메뉴 건너뛰기




Volumn 9, Issue 4, 2002, Pages 312-322

Fibrates and coronary heart disease reduction in diabetes

Author keywords

[No Author keywords available]

Indexed keywords

BEZAFIBRATE; CERIVASTATIN; CLOFIBRATE; FIBRIC ACID DERIVATIVE; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN; INSULIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL;

EID: 0036705773     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-200208000-00004     Document Type: Review
Times cited : (12)

References (116)
  • 1
    • 0015240489 scopus 로고
    • Trial of clofibrate in the treatment of ischemic heart disease
    • Group of Physicians of the Newcastle upon Tyne Region. Trial of clofibrate in the treatment of ischemic heart disease. BMJ 1971, 4:767-775.
    • (1971) BMJ , vol.4 , pp. 767-775
  • 2
    • 0015240617 scopus 로고
    • Ischemic heart disease: A secondary prevention trial using clofibrate
    • Research Committee of the Scottish Society of Physicians. Ischemic heart disease: A secondary prevention trial using clofibrate. BMJ 1971;4:775-784.
    • (1971) BMJ , vol.4 , pp. 775-784
  • 3
    • 0016630250 scopus 로고
    • Clofibrate and niacin in coronary heart disease
    • Coronary Drug Project Research Group. Clofibrate and niacin in coronary heart disease. JAMA 1975;231:360-381.
    • (1975) JAMA , vol.231 , pp. 360-381
  • 4
    • 0018117095 scopus 로고
    • A co-operative trial in the primary prevention of ischemic heart disease using clofibrate
    • Committee of Principal Investigators. A co-operative trial in the primary prevention of ischemic heart disease using clofibrate. Br Heart J 1978;40:1069-1118.
    • (1978) Br Heart J , vol.40 , pp. 1069-1118
  • 5
    • 0023232216 scopus 로고
    • Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia
    • Frick MH, Elo O, Haapa K, et al.: Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. N Engl J Med 1987;317:1237-1245.
    • (1987) N Engl J Med , vol.317 , pp. 1237-1245
    • Frick, M.H.1    Elo, O.2    Haapa, K.3
  • 6
    • 0023910325 scopus 로고
    • Reduction of mortality in the Stockholm Ischemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid
    • Carlson LA, Rosenhamer G. Reduction of mortality in the Stockholm Ischemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid. Acta Med Scand 1988, 223:405-418.
    • (1988) Acta Med Scand , vol.223 , pp. 405-418
    • Carlson, L.A.1    Rosenhamer, G.2
  • 7
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol
    • Rubins HB, Robins SJ, Collins D, et al.: Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. N Engl J Med 1999, 341:410-418.
    • (1999) N Engl J Med , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3
  • 8
    • 0034604225 scopus 로고    scopus 로고
    • Secondary prevention by raising HDL-chotesterol and reducing triglycerides in patients with coronary artery disease. The Bezafibrate Infarction Prevention (BIP) Study
    • The BIP Study Group. Secondary prevention by raising HDL-chotesterol and reducing triglycerides in patients with coronary artery disease: The Bezafibrate Infarction Prevention (BIP) Study. Circulation 2000, 102:21-27. A large, placebo-controlled clinical trial that showed in contrast to VA-HIT that a fibrate did not reduce CHD events. However, the population recruited for BIP had fewer diabetics and an overall lower body weight (consistent with less insulin resistance) than in VA-HIT.
    • (2000) Circulation , vol.102 , pp. 21-27
  • 9
    • 0029982038 scopus 로고    scopus 로고
    • Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients
    • Ericsson C-G, Hamsten A, Nilsson J, et al.: Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients. Lancet 1996, 347:849-853.
    • (1996) Lancet , vol.347 , pp. 849-853
    • Ericsson, C.-G.1    Hamsten, A.2    Nilsson, J.3
  • 10
    • 0032506254 scopus 로고    scopus 로고
    • Associations between lipoproteins and the progression of coronary and vein-graft atherosclerosis in a controlled trial with gemfibrozil in men with low baseline levels of HDL cholesterol
    • Syvanne M, Nieminen MS, Frick MH, et al.: Associations between lipoproteins and the progression of coronary and vein-graft atherosclerosis in a controlled trial with gemfibrozil in men with low baseline levels of HDL cholesterol. Circulation 1998, 98:1993-1999.
    • (1998) Circulation , vol.98 , pp. 1993-1999
    • Syvanne, M.1    Nieminen, M.S.2    Frick, M.H.3
  • 11
    • 0035941990 scopus 로고    scopus 로고
    • Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: The Diabetes Atherosclerosis Intervention Study, a randomized study
    • Diabetes Atherosclerosis Intervention Study Investigators. Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomized study. Lancet 2001, 357:905-910. This angiographic trial with the acronym DAIS, thus far the only coronary intervention trial which has exclusively recruited subjects with diabetes, found a significant reduction in coronary artery narrowing with a fibrate therapy compared with placebo.
    • (2001) Lancet , vol.357 , pp. 905-910
  • 12
    • 0027192050 scopus 로고
    • Declining serum chotesterol levels among US adults.The National Health and Nutrition Examination Surveys
    • Johnson CL, Rifkind BM, Sempos CT, et al.: Declining serum chotesterol levels among US adults. The National Health and Nutrition Examination Surveys. JAMA 1993, 269:3002-3008.
    • (1993) JAMA , vol.269 , pp. 3002-3008
    • Johnson, C.L.1    Rifkind, B.M.2    Sempos, C.T.3
  • 13
    • 0026572204 scopus 로고
    • Lipoprotein cholesterol, apolipoprotein A-I and B and lipoprotein (a) abnormalities in men with premature coronary artery disease
    • Genest J Jr, McNamara JR, Ordovas JM, et al.: Lipoprotein cholesterol, apolipoprotein A-I and B and lipoprotein (a) abnormalities in men with premature coronary artery disease. J Am Coll Cardiol 1992, 19:792-802.
    • (1992) J Am Coll Cardiol , vol.19 , pp. 792-802
    • Genest J., Jr.1    McNamara, J.R.2    Ordovas, J.M.3
  • 14
    • 58149212612 scopus 로고
    • Distribution of lipids in 8,500 men with coronary artery disease
    • Rubins HB, Robins SJ, Collins D, et al.: Distribution of lipids in 8,500 men with coronary artery disease. Am J Cardiol 1995, 75:1196-1201.
