Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 6, 2014, Pages 1565-1570

  Choi, Doo Li ^a   Jang, Sun Jeong ^a   Cho, Sehyeon ^a   Choi, Hye Eun ^a   Rim, Hong Kun ^a   Lee, Kyung Tae ^a   Lee, Jae Yeol ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Antagonist; Apoptosis; Caspases; Cell cycle arrest; Human lung adenocarcinoma (A549) cells; Pancreatic cancer (MiaPaCa2) cells; T type calcium channel

Indexed keywords

3,4 QUINAZOLINEDIOL DERIVATIVE; BK 10040; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; CASPASE 3; CASPASE 9; KYS 05090; LIPOCORTIN 5; MIBEFRADIL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CARCINOMA CELL; CELL CYCLE PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MTT ASSAY; PROTEIN CLEAVAGE;

ANTAGONIST; APOPTOSIS; CASPASES; CELL CYCLE ARREST; HUMAN LUNG ADENOCARCINOMA (A549) CELLS; PANCREATIC CANCER (MIAPACA2) CELLS; T-TYPE CALCIUM CHANNEL;

ADENOCARCINOMA; APOPTOSIS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; HUMANS; LUNG NEOPLASMS; PIPERAZINES; QUINAZOLINES;

EID: 84895834428     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.01.071     Document Type: Article

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