메뉴 건너뛰기




Volumn 9, Issue 2, 2014, Pages

Modeling damage complexity-dependent non-homologous end-joining repair pathway

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAK FILLING MODEL; CHROMOSOME ABERRATION; CONTROLLED STUDY; DIFFUSION; DNA DAMAGE; DNA END JOINING REPAIR; FLUORESCENCE; HUMAN; HUMAN CELL; KINETICS; LINEAR ENERGY TRANSFER; MAMMAL CELL; MATHEMATICAL MODEL; MATHEMATICAL PARAMETERS; PREDICTION; PROBABILITY; RADIATION; SIMULATION; SYNAPSIS FORMATION MODEL;

EID: 84895540434     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0085816     Document Type: Article
Times cited : (28)

References (57)
  • 1
    • 84870587195 scopus 로고    scopus 로고
    • The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage
    • Reynolds P, Anderson JA, Harper JV, Hill MA, Botchway SW, et al. (2012) The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage. Nucleic Acids Res 40(21): 10821-10831.
    • (2012) Nucleic Acids Res , vol.40 , Issue.21 , pp. 10821-10831
    • Reynolds, P.1    Anderson, J.A.2    Harper, J.V.3    Hill, M.A.4    Botchway, S.W.5
  • 3
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • DOI 10.1093/nar/gkl840
    • Wang M, Wu W, Wu W, Rosidi B, Zhang L, et al. (2006) PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res 34(21): 6170-6182. (Pubitemid 44942738)
    • (2006) Nucleic Acids Research , vol.34 , Issue.21 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Wu, W.3    Rosidi, B.4    Zhang, L.5    Wang, H.6    Iliakis, G.7
  • 4
    • 0042839614 scopus 로고    scopus 로고
    • Mechanism and regulation of human non-homologous DNA end-joining
    • DOI 10.1038/nrm1202
    • Lieber MR, Ma Y, Pannicke U, Schwarz K (2003) Mechanism and regulation of human non-homologous DNA end-joining. Nature reviews. Mol Cell Biol 4(9): 712-720. (Pubitemid 37082186)
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.9 , pp. 712-720
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 5
    • 59849089955 scopus 로고    scopus 로고
    • Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    • Mahaney BL, Meek K, Lees-Miller SP (2009) Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J 417(3): 639-650.
    • (2009) Biochem J , vol.417 , Issue.3 , pp. 639-650
    • Mahaney, B.L.1    Meek, K.2    Lees-Miller, S.P.3
  • 6
    • 3242875642 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase: The director at the end
    • DOI 10.1111/j.0105-2896.2004.00162.x
    • Meek K, Gupta S, Ramsden DA, Lees-Miller SP (2004) The DNA-dependent protein kinase: the director at the end. Immun Rev 200: 132-141. (Pubitemid 38998198)
    • (2004) Immunological Reviews , vol.200 , pp. 132-141
    • Meek, K.1    Gupta, S.2    Ramsden, D.A.3    Lees-Miller, S.P.4
  • 7
    • 45749124305 scopus 로고    scopus 로고
    • Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway
    • Yano K, Chen DJ (2008) Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway. Cell Cycle 7(10): 1321-1325. (Pubitemid 351872567)
    • (2008) Cell Cycle , vol.7 , Issue.10 , pp. 1321-1325
    • Yano, K.-I.1    Chen, D.J.2
  • 9
    • 74049134920 scopus 로고    scopus 로고
    • Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex
    • Hammel M, Mahaney BL, Cai B, Ye R, et al. (2010) Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem 285(2): 1414-1423.
    • (2010) J Biol Chem , vol.285 , Issue.2 , pp. 1414-1423
    • Hammel, M.1    Mahaney, B.L.2    Cai, B.3    Ye, R.4
  • 10
    • 84862777942 scopus 로고    scopus 로고
    • Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination
    • Shao Z, Davis AJ, Fattah KR, So S, Sun J et al. (2012) Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination. DNA Repair 11(3): 310-316.