    • (1995) Am J Cardiol , vol.75 , pp. 1196-1201
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3
  • 15
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
    • Sacks FM, Pfeffer MA, Moye LA, et al.: The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 1996, 335:1001-1009.
    • (1996) N Engl J Med , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3
  • 16
    • 0018751628 scopus 로고
    • Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations
    • Welborn TA, Wearne K. Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations. Diabetes Care 1979, 2:154-160.
    • (1979) Diabetes Care , vol.2 , pp. 154-160
    • Welborn, T.A.1    Wearne, K.2
  • 17
    • 0029862973 scopus 로고    scopus 로고
    • Hyperinsulinemia as an independent risk factor for ischemic heart disease
    • Despres J-P, Lamarche B, Mauriege P, et al.: Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996, 334:952-957.
    • (1996) N Engl J Med , vol.334 , pp. 952-957
    • Despres, J.-P.1    Lamarche, B.2    Mauriege, P.3
  • 18
    • 2542507751 scopus 로고    scopus 로고
    • Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men
    • Lempiainen P, Mykkanen L, Pyorala K, et al.: Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men. Circulation 1999, 100:123-128.
    • (1999) Circulation , vol.100 , pp. 123-128
    • Lempiainen, P.1    Mykkanen, L.2    Pyorala, K.3
  • 19
    • 0034709065 scopus 로고    scopus 로고
    • Hyperinsulinemia and the risk of cardiovascular death and acute coronary and cerebrovascular events in men. The Kuopio ischemic heart disease risk factor study
    • Lakka HM, Lakka TA, Tuomilehto J, et al.: Hyperinsulinemia and the risk of cardiovascular death and acute coronary and cerebrovascular events in men. The Kuopio ischemic heart disease risk factor study. Arch Intern Med 2000, 160:1160-1168.
    • (2000) Arch Intern Med , vol.160 , pp. 1160-1168
    • Lakka, H.M.1    Lakka, T.A.2    Tuomilehto, J.3
  • 20
    • 0035846550 scopus 로고    scopus 로고
    • Comparison of use of medications after acute myocardial infarction in the Veterans Health Administration and Medicare
    • Petersen LA, Normand ST, Leape LL, et al.: Comparison of use of medications after acute myocardial infarction in the Veterans Health Administration and Medicare. Circulation 2001, 104:2898-2904.
    • (2001) Circulation , vol.104 , pp. 2898-2904
    • Petersen, L.A.1    Normand, S.T.2    Leape, L.L.3
  • 21
    • 0023774485 scopus 로고
    • Mortality among diabetics in a national sample
    • Kleinman JC, Donahue RP, Harris MI, et al.: Mortality among diabetics in a national sample. Am J Epidemiol 1988, 128:389-401.
    • (1988) Am J Epidemiol , vol.128 , pp. 389-401
    • Kleinman, J.C.1    Donahue, R.P.2    Harris, M.I.3
  • 22
    • 0033553188 scopus 로고    scopus 로고
    • Diabetes and decline in heart disease mortality in US adults
    • Gu K, Cowie CC, Harris MI. Diabetes and decline in heart disease mortality in US adults. JAMA 1999, 281:1291-1297.
    • (1999) JAMA , vol.281 , pp. 1291-1297
    • Gu, K.1    Cowie, C.C.2    Harris, M.I.3
  • 23
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001, 285:2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 24
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998, 352:837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 25
    • 0035171455 scopus 로고    scopus 로고
    • Management of dyslipidemia in adults with diabetes
    • American Diabetes Association. Management of dyslipidemia in adults with diabetes. Diabetes Care 2001, 24 (suppl 1):S58-S61.
    • (2001) Diabetes Care , vol.24 , Issue.SUPPL. 1
  • 26
    • 0032816777 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
    • Fruchart JC, Duriez P, Staels B. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol 1999, 10:245-257.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 245-257
    • Fruchart, J.C.1    Duriez, P.2    Staels, B.3
  • 27
    • 0034993832 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: From transcriptional control to clinical practice
    • Pineda Torra I, Chinetti G, Dural C, et al.: Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice. Curr Opin Lipidol 2001, 12:245-254.
    • (2001) Curr Opin Lipidol , vol.12 , pp. 245-254
    • Pineda Torra, I.1    Chinetti, G.2    Dural, C.3
  • 28
    • 0028036723 scopus 로고
    • Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element
    • Vu-Dac N, Schoonjans K, Laine B, et al.: Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element. J Biol Chem 1994, 269:31012-31018.
    • (1994) J Biol Chem , vol.269 , pp. 31012-31018
    • Vu-Dac, N.1    Schoonjans, K.2    Laine, B.3
  • 29
    • 0029119082 scopus 로고
    • Fibrates increase human apolipoprotein A-II expression through activation of peroxisome proliferator-activated receptor
    • Vu-Dac N, Schoonjans K, Kosykh V, et al.: Fibrates increase human apolipoprotein A-II expression through activation of peroxisome proliferator-activated receptor. J Clin Invest 1995, 96:741-750.
    • (1995) J Clin Invest , vol.96 , pp. 741-750
    • Vu-Dac, N.1    Schoonjans, K.2    Kosykh, V.3
  • 30
    • 0010561183 scopus 로고
    • Fibrates and fatty acids induce lipoprotein lipase gene expression via the peroxisome proliferator activated receptors
    • Schoonjans K, Staels B, Deeb S, et al.: Fibrates and fatty acids induce lipoprotein lipase gene expression via the peroxisome proliferator activated receptors. Circulation 1995, 92/8 (Suppl 1):1-495.
    • (1995) Circulation , vol.92 , Issue.8 SUPPL. 1 , pp. 1-495
    • Schoonjans, K.1    Staels, B.2    Deeb, S.3
  • 31
    • 0035138625 scopus 로고    scopus 로고
    • PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
    • Chinetti G, Lestavel S, Bocher V, et al.: PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nature Med 2001, 7:53-58.
    • (2001) Nature Med , vol.7 , pp. 53-58
    • Chinetti, G.1    Lestavel, S.2    Bocher, V.3
  • 32
    • 0034705071 scopus 로고    scopus 로고
    • CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors
    • Chinetti G, Gbaguidi FG, Griglio S, et al.: CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors. Circulation 2000, 101:2411-2417.
