Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through ε protein kinase C

Cardiovascular Research

Volumn 50, Issue 1, 2001, Pages 65-74

  Mackay, Katrina ^a   Mochly Rosen, Daria ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chronotropic agents; Ischaemia; Preconditioning; Signal transduction

Indexed keywords

ARACHIDONIC ACID; CHELERYTHRINE; ICOSAPENTAENOIC ACID; ISOENZYME; LACTATE DEHYDROGENASE; OLEIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CELL FRACTIONATION; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; HEART CONTRACTION; HEART MUSCLE ISCHEMIA; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARACHIDONIC ACID; CELL CULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; TRANSLOCATION, GENETIC;

EID: 0035088123     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(00)00322-9     Document Type: Article

References (60)

1. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
2. Ischemic preconditioning reduces infarct size in swine myocardium
3. Ischemic preconditioning protects against infarction in rat heart
4. Preconditioning causes improved wall motion as well as smaller infarcts after transient coronary occlusion in rabbits
5. Ischaemic preconditioning reduces troponin T release in patients undergoing coronary artery bypass surgery
6. Preconditioning protects ischemic rabbit heart by protein kinase C activation
7. Cardioprotection in an in vitro model of hypoxic preconditioning
8. A selective ε-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death
9. Protein kinase C. Its role in ischemic preconditioning in the rat
10. Protection of the myocardium by ischemic preconditioning: Mechanisms and therapeutic implications
11. Ischemic preconditioning induces selective translocation of protein kinase C isoforms ε and η in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity
12. Sustained in vivo cardiac protection by a rationally designed peptide that causes ε protein kinase C translocation
13. The expression of constitutively active isotypes of protein kinase C to investigate preconditioning
14. 2+-dependent protein kinase
15. 2+
16. Isolation and characterization of the ε subspecies of protein kinase C from rat brain
17. Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C
18. Activation of mitogen-activated protein kinase by arachidonic acid in rat liver epithelial WB cells by a protein kinase C-dependent mechanism
19. Arachidonic acid stimulates protein kinase C-epsilon redistribution in heart cells
20. Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for a cell-type specific activation of mitogen-activated protein kinases
21. Arachidonic acid-dependent phosphorylation of troponin I and myosin light chain 2 in cardiac myocytes
22. Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids
23. Reduced arachidonate metabolism in ATP-depleted myocardial cells occurs early in cell injury
24. Role of lipoxygenase metabolites in ischemic preconditioning
25. Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischemic preconditioning of rat heart
26. Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol
27. An inhibitor of p38 mitogen-activated protein kinase protects neonatal rat cardiac myoyctes from ischemia
28. Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat
29. The third helix of the Antennapedia homeodomain translocates through biological membranes
30. Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse
31. 2+, phospholipid-dependent protein kinase associated with plasma membrane
32. Localization of protein kinase C isozymes in cardiac myocytes
33. Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the ε isozyme
34. Protein kinase C isoform diversity in the heart
35. Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes
36. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function
37. An improved permeabilization protocol for introduction of peptides into cardiac myocytes: Application to protein kinase C
38. C2 region-derived peptides inhibit translocation and function of β protein kinase C in vivo
39. Chelerythrine is a potent and specific inhibitor of protein kinase C
40. Peptide modulators of protein-protein interactions in intracellular signaling
41. Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion
42. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs
43. + channels. Possible mechanism of cardioprotection
44. + channels by protein kinase C
45. ATP channel
46. Angiotensin II stimulates the release of phospholipid-derived second messengers through multiple receptor subtypes in heart cells
47. Hormone selective lipase activation in the isolated rabbit heart
48. Endothelin stimulates degradation of phospholipids in isolated rat hearts
49. Pinacidil pretreatment extends ischemia tolerance of neonatal rabbit hearts
50. Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes
51. Do adult rat ventricular myocytes express protein kinase C-alpha?
52. Protein kinase C isoenzymes in rat and human cardiovascular tissues
53. Expression of PKC isoforms during cardiac ventricular development
54. Use of a PCR-base method to characterize protein kinase C isoform expression in cardiac cells
55. PKC-lambda is the atypical protein kinase isoform expressed by immature ventricle
56. Dietary fats and cardiac arrhythmias in primates
57. The cardiac antiarrhythmic effects of polyunsaturated fatty acid
58. Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes
59. 2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes
60. + channels by directly binding to the channel proteins