    • (2012) DNA Repair , vol.11 , Issue.3 , pp. 310-316
    • Shao, Z.1    Davis, A.J.2    Fattah, K.R.3    So, S.4    Sun, J.5
  • 14
    • 1642556817 scopus 로고    scopus 로고
    • A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity
    • DOI 10.1158/0008-5472.CAN-03-2384
    • Kuhne M, Riballo E, Rief N, Rothkamm K, Jeggo PA, et al. (2004) A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res 64(2): 500-508. (Pubitemid 38120888)
    • (2004) Cancer Research , vol.64 , Issue.2 , pp. 500-508
    • Kuhne, M.1    Riballo, E.2    Rief, N.3    Rothkamm, K.4    Jeggo, P.A.5    Lobrich, M.6
  • 15
    • 20644471358 scopus 로고    scopus 로고
    • Harmonising the response to DSBs: A new string in the ATM bow
    • DOI 10.1016/j.dnarep.2004.12.008, PII S1568786404003519
    • Lobrich M, Jeggo PA (2005) Harmonising the response to DSBs: a new string in the ATM bow. DNA Repair 4(7): 749-759. (Pubitemid 40835847)
    • (2005) DNA Repair , vol.4 , Issue.7 , pp. 749-759
    • Lobrich, M.1    Jeggo, P.A.2
  • 16
    • 46649102827 scopus 로고    scopus 로고
    • Interplay of two major repair pathways in the processing of complex double-strand DNA breaks
    • Dobbs TA, Palmer P, Manizou Z, Lomax ME, O'Neill P (2008) Interplay of two major repair pathways in the processing of complex double-strand DNA breaks. DNA Repair 7(8): 1372-1383.
    • (2008) DNA Repair , vol.7 , Issue.8 , pp. 1372-1383
    • Dobbs, T.A.1    Palmer, P.2    Manizou, Z.3    Lomax, M.E.4    O'Neill, P.5
  • 17
    • 23044477801 scopus 로고    scopus 로고
    • Characterization of complex apurinic/apyrimidinic-site clustering associated with an authentic site-specific radiation-induced DNA double-strand break
    • DOI 10.1073/pnas.0503975102
    • Datta K, Neumann RD, Winters TA (2005) Characterization of complex apurinic/apyrimidinic-site clustering associated with an authentic site-specific radiation-induced DNA double-strand break. Proc Nat Acad Sci U S A 102(30): 10569-10574. (Pubitemid 41061595)
    • (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , Issue.30 , pp. 10569-10574
    • Datta, K.1    Neumann, R.D.2    Winters, T.A.3
  • 18
    • 0025739820 scopus 로고
    • Kinetics of DNA double-strand break repair throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells
    • Metzger L, Iliakis G (1991) Kinetics of DNA double-strand break repair throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells. Int J Radiat Biol 59(6): 1325-1339.
    • (1991) Int J Radiat Biol , vol.59 , Issue.6 , pp. 1325-1339
    • Metzger, L.1    Iliakis, G.2
  • 19
    • 2542637919 scopus 로고    scopus 로고
    • Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation
    • DOI 10.1093/nar/gkh306
    • Gulston M, de Lara C, Jenner T, Davis E, O'Neill P (2004), Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. Nucleic Acids Res 32(4): 1602-1609. (Pubitemid 38854757)
    • (2004) Nucleic Acids Research , vol.32 , Issue.4 , pp. 1602-1609
    • Gulston, M.1    De Lara, C.2    Jenner, T.3    Davis, E.4    O'Neill, P.5
  • 20
    • 42249098075 scopus 로고    scopus 로고
    • The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation
    • Wang H, Wang X, Zhang P, Wang Y (2008) The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation. DNA Repair 7(5): 725-733.
    • (2008) DNA Repair , vol.7 , Issue.5 , pp. 725-733
    • Wang, H.1    Wang, X.2    Zhang, P.3    Wang, Y.4
  • 21
    • 84866434922 scopus 로고    scopus 로고
    • A stochastic model of DNA fragments rejoining
    • Li Y, Wang Y, Qian H, Cucinotta FA (2012) A stochastic model of DNA fragments rejoining. PloS One 7(9): e44293.
    • (2012) PloS One , vol.7 , Issue.9
    • Li, Y.1    Wang, Y.2    Qian, H.3    Cucinotta, F.A.4
  • 22
    • 84861604997 scopus 로고    scopus 로고
    • Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy
    • Lorat Y, Schanz S, Schuler K, Wennemuth G, Rube C, et al. (2012) Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy. PloS One 7(5): e38165.