    • (2000) Circulation , vol.101 , pp. 2411-2417
    • Chinetti, G.1    Gbaguidi, F.G.2    Griglio, S.3
  • 33
    • 0029922002 scopus 로고    scopus 로고
    • Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse
    • Chianale J, Vollrath V, Wielandt AM, et al.: Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse. Biochem J 1996, 314:781-786.
    • (1996) Biochem J , vol.314 , pp. 781-786
    • Chianale, J.1    Vollrath, V.2    Wielandt, A.M.3
  • 34
    • 0028817459 scopus 로고
    • Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase
    • Staels B, Vu-Doc N, Kosykh VA, et al.: Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. J Clin Invest 1995, 95:705-712.
    • (1995) J Clin Invest , vol.95 , pp. 705-712
    • Staels, B.1    Vu-Doc, N.2    Kosykh, V.A.3
  • 35
    • 0029610832 scopus 로고
    • Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: A potential physiologic basis for their mode of action
    • Haubenwallner S, Essenburg AD, Barnett BC, et al.: Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action. J Lipid Res 1995, 36:2541-2551.
    • (1995) J Lipid Res , vol.36 , pp. 2541-2551
    • Haubenwallner, S.1    Essenburg, A.D.2    Barnett, B.C.3
  • 36
    • 0035570381 scopus 로고    scopus 로고
    • Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase expression
    • Post SM, Duez H, Gervois PP, et al.: Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase expression. Arterioscler Thromb Vasc Biol 2001, 21:1840-1845.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1840-1845
    • Post, S.M.1    Duez, H.2    Gervois, P.P.3
  • 37
    • 0029793860 scopus 로고    scopus 로고
    • Gemfibrozil stimulates apolipoprotein A-I synthesis and secretion by stabilization of mRNA transcripts in human hepatoblastoma cell Pine (Hep G2)
    • Jin F-Y, Kamanna VS, Chuang M-Y, et al.: Gemfibrozil stimulates apolipoprotein A-I synthesis and secretion by stabilization of mRNA transcripts in human hepatoblastoma cell Pine (Hep G2). Arterioscler Thromb Vasc Biol 1996, 16:1052-1062.
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , pp. 1052-1062
    • Jin, F.-Y.1    Kamanna, V.S.2    Chuang, M.-Y.3
  • 38
    • 0020533327 scopus 로고
    • Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects
    • Heller F, Harvengt C. Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects. Eur J Clin Pharmacol 1983, 25:57-63.
    • (1983) Eur J Clin Pharmacol , vol.25 , pp. 57-63
    • Heller, F.1    Harvengt, C.2
  • 39
    • 0016686060 scopus 로고
    • Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat
    • Mjos OD, Faergeman O, Hamilton RL, et al.: Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat. J Clin Invest 1975, 56:603-615.
    • (1975) J Clin Invest , vol.56 , pp. 603-615
    • Mjos, O.D.1    Faergeman, O.2    Hamilton, R.L.3
  • 40
    • 0018750544 scopus 로고
    • Quantitation of the transfer of surface phospholipid of chylomicrons to the high density lipoprotein fraction during catabolism of chylomicrons in the rat
    • Redgrave TG, Small DM. Quantitation of the transfer of surface phospholipid of chylomicrons to the high density lipoprotein fraction during catabolism of chylomicrons in the rat. J Clin Invest 1979, 64:162-171.
    • (1979) J Clin Invest , vol.64 , pp. 162-171
    • Redgrave, T.G.1    Small, D.M.2
  • 41
    • 0028799756 scopus 로고
    • Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse
    • Oude Elferink RPJ, Ottenhoff R, van Wijland M, et al.: Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. J Clin Invest 1995, 95:31-38.
    • (1995) J Clin Invest , vol.95 , pp. 31-38
    • Oude Elferink, R.P.J.1    Ottenhoff, R.2    Van Wijland, M.3
  • 42
    • 0028998129 scopus 로고
    • Mode of action of peroxisome proliferators as hypolipidemic drugs, suppression of apolipoprotein C-III
    • Hertz R, Bishara-Shieban J. Mode of action of peroxisome proliferators as hypolipidemic drugs, suppression of apolipoprotein C-III. J Biol Chem 1995, 270:13470-13475.
    • (1995) J Biol Chem , vol.270 , pp. 13470-13475
    • Hertz, R.1    Bishara-Shieban, J.2
  • 43
    • 0025873036 scopus 로고
    • Low density lipoprotein density and composition in hypercholesterolemic men treated with HMG CoA reductase inhibitors and gemfibrozil
    • Tilly-Kiesi M, Tikkanen MJ. Low density lipoprotein density and composition in hypercholesterolemic men treated with HMG CoA reductase inhibitors and gemfibrozil. J Intern Med 1991, 229:427-434.
    • (1991) J Intern Med , vol.229 , pp. 427-434
    • Tilly-Kiesi, M.1    Tikkanen, M.J.2
  • 44
    • 0026458728 scopus 로고
    • Change in LDL particle size is associated with change in plasma triglyceride concentration
    • McNamara JR, Jenner JL, Li Z, et al.: Change in LDL particle size is associated with change in plasma triglyceride concentration. Arterioscler Thromb 1992, 12:1284-1290.
    • (1992) Arterioscler Thromb , vol.12 , pp. 1284-1290
    • McNamara, J.R.1    Jenner, J.L.2    Li, Z.3
  • 45
    • 0028125174 scopus 로고
    • Changes in composition and distribution of LDL subspecies in hypertriglyceridemic and hypercholesterolemic patients during gemfibrozil therapy
    • Yuan J, Tsai MY, Hunninghake DB. Changes in composition and distribution of LDL subspecies in hypertriglyceridemic and hypercholesterolemic patients during gemfibrozil therapy. Atherosclerosis. 1994, 110:1-11.
    • (1994) Atherosclerosis , vol.110 , pp. 1-11
    • Yuan, J.1    Tsai, M.Y.2    Hunninghake, D.B.3
  • 46
    • 0028905504 scopus 로고
    • Effect of gemfibrozil treatment in hypercholesterolemia on low density lipoprotein (LDL) subclass distribution and LDL-cell interaction
    • Franceschini G, Lovati MR, Manzoni C, et al.: Effect of gemfibrozil treatment in hypercholesterolemia on low density lipoprotein (LDL) subclass distribution and LDL-cell interaction. Atherosclerosis 1995, 114:61-71.
