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Volumn 114, Issue 2, 2014, Pages 315-324

Role of exosomes in myocardial remodeling

Author keywords

Biogenesis; Cardiac; Myocytes; Nucleic acids; Transfection

Indexed keywords

CHAPERONIN 60; DNA; MEMBRANE PROTEIN; NANOPARTICLE; RNA; NUCLEIC ACID;

EID: 84895475039     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.114.300584     Document Type: Review
Times cited : (127)

References (140)
  • 3
    • 84873034262 scopus 로고    scopus 로고
    • Proteotoxicity and cardiac dysfunction-Alzheimer's disease of the heart?
    • Willis MS, Patterson C. Proteotoxicity and cardiac dysfunction-Alzheimer's disease of the heart? N Engl J Med. 2013;368:455-464.
    • (2013) N Engl J Med. , vol.368 , pp. 455-464
    • Willis, M.S.1    Patterson, C.2
  • 4
    • 0017406515 scopus 로고
    • Restoration of detergent-inactivated adenosine triphosphatase activity of human prostatic fluid with concanavalin A
    • Ronquist G, Hedström M. Restoration of detergent-inactivated adenosine triphosphatase activity of human prostatic fluid with concanavalin A. Biochim Biophys Acta. 1977;483:483-486.
    • (1977) Biochim Biophys Acta. , vol.483 , pp. 483-486
    • Ronquist, G.1    Hedström, M.2
  • 5
    • 0017902157 scopus 로고
    • An Mg2+ and Ca2+- stimulated adenosine triphosphatase in human prostatic fluid: Part I
    • Ronquist G, Brody I, Gottfries A, Stegmayr B. An Mg2+ and Ca2+- stimulated adenosine triphosphatase in human prostatic fluid: part I. Andrologia. 1978;10:261-272.
    • (1978) Andrologia , vol.10 , pp. 261-272
    • Ronquist, G.1    Brody, I.2    Gottfries, A.3    Stegmayr, B.4
  • 6
    • 0018197793 scopus 로고
    • An Mg2+ and Ca2+- stimulated adenosine triphosphatase in human prostatic fluid-part II
    • Ronquist G, Brody I, Gottfries A, Stegmayr B. An Mg2+ and Ca2+- stimulated adenosine triphosphatase in human prostatic fluid-part II. Andrologia. 1978;10:427-433.
    • (1978) Andrologia , vol.10 , pp. 427-433
    • Ronquist, G.1    Brody, I.2    Gottfries, A.3    Stegmayr, B.4
  • 7
    • 0022201056 scopus 로고
    • Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
    • Pan BT, Teng K, Wu C, Adam M, Johnstone RM. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol. 1985;101:942-948.
    • (1985) J Cell Biol. , vol.101 , pp. 942-948
    • Pan, B.T.1    Teng, K.2    Wu, C.3    Adam, M.4    Johnstone, R.M.5
  • 8
    • 0021719707 scopus 로고
    • Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: Demonstration of a pathway for receptor shedding
    • Harding C, Heuser J, Stahl P. Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: Demonstration of a pathway for receptor shedding. Eur J Cell Biol. 1984;35:256-263.
    • (1984) Eur J Cell Biol. , vol.35 , pp. 256-263
    • Harding, C.1    Heuser, J.2    Stahl, P.3
  • 9
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
    • Johnstone RM, Adam M, Hammond JR, Orr L, Turbide C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem. 1987;262:9412-9420.
    • (1987) J Biol Chem. , vol.262 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3    Orr, L.4    Turbide, C.5
  • 10
    • 0033255046 scopus 로고    scopus 로고
    • Expression of prostasome-like granules by the prostate cancer cell lines PC3, Du145 and LnCaP grown in monolayer
    • Nilsson BO, Lennartsson L, Carlsson L, Nilsson S, Ronquist G. Expression of prostasome-like granules by the prostate cancer cell lines PC3, Du145 and LnCaP grown in monolayer. Ups J Med Sci. 1999;104:199-206.
    • (1999) Ups J Med Sci. , vol.104 , pp. 199-206
    • Nilsson, B.O.1    Lennartsson, L.2    Carlsson, L.3    Nilsson, S.4    Ronquist, G.5
  • 13
    • 10644236207 scopus 로고    scopus 로고
    • Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry
    • Mears R, Craven RA, Hanrahan S, Totty N, Upton C, Young SL, Patel P, Selby PJ, Banks RE. Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Proteomics. 2004;4:4019-4031.
    • (2004) Proteomics , vol.4 , pp. 4019-4031
    • Mears, R.1    Craven, R.A.2    Hanrahan, S.3    Totty, N.4    Upton, C.5    Young, S.L.6    Patel, P.7    Selby, P.J.8    Banks, R.E.9
  • 14
    • 14844334129 scopus 로고    scopus 로고
    • Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
    • Taylor DD, Gerçel-Taylor C. Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br J Cancer. 2005;92:305-311.
    • (2005) Br J Cancer , vol.92 , pp. 305-311
    • Taylor, D.D.1    Gerçel-Taylor, C.2
  • 15
    • 0033774428 scopus 로고    scopus 로고
    • Dendritic cell-based immunotherapy of cancer
    • Zitvogel L, Angevin E, Tursz T. Dendritic cell-based immunotherapy of cancer. Ann Oncol. 2000;11(suppl 3):199-205.