    • (2012) PloS One , vol.7 , Issue.5
    • Lorat, Y.1    Schanz, S.2    Schuler, K.3    Wennemuth, G.4    Rube, C.5
  • 23
    • 79961207835 scopus 로고    scopus 로고
    • DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
    • Jakob B, Splinter J, Conrad S, Voss KO, Zink D, et al. (2011) DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin. Nucleic Acids Res 39(15): 6489-6499.
    • (2011) Nucleic Acids Res , vol.39 , Issue.15 , pp. 6489-6499
    • Jakob, B.1    Splinter, J.2    Conrad, S.3    Voss, K.O.4    Zink, D.5
  • 24
    • 79952314830 scopus 로고    scopus 로고
    • Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair
    • Chiolo I, Minoda A, Comenares SU, Polyzos A, Costes SV, et al. (2011) Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell 144(5): 732-744.
    • (2011) Cell , vol.144 , Issue.5 , pp. 732-744
    • Chiolo, I.1    Minoda, A.2    Comenares, S.U.3    Polyzos, A.4    Costes, S.V.5
  • 25
    • 79957686784 scopus 로고    scopus 로고
    • Unrepaired clustered DNA lesions induce chromosome breakage in human cells
    • Asaithamby A, Hu B, and Chen DJ (2011) Unrepaired clustered DNA lesions induce chromosome breakage in human cells. Proc Nat Acad Sci U S A 108(20): 8293-8298.
    • (2011) Proc Nat Acad Sci U S A , vol.108 , Issue.20 , pp. 8293-8298
    • Asaithamby, A.1    Hu, B.2    Chen, D.J.3
  • 26
    • 0037036442 scopus 로고    scopus 로고
    • Efficient rejoining of radiation-induced DNA double-strand breaks in centromeric DNA of human cells
    • DOI 10.1074/jbc.M200265200
    • Rief N, and Lobrich M (2002) Efficient rejoining of radiation-induced DNA double-strand breaks in centromeric DNA of human cells. J Biol Chem 277(23): 20572-20582. (Pubitemid 34967358)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.23 , pp. 20572-20582
    • Rief, N.1    Lobrich, M.2
  • 27
    • 39749184636 scopus 로고    scopus 로고
    • Biochemical kinetics model of DSB repair and induction of gamma-H2AX foci by non-homologous end joining
    • DOI 10.1667/RR1035.1
    • Cucinotta FA, Pluth JM, Anderson J, Harber JV, O'Neill P (2008) Biochemical kinetics model of DSB repair and induction of gamma-H2AX foci by non-homologous end joining. Radiat Res 169(2): 214-222. (Pubitemid 351295079)
    • (2008) Radiation Research , vol.169 , Issue.2 , pp. 214-222
    • Cucinotta, F.A.1    Pluth, J.M.2    Anderson, J.A.3    Harper, J.V.4    O'Neill, P.5
  • 28
    • 79958288747 scopus 로고    scopus 로고
    • Modeling non-homologous end joining
    • Li Y, Cucinotta FA (2011) Modeling non-homologous end joining. J Theor Biol 283(1) 122-35.
    • (2011) J Theor Biol , vol.283 , Issue.1 , pp. 122-135
    • Li, Y.1    Cucinotta, F.A.2
  • 29
    • 0033756415 scopus 로고    scopus 로고
    • Kinetics in DSB rejoining and formation of simple chromosome exchange aberrations
    • Cucinotta FA, Nikjoo H, O'Neill P, Goodhead DT (2000) Kinetics in DSB rejoining and formation of simple chromosome exchange aberrations. Int J Radiat Biol 76: 1463-1474.
    • (2000) Int J Radiat Biol , vol.76 , pp. 1463-1474
    • Cucinotta, F.A.1    Nikjoo, H.2    O'Neill, P.3    Goodhead, D.T.4
  • 30
    • 0033654353 scopus 로고    scopus 로고
    • On the Development of Biophysical Models for Space Radiation Risk Assessment
    • Cucinotta FA, Dicello JF (2000) On the Development of Biophysical Models for Space Radiation Risk Assessment. Adv Space Res 25(10): 2131-2140.