    • (1995) Atherosclerosis , vol.114 , pp. 61-71
    • Franceschini, G.1    Lovati, M.R.2    Manzoni, C.3
  • 47
    • 0032126208 scopus 로고    scopus 로고
    • Beneficial effect of gemfibrozil on the chemical composition and oxidative susceptibility of low density lipoprotein: A randomized, double-blind, placebo-controlled study
    • Yoshida H, Ishikawa T, Ayaori M, et al.: Beneficial effect of gemfibrozil on the chemical composition and oxidative susceptibility of low density lipoprotein: a randomized, double-blind, placebo-controlled study. Atherosclerosis 1998, 139:179-187.
    • (1998) Atherosclerosis , vol.139 , pp. 179-187
    • Yoshida, H.1    Ishikawa, T.2    Ayaori, M.3
  • 48
    • 0029143455 scopus 로고
    • Effects of different phenotypes of hyperlipoproteinemia and of treatment with fibric derivatives on the rates of cholesterol 7α-hydroxylation in humans
    • Bertolotti M, Concari M, Loria P, et al.: Effects of different phenotypes of hyperlipoproteinemia and of treatment with fibric derivatives on the rates of cholesterol 7α-hydroxylation in humans. Arterioscler Thromb Vasc Biol 1995, 15:1064-1069.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1064-1069
    • Bertolotti, M.1    Concari, M.2    Loria, P.3
  • 49
    • 0021988516 scopus 로고
    • Effect of gemfibrozil on biliary lipid metabolism in normolipemic subjects
    • Leiss O, von Bergmann K, Gnasso A, et al.: Effect of gemfibrozil on biliary lipid metabolism in normolipemic subjects. Metabolism 1985, 34:74-82.
    • (1985) Metabolism , vol.34 , pp. 74-82
    • Leiss, O.1    Von Bergmann, K.2    Gnasso, A.3
  • 50
    • 0030730810 scopus 로고    scopus 로고
    • Transient triglyceridemia decreases vascular reactivity in young healthy men without risk factors for coronary heart disease
    • Lundman P, Eriksson M, Schenck-Gustaffson K, et al.: Transient triglyceridemia decreases vascular reactivity in young healthy men without risk factors for coronary heart disease. Circulation 1997, 10:3266-3268.
    • (1997) Circulation , vol.10 , pp. 3266-3268
    • Lundman, P.1    Eriksson, M.2    Schenck-Gustaffson, K.3
  • 51
    • 17944401657 scopus 로고    scopus 로고
    • Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus
    • Evans M, Anderson RA, Graham J, et al.: Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus. Circulation 2000, 101:1773-1779.
    • (2000) Circulation , vol.101 , pp. 1773-1779
    • Evans, M.1    Anderson, R.A.2    Graham, J.3
  • 52
    • 0026505819 scopus 로고
    • Direct effects of gemfibrozil on the fibrinolytic system. Diminution of synthesis of plasminogen activator inhibitor type 1
    • Fujii S, Sobel BE. Direct effects of gemfibrozil on the fibrinolytic system. Diminution of synthesis of plasminogen activator inhibitor type 1. Circulation 1992, 85:1888-1893.
    • (1992) Circulation , vol.85 , pp. 1888-1893
    • Fujii, S.1    Sobel, B.E.2
  • 53
    • 0027983862 scopus 로고
    • The decrease of plasminogen activator inhibitor after normalization of triglycerides during treatment with fibrates
    • Keber I, Lavre J,Suc S, et al.: The decrease of plasminogen activator inhibitor after normalization of triglycerides during treatment with fibrates. Fibrinolysis 1994, 8 (Suppl 2) 57-59.
    • (1994) Fibrinolysis , vol.8 , Issue.SUPPL. 2 , pp. 57-59
    • Keber, I.1    Lavre, J.2    Suc, S.3
  • 54
    • 0026596304 scopus 로고
    • Gemfibrozil reduces plasma prothrombin fragment F1+2 concentration, a marker of coagulability, in patients with coronary heart disease
    • Wilkes HC, Meade TW, Barzegar S, et al.: Gemfibrozil reduces plasma prothrombin fragment F1+2 concentration, a marker of coagulability, in patients with coronary heart disease. Thromb Haemostas 1992, 67:503-506.
    • (1992) Thromb Haemostas , vol.67 , pp. 503-506
    • Wilkes, H.C.1    Meade, T.W.2    Barzegar, S.3
  • 55
    • 0026714027 scopus 로고
    • Bezafibrate lowers plasma lipids, fibrinogen and platelet aggregability in hypertriglyceridaemia
    • Pazzucconi F, Mannucci L, Mussoni L, et al.: Bezafibrate lowers plasma lipids, fibrinogen and platelet aggregability in hypertriglyceridaemia. Eur J Olin Pharmacol 1992, 43:219-223.
    • (1992) Eur J Olin Pharmacol , vol.43 , pp. 219-223
    • Pazzucconi, F.1    Mannucci, L.2    Mussoni, L.3
  • 56
    • 0035045169 scopus 로고    scopus 로고
    • HDL and the inflammatory response induced by LDL-derived oxidized phospholipids
    • Navab M, Berliner JA, Subbanagounder G, et al.: HDL and the inflammatory response induced by LDL-derived oxidized phospholipids. Arterioscler Thromb Vasc Biol 2001, 21:481-488.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 481-488
    • Navab, M.1    Berliner, J.A.2    Subbanagounder, G.3
  • 58
    • 0032169240 scopus 로고    scopus 로고
    • Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol values
    • Ridker PM, Rifai N, Pfeffer MA, et al.: Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol values. Circulation 1998, 98:839-844.
    • (1998) Circulation , vol.98 , pp. 839-844
    • Ridker, P.M.1    Rifai, N.2    Pfeffer, M.A.3
  • 59
    • 0034704893 scopus 로고    scopus 로고
    • C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    • Ridker PM, Hennekens OH, Buring JE, et al.: C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Meal 2000, 342:836-843.
    • (2000) N Engl J Meal , vol.342 , pp. 836-843
    • Ridker, P.M.1    Hennekens, O.H.2    Buring, J.E.3
  • 60
    • 0035799331 scopus 로고    scopus 로고
    • High sensitivity C-reactive protein. Potential adjunct for global risk assessment in the primary prevention of cardiovascular disease
    • Ridker PM. High sensitivity C-reactive protein. Potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation 2001, 103:1813-1818.
