Screen of whole blood responses to flagellin identifies TLR5 variation associated with outcome in melioidosis

Genes and Immunity

Volumn 15, Issue 2, 2014, Pages 63-71

  Chantratita, N ^a   Tandhavanant, S ^a   Myers, N D ^b   Chierakul, W ^a   Robertson, J D ^b   Mahavanakul, W ^c   Singhasivanon, P ^a   Emond, M J ^b   Peacock, S J ^a,d   West, T E ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Sappasitthiprasong Hospital   (Thailand)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Flagellin; Genetic variation; Innate immune response; Melioidosis; TLR5

Indexed keywords

FLAGELLIN; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLL LIKE RECEPTOR 5; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; ASIAN; BLOOD SAMPLING; CAUSE OF DEATH; CYTOKINE RESPONSE; ENZYME ACTIVATION; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE MAP; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; MALE; MELIOIDOSIS; MIDDLE AGED; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL;

BACTERIA (MICROORGANISMS); BURKHOLDERIA PSEUDOMALLEI; THAIS;

ADULT; BURKHOLDERIA PSEUDOMALLEI; CELL LINE; CYTOKINES; FEMALE; FLAGELLIN; GENOTYPE; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; LINKAGE DISEQUILIBRIUM; MALE; MELIOIDOSIS; NF-KAPPA B; POLYMORPHISM, SINGLE NUCLEOTIDE; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 5; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84895857235     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2013.60     Document Type: Article

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