    • (2000) Adv Space Res , vol.25 , Issue.10 , pp. 2131-2140
    • Cucinotta, F.A.1    Dicello, J.F.2
  • 31
    • 0036023742 scopus 로고    scopus 로고
    • Biocomputational models of gene expression following DNA damage by radiation
    • Cucinotta FA, Dicello JF, Nikjoo H, Cherubini R (2002) Biocomputational models of gene expression following DNA damage by radiation. Radiat Prot Dosim 99: 85-90.
    • (2002) Radiat Prot Dosim , vol.99 , pp. 85-90
    • Cucinotta, F.A.1    Dicello, J.F.2    Nikjoo, H.3    Cherubini, R.4
  • 32
    • 79952318238 scopus 로고    scopus 로고
    • Mechanistic simulation of radiation damage to DNA and its repair: On the track towards systems radiation biology modelling
    • Friedland W, Jacob P, Kundrat P (2011) Mechanistic simulation of radiation damage to DNA and its repair: On the track towards systems radiation biology modelling. Radiat Prot Dosim 143: 542-548.
    • (2011) Radiat Prot Dosim , vol.143 , pp. 542-548
    • Friedland, W.1    Jacob, P.2    Kundrat, P.3
  • 33
    • 77951782095 scopus 로고    scopus 로고
    • Stochastic simulation of DNA double-strand break repair by non-homologous end joining based on track structure calculations
    • Friedland W, Jacob P, Kundrat P (2010) Stochastic simulation of DNA double-strand break repair by non-homologous end joining based on track structure calculations. Radiat Res 173: 677-688.
    • (2010) Radiat Res , vol.173 , pp. 677-688
    • Friedland, W.1    Jacob, P.2    Kundrat, P.3
  • 34
    • 84876963792 scopus 로고    scopus 로고
    • The non-homologous end-joining (NHEJ) pathway for the repair of DNA double-strand breaks: I. A mathematical model
    • Taleei R, Nikjoo H (2013) The non-homologous end-joining (NHEJ) pathway for the repair of DNA double-strand breaks: I. A mathematical model. Radiat Res 179: 530-539.
    • (2013) Radiat Res , vol.179 , pp. 530-539
    • Taleei, R.1    Nikjoo, H.2
  • 35
    • 84876996259 scopus 로고    scopus 로고
    • The Non-homologous End-Joining (NHEJ) Mathematical Model for the Repair of Double-Strand Breaks: II. Application to Damage Induced by Ultrasoft X Rays and Low-Energy Electrons
    • Taleei R, Nikjoo H (2013) The Non-homologous End-Joining (NHEJ) Mathematical Model for the Repair of Double-Strand Breaks: II. Application to Damage Induced by Ultrasoft X Rays and Low-Energy Electrons. Radiat Res 179: 540-548.
    • (2013) Radiat Res , vol.179 , pp. 540-548
    • Taleei, R.1    Nikjoo, H.2
  • 36
    • 84884206125 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of DNA repair proteins following laser microbeam induced DNA damage - When is a DSB not a DSB?
    • Reynolds P, Botchway SW, Parker AW, O'Neill P (2013) Spatiotemporal dynamics of DNA repair proteins following laser microbeam induced DNA damage - When is a DSB not a DSB? Mut Res 756: 14-20.
    • (2013) Mut Res , vol.756 , pp. 14-20
    • Reynolds, P.1    Botchway, S.W.2    Parker, A.W.3    O'Neill, P.4
  • 37
    • 77951967843 scopus 로고    scopus 로고
    • Biological dose estimation of UVA laser microirradiation utilizing charged particle-induced protein foci
    • Splinter J, Jacob B, Lang M, Yano K, Engelardt J, et al. (2010) Biological dose estimation of UVA laser microirradiation utilizing charged particle-induced protein foci. Mutagenesis 25(3): 289-97.
    • (2010) Mutagenesis , vol.25 , Issue.3 , pp. 289-297
    • Splinter, J.1    Jacob, B.2    Lang, M.3    Yano, K.4    Engelardt, J.5
  • 38
    • 55649098355 scopus 로고    scopus 로고
    • Induction of persistent double strand breaks following multiphoton irradiation of cycling and G1-arrested mammalian cells-replication-induced double strand breaks
    • Harper JV, Reynolds P, Leatherbarrow EL, Botchway SW, Parker AW, O'Neill P (2008) Induction of persistent double strand breaks following multiphoton irradiation of cycling and G1-arrested mammalian cells-replication-induced double strand breaks. Photochem Photobiol 84: 1506-1514.