    • (2001) Circulation , vol.103 , pp. 1813-1818
    • Ridker, P.M.1
  • 61
    • 0033813079 scopus 로고    scopus 로고
    • C-reactive protein in the arterial intima. Role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis
    • Torzewski M, Rist C, Mortensen RF, et al.: C-reactive protein in the arterial intima. Role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis. Circulation 2000, 20:2094-2099.
    • (2000) Circulation , vol.20 , pp. 2094-2099
    • Torzewski, M.1    Rist, C.2    Mortensen, R.F.3
  • 62
    • 0032943709 scopus 로고    scopus 로고
    • C-reactive protein in healthy subjects: Associations with obesity, insulin resistance, and endothelial dysfunction. A potential role for cytokines originating from adipose tissue?
    • Yudkin JS, Stehouwer CDA, Emeis JJ, et al.: C-reactive protein in healthy subjects: Associations with obesity, insulin resistance, and endothelial dysfunction. A potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999, 19:972-978.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 972-978
    • Yudkin, J.S.1    Stehouwer, C.D.A.2    Emeis, J.J.3
  • 63
    • 0032790922 scopus 로고    scopus 로고
    • Associations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women
    • Hak AE, Coen DA, Stehouwer MLB, et al.: Associations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women. Arterioscler Thromb Vasc Biol 1999, 19:1986-1991.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 1986-1991
    • Hak, A.E.1    Coen, D.A.2    Stehouwer, M.L.B.3
  • 64
    • 0033660004 scopus 로고    scopus 로고
    • Association between C-reactive protein and features of the metabolic syndrome
    • Frohlich M, Imhof A, Berg G, et al.: Association between C-reactive protein and features of the metabolic syndrome. Diabetes Care 2000, 23:1835-1839.
    • (2000) Diabetes Care , vol.23 , pp. 1835-1839
    • Frohlich, M.1    Imhof, A.2    Berg, G.3
  • 65
    • 0035717514 scopus 로고    scopus 로고
    • Elevated C-reactive protein. Another component of the atherothrombotic profile of abdominal obesity
    • Lemieux I, Pascot A, Prud'homme D, et al.: Elevated C-reactive protein. Another component of the atherothrombotic profile of abdominal obesity. Arterioscler Thromb Vasc Biol 2001, 21:961-967. This study supports previous observations linking high plasma levels of CRP to obesity but additionally shows with computed tomography that CRP is strongly correlated with abdominal adipose tissue accumulation and plasma insulin levels but not with plasma lipoprotein profiles.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 961-967
    • Lemieux, I.1    Pascot, A.2    Prud'homme, D.3
  • 66
    • 0032565868 scopus 로고    scopus 로고
    • Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
    • Staels B, Koenig W, Habib A, et al.: Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature 1998, 393:790-793.
    • (1998) Nature , vol.393 , pp. 790-793
    • Staels, B.1    Koenig, W.2    Habib, A.3
  • 67
    • 0035895326 scopus 로고    scopus 로고
    • PPARα activators inhibit tissue factor expression and activity in human monocytes
    • Marx N, Mackman N, Schonbeck U, et al.: PPARα activators inhibit tissue factor expression and activity in human monocytes. Circulation 2001, 103:213-219.
    • (2001) Circulation , vol.103 , pp. 213-219
    • Marx, N.1    Mackman, N.2    Schonbeck, U.3
  • 68
    • 0035895313 scopus 로고    scopus 로고
    • PPARα agonists inhibit tissue factor expression in human monocytes and macrophages
    • Neve BP, Corseaux D, Chinetti G, et al.: PPARα agonists inhibit tissue factor expression in human monocytes and macrophages. Circulation 2001, 103:207-212.
    • (2001) Circulation , vol.103 , pp. 207-212
    • Neve, B.P.1    Corseaux, D.2    Chinetti, G.3
  • 69
    • 0035830376 scopus 로고    scopus 로고
    • Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selectin in an in vivo model of acute inflammation
    • Cockerill GW Huehns TY, Weerasinghe A, et al.: Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selectin in an in vivo model of acute inflammation. Circulation 2001, 103:108-112. Strong evidence fo yet another mechanism by which increased plasma levels of HDL may be cardicprotective, by a mechanism blunting the early vascular inflammatory response to cytokines.
    • (2001) Circulation , vol.103 , pp. 108-112
    • Cockerill, G.W.1    Huehns, T.Y.2    Weerasinghe, A.3
  • 70
    • 0031666749 scopus 로고    scopus 로고
    • Factors influencing the ability of HDL to inhibit expression of vascular cell adhesion molecule-1 in endothelial cells
    • Ashby DT, Rye KA, Clay MA, et al.: Factors influencing the ability of HDL to inhibit expression of vascular cell adhesion molecule-1 in endothelial cells. Arterioscler Thromb Vasc Biol 1998, 18:1450-1455.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 1450-1455
    • Ashby, D.T.1    Rye, K.A.2    Clay, M.A.3
  • 71
    • 0023221174 scopus 로고
    • Change in composition of high density lipoprotein during gemfibrozil therapy
    • Sorisky A, Odi TC, Simo IE, et al.: Change in composition of high density lipoprotein during gemfibrozil therapy. Atherosclerosis 1987, 67:181-189.
    • (1987) Atherosclerosis , vol.67 , pp. 181-189
    • Sorisky, A.1    Odi, T.C.2    Simo, I.E.3
  • 72
    • 0031906692 scopus 로고    scopus 로고
    • Production of small high-density lipoprotein particles after stimulation of in vivo lipolysis in hypertriglyceridemic individuals: Studies before and after triglyceride-lowering therapy
    • Lewis GF, Uflelman B, Lamarche B, et al.: Production of small high-density lipoprotein particles after stimulation of in vivo lipolysis in hypertriglyceridemic individuals: Studies before and after triglyceride-lowering therapy. Metabolism 1998, 47:234-242.
    • (1998) Metabolism , vol.47 , pp. 234-242
    • Lewis, G.F.1    Uflelman, B.2    Lamarche, B.3
  • 73
    • 0028766689 scopus 로고
    • Diabetic dyslipidemia
    • Betteridge DJ. Diabetic dyslipidemia. Am J Med 1994, 96 (suppl 6A):22S-31S.
    • (1994) Am J Med , vol.96 , Issue.SUPPL. 6A
    • Betteridge, D.J.1
  • 74
    • 0026701938 scopus 로고
    • Plasma lipid and lipoprotein disorders in IDDM
    • Dunn FL. Plasma lipid and lipoprotein disorders in IDDM. Diabetes 1992, 41 (suppl 2):102-106.
