Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Roat, Regan ^a   Rao, Vandana ^a   Doliba, Nicolai M ^a   Matschinsky, Franz M ^a   Tobias, John W ^a   Garcia, Eden ^b   Ahima, Rexford S ^a   Imai, Yumi ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; GLUCOSE; INSULIN; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL METABOLIC RATE; CONTROLLED STUDY; GENE; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GLUCOSE BLOOD LEVEL; GLUCOSE STIMULATED INSULIN SECRETION; GLUCOSE TOLERANCE TEST; HYPERINSULINEMIA; HYPOXIA UPREGULATED PROTEIN 1 GENE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; LIPID DIET; MALE; MICROARRAY ANALYSIS; MOUSE; MUTATIONAL ANALYSIS; NNT GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; PANCREAS ISLET; PGC1 ALPHA GENE; UPREGULATION;

ANIMALS; DIETARY FATS; GENE DELETION; HYPERINSULINISM; HYPOXIA-INDUCIBLE FACTOR 1; INSULIN; INSULIN-SECRETING CELLS; MICE; MITOCHONDRIAL PROTEINS; NADP TRANSHYDROGENASE, AB-SPECIFIC; OBESITY; OXIDATIVE STRESS; OXYGEN CONSUMPTION; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84895514508     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086815     Document Type: Article

References (43)