    • (2008) Photochem Photobiol , vol.84 , pp. 1506-1514
    • Harper, J.V.1    Reynolds, P.2    Leatherbarrow, E.L.3    Botchway, S.W.4    Parker, A.W.5    O'Neill, P.6
  • 39
    • 84855969346 scopus 로고    scopus 로고
    • Laser-induced radiation microbeam technology and simultaneous real-time fluorescence imaging in live cells
    • Botchway SW, Reynolds P, Parker AW, O'Neill P (2012) Laser-induced radiation microbeam technology and simultaneous real-time fluorescence imaging in live cells. Meth Enzym 504: 3-28.
    • (2012) Meth Enzym , vol.504 , pp. 3-28
    • Botchway, S.W.1    Reynolds, P.2    Parker, A.W.3    O'Neill, P.4
  • 40
    • 0037124373 scopus 로고    scopus 로고
    • Synapsis of DNA ends by DNA-dependent protein kinase
    • DOI 10.1093/emboj/cdf299
    • DeFazio LG, Stansel RM, Griffith JD, Chu G (2002) Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J 21(12): 3192-3200. (Pubitemid 34670402)
    • (2002) EMBO Journal , vol.21 , Issue.12 , pp. 3192-3200
    • DeFazio, L.G.1    Stansel, R.M.2    Griffith, J.D.3    Chu, G.4
  • 41
    • 80053447704 scopus 로고    scopus 로고
    • Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks
    • Langerak P, Mejia-Ramirez, Limbo O, Russel P (2011) Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks. PLoS Gen 7(9): e1002271.
    • (2011) PLoS Gen , vol.7 , Issue.9
    • Langerak, P.1    Mejia-Ramirez2    Limbo, O.3    Russel, P.4
  • 42
    • 33748872519 scopus 로고    scopus 로고
    • Interplay between Ku, artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends
    • DOI 10.1074/jbc.M603047200
    • Drouet J, Frit P, Delteil C, Villartay J, Salles B, et al. (2006) Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends. J Biol Chem 281(38): 27784-27793. (Pubitemid 44418983)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.38 , pp. 27784-27793
    • Drouet, J.1    Frit, P.2    Delteil, C.3    De Villartay, J.-P.4    Salles, B.5    Calsou, P.6
  • 43
    • 57949116437 scopus 로고    scopus 로고
    • DNA-PK: The means to justify the ends?
    • Meek K, Dang V, Lees-Miller SP (2008) DNA-PK: the means to justify the ends? Adv immun 99: 33-58.
    • (2008) Adv Immun , vol.99 , pp. 33-58
    • Meek, K.1    Dang, V.2    Lees-Miller, S.P.3
  • 44
    • 0032971199 scopus 로고    scopus 로고
    • Absence of DNA ligase IV protein in XR-1 cells: Evidence for stabilization by XRCC4
    • DOI 10.1016/S0921-8777(98)00063-9, PII S0921877798000639
    • Bryans M, Valenzano MC, Stamato TD (1999) Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4. Mut Res 433(1): 53-58. (Pubitemid 29073670)
    • (1999) Mutation Research - DNA Repair , vol.433 , Issue.1 , pp. 53-58
    • Bryans, M.1    Valenzano, M.C.2    Stamato, T.D.3
  • 46
    • 4043073590 scopus 로고    scopus 로고
    • Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends
    • DOI 10.1093/nar/gkh761
    • Block WD, Yu Y, Merkle D, Gifford JL, Ding Q, et al. (2004) Autophospho-rylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Res 32(14): 4351-4357. (Pubitemid 39232307)
    • (2004) Nucleic Acids Research , vol.32 , Issue.14 , pp. 4351-4357
    • Block, W.D.1    Yu, Y.2    Merkle, D.3    Gifford, J.L.4    Ding, Q.5    Meek, K.6    Lees-Miller, S.P.7
  • 47
    • 0023018810 scopus 로고
    • Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders
    • Mimori T, Hardin JA, Steitz JA (1886) Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. J Biol Chem 261(5): 2274-2278.