    • (1992) Diabetes , vol.41 , Issue.SUPPL. 2 , pp. 102-106
    • Dunn, F.L.1
  • 75
    • 0029845227 scopus 로고    scopus 로고
    • Lipids and lipoproteins as risk factors for coronary heart disease in non-insulin-dependent diabetes mellitus
    • Laakso M. Lipids and lipoproteins as risk factors for coronary heart disease in non-insulin-dependent diabetes mellitus. Ann Med 1996, 28:341-345.
    • (1996) Ann Med , vol.28 , pp. 341-345
    • Laakso, M.1
  • 76
    • 0025857172 scopus 로고
    • Hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities
    • Lewis GF, O'Meara NM, Soltys PA, et al.: Hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities. J Clin Endocrinol Metab 1991, 72:934-944.
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 934-944
    • Lewis, G.F.1    O'Meara, N.M.2    Soltys, P.A.3
  • 77
    • 0027397617 scopus 로고
    • Gemfibrozil reduces post-prandial lipernia in non-insulin-dependent diabetes mellitus
    • Syvanne M, Vuorinen-Markkola H, Hilden H, et al.: Gemfibrozil reduces post-prandial lipernia in non-insulin-dependent diabetes mellitus. Arterioscler Thromb 1993, 13:286-295.
    • (1993) Arterioscler Thromb , vol.13 , pp. 286-295
    • Syvanne, M.1    Vuorinen-Markkola, H.2    Hilden, H.3
  • 78
    • 0023544623 scopus 로고
    • Weight reduction increases adipose tissue lipoprotein lipase responsiveness in obese women
    • Eckel RH, Yost TJ. Weight reduction increases adipose tissue lipoprotein lipase responsiveness in obese women. J Clin Invest 1987, 80:992-997.
    • (1987) J Clin Invest , vol.80 , pp. 992-997
    • Eckel, R.H.1    Yost, T.J.2
  • 79
    • 0018364379 scopus 로고
    • Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia
    • Grundy SM, Mok HY, Zech L, et al.: Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia. J Clin Invest 1979, 63:1274-1283.
    • (1979) J Clin Invest , vol.63 , pp. 1274-1283
    • Grundy, S.M.1    Mok, H.Y.2    Zech, L.3
  • 80
    • 0021378892 scopus 로고
    • Hyperinsulinemia and in vivo very-low-density lipoprotein-triglyceride kinetics
    • Steiner G, Haynes FJ, Yoshino G, et al.: Hyperinsulinemia and in vivo very-low-density lipoprotein-triglyceride kinetics. Am J Physiol 1982, 246:E187-192.
    • (1982) Am J Physiol , vol.246
    • Steiner, G.1    Haynes, F.J.2    Yoshino, G.3
  • 81
    • 0031737794 scopus 로고    scopus 로고
    • LDL size distribution in relation to insulin sensitivity and lipoprotein pattern in young and healthy subjects
    • Ambrosch A, Muhlen I, Kopf D, et al.: LDL size distribution in relation to insulin sensitivity and lipoprotein pattern in young and healthy subjects. Diabetes Care 1998, 21:2077-2084.
    • (1998) Diabetes Care , vol.21 , pp. 2077-2084
    • Ambrosch, A.1    Muhlen, I.2    Kopf, D.3
  • 82
    • 0028886424 scopus 로고
    • A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects
    • Haffner SM, Mykkanen L, Robbins D, et al.: A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects. Diabetologia 1995, 38:1328-1336.
    • (1995) Diabetologia , vol.38 , pp. 1328-1336
    • Haffner, S.M.1    Mykkanen, L.2    Robbins, D.3
  • 83
    • 0034639491 scopus 로고    scopus 로고
    • Hyperinsulinemia, hyperglycemia, and impaired hemostasis. The Framingham Offspring Study
    • Meigs JB, Mittleman MA, Nathan DM, et al.: Hyperinsulinemia, hyperglycemia, and impaired hemostasis. The Framingham Offspring Study. JAMA 2000, 283:221-223.
    • (2000) JAMA , vol.283 , pp. 221-223
    • Meigs, J.B.1    Mittleman, M.A.2    Nathan, D.M.3
  • 84
    • 0034730098 scopus 로고    scopus 로고
    • Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease
    • Fichtlscherer S, Rosenberger G, Walter DH, et al.: Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 2000, 102:1000-1006.
    • (2000) Circulation , vol.102 , pp. 1000-1006
    • Fichtlscherer, S.1    Rosenberger, G.2    Walter, D.H.3
  • 85
    • 0029972540 scopus 로고    scopus 로고
    • Endothelium and inelastic arteries: An early marker of vascular dysfunction in non-insulin dependent diabetes
    • Goodfellow J, Ramsey MW, Luddington LA, et al.: Endothelium and inelastic arteries: an early marker of vascular dysfunction in non-insulin dependent diabetes. BMJ 1996, 312:744-745.
    • (1996) BMJ , vol.312 , pp. 744-745
    • Goodfellow, J.1    Ramsey, M.W.2    Luddington, L.A.3
  • 86
    • 0030782093 scopus 로고    scopus 로고
    • Low density lipoprotein size, high lipoprotein concentration and endothelial dysfunction in non-insulin diabetes
    • O'Brien SFO, Watts GF, Playford DA, et al.: Low density lipoprotein size, high lipoprotein concentration and endothelial dysfunction in non-insulin diabetes. Diabet Med 1997, 14:974-978.
    • (1997) Diabet Med , vol.14 , pp. 974-978
    • O'Brien, S.F.O.1    Watts, G.F.2    Playford, D.A.3
  • 87
    • 0037022206 scopus 로고    scopus 로고
    • Insulin causes endothelial dysfunction in humans. Sites and mechanisms
    • Arcaro G, Cretti A, Balzano S, et al.: Insulin causes endothelial dysfunction in humans. Sites and mechanisms. Circulation 2002, 105:576-582.
    • (2002) Circulation , vol.105 , pp. 576-582
    • Arcaro, G.1    Cretti, A.2    Balzano, S.3
  • 88
    • 0025936533 scopus 로고
    • Altering triglyceride concentrations changes insulin-glucose relationships in hypertriglyceridemic patients
    • Steiner G. Altering triglyceride concentrations changes insulin-glucose relationships in hypertriglyceridemic patients. Diabetes Care 1991, 14:1077-1081.