1. Lam DW, LeRoith D (2012) The worldwide diabetes epidemic. Curr Opin Endocrinol Diabetes Obes 19: 93-96.
2. Sachdeva MM, Stoffers DA (2009) Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. Mol Endocrinol 23: 747-758.
3. Prentki M, Nolan CJ (2006) Islet beta cell failure in type 2 diabetes. J Clin Invest 116: 1802-1812. (Pubitemid 44033300)
4. Boitard C, Accili D, Ahren B, Cerasi E, Seino S, et al. (2012) The hyperstimulated beta-cell: prelude to diabetes? Diabetes Obes Metab 14 Suppl 3: iv-viii.
5. Imamura M, Maeda S (2011) Genetics of type 2 diabetes: the GWAS era and future perspectives [Review]. Endocr J 58: 723-739.
6. McGill JB (2012) Pharmacotherapy in type 2 diabetes: a functional schema for drug classification. Curr Diabetes Rev 8: 257-267.
7. King AJ (2012) The use of animal models in diabetes research. Br J Pharmacol 166: 877-894.
8. Hariri N, Thibault L (2010) High-fat diet-induced obesity in animal models. Nutr Res Rev 23: 270-299.
9. Surwit RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN (1988) Diet-induced type II diabetes in C57BL/6J mice. Diabetes 37: 1163-1167. (Pubitemid 19035045)
10. Freeman HC, Hugill A, Dear NT, Ashcroft FM, Cox RD (2006) Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice. Diabetes 55: 2153-2156. (Pubitemid 44514958)
11. Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA (2005) Very slow turnover of beta-cells in aged adult mice. Diabetes 54: 2557-2567. (Pubitemid 41233576)
12. Imai Y, Patel HR, Hawkins EJ, Doliba NM, Matschinsky FM, et al. (2007) Insulin secretion is increased in pancreatic islets of neuropeptide Y-deficient mice. Endocrinology 148: 5716-5723. (Pubitemid 350146158)
13. Imai Y, Patel HR, Doliba NM, Matschinsky FM, Tobias JW, et al. (2008) Analysis of gene expression in pancreatic islets from diet-induced obese mice. Physiol Genomics 36: 43-51.
14. Doliba NM, Qin W, Najafi H, Liu C, Buettger CW, et al. (2012) Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics. Am J Physiol Endocrinol Metab 302: E87-E102.
15. Liang Y, Bai G, Doliba N, Buettger C, Wang L, et al. (1996) Glucose metabolism and insulin release in mouse beta HC9 cells, as model for wild-type pancreatic beta-cells. Am J Physiol 270: E846-857.
16. Varela GM, Antwi DA, Dhir R, Yin X, Singhal NS, et al. (2008) Inhibition of ADRP prevents diet-induced insulin resistance. Am J Physiol Gastrointest Liver Physiol 295: G621-628.
17. Rankin MM, Kushner JA (2009) Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes 58: 1365-1372.
18. Kahn SE (2001) Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 86: 4047-4058.
19. Ahmed M, Forsberg J, Bergsten P (2005) Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. J Proteome Res 4: 931-940. (Pubitemid 40863282)
20. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, et al. (2003) Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell 5: 73-83. (Pubitemid 36827343)
21. Winzell MS, Ahren B (2004) The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes 53 Suppl 3: S215-219. (Pubitemid 39564546)
22. Hull RL, Kodama K, Utzschneider KM, Carr DB, Prigeon RL, et al. (2005) Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation. Diabetologia 48: 1350-1358. (Pubitemid 41186101)
23. Peyot ML, Pepin E, Lamontagne J, Latour MG, Zarrouki B, et al. (2010) Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass. Diabetes 59: 2178-2187.
24. Karasawa H, Nagata-Goto S, Takaishi K, Kumagae Y (2009) A novel model of type 2 diabetes mellitus based on obesity induced by high-fat diet in BDF1 mice. Metabolism 58: 296-303.
25. Tschen SI, Dhawan S, Gurlo T, Bhushan A (2009) Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. Diabetes 58: 1312-1320.
26. Ahren J, Ahren B, Wierup N (2010) Increased beta-cell volume in mice fed a high-fat diet: a dynamic study over 12 months. Islets 2: 353-356.
27. Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, et al. (2008) Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 8: 325-332.
28. Collins SC, Hoppa MB, Walker JN, Amisten S, Abdulkader F, et al. (2010) Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles. Diabetes 59: 1192-1201.
29. Ling C, Del Guerra S, Lupi R, Ronn T, Granhall C, et al. (2008) Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia 51: 615-622.
30. Ikeda J, Kaneda S, Kuwabara K, Ogawa S, Kobayashi T, et al. (1997) Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150. Biochem Biophys Res Commun 230: 94-99. (Pubitemid 27210250)
31. Kobayashi T, Ogawa S, Yura T, Yanagi H (2000) Abundant expression of 150-kDa oxygen-regulated protein in mouse pancreatic beta cells is correlated with insulin secretion. Biochem Biophys Res Commun 267: 831-837. (Pubitemid 30099409)
32. Ozawa K, Miyazaki M, Matsuhisa M, Takano K, Nakatani Y, et al. (2005) The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes 54: 657-663. (Pubitemid 40322067)
33. Sanson M, Auge N, Vindis C, Muller C, Bando Y, et al. (2009) Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. Circ Res 104: 328-336.
34. Wang Y, Wu Z, Li D, Wang D, Wang X, et al. (2011) Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress. J Biol Chem 286: 11119-11131.
35. Kobayashi T, Ohta Y (2005) 150-kD oxygen-regulated protein is an essential factor for insulin release. Pancreas 30: 299-306. (Pubitemid 40586805)
36. Jensen LT, Host NB (1997) Collagen: scaffold for repair or execution. Cardiovasc Res 33: 535-539. (Pubitemid 27092854)
37. Barallobre-Barreiro J, Didangelos A, Schoendube FA, Drozdov I, Yin X, et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125: 789-802.
38. Ikegawa S (2008) Expression, regulation and function of asporin, a susceptibility gene in common bone and joint diseases. Curr Med Chem 15: 724-728.
39. Homo-Delarche F, Calderari S, Irminger JC, Gangnerau MN, Coulaud J, et al. (2006) Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat. Diabetes 55: 1625-1633. (Pubitemid 44324114)
40. Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, et al. (1998) Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes 47: 358-364. (Pubitemid 28104196)
41. Ko SH, Kwon HS, Kim SR, Moon SD, Ahn YB, et al. (2004) Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats. Biochem Biophys Res Commun 316: 114-122.
42. Masuyama T, Komeda K, Hara A, Noda M, Shinohara M, et al. (2004) Chronological characterization of diabetes development in male Spontaneously Diabetic Torii rats. Biochem Biophys Res Commun 314: 870-877. (Pubitemid 38112880)
43. Stendahl JC, Kaufman DB, Stupp SI (2009) Extracellular matrix in pancreatic islets: relevance to scaffold design and transplantation. Cell Transplant 18: 1-12.