    • (1886) J Biol Chem , vol.261 , Issue.5 , pp. 2274-2278
    • Mimori, T.1    Hardin, J.A.2    Steitz, J.A.3
  • 49
    • 25444502657 scopus 로고    scopus 로고
    • Artemis links ATM to double strand break rejoining
    • Jeggo PA, Lobrich M (2005), Artemis links ATM to double strand break rejoining. Cell Cycle 4(3): 359-362. (Pubitemid 41359714)
    • (2005) Cell Cycle , vol.4 , Issue.3 , pp. 359-362
    • Jeggo, P.A.1    Lobrich, M.2
  • 50
    • 29644443959 scopus 로고    scopus 로고
    • Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway
    • DOI 10.1667/RR3489.1
    • Okayasu R, Okada M, Okabe A, Noquchi M, Takakura K, et al. (2006) Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway. Radiat Res 165(1): 59-67. (Pubitemid 43023325)
    • (2006) Radiation Research , vol.165 , Issue.1 , pp. 59-67
    • Okayasu, R.1    Okada, M.2    Okabe, A.3    Noguchi, M.4    Takakura, K.5    Takahashi, S.6
  • 51
    • 0027976408 scopus 로고
    • Initial events in the cellular effects of ionizing-radiations - clustered damage in DNA
    • Goodhead DT (1994) Initial events in the cellular effects of ionizing-radiations - clustered damage in DNA International Journal of Radiat Biol 65(1): 7-17.
    • (1994) International Journal of Radiat Biol , vol.65 , Issue.1 , pp. 7-17
    • Goodhead, D.T.1
  • 53
    • 33645144591 scopus 로고    scopus 로고
    • Induction and quantification of gamma-H2AX foci following low and high LET-irradiation
    • Leatherbarrow EL, Harper JV, Cucinotta FA, O'Neill P (2006) Induction and quantification of gamma-H2AX foci following low and high LET-irradiation. Int J Radiat Biol 82(2): 111-118.
    • (2006) Int J Radiat Biol , vol.82 , Issue.2 , pp. 111-118
    • Leatherbarrow, E.L.1    Harper, J.V.2    Cucinotta, F.A.3    O'Neill, P.4
  • 54
    • 0030806073 scopus 로고    scopus 로고
    • Induction and rejoining of DNA double-strand breaks in Chinese hamster V79-4 cells irradiated with characteristic aluminum K and copper L ultrasoft X rays
    • DOI 10.2307/3579516
    • Botchway SW, Stevens DL, Hill MA, Jenner TJ, O'Neill P (1997) Induction and rejoining of DNA double-strand breaks in Chinese hamster V79-4 cells irradiated with characteristic aluminum K and copper L ultrasoft X rays. Radiat Res 148(4) 317-324. (Pubitemid 27435631)
    • (1997) Radiation Research , vol.148 , Issue.4 , pp. 317-324
    • Botchway, S.W.1    Stevens, D.L.2    Hill, M.A.3    Jenner, T.J.4    O'Neill, P.5
  • 55
    • 0034074917 scopus 로고    scopus 로고
    • Model for radial dependence of frequency distributions for energy imparted in nanometer volumes from HZE particles
    • Cucinotta FA, Nikjoo H, Goodhead DT (2000) Model for radial dependence of frequency distributions for energy imparted in nanometer volumes from HZE particles. Radiat Res 153(4): 459-468. (Pubitemid 30185401)
    • (2000) Radiation Research , vol.153 , Issue.4 , pp. 459-468
    • Cucinotta, F.A.1    Nikjoo, H.2    Goodhead, D.T.3
  • 56
    • 33645991783 scopus 로고    scopus 로고
    • Cancer risk from exposure to galactic cosmic rays: Implications for space exploration by human beings
    • Cucinotta FA, Durante M (2006) Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings. Lancet Oncol 7(5): 431-435.
    • (2006) Lancet Oncol , vol.7 , Issue.5 , pp. 431-435
    • Cucinotta, F.A.1    Durante, M.2
  • 57
    • 47349107760 scopus 로고    scopus 로고
    • ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin
    • DOI 10.1016/j.molcel.2008.05.017, PII S109727650800395X
    • Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, et al. (2008) ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol Cell 31(2): 167-77. (Pubitemid 352001394)
    • (2008) Molecular Cell , vol.31 , Issue.2 , pp. 167-177
    • Goodarzi, A.A.1    Noon, A.T.2    Deckbar, D.3    Ziv, Y.4    Shiloh, Y.5    Lobrich, M.6    Jeggo, P.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.