The human liver fatty acid binding protein t94a variant alters the structure, stability, and interaction with fibrates

Biochemistry

Volumn 52, Issue 51, 2013, Pages 9347-9357

  Martin, Gregory G ^a   McIntosh, Avery L ^a   Huang, Huan ^a   Gupta, Shipra ^b   Atshaves, Barbara P ^b   Landrock, Kerstin K ^c   Landrock, Danilo ^c   Kier, Ann B ^c   Schroeder, Friedhelm ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Michigan State University   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CYTOLOGY; FATTY ACIDS; PROTEINS;

ACTIVE METABOLITES; FATTY ACID-BINDING PROTEINS; FUNCTIONAL RESPONSE; HELICAL STRUCTURES; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PRIMARY HUMAN HEPATOCYTES; SECONDARY STRUCTURES; SINGLE NUCLEOTIDE POLYMORPHISMS;

LIGANDS;

FATTY ACID BINDING PROTEIN; FENOFIBRATE; FENOFIBRIC ACID; LIVER PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PHYTANIC ACID; PROTEIN VARIANT; ANTILIPEMIC AGENT; DRUG DERIVATIVE; FABP1 PROTEIN, HUMAN; FATTY ACID TRANSPORTER; FIBRIC ACID DERIVATIVE; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RECOMBINANT PROTEIN; SLC27A5 PROTEIN, HUMAN;

ARTICLE; BETA SHEET; BINDING AFFINITY; CELL CULTURE; HUMAN; LIGAND BINDING; LIVER; LIVER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; THERMOSTABILITY; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; HEAT; METABOLISM; MOUSE; RAT; AGONISTS; ANALOGS AND DERIVATIVES; DRUG EFFECTS;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CELLS, CULTURED; FATTY ACID TRANSPORT PROTEINS; FATTY ACID-BINDING PROTEINS; FENOFIBRATE; FIBRIC ACIDS; GENE EXPRESSION REGULATION; HOT TEMPERATURE; HUMANS; HYPOLIPIDEMIC AGENTS; LIGANDS; LIVER; MICE; PHYTANIC ACID; POLYMORPHISM, SINGLE NUCLEOTIDE; PPAR ALPHA; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; RATS; RECOMBINANT PROTEINS;

EID: 84895776004     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401014k     Document Type: Article

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