    • (2000) Ann Oncol , vol.11 , pp. 199-205
    • Zitvogel, L.1    Angevin, E.2    Tursz, T.3
  • 17
    • 0036032980 scopus 로고    scopus 로고
    • Immunoregulatory properties of mast cell-derived exosomes
    • Skokos D, Goubran-Botros H, Roa M, Mécheri S. Immunoregulatory properties of mast cell-derived exosomes. Mol Immunol. 2002;38:1359-1362.
    • (2002) Mol Immunol , vol.38 , pp. 1359-1362
    • Skokos, D.1    Goubran-Botros, H.2    Roa, M.3    Mécheri, S.4
  • 18
    • 0032322157 scopus 로고    scopus 로고
    • Anti-tumour immunotherapy using dendritic-cell-derived exosomes
    • Amigorena S. Anti-tumour immunotherapy using dendritic-cell-derived exosomes. Res Immunol. 1998;149:661-662.
    • (1998) Res Immunol , vol.149 , pp. 661-662
    • Amigorena, S.1
  • 19
    • 0033485648 scopus 로고    scopus 로고
    • Activated platelets release two types of membrane vesicles: Microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules
    • Heijnen HF, Schiel AE, Fijnheer R, Geuze HJ, Sixma JJ. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood. 1999;94:3791-3799.
    • (1999) Blood , vol.94 , pp. 3791-3799
    • Heijnen, H.F.1    Schiel, A.E.2    Fijnheer, R.3    Geuze, H.J.4    Sixma, J.J.5
  • 22
    • 34447525068 scopus 로고    scopus 로고
    • HSP60 trafficking in adult cardiac myocytes: Role of the exosomal pathway
    • Gupta S, Knowlton AA. HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway. Am J Physiol Heart Circ Physiol. 2007;292:3052-3056.
    • (2007) Am J Physiol Heart Circ Physiol. , vol.292 , pp. 3052-3056
    • Gupta, S.1    Knowlton, A.A.2
  • 24
    • 0002824050 scopus 로고
    • The probable origin and physiological significance of cellular osmotic properties
    • Overton E. The probable origin and physiological significance of cellular osmotic properties. Vierteljahrschrift der Naturforschende Gesselschaft. 1899;44:88-135.
    • (1899) Vierteljahrschrift, der Naturforschende Gesselschaft , vol.44 , pp. 88-135
    • Overton, E.1
  • 25
    • 0343800636 scopus 로고
    • On bimolecular layers of lipoids on the chromocytes of the blood
    • Gorter E, Grendel F. On bimolecular layers of lipoids on the chromocytes of the blood. J Exp Med. 1925;41:439-443.
    • (1925) J Exp Med. , vol.41 , pp. 439-443
    • Gorter, E.1    Grendel, F.2
  • 26
    • 84905690627 scopus 로고
    • Studies on the permeability of erythrocytes: Factors in cation permeability
    • Davson H, Danielli JF. Studies on the permeability of erythrocytes: factors in cation permeability. Biochem J. 1938;32:991-1001.
    • (1938) Biochem J. , vol.32 , pp. 991-1001
    • Davson, H.1    Danielli, J.F.2
  • 27
    • 0008394796 scopus 로고
    • The molecular structure and contact relationships of cell membranes
    • Robertson JD. The molecular structure and contact relationships of cell membranes. Prog Biophys Mol Biol. 1960;10:343-418.
    • (1960) Prog Biophys Mol Biol. , vol.10 , pp. 343-418
    • Robertson, J.D.1
  • 28
    • 0015514472 scopus 로고
    • The fluid mosaic model of the structure of cell membranes
    • Singer SJ, Nicolson GL. The fluid mosaic model of the structure of cell membranes. Science. 1972;175:720-731.
    • (1972) Science , vol.175 , pp. 720-731
    • Singer, S.J.1    Nicolson, G.L.2
  • 29
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • Simons K, Ikonen E. Functional rafts in cell membranes. Nature. 1997;387:569-572.
    • (1997) Nature , vol.387 , pp. 569-572
    • Simons, K.1    Ikonen, E.2
  • 30
    • 0022257512 scopus 로고
    • The prostasome: Its secretion and function in man
    • Ronquist G, Brody I. The prostasome: its secretion and function in man. Biochim Biophys Acta. 1985;822:203-218.
    • (1985) Biochim Biophys Acta , vol.822 , pp. 203-218
    • Ronquist, G.1    Brody, I.2
  • 31
    • 0020384213 scopus 로고
    • Promotive effect on human sperm progressive motility by prostasomes
    • Stegmayr B, Ronquist G. Promotive effect on human sperm progressive motility by prostasomes. Urol Res. 1982;10:253-257.
    • (1982) Urol Res , vol.10 , pp. 253-257
    • Stegmayr, B.1    Ronquist, G.2
  • 32
    • 0036236122 scopus 로고    scopus 로고
    • Transfer of prostasomal CD59 to CD59-deficient red blood cells results in protection against complement-mediated hemolysis
    • Babiker AA, Ronquist G, Nilsson UR, Nilsson B. Transfer of prostasomal CD59 to CD59-deficient red blood cells results in protection against complement-mediated hemolysis. Am J Reprod Immunol. 2002;47:183-192.
