Hydrogen sulfide inhibits A2A adenosine receptor agonist induced β-amyloid production in SH-SY5Y neuroblastoma cells via a cAMP dependent pathway

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Nagpure, Bhushan Vijay ^a   Bian, Jin Song ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

2 HEXYNYLADENOSINE 59 N ETHYLCARBOXAMIDE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; ADENYLATE CYCLASE; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE 1; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; GAMMA SECRETASE; HYDROGEN SULFIDE; ISOBUTYLMETHYLXANTHINE; MESSENGER RNA; PRESENILIN; PRESENILIN 1; SODIUM HYDROGEN SULFIDE; UNCLASSIFIED DRUG; ADENOSINE A2 RECEPTOR AGONIST; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; ISOPROTEIN; PEPTIDE FRAGMENT; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; NEUROBLASTOMA CELL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS INHIBITION; CELL SURVIVAL; CHEMISTRY; GENE EXPRESSION REGULATION; METABOLISM; NEUROBLASTOMA; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADENOSINE A2 RECEPTOR AGONISTS; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIC AMP; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROGEN SULFIDE; NEUROBLASTOMA; PEPTIDE FRAGMENTS; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION;

EID: 84895728714     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088508     Document Type: Article

References (66)

1. Reitz C, Brayne C, Mayeux R (2011) Epidemiology of Alzheimer disease. Nat Rev Neurol 7: 137-152.
2. Castellani RJ, Rolston RK, Smith MA (2010) Alzheimer Disease. Disease-a-Month 56: 484-546.
3. Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298: 789-791.
4. Mattson MP (2004) Pathways towards and away from Alzheimer's disease. Nature 430: 631-639.
5. Selkoe DJ (1991) The molecular pathology of Alzheimer's disease. Neuron 6: 487-498.
6. Cummings JL, Vinters HV, Cole GM, Khachaturian ZS (1998) Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 51: S2-17; discussion S65-17.
7. de Mendonça A, Ribeiro JA (2001) Adenosine and synaptic plasticity. Drug Development Research 52: 283-290.
8. Ribeiro JA, Sebastião AM, de Mendonça A (2002) Adenosine receptors in the nervous system: pathophysiological implications. Progress in Neurobiology 68: 377-392.
9. Fredholm BB, Chen J-F, Cunha RA, Svenningsson P, Vaugeois J-M (2005) Adenosine and Brain Function. International Review of Neurobiology: Academic Press. pp. 191-270.
10. Cunha RA (2001) Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors. Neurochemistry International 38: 107-125.
11. Abbracchio MP, Cattabeni F (1999) Brain adenosine receptors as targets for therapeutic intervention in neurodegenerative diseases. Ann N Y Acad Sci 890: 79-92. (Pubitemid 30040367)
12. Albasanz JL, Perez S, Barrachina M, Ferrer I, Martin M (2008) Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease. Brain Pathol 18: 211-219. (Pubitemid 351430397)
13. Fuxe K, Marcellino D, Borroto-Escuela DO, Guescini M, Fernandez-Duenas V, et al. (2010) Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS Neurosci Ther 16: e18-42.
14. Blum D, Hourez R, Galas MC, Popoli P, Schiffmann SN (2003) Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics. Lancet Neurol 2: 366-374. (Pubitemid 38352564)
15. Boison D (2006) Adenosine kinase, epilepsy and stroke: mechanisms and therapies. Trends in Pharmacological Sciences 27: 652-658.
16. Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 23: 134-147.
17. Christen Y (2000) Oxidative stress and Alzheimer disease. Am J Clin Nutr 71: 621S-629S.
18. Park J, Gupta R (2013) Adenosine Metabolism, Adenosine Kinase, and Evolution. In: Masino S, Boison D, editors. Adenosine: Springer New York. pp. 23-54.
19. Headrick JP, Willis RJ (1990) Adenosine formation and energy metabolism: a 31P-NMR study in isolated rat heart. Am J Physiol 258: H617-624. (Pubitemid 20103189)
20. Ballard FJ (1970) Adenine nucleotides and the adenylate kinase equilibrium in livers of foetal and newborn rats. Biochem J 117: 231-235.
