, Chiba T, et al. Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 2008; 28:685-691. This study showed that addition of dietary cholesterol to a high-fat, high-carbohydrate diet worsens adipose tissue macrophage accumulation, systemic inflammation and atherosclerosis in mice.
40. Han KH, Tangirala RK, Green SR, Quehenberger O. Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1 -mediated chemotaxis in human monocytes. A regulatory role for plasma LDL Arterioscler Thromb Vasc Biol 1998; 18:1983-1991.
41. Rogers KA, Hoover RL, Castellot JJ Jr, et al. Dietary cholesterol-induce changes in macrophage characteristics. Relationship to atherosclerosis. Am J Pathol 1986; 125:284-291.
42. Fan JL, Yamada T, Tokunaga O, Watanabe T. Alterations in the functional characteristics of macrophages induced by hypercholesterolemia. Virchows Arch B Cell Pathol Incl Mol Pathol 1991; 61:19-27.
43. Han CY, Subramanian S, Chan CK, et al. Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes 2007; 56:2260-2273.
44. Czepluch FS, Bergler A, Waltenberger J. Hypercholesterolemia impairs monocyte function in CAD patients. J Intern Med 2007; 261:201 -204.
45. Liu Y, Hulten LM, Wiklund O. Macrophages isolated from human atherosclerotic plaques produce IL-8, and oxysterols may have a regulatory functio for IL-8 production. Arterioscler Thromb Vasc Biol 1997; 17:317-323.
46. Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovasculi disease. Circ Res 2005; 96:939-949.
47. Ohman MK, Shen Y, Obimba CI, et al. Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 2008; 117:798-805. This important study showed that visceral adipose tissue accelerates atherosclerosis in mice using fat pad transplantation.
48. Chait A, Han CY, Oram JF, Heinecke JW. Thematic review series: the immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease? J Lipid Res 2005; 46:389-403