    • (2002) Am J Reprod Immunol , vol.47 , pp. 183-192
    • Babiker, A.A.1    Ronquist, G.2    Nilsson, U.R.3    Nilsson, B.4
  • 33
    • 0026826746 scopus 로고
    • Maturation of reticulocytes: Formation of exosomes as a mechanism for shedding membrane proteins
    • Johnstone RM. Maturation of reticulocytes: formation of exosomes as a mechanism for shedding membrane proteins. Biochem Cell Biol. 1992;70:179-190.
    • (1992) Biochem Cell Biol. , vol.70 , pp. 179-190
    • Johnstone, R.M.1
  • 35
    • 0028891783 scopus 로고
    • Apoptosis, oncosis, and necrosis. An overview of cell death
    • Majno G, Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol. 1995;146:3-15.
    • (1995) Am J Pathol. , vol.146 , pp. 3-15
    • Majno, G.1    Joris, I.2
  • 36
    • 0030896981 scopus 로고    scopus 로고
    • The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection
    • Aupeix K, Hugel B, Martin T, Bischoff P, Lill H, Pasquali JL, Freyssinet JM. The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection. J Clin Invest. 1997;99:1546-1554.
    • (1997) J Clin Invest. , vol.99 , pp. 1546-1554
    • Aupeix, K.1    Hugel, B.2    Martin, T.3    Bischoff, P.4    Lill, H.5    Pasquali, J.L.6    Freyssinet, J.M.7
  • 37
    • 0036830046 scopus 로고    scopus 로고
    • Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin
    • Kim CW, Lee HM, Lee TH, Kang C, Kleinman HK, Gho YS. Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin. Cancer Res. 2002;62:6312-6317.
    • (2002) Cancer Res. , vol.62 , pp. 6312-6317
    • Kim, C.W.1    Lee, H.M.2    Lee, T.H.3    Kang, C.4    Kleinman, H.K.5    Gho, Y.S.6
  • 38
    • 34948834742 scopus 로고    scopus 로고
    • Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA
    • Deregibus MC, Cantaluppi V, Calogero R, Lo Iacono M, Tetta C, Biancone L, Bruno S, Bussolati B, Camussi G. Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. Blood. 2007;110:2440-2448.
    • (2007) Blood , vol.110 , pp. 2440-2448
    • Deregibus, M.C.1    Cantaluppi, V.2    Calogero, R.3    Lo, I.M.4    Tetta, C.5    Biancone, L.6    Bruno, S.7    Bussolati, B.8    Camussi, G.9
  • 41
    • 84858864047 scopus 로고    scopus 로고
    • Prostasomes are mediators of intercellular communication: From basic research to clinical implications
    • Ronquist G. Prostasomes are mediators of intercellular communication: from basic research to clinical implications. J Intern Med. 2012;271:400-413.
    • (2012) J Intern Med , vol.271 , pp. 400-413
    • Ronquist, G.1
  • 42
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9:581-593.
    • (2009) Nat Rev Immunol. , vol.9 , pp. 581-593
    • Théry, C.1    Ostrowski, M.2    Segura, E.3
  • 45
    • 0031692336 scopus 로고    scopus 로고
    • The caveolae membrane system
    • Anderson RG. The caveolae membrane system. Annu Rev Biochem. 1998;67:199-225.
    • (1998) Annu Rev Biochem. , vol.67 , pp. 199-225
    • Anderson, R.G.1
  • 46
    • 0034625373 scopus 로고    scopus 로고
    • Structure and function of sphingolipid- And cholesterol- rich membrane rafts
    • Brown DA, London E. Structure and function of sphingolipid- And cholesterol- rich membrane rafts. J Biol Chem. 2000;275:17221-17224.
    • (2000) J Biol Chem. , vol.275 , pp. 17221-17224
    • Brown, D.A.1    London, E.2
  • 47
    • 0031457805 scopus 로고    scopus 로고
    • Post-Golgi biosynthetic trafficking
    • Keller P, Simons K. Post-Golgi biosynthetic trafficking. J Cell Sci. 1997;110(Pt 24):3001-3009.
    • (1997) J Cell Sci. , vol.110 , pp. 3001-3009
    • Keller, P.1    Simons, K.2
  • 48
  • 49
    • 0024460831 scopus 로고
    • Human prostasome membranes exhibit very high cholesterol/phospholipid ratios yielding high molecular ordering
    • Arvidson G, Ronquist G, Wikander G, Ojteg AC. Human prostasome membranes exhibit very high cholesterol/phospholipid ratios yielding high molecular ordering. Biochim Biophys Acta. 1989;984:167-173.
    • (1989) Biochim Biophys Acta. , vol.984 , pp. 167-173
    • Arvidson, G.1    Ronquist, G.2    Wikander, G.3    Ojteg, A.C.4
  • 50
    • 0036842257 scopus 로고    scopus 로고
    • Ultrastructure of the secretion of prostasomes from benign and malignant epithelial cells in the prostate
    • Sahlén GE, Egevad L, Ahlander A, Norlén BJ, Ronquist G, Nilsson BO. Ultrastructure of the secretion of prostasomes from benign and malignant epithelial cells in the prostate. Prostate. 2002;53:192-199.