21. Decking UK, Schlieper G, Kroll K, Schrader J (1997) Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release. Circ Res 81: 154-164. (Pubitemid 27342482)
22. Bhatia M, Wong FL, Fu D, Lau HY, Moochhala SM, et al. (2005) Role of hydrogen sulfide in acute pancreatitis and associated lung injury. FASEB J 19: 623-625. (Pubitemid 40471265)
23. Jeong SO, Pae HO, Oh GS, Jeong GS, Lee BS, et al. (2006) Hydrogen sulfide potentiates interleukin-1beta-induced nitric oxide production via enhancement of extracellular signal-regulated kinase activation in rat vascular smooth muscle cells. Biochem Biophys Res Commun 345: 938-944.
24. Lee SW, Hu YS, Hu LF, Lu Q, Dawe GS, et al. (2006) Hydrogen sulphide regulates calcium homeostasis in microglial cells. Glia 54: 116-124. (Pubitemid 44078133)
25. Yong QC, Choo CH, Tan BH, Low CM, Bian JS (2010) Effect of hydrogen sulfide on intracellular calcium homeostasis in neuronal cells. Neurochem Int 56: 508-515.
26. Nagai Y, Tsugane M, Oka J, Kimura H (2004) Hydrogen sulfide induces calcium waves in astrocytes. FASEB J 18: 557-559.
27. Yamada K, Inagaki N (2005) Neuroprotection by KATP channels. Journal of Molecular and Cellular Cardiology 38: 945-949.
28. Tan BH, Wong PTH, Bian J-S (2010) Hydrogen sulfide: A novel signaling molecule in the central nervous system. Neurochemistry International 56: 3-10.
29. Hu LF, Lu M, Hon Wong PT, Bian JS (2011) Hydrogen sulfide: neurophysiology and neuropathology. Antioxid Redox Signal 15: 405-419.
30. Qu K, Lee SW, Bian JS, Low CM, Wong PT (2008) Hydrogen sulfide: neurochemistry and neurobiology. Neurochem Int 52: 155-165. (Pubitemid 350235691)
31. Abe K, Kimura H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16: 1066-1071. (Pubitemid 26140863)
32. Li L, Rose P, Moore PK (2011) Hydrogen sulfide and cell signaling. Annu Rev Pharmacol Toxicol 51: 169-187.
33. Hu LF, Lu M, Tiong CX, Dawe GS, Hu G, et al. (2010) Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models. Aging Cell 9: 135-146.
34. Hu L-F, Wong PTH, Moore PK, Bian J-S (2007) Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia. Journal of Neurochemistry 100: 1121-1128. (Pubitemid 46213934)
35. Lu M, Hu LF, Hu G, Bian JS (2008) Hydrogen sulfide protects astrocytes against H(2)O(2)-induced neural injury via enhancing glutamate uptake. Free Radic Biol Med 45: 1705-1713.
36. Reiffenstein RJ, Hulbert WC, Roth SH (1992) TOXICOLOGY OF HYDROGEN-SULFIDE. Annual Review of Pharmacology and Toxicology 32: 109-134.
37. Mackay K, Mochly-Rosen D (2001) Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C. Cardiovasc Res 50: 65-74. (Pubitemid 32244386)
38. Pan TT, Neo KL, Hu LF, Yong QC, Bian JS (2008) H2S preconditioning- induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes. Am J Physiol Cell Physiol 294: C169-177.
39. Yong QC, Pan T-T, Hu L-F, Bian J-S (2008) Negative regulation of badrenergic function by hydrogen sulphide in the rat hearts. Journal of Molecular and Cellular Cardiology 44: 701-710.
40. Farmery MR, Tjernberg LO, Pursglove SE, Bergman A, Winblad B, et al. (2003) Partial purification and characterization of gamma-secretase from post-mortem human brain. J Biol Chem 278: 24277-24284. (Pubitemid 37548577)
41. Kolachala V, Asamoah V, Wang L, Srinivasan S, Merlin D, et al. (2005) Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase. J Biol Chem 280: 4048-4057. (Pubitemid 40288568)
42. Satoh J, Kuroda Y (1999) Constitutive and cytokine-regulated expression of presenilin-1 and presenilin-2 genes in human neural cell lines. Neuropathol Appl Neurobiol 25: 492-503. (Pubitemid 30045423)
43. Canals M, Angulo E, Casado V, Canela EI, Mallol J, et al. (2005) Molecular mechanisms involved in the adenosine A and A receptor-induced neuronal differentiation in neuroblastoma cells and striatal primary cultures. J Neurochem 92: 337-348. (Pubitemid 40194024)
