Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes

Journal of Extracellular Vesicles

Volumn 2, Issue 1, 2013, Pages

  Gennebäck, Nina ^a   Hellman, Urban ^a   Malm, Linus ^a   Larsson, Göran ^a   Ronquist, Gunnar ^b   Waldenström, Anders ^a   Mörner, Stellan ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cardiomyocytes; Exosomes; Extracellular vesicles; Gene expression; Growth factors

Indexed keywords

MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR BB; TRANSFORMING GROWTH FACTOR BETA2;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CENTRIFUGATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENERGY METABOLISM; EXOSOME; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HEART MUSCLE CELL; LIGHT SCATTERING; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; ORGANELLE SHAPE; ORGANELLE SIZE; RNA ANALYSIS; SUCROSE DENSITY GRADIENT CENTRIFUGATION; WESTERN BLOTTING;

EID: 84887518558     PISSN: None     EISSN: 20013078     Source Type: Journal    
DOI: 10.3402/jev.v2i0.20167     Document Type: Article

References (33)

1. Keller S, Sanderson MP, Stoeck A, Altevogt P. Exosomes: from biogenesis and secretion to biological function. Immunol Lett. 2006;107:102-8.
2. Simons M, Raposo G. Exosomes-vesicular carriers for intercellular communication. Curr Opin Cell Biol. 2009;21:575-81.
3. Raposo G, Nijman HW, Stoorvogel W, Liejendekker R, Harding CV, Melief CJ. B lymphocytes secrete antigenpresenting vesicles. J Exp Med. 1996;183:1161-72.
4. Babiker AA, Nilsson B, Ronquist G, Carlsson L, Ekdahl KN. Transfer of functional prostasomal CD59 of metastatic prostatic cancer cell origin protects cells against complement attack. Prostate. 2005;62:105-14.
5. Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9:654-9.
6. Ronquist GK, Larsson A, Ronquist G, Isaksson A, Hreinsson J, Carlsson L, et al. Prostasomal DNA characterization and transfer into human sperm. Mol Reprod Dev. 2011;78: 467-76.
7. Waldenstrom A, Gennebäck N, Hellman U, Ronquist G. Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells. PLoS One. 2012;7:e34653.
8. Camussi G, Deregibus MC, Bruno S, Cantaluppi V, Biancone L. Exosomes/microvesicles as a mechanism of cell-to-cell communication. Kidney Int. 2010;78:838-48.
9. Blanchard N, Lankar D, Faure F, Regnault A, Dumont C, Raposo G, et al. TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. J Immunol. 2002;168:3235-41.
10. Koga K, Matsumoto K, Akiyoshi T, Kubo M, Yamanaka N, Tasaki A, et al. Purification, characterization and biological significance of tumor-derived exosomes. Anticancer Res. 2005; 25:3703-7.
11. Llorente A, de Marco MC, Alonso MA. Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line. J Cell Sci. 2004;117:5343-51.
12. Wolfers J, Lozier A, Raposo G, Regnault A, Théry C, Masurier C, et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med. 2001;7:297-303.
13. Skokos D, Le Panse S, Villa I, Rousselle JC, Peronet R, David B, et al. Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. J Immunol. 2001;166:868-76.
14. Ronquist G, Hedstrom M. Restoration of detergent-inactivated adenosine triphosphatase activity of human prostatic fluid with concanavalin A. Biochim Biophys Acta. 1977;483:483-6.
15. Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, et al. Exosomes are released by cultured cortical neurones. Mol Cell Neurosci. 2006;31:642-8.
16. Gupta S, Knowlton AA. HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway. Am J Physiol Heart Circ Physiol. 2007;292:H3052-6.
17. Hellman U, Mörner S, Engström-Laurent A, Samuel JL, Waldenström A. Temporal correlation between transcriptional changes and increased synthesis of hyaluronan in experimental cardiac hypertrophy. Genomics. 2010;96:73-81.
18. Azhar M, Brown K, Gard C, Chen H, Rajan S, Elliott DA, et al. Transforming growth factor beta2 is required for valve remodeling during heart development. Dev Dyn. 2011;240: 2127-41.
19. Singla DK, Sun B. Transforming growth factor-beta2 enhances differentiation of cardiac myocytes from embryonic stem cells. Biochem Biophys Res Commun. 2005;332:135-41.
20. Azhar M, Schultz Jel J, Grupp I, Dorn GW 2nd, Meneton P, Molin DG, et al. Transforming growth factor beta in cardiovascular development and function. Cytokine Growth Factor Rev. 2003;14:391-407.
21. Parker TG, Packer SE, Schneider MD. Peptide growth factors can provoke "fetal" contractile protein gene expression in rat cardiac myocytes. J Clin Invest. 1990;85:507-14.
22. Romano F, Chiarenza C, Palombi F, Filippini A, Padula F, Ziparo E, et al. Platelet-derived growth factor-BB-induced hypertrophy of peritubular smooth muscle cells is mediated by activation of p38 MAP-kinase and of rho-kinase. J Cell Physiol. 2006;207:123-31.
23. Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature. 1999;401:86-90.
24. Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL, et al. Cardiomyocyte PDGFR-b signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest. 2010;120:472-84.
25. Claycomb WC, Lanson NA Jr., Stallworth BS, Egeland DB, Delcarpio JB, Bahinski A, et al. HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci U S A. 1998; 95:2979-84.
26. Mathivanan S, Simpson RJ. ExoCarta: a compendium of exosomal proteins and RNA. Proteomics. 2009;9:4997-5000.
27. Banhegyi G, Baumeister P, Benedetti A, Dong D, Fu Y, Lee AS, et al. Endoplasmic reticulum stress. Ann N Y Acad Sci. 2007;1113:58-71.
28. Miller JC, Miller JN. Statistics for analytical chemistry. 3rd ed. Chichster: Ellis Horwood; 1993.
29. Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, et al. Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol. 2012;10: e1001450.
30. Mak MC, Lam KM, Chan PK, Lau YB, Tang WH, Yeung PK, et al. Embryonic lethality in mice lacking the nuclear factor of activated T Cells 5 protein due to impaired cardiac development and function. Plos One. 2011;6:e19186.
31. Rohinia A, Agrawal N, Koyani CN, Singh R. Molecular targets and regulators of cardiachypertrophy. Pharmacol Res. 2010;61:269-80.
32. Karamboulas C, Swedani A, Ward C, Al-Madhoun AS, Wilton S, Boisvenue S, et al. HDAC activity regulates entry of mesoderm cells into the cardiac muscle lineage. J Cell Sci. 2006;119:4305-14.
33. Backs J, Olson EN. Control of cardiac growth by histone acetylation/deacetylation. Circ Res. 2006;98:15-24.