    • (2002) Prostate , vol.53 , pp. 192-199
    • Sahlén, G.E.1    Egevad, L.2    Ahlander, A.3    Norlén, B.J.4    Ronquist, G.5    Nilsson, B.O.6
  • 51
    • 3142630225 scopus 로고    scopus 로고
    • Exosomes: Endosomal-derived vesicles shipping extracellular messages
    • Février B, Raposo G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol. 2004;16:415-421.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 415-421
    • Février, B.1    Raposo, G.2
  • 52
    • 77953922692 scopus 로고    scopus 로고
    • The role of placental exosomes in reproduction
    • Mincheva-Nilsson L, Baranov V. The role of placental exosomes in reproduction. Am J Reprod Immunol. 2010;63:520-533.
    • (2010) Am J Reprod Immunol , vol.63 , pp. 520-533
    • Mincheva-Nilsson, L.1    Baranov, V.2
  • 54
    • 0032940456 scopus 로고    scopus 로고
    • Identification of dipeptidyl peptidase IV as the antigen of a monoclonal anti-prostasome antibody
    • Schrimpf SP, Hellman U, Carlsson L, Larsson A, Ronquist G, Nilsson BO. Identification of dipeptidyl peptidase IV as the antigen of a monoclonal anti-prostasome antibody. Prostate. 1999;38:35-39.
    • (1999) Prostate , vol.38 , pp. 35-39
    • Schrimpf, S.P.1    Hellman, U.2    Carlsson, L.3    Larsson, A.4    Ronquist, G.5    Nilsson, B.O.6
  • 58
    • 58849151841 scopus 로고    scopus 로고
    • Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen
    • Poliakov A, Spilman M, Dokland T, Amling CL, Mobley JA. Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen. Prostate. 2009;69:159-167.
    • (2009) Prostate , vol.69 , pp. 159-167
    • Poliakov, A.1    Spilman, M.2    Dokland, T.3    Amling, C.L.4    Mobley, J.A.5
  • 59
    • 0020064759 scopus 로고
    • A biochemical and ultrastructural study on the endogenous protein kinase activity of secretory granule membranes of prostatic origin in human seminal plasma
    • Stegmayr B, Brody I, Ronquist G. A biochemical and ultrastructural study on the endogenous protein kinase activity of secretory granule membranes of prostatic origin in human seminal plasma. J Ultrastruct Res. 1982;78:206-214.
    • (1982) J Ultrastruct Res. , vol.78 , pp. 206-214
    • Stegmayr, B.1    Brody, I.2    Ronquist, G.3
  • 60
    • 9444253500 scopus 로고    scopus 로고
    • Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line
    • Llorente A, de Marco MC, Alonso MA. Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line. J Cell Sci. 2004;117:5343-5351.
    • (2004) J Cell Sci. , vol.117 , pp. 5343-5351
    • Llorente, A.1    De Marco, M.C.2    Alonso, M.A.3
  • 62
    • 0035877018 scopus 로고    scopus 로고
    • Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles
    • Théry C, Boussac M, Véron P, Ricciardi-Castagnoli P, Raposo G, Garin J, Amigorena S. Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles. J Immunol. 2001;166:7309-7318.
    • (2001) J Immunol , vol.166 , pp. 7309-7318
    • Théry, C.1    Boussac, M.2    Véron, P.3    Ricciardi-Castagnoli, P.4    Raposo, G.5    Garin, J.6    Amigorena, S.7
  • 63
    • 70350449455 scopus 로고    scopus 로고
    • ExoCarta: A compendium of exosomal proteins and RNA
    • Mathivanan S, Simpson RJ. ExoCarta: A compendium of exosomal proteins and RNA. Proteomics. 2009;9:4997-5000.
    • (2009) Proteomics , vol.9 , pp. 4997-5000
    • Mathivanan, S.1    Simpson, R.J.2
  • 65
    • 0036533633 scopus 로고    scopus 로고
    • TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex
    • Blanchard N, Lankar D, Faure F, Regnault A, Dumont C, Raposo G, Hivroz C. TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. J Immunol. 2002;168:3235-3241.
    • (2002) J Immunol. , vol.168 , pp. 3235-3241
    • Blanchard, N.1    Lankar, D.2    Faure, F.3    Regnault, A.4    Dumont, C.5    Raposo, G.6    Hivroz, C.7
  • 67
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: Composition, biogenesis and function
    • Théry C, Zitvogel L, Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002;2:569-579.
    • (2002) Nat Rev Immunol , vol.2 , pp. 569-579
    • Théry, C.1    Zitvogel, L.2    Amigorena, S.3
  • 68
    • 0032493658 scopus 로고    scopus 로고
    • Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
    • Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem. 1998;273:20121-20127.
    • (1998) J Biol Chem. , vol.273 , pp. 20121-20127
    • Escola, J.M.1    Kleijmeer, M.J.2    Stoorvogel, W.3    Griffith, J.M.4    Yoshie, O.5    Geuze, H.J.6
  • 71
    • 76649094917 scopus 로고    scopus 로고
    • Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature
    • Mathivanan S, Lim JW, Tauro BJ, Ji H, Moritz RL, Simpson RJ. Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. Mol Cell Proteomics. 2010;9:197-208.