    • (1991) Diabetes Care , vol.14 , pp. 1077-1081
    • Steiner, G.1
  • 89
    • 0033964873 scopus 로고    scopus 로고
    • Effects of gemfibrozil on insulin sensitivity and on haemostatic variables in hypertriglyceridemic patients
    • Mussoni L, Mannucci L, Sirtori C, et al.: Effects of gemfibrozil on insulin sensitivity and on haemostatic variables in hypertriglyceridemic patients. Atherosclerosis 2000, 148:397-406.
    • (2000) Atherosclerosis , vol.148 , pp. 397-406
    • Mussoni, L.1    Mannucci, L.2    Sirtori, C.3
  • 90
    • 0033784645 scopus 로고    scopus 로고
    • Effects of comicronised fenofibrate on lipid and insulin sensitivity in patients with polymetabolic syndrome X
    • Idzior-Walus B, Sieradzki J, Rostworowski W, et al.: Effects of comicronised fenofibrate on lipid and insulin sensitivity in patients with polymetabolic syndrome X. Eur J Clin Invest 2000, 30:871-878.
    • (2000) Eur J Clin Invest , vol.30 , pp. 871-878
    • Idzior-Walus, B.1    Sieradzki, J.2    Rostworowski, W.3
  • 91
    • 0029945403 scopus 로고    scopus 로고
    • Gemfibrozil treatment of endogenous hypertriglyceridemia: Effect on insulin-mediated glucose disposal and plasma insulin concentrations
    • Jeng C-Y, Sheu WH, Fuh MM, et al.: Gemfibrozil treatment of endogenous hypertriglyceridemia: Effect on insulin-mediated glucose disposal and plasma insulin concentrations. J Clin Endocrinol Metab 1996, 81:2550-2553.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2550-2553
    • Jeng, C.-Y.1    Sheu, W.H.2    Fuh, M.M.3
  • 92
    • 0027455374 scopus 로고
    • Lowering of triglyceridesby gemfibrozil affects neither the glucoregulatory nor antilipolytic effect of insulin in Type 2 (non-insulin-dependent) diabetic patients
    • Vuorinen-Markkola H, Yki-Jarvinen H, Taskinen MR. Lowering of triglyceridesby gemfibrozil affects neither the glucoregulatory nor antilipolytic effect of insulin in Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993, 36:161-169.
    • (1993) Diabetologia , vol.36 , pp. 161-169
    • Vuorinen-Markkola, H.1    Yki-Jarvinen, H.2    Taskinen, M.R.3
  • 93
    • 0024520373 scopus 로고
    • Effects of bezafibrate on insulin secretion and peripheral insulin sensitivity in hyperlipidemic patients with and without diabetes
    • Riccardi G, Genovese S, Saldamacchia G, et al.: Effects of bezafibrate on insulin secretion and peripheral insulin sensitivity in hyperlipidemic patients with and without diabetes. Atherosclerosis 1989, 75:175-181.
    • (1989) Atherosclerosis , vol.75 , pp. 175-181
    • Riccardi, G.1    Genovese, S.2    Saldamacchia, G.3
  • 94
    • 0026677669 scopus 로고
    • Effects of bezafibrate on insulin sensitivity and glucose tolerance in subjects with combined hyperlipidemia
    • Karhapaa P, Uusitupa M, Voutilainen E, et al.: Effects of bezafibrate on insulin sensitivity and glucose tolerance in subjects with combined hyperlipidemia. Clin Pharmacol Ther 1992, 52:620-626.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 620-626
    • Karhapaa, P.1    Uusitupa, M.2    Voutilainen, E.3
  • 95
    • 0034595980 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor e activators improve insulin sensitivity and reduce adiposity
    • Guerre-Millo M, Gervois P, Raspe E, et al.: Peroxisome proliferator-activated receptor e activators improve insulin sensitivity and reduce adiposity. J Biol Chem 2000, 275:16638-16642.
    • (2000) J Biol Chem , vol.275 , pp. 16638-16642
    • Guerre-Millo, M.1    Gervois, P.2    Raspe, E.3
  • 96
    • 0034753632 scopus 로고    scopus 로고
    • Effects of fenofibrate on lipid parameters in obese rhesus monkeys
    • Winegar DA, Brown PJ, Wilkison WO, et al.: Effects of fenofibrate on lipid parameters in obese rhesus monkeys. J Lipid Res 2001, 42:1543-1551.
    • (2001) J Lipid Res , vol.42 , pp. 1543-1551
    • Winegar, D.A.1    Brown, P.J.2    Wilkison, W.O.3
  • 97
    • 0021350001 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA 1984, 251:351-364.
    • (1984) JAMA , vol.251 , pp. 351-364
  • 98
    • 0027987849 scopus 로고
    • Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994, 344:1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 99
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels
    • Downs JR, Clearfield M, Weis S, et al.: Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels. JAMA 1998, 279:1615-1622.
    • (1998) JAMA , vol.279 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weis, S.3
  • 100
    • 84948007950 scopus 로고
    • Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts
    • Blankenhorn DH, Nessim SA, Johnson RL, et al.: Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA 1987, 247:3233-3240.
    • (1987) JAMA , vol.247 , pp. 3233-3240
    • Blankenhorn, D.H.1    Nessim, S.A.2    Johnson, R.L.3
  • 101
    • 0026710526 scopus 로고
    • Coronary heart disease incidence in NIDDM patients in the Helsinki Heart Study
    • Koskinen P, Manttari M, Manninen V, et al.: Coronary heart disease incidence in NIDDM patients in the Helsinki Heart Study. Diabetes Care 1992, 15:820-825.
    • (1992) Diabetes Care , vol.15 , pp. 820-825
    • Koskinen, P.1    Manttari, M.2    Manninen, V.3
  • 102
    • 0026597808 scopus 로고
    • Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study
    • Manninen V, Tenkanen L, Koshinen P, et al.: Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Circulation 1992, 85:37-45.
    • (1992) Circulation , vol.85 , pp. 37-45
    • Manninen, V.1    Tenkanen, L.2    Koshinen, P.3
  • 103
    • 0029127208 scopus 로고
    • Some coronary risk factors related to the insulin resistance syndrome and treatment with gemfibrozil. Experience from the Helsinki Heart Study
    • Tenkanen L, Manttari M, Manninen V. Some coronary risk factors related to the insulin resistance syndrome and treatment with gemfibrozil. Experience from the Helsinki Heart Study. Circulation 1995, 92:1779-1785.