44. Tomita S, Kirino Y, Suzuki T (1998) A Basic Amino Acid in the Cytoplasmic Domain of Alzheimer's b-Amyloid Precursor Protein (APP) Is Essential for Cleavage of APP at the a-Site. Journal of Biological Chemistry 273: 19304-19310. (Pubitemid 28366331)
45. Nordstedt C, Gandy SE, Alafuzoff I, Caporaso GL, Iverfeldt K, et al. (1991) Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment. Proc Natl Acad Sci U S A 88: 8910-8914. (Pubitemid 21915539)
46. Cunha RA (2005) Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade. Purinergic Signal 1: 111-134.
47. Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, et al. (2006) Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production. Neuroscience 142: 941-952. (Pubitemid 44740473)
48. Takahashi RN, Pamplona FA, Prediger RDS (2008) Adenosine receptor antagonists for cognitive dysfunction: A review of animal studies. Frontiers in Bioscience 13: 2614-2632. (Pubitemid 351599708)
49. Dall'lgna OP, Porciúncula LO, Souza DO, Cunha RA, Lara DR (2003) Neuroprotection by caffeine and adenosine A2A receptor blockade of b-amyloid neurotoxicity. British Journal of Pharmacology 138: 1207-1209. (Pubitemid 36543116)
50. Canas PM, Porciuncula LO, Cunha GM, Silva CG, Machado NJ, et al. (2009) Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway. J Neurosci 29: 14741-14751.
51. Stone TW (2002) Purines and neuroprotection. Adv Exp Med Biol 513: 249-280.
52. Klein AM, Kowall NW, Ferrante RJ (1999) Neurotoxicity and oxidative damage of beta amyloid 1-42 versus beta amyloid 1-40 in the mouse cerebral cortex. Ann N Y Acad Sci 893: 314-320. (Pubitemid 30038095)
53. Lee RK, Araki W, Wurtman RJ (1997) Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation. Proc Natl Acad Sci U S A 94: 5422-5426. (Pubitemid 27214799)
54. Kumar A, La Rosa FG, Hovland AR, Cole WC, Edwards-Prasad J, et al. (1999) Adenosine 39,59-cyclic monophosphate increases processing of amyloid precursor protein (APP) to beta-amyloid in neuroblastoma cells without changing APP levels or expression of APP mRNA. Neurochem Res 24: 1209-1215. (Pubitemid 29420266)
55. Su Y, Ryder J, Ni B (2003) Inhibition of Abeta production and APP maturation by a specific PKA inhibitor. FEBS Lett 546: 407-410. (Pubitemid 36782448)
56. Lu M, Liu Y-H, Ho CY, Tiong CX, Bian J-S (2012) Hydrogen sulfide regulates cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cells. American Journal of Physiology - Cell Physiology 302: C59-C66.
57. Lim JJ, Liu Y-H, Khin ESW, Bian J-S (2008) Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells. American Journal of Physiology - Cell Physiology 295: C1261-C1270. (Pubitemid 352790339)
58. Kimura H (2000) Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor. Biochem Biophys Res Commun 267: 129-133.
59. Defer N, Best-Belpomme M, Hanoune J (2000) Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase. American Journal of Physiology - Renal Physiology 279: F400-F416.
60. Yang HY, Wu ZY, Wood M, Whiteman M, Bian JS (2013) Hydrogen Sulfide Attenuates Opioid Dependence by Suppression of Adenylate Cyclase/cAMP Pathway. Antioxid Redox Signal.
61. Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, et al. (1997) Enhanced Production and Oligomerization of the 42-residue Amyloid b-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins. Journal of Biological Chemistry 272: 7977-7982. (Pubitemid 27137361)
62. Haass C, Lemere CA, Capell A, Citron M, Seubert P, et al. (1995) The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med 1: 1291-1296.
63. Chen Y, Zhao J, Du J, Xu G, Tang C, et al. (2012) Hydrogen sulfide regulates cardiac sarcoplasmic reticulum Ca2 + uptake via KATP channel and PI3K/Akt pathway. Life Sciences 91: 271-278.
64. Zhang H, Gao Y, Zhao F, Dai Z, Meng T, et al. (2011) Hydrogen sulfide reduces mRNA and protein levels of beta-site amyloid precursor protein cleaving enzyme 1 in PC12 cells. Neurochem Int 58: 169-175.
65. De Strooper B (2003) Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron 38: 9-12.
66. St George-Hyslop PH (2000) Molecular genetics of Alzheimer's disease. Biological psychiatry 47: 183-199.