    • (2010) Mol Cell Proteomics , vol.9 , pp. 197-208
    • Mathivanan, S.1    Lim, J.W.2    Tauro, B.J.3    Ji, H.4    Moritz, R.L.5    Simpson, R.J.6
  • 72
    • 79960147502 scopus 로고    scopus 로고
    • Exosome isolation for proteomic analyses and RNA profiling
    • Taylor DD, Zacharias W, Gercel-Taylor C. Exosome isolation for proteomic analyses and RNA profiling. Methods Mol Biol. 2011;728:235-246.
    • (2011) Methods Mol Biol. , vol.728 , pp. 235-246
    • Taylor, D.D.1    Zacharias, W.2    Gercel-Taylor, C.3
  • 73
    • 0344791683 scopus 로고    scopus 로고
    • Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails
    • Mukherjee S, Soe TT, Maxfield FR. Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails. J Cell Biol. 1999;144:1271-1284.
    • (1999) J Cell Biol. , vol.144 , pp. 1271-1284
    • Mukherjee, S.1    Soe, T.T.2    Maxfield, F.R.3
  • 76
    • 0027433570 scopus 로고
    • Arachidonic acid 15- lipoxygenase and traces of E prostaglandins in purified human prostasomes
    • Oliw EH, Fabiani R, Johansson L, Ronquist G. Arachidonic acid 15- lipoxygenase and traces of E prostaglandins in purified human prostasomes. J Reprod Fertil. 1993;99:195-199.
    • (1993) J Reprod Fertil. , vol.99 , pp. 195-199
    • Oliw, E.H.1    Fabiani, R.2    Johansson, L.3    Ronquist, G.4
  • 78
    • 77955496871 scopus 로고    scopus 로고
    • A membranous form of ICAM-1 on exosomes efficiently blocks leukocyte adhesion to activated endothelial cells
    • Lee HM, Choi EJ, Kim JH, Kim TD, Kim YK, Kang C, Gho YS. A membranous form of ICAM-1 on exosomes efficiently blocks leukocyte adhesion to activated endothelial cells. Biochem Biophys Res Commun. 2010;397:251-256.
    • (2010) Biochem Biophys Res Commun. , vol.397 , pp. 251-256
    • Lee, H.M.1    Choi, E.J.2    Kim, J.H.3    Kim, T.D.4    Kim, Y.K.5    Kang, C.6    Gho, Y.S.7
  • 79
    • 84907124130 scopus 로고
    • Interaction between prostasomes and spermatozoa from human semen
    • Ronquist G, Nilsson BO, Hjertën S. Interaction between prostasomes and spermatozoa from human semen. Arch Androl. 1990;24:147-157.
    • (1990) Arch Androl. , vol.24 , pp. 147-157
    • Ronquist, G.1    Nilsson, B.O.2    Hjertën, S.3
  • 80
    • 77957269172 scopus 로고    scopus 로고
    • Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy
    • Tian T, Wang Y, Wang H, Zhu Z, Xiao Z. Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy. J Cell Biochem. 2010;111:488-496.
    • (2010) J Cell Biochem. , vol.111 , pp. 488-496
    • Tian, T.1    Wang, Y.2    Wang, H.3    Zhu, Z.4    Xiao, Z.5
  • 81
    • 84859608013 scopus 로고    scopus 로고
    • Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells
    • Waldenström A, Gennebäck N, Hellman U, Ronquist G. Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells. PLoS One. 2012;7:34653.
    • (2012) PLoS One , vol.7 , pp. 34653
    • Waldenström, A.1    Gennebäck, N.2    Hellman, U.3    Ronquist, G.4
  • 82
    • 57149133410 scopus 로고    scopus 로고
    • Heart failure after acute myocardial infarction: A lost battle in the war on heart failure?
    • Jhund PS, McMurray JJ. Heart failure after acute myocardial infarction: A lost battle in the war on heart failure? Circulation. 2008;118:2019-2021.
    • (2008) Circulation , vol.118 , pp. 2019-2021
    • Jhund, P.S.1    Mcmurray, J.J.2
  • 84
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 85
    • 0038299558 scopus 로고    scopus 로고
    • Role of microRNAs in plant and animal development
    • Carrington JC, Ambros V. Role of microRNAs in plant and animal development. Science. 2003;301:336-338.
    • (2003) Science , vol.301 , pp. 336-338
    • Carrington, J.C.1    Ambros, V.2
  • 86
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 88
    • 84877583076 scopus 로고    scopus 로고
    • MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress
    • Huang ZP, Chen J, Seok HY, Zhang Z, Kataoka M, Hu X, Wang DZ. MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress. Circ Res. 2013;112:1234-1243.
    • (2013) Circ Res. , vol.112 , pp. 1234-1243
    • Huang, Z.P.1    Chen, J.2    Seok, H.Y.3    Zhang, Z.4    Kataoka, M.5    Hu, X.6    Wang, D.Z.7
  • 90
    • 33847038668 scopus 로고    scopus 로고
    • MicroRNAs play an essential role in the development of cardiac hypertrophy
    • Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res. 2007;100:416-424.