    • (1995) Circulation , vol.92 , pp. 1779-1785
    • Tenkanen, L.1    Manttari, M.2    Manninen, V.3
  • 104
    • 0032055822 scopus 로고    scopus 로고
    • Metabolic risk factors worsen continuously across the spectrum of nondiabetic glucose tolerance. The Framingham Offspring Study
    • Meigs JB, Nathan DM, Wilson PWF, et al.:. Metabolic risk factors worsen continuously across the spectrum of nondiabetic glucose tolerance. The Framingham Offspring Study. Ann Intern Med 1998, 128:524-533.
    • (1998) Ann Intern Med , vol.128 , pp. 524-533
    • Meigs, J.B.1    Nathan, D.M.2    Wilson, P.W.F.3
  • 105
    • 0000225920 scopus 로고    scopus 로고
    • Diabetes, hyperinsulinemia, and recurrent coronary events in the VA-High Density Lipoprotein Intervention Trial (VA-HIT)
    • Robins SJ, Collins D, Rubins HB. Diabetes, hyperinsulinemia, and recurrent coronary events in the VA-High Density Lipoprotein Intervention Trial (VA-HIT). Circulation 2000, 102:II-847. A prespecified analysis showing that CHD reduction with gemfibrozil was almost exclusively confined to a subgroup comprising almost half of the VA-HIT population with a low HDL-C who had either diabetes or hyperinsulinemia without diabetes.
    • (2000) Circulation , vol.102 , Issue.2 , pp. 847
    • Robins, S.J.1    Collins, D.2    Rubins, H.B.3
  • 106
    • 0035962077 scopus 로고    scopus 로고
    • Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: A randomized controlled trial
    • Robins SJ, Collins D, Wittes JT, et al.:. Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial. JAMA 2001, 285:1585-1591. Additional analysis from VA-HIT demonstrating that in a multivariate model adjusted for all major CHD risk factors, only the increase in HDL-C with gemfibrozil predicted a reduction in CHD events, but could explain only a relatively small amount of the benefit of therapy.
    • (2001) JAMA , vol.285 , pp. 1585-1591
    • Robins, S.J.1    Collins, D.2    Wittes, J.T.3
  • 107
    • 0012606201 scopus 로고    scopus 로고
    • Inflammation, gemfibrozil, and coronary heart disease: The Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT)
    • Cushman M, Collins, D, Tracy RP, et al.: Inflammation, gemfibrozil, and coronary heart disease: the Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT). Circulation 2002, 105:86. A substudy from VA-HIT, presented and published to-date only in abstract form but demonstrating that like statins, a fibrate can reduce plasma CRP levels and the reduction in CRP is significantly related to a reduction in CHD events.
    • (2002) Circulation , vol.105 , pp. 86
    • Cushman, M.1    Collins, D.2    Tracy, R.P.3
  • 108
    • 20244370323 scopus 로고
    • Rationale and design of a secondary prevention trial of increasing serum high-density lipoprotein cholesterol and reducing triglycerides in patients with clinically manifest atherosclerotic heart disease (the Bezafibrate Infarction Prevention Trial)
    • Goldbourt U, Behar S, Reicher-Reiss H, et al.: for the Bezafibrate Infarction Prevention Study Group. Rationale and design of a secondary prevention trial of increasing serum high-density lipoprotein cholesterol and reducing triglycerides in patients with clinically manifest atherosclerotic heart disease (the Bezafibrate Infarction Prevention Trial). Am J Cardiol 1993, 71:909-915.
    • (1993) Am J Cardiol , vol.71 , pp. 909-915
    • Goldbourt, U.1    Behar, S.2    Reicher-Reiss, H.3
  • 109
    • 0026445968 scopus 로고
    • WHO clofibrate/cholesterol trial: Clarifications
    • Heady JA, Morris JN, Oliver MF. WHO clofibrate/cholesterol trial: clarifications. Lancet 1992, 340:1405-1406.
    • (1992) Lancet , vol.340 , pp. 1405-1406
    • Heady, J.A.1    Morris, J.N.2    Oliver, M.F.3
  • 110
    • 0033611310 scopus 로고    scopus 로고
    • Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels
    • Haffner SM, Alexander CM, Cook TJ, et al.: Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels. Arch Intern Med 1999, 159:2661-2667.
    • (1999) Arch Intern Med , vol.159 , pp. 2661-2667
    • Haffner, S.M.1    Alexander, C.M.2    Cook, T.J.3
  • 111
    • 0032497945 scopus 로고    scopus 로고
    • Cardiovascular events and their reduction with pravastatin in diabetic and glucose-intolerant myocardial infarction survivors with average cholesterol levels. Subgroup analyses in the Cholesterol and Recurrent Events (CARE) Trial
    • Goldberg RB, Mellies MJ, Sacks FM, et al.: Cardiovascular events and their reduction with pravastatin in diabetic and glucose-intolerant myocardial infarction survivors with average cholesterol levels. Subgroup analyses in the Cholesterol and Recurrent Events (CARE) Trial. Circulation 1998, 98:2513-2519.
    • (1998) Circulation , vol.98 , pp. 2513-2519
    • Goldberg, R.B.1    Mellies, M.J.2    Sacks, F.M.3
  • 112
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • The Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998, 339:1349-1357.
    • (1998) N Engl J Med , vol.339 , pp. 1349-1357
  • 113
    • 0033135795 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: Early safety and efficacy experience
    • MRC/BHF Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience. Eur Heart J 1999, 20:725-741.
    • (1999) Eur Heart J , vol.20 , pp. 725-741
  • 114
    • 0034680352 scopus 로고    scopus 로고
    • Effect of pravastatin on coronary disease events in subgroups defined by coronary risk factors. The Prospective Pravastatin Pooling Project
    • Sacks FM, Tonkin AM, Shepherd J, et al.: Effect of pravastatin on coronary disease events in subgroups defined by coronary risk factors. The Prospective Pravastatin Pooling Project. Circulation 2000, 102:1893-1900.
    • (2000) Circulation , vol.102 , pp. 1893-1900
    • Sacks, F.M.1    Tonkin, A.M.2    Shepherd, J.3
  • 116
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults. Findings from the Third National Health and Nutrition Survey
    • Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults. Findings from the Third National Health and Nutrition Survey. JAMA 2002, 287:356-359.
    • (2002) JAMA , vol.287 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.