    • (2007) Circ Res. , vol.100 , pp. 416-424
    • Sayed, D.1    Hong, C.2    Chen, I.Y.3    Lypowy, J.4    Abdellatif, M.5
  • 91
    • 77953285559 scopus 로고    scopus 로고
    • MicroRNA profiling in early hypertrophic growth of the left ventricle in rats
    • Busk PK, Cirera S. MicroRNA profiling in early hypertrophic growth of the left ventricle in rats. Biochem Biophys Res Commun. 2010;396:989-993.
    • (2010) Biochem Biophys Res Commun. , vol.396 , pp. 989-993
    • Busk, P.K.1    Cirera, S.2
  • 92
    • 62349141343 scopus 로고    scopus 로고
    • MicroRNA expression in response to murine myocardial infarction: MiR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue
    • Roy S, Khanna S, Hussain SR, Biswas S, Azad A, Rink C, Gnyawali S, Shilo S, Nuovo GJ, Sen CK. MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc Res. 2009;82:21-29.
    • (2009) Cardiovasc Res. , vol.82 , pp. 21-29
    • Roy, S.1    Khanna, S.2    Hussain, S.R.3    Biswas, S.4    Azad, A.5    Rink, C.6    Gnyawali, S.7    Shilo, S.8    Nuovo, G.J.9    Sen, C.K.10
  • 94
    • 79955800181 scopus 로고    scopus 로고
    • Elevated miR-499 levels blunt the cardiac stress response
    • Shieh JT, Huang Y, Gilmore J, Srivastava D. Elevated miR-499 levels blunt the cardiac stress response. PLoS One. 2011;6:19481.
    • (2011) PLoS One , vol.6 , pp. 19481
    • Shieh, J.T.1    Huang, Y.2    Gilmore, J.3    Srivastava, D.4
  • 95
    • 84874700585 scopus 로고    scopus 로고
    • MicroRNA-34a regulates cardiac ageing and function
    • Boon RA, Iekushi K, Lechner S, et al. MicroRNA-34a regulates cardiac ageing and function. Nature. 2013;495:107-110.
    • (2013) Nature , vol.495 , pp. 107-110
    • Boon, R.A.1    Iekushi, K.2    Lechner, S.3
  • 99
    • 84857968441 scopus 로고    scopus 로고
    • The majority of microRNAs detectable in serum and saliva is concentrated in exosomes
    • Gallo A, Tandon M, Alevizos I, Illei GG. The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PLoS One. 2012;7:30679.
    • (2012) PLoS One , vol.7 , pp. 30679
    • Gallo, A.1    Tandon, M.2    Alevizos, I.3    Illei, G.G.4
  • 102
    • 84868609009 scopus 로고    scopus 로고
    • Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction
    • Eitel I, Adams V, Dieterich P, Fuernau G, de Waha S, Desch S, Schuler G, Thiele H. Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction. Am Heart J. 2012;164:706-714.
    • (2012) Am Heart J. , vol.164 , pp. 706-714
    • Eitel, I.1    Adams, V.2    Dieterich, P.3    Fuernau, G.4    De Waha, S.5    Desch, S.6    Schuler, G.7    Thiele, H.8
  • 104
    • 84875865814 scopus 로고    scopus 로고
    • Circulating miRNAs: Novel biomarkers of acute coronary syndrome?
    • Pleister A, Selemon H, Elton SM, Elton TS. Circulating miRNAs: novel biomarkers of acute coronary syndrome? Biomark Med. 2013;7:287-305.
    • (2013) Biomark Med. , vol.7 , pp. 287-305
    • Pleister, A.1    Selemon, H.2    Elton, S.M.3    Elton, T.S.4
  • 105
    • 79954617730 scopus 로고    scopus 로고
    • The cardiokine story unfolds: Ischemic stress-induced protein secretion in the heart
    • Doroudgar S, Glembotski CC. The cardiokine story unfolds: ischemic stress-induced protein secretion in the heart. Trends Mol Med. 2011;17:207-214.
    • (2011) Trends Mol Med. , vol.17 , pp. 207-214
    • Doroudgar, S.1    Glembotski, C.C.2
  • 108
    • 79954629901 scopus 로고    scopus 로고
    • Human cardiac stem cell differentiation is regulated by a mircrine mechanism
    • Hosoda T, Zheng H, Cabral-da-Silva M, et al. Human cardiac stem cell differentiation is regulated by a mircrine mechanism. Circulation. 2011;123:1287-1296.
    • (2011) Circulation , vol.123 , pp. 1287-1296
    • Hosoda, T.1    Zheng, H.2    Cabral-Da-silva, M.3
  • 109
    • 84875793723 scopus 로고    scopus 로고
    • New cells in old hearts
    • Boström P, Frisén J. New cells in old hearts. N Engl J Med. 2013;368:1358-1360.
    • (2013) N Engl J Med. , vol.368 , pp. 1358-1360
    • Boström, P.1    Frisén, J.2
  • 110
    • 84863231848 scopus 로고    scopus 로고
    • Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2
    • Zhang X, Wang X, Zhu H, Kranias EG, Tang Y, Peng T, Chang J, Fan GC. Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. PLoS One. 2012;7:32765.
    • (2012) PLoS One , vol.7 , pp. 32765
    • Zhang, X.1    Wang, X.2    Zhu, H.3    Kranias, E.G.4    Tang, Y.5    Peng, T.6    Chang, J.7    Fan, G.C.8
  • 111
    • 84887518558 scopus 로고    scopus 로고
    • Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes
    • May 17 [Epub ahead of print
    • Gennebäck N, HellmanU, Malm L, Larsson G, Ronquist G, Waldenström A, Mörner M. Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes. J Extracell Vesicles. 2013 May 17 [Epub ahead of print].
    • (2013) J Extracell Vesicles.
    • Gennebäck, N.1    Hellman, U.2    Malm, L.3    Larsson, G.4    Ronquist, G.5    Waldenström, A.6    Mörner, M.7
  • 112
    • 74049114704 scopus 로고    scopus 로고
    • Intramyocardial fibroblast myocyte communication
    • Kakkar R, Lee RT. Intramyocardial fibroblast myocyte communication. Circ Res. 2010;106:47-57.
    • (2010) Circ Res. , vol.106 , pp. 47-57
    • Kakkar, R.1    Lee, R.T.2
  • 116
    • 77950890007 scopus 로고    scopus 로고
    • Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice
    • Chimenti I, Smith RR, Li TS, Gerstenblith G, Messina E, Giacomello A, Marbán E. Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res. 2010;106:971-980.
    • (2010) Circ Res. , vol.106 , pp. 971-980
    • Chimenti, I.1    Smith, R.R.2    Li, T.S.3    Gerstenblith, G.4    Messina, E.5    Giacomello, A.6    Marbán, E.7
  • 117
    • 57049181418 scopus 로고    scopus 로고
    • Embryonic stem cells attenuate myocardial dysfunction and inflammation after surgical global ischemia via paracrine actions
    • Crisostomo PR, Abarbanell AM, Wang M, Lahm T, Wang Y, Meldrum DR. Embryonic stem cells attenuate myocardial dysfunction and inflammation after surgical global ischemia via paracrine actions. Am J Physiol Heart Circ Physiol. 2008;295:1726-1735.
    • (2008) Am J Physiol Heart, Circ Physiol , vol.295 , pp. 1726-1735
    • Crisostomo, P.R.1    Abarbanell, A.M.2    Wang, M.3    Lahm, T.4    Wang, Y.5    Meldrum, D.R.6
  • 120
    • 77950827291 scopus 로고    scopus 로고
    • Ischaemic preconditioning is related to decreasing levels of extracellular adenosine that may be metabolically useful in the at-risk myocardium: An experimental study in the pig
    • Waldenström A, Haney M, Biber B, Kavianipour M, Moritz T, Strandén P, Wikström G, Ronquist G. Ischaemic preconditioning is related to decreasing levels of extracellular adenosine that may be metabolically useful in the at-risk myocardium: An experimental study in the pig. Acta Physiol (Oxf). 2010;199:1-9.
    • (2010) Acta Physiol (Oxf). , vol.199 , pp. 1-9
    • Waldenström, A.1    Haney, M.2    Biber, B.3    Kavianipour, M.4    Moritz, T.5    Strandén, P.6    Wikström, G.7    Ronquist, G.8
  • 121
    • 0027471927 scopus 로고
    • Ischemic preconditioning increases adenosine release and 5'-nucleotidase activity during myocardial ischemia and reperfusion in canine myocardium
    • Kitakatze M, Hori M, Takashima S, Sato H, Inoue M, Kamada T. Ischemic preconditioning increases adenosine release and 5'-nucleotidase activity during myocardial ischemia and reperfusion in canine myocardium. Circulation. 1993;87:208-215.
    • (1993) Circulation , vol.87 , pp. 208-215
    • Kitakatze, M.1    Hori, M.2    Takashima, S.3    Sato, H.4    Inoue, M.5    Kamada, T.6
  • 122
    • 0026047960 scopus 로고
    • Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart
    • Liu GS, Thornton J, Van Winkle DM, Stanley AW, Olsson RA, Downey JM. Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation. 1991;84:350-356.
    • (1991) Circulation , vol.84 , pp. 350-356
    • Liu, G.S.1    Thornton, J.2    Van Winkle, D.M.3    Stanley, A.W.4    Olsson, R.A.5    Downey, J.M.6
  • 123
    • 84873919177 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
    • Arslan F, Lai RC, Smeets MB, Akeroyd L, Choo A, Aguor EN, Timmers L, van Rijen HV, Doevendans PA, Pasterkamp G, Lim SK, de Kleijn DP. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res. 2013;10:301-312.
    • (2013) Stem Cell Res. , vol.10 , pp. 301-312
    • Arslan, F.1    Lai, R.C.2    Smeets, M.B.3    Akeroyd, L.4    Choo, A.5    Aguor, E.N.6    Timmers, L.7    Van, R.H.V.8    Doevendans, P.A.9    Pasterkamp, G.10    Lim, S.K.11    De Kleijn, D.P.12
  • 124
    • 84869212180 scopus 로고    scopus 로고
    • Exosomal miRNAs: Biological properties and therapeutic potential
    • Hu G, Drescher KM, Chen XM. Exosomal miRNAs: biological properties and therapeutic potential. Front Genet. 2012;3:56.
    • (2012) Front Genet. , vol.3 , pp. 56
    • Hu, G.1    Drescher, K.M.2    Chen, X.M.3
  • 126
    • 41849147892 scopus 로고    scopus 로고
    • Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion
    • Sanderson MP, Keller S, Alonso A, Riedle S, Dempsey PJ, Altevogt P. Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion. J Cell Biochem. 2008;103:1783-1797.
    • (2008) J Cell Biochem. , vol.103 , pp. 1783-1797
    • Sanderson, M.P.1    Keller, S.2    Alonso, A.3    Riedle, S.4    Dempsey, P.J.5    Altevogt, P.6
  • 127
    • 41449107062 scopus 로고    scopus 로고
    • Unconventional secretion of fibroblast growth factor 2 and galectin-1 does not require shedding of plasmamembrane- derived vesicles
    • Claudia S, Carolin S, Walter N. Unconventional secretion of fibroblast growth factor 2 and galectin-1 does not require shedding of plasmamembrane- derived vesicles. FEBS Lett. 2008;582:1362-1368.
    • (2008) FEBS Lett. , vol.582 , pp. 1362-1368
    • Claudia, S.1    Carolin, S.2    Walter, N.3
  • 128
    • 34547686145 scopus 로고    scopus 로고
    • Human tumour derived exosomes selectively impair lymphocyte responses to interleukin- 2
    • Clayton A, Mitchell JP, Court J, Mason MD, Tabi Z. Human tumour derived exosomes selectively impair lymphocyte responses to interleukin- 2. Cancer Res. 2007;67:7458-7466.
    • (2007) Cancer Res. , vol.67 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Mason, M.D.4    Tabi, Z.5
  • 129
    • 0022970945 scopus 로고
    • Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
    • Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation. 1986;74:1124-1136.
    • (1986) Circulation , vol.74 , pp. 1124-1136
    • Murry, C.E.1    Jennings, R.B.2    Reimer, K.A.3
  • 130
    • 0026047960 scopus 로고
    • Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart
    • Liu GS, Thornton J, Van Winkle DM, Stanley AW, Olsson RA, Downey JM. Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation. 1991;84:350-356.
    • (1991) Circulation , vol.84 , pp. 350-356
    • Liu, G.S.1    Thornton, J.2    Van Winkle, D.M.3    Stanley, A.W.4    Olsson, R.A.5    Downey, J.M.6
  • 132
    • 1142273368 scopus 로고    scopus 로고
    • Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection
    • Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection. Cardiovasc Res. 2004;61:372-385.
    • (2004) Cardiovasc Res. , vol.61 , pp. 372-385
    • Halestrap, A.P.1    Clarke, S.J.2    Javadov, S.A.3
  • 133
    • 0034711508 scopus 로고    scopus 로고
    • The late phase of preconditioning
    • Bolli R. The late phase of preconditioning. Circ Res. 2000;87:972-983.
    • (2000) Circ Res. , vol.87 , pp. 972-983
    • Bolli, R.1
  • 135
    • 63649126549 scopus 로고    scopus 로고
    • A novel role of microRNA in late preconditioning: Upregulation of endothelial nitric oxide synthase and heat shock protein 70
    • Yin C, Salloum FN, Kukreja RC. A novel role of microRNA in late preconditioning: upregulation of endothelial nitric oxide synthase and heat shock protein 70. Circ Res. 2009;104:572-575.
    • (2009) Circ Res. , vol.104 , pp. 572-575
    • Yin, C.1    Salloum, F.N.2    Kukreja, R.C.3
  • 136
    • 77954766181 scopus 로고    scopus 로고
    • Downregulation of microRNA- 29 by antisense inhibitors and a PPAR-gamma agonist protects against myocardial ischaemia-reperfusion injury
    • Ye Y, Hu Z, Lin Y, Zhang C, Perez-Polo JR. Downregulation of microRNA- 29 by antisense inhibitors and a PPAR-gamma agonist protects against myocardial ischaemia-reperfusion injury. Cardiovasc Res. 2010;87:535-544.
    • (2010) Cardiovasc Res. , vol.87 , pp. 535-544
    • Ye, Y.1    Hu, Z.2    Lin, Y.3    Zhang, C.4    Perez-Polo, J.R.5
  • 137
    • 34948829119 scopus 로고    scopus 로고
    • The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes
    • Xu C, Lu Y, Pan Z, Chu W, Luo X, Lin H, Xiao J, Shan H, Wang Z, Yang B. The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. J Cell Sci. 2007;120:3045-3052.
    • (2007) J Cell Sci. , vol.120 , pp. 3045-3052
    • Xu, C.1    Lu, Y.2    Pan, Z.3    Chu, W.4    Luo, X.5    Lin, H.6    Xiao, J.7    Shan, H.8    Wang, Z.9    Yang, B.10
  • 138
    • 78651232227 scopus 로고    scopus 로고
    • MiR- 499 regulates mitochondrial dynamics by targeting calcineurin and dynamin- related protein-1
    • Wang JX, Jiao JQ, Li Q, Long B, Wang K, Liu JP, Li YR, Li PF. miR- 499 regulates mitochondrial dynamics by targeting calcineurin and dynamin- related protein-1. Nat Med. 2011;17:71-78.
    • (2011) Nat Med. , vol.17 , pp. 71-78
    • Wang, J.X.1    Jiao, J.Q.2    Li, Q.3    Long, B.4    Wang, K.5    Liu, J.P.6    Li, Y.R.7    Li, P.F.8


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