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Volumn 16, Issue 3, 2014, Pages 245-254

α-Catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; PROTEASOME; PROTEIN P50; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR ALPHA; TUMOR SUPPRESSOR PROTEIN; UVOMORULIN;

EID: 84895440197     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2909     Document Type: Article
Times cited : (73)

References (46)
  • 1
    • 77949271600 scopus 로고    scopus 로고
    • Management of breast cancer with targeted agents: Importance of heterogeneity. [corrected]
    • Di Cosimo, S. & Baselga, J. Management of breast cancer with targeted agents: importance of heterogeneity. [corrected]. Nat. Rev. Clin. Oncol. 7, 139-147 (2010).
    • (2010) Nat. Rev. Clin. Oncol , vol.7 , pp. 139-147
    • Di Cosimo, S.1    Baselga, J.2
  • 2
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou, C. M. et al. Molecular portraits of human breast tumours. Nature 406, 747-752 (2000).
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1
  • 3
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie, T. et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl Acad. Sci. USA 100, 8418-8423 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8418-8423
    • Sorlie, T.1
  • 4
    • 78951482208 scopus 로고    scopus 로고
    • Deconstructing the molecular portraits of breast cancer
    • Prat, A. & Perou, C. M. Deconstructing the molecular portraits of breast cancer. Mol. Oncol. 5, 5-23 (2011).
    • (2011) Mol. Oncol , vol.5 , pp. 5-23
    • Prat, A.1    Perou, C.M.2
  • 6
    • 79959520764 scopus 로고    scopus 로고
    • Molecular stratification of triple-negative breast cancers
    • Perou, C. M. Molecular stratification of triple-negative breast cancers. Oncologist 16 (Suppl 1), 61-70 (2011).
    • (2011) Oncologist , vol.16 , Issue.SUPPL. 1 , pp. 61-70
    • Perou, C.M.1
  • 7
    • 0032569831 scopus 로고    scopus 로고
    • Tamoxifen in the treatment of breast cancer
    • Osborne, C. K. Tamoxifen in the treatment of breast cancer. New Engl. J. Med. 339, 1609-1618 (1998).
    • (1998) New Engl. J. Med , vol.339 , pp. 1609-1618
    • Osborne, C.K.1
  • 8
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon, D. J. et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244, 707-712 (1989).
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1
  • 9
    • 3543148258 scopus 로고    scopus 로고
    • α-Catenin: At the junction of intercellular adhesion and actin dynamics
    • Kobielak, A. & Fuchs, E. catenin: at the junction of intercellular adhesion and actin dynamics. Nat. Rev. Mol. Cell Biol. 5, 614-625 (2004).
    • (2004) Nat. Rev. Mol. Cell Biol , vol.5 , pp. 614-625
    • Kobielak, A.1    Fuchs, E.2
  • 10
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • The Cancer Genome Atlas Network
    • The Cancer Genome Atlas Network, Comprehensive molecular portraits of human breast tumours. Nature 490, 61-70 (2012).
    • (2012) Nature , vol.490 , pp. 61-70
  • 11
    • 44449111555 scopus 로고    scopus 로고
    • Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    • Onder, T. T. et al. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 68, 3645-3654 (2008).
    • (2008) Cancer Res , vol.68 , pp. 3645-3654
    • Onder, T.T.1
  • 12
    • 33750614651 scopus 로고    scopus 로고
    • Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
    • Derksen, P. W. et al. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell 10, 437-449 (2006).
    • (2006) Cancer Cell , vol.10 , pp. 437-449
    • Derksen, P.W.1
  • 13
    • 33847740988 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in cancer stemness and malignant behavior
    • Fodde, R. & Brabletz, T. Wnt/β-catenin signaling in cancer stemness and malignant behavior. Curr. Opin. Cell Biol. 19, 150-158 (2007).
    • (2007) Curr. Opin. Cell Biol , vol.19 , pp. 150-158
    • Fodde, R.1    Brabletz, T.2
  • 14
    • 33846113924 scopus 로고    scopus 로고
    • Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin (CTNNA1) in myeloid cell transformation
    • Liu, T. X. et al. Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin (CTNNA1) in myeloid cell transformation. Nat. Med. 13, 78-83 (2007).
    • (2007) Nat. Med , vol.13 , pp. 78-83
    • Liu, T.X.1
  • 15
    • 79959796807 scopus 로고    scopus 로고
    • α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-Catenin transactivation
    • Ji, H., Wang, J., Fang, B., Fang, X. & Lu, Z. α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation. J. Neurooncol. 103, 445-451 (2011).
    • (2011) J. Neurooncol , vol.103 , pp. 445-451
    • Ji, H.1    Wang, J.2    Fang, B.3    Fang, X.4    Lu, Z.5
  • 16
    • 79952298459 scopus 로고    scopus 로고
    • Yap1 acts downstream of α-catenin to control epidermal proliferation
    • Schlegelmilch, K. et al. Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell 144, 782-795 (2011).
    • (2011) Cell , vol.144 , pp. 782-795
    • Schlegelmilch, K.1
  • 17
    • 79957462240 scopus 로고    scopus 로고
    • α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1
    • Silvis, M. R. et al. α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci. Signal. 4, ra33 (2011).
    • (2011) Sci. Signal , vol.4
    • Silvis, M.R.1
  • 18
    • 67650546985 scopus 로고    scopus 로고
    • Loss of α-catenin decreases the strength of single E-cadherin bonds between human cancer cells
    • Bajpai, S., Feng, Y., Krishnamurthy, R., Longmore, G. D. & Wirtz, D. Loss of α-catenin decreases the strength of single E-cadherin bonds between human cancer cells. J. Biol. Chem. 284, 18252-18259 (2009).
    • (2009) J. Biol. Chem , vol.284 , pp. 18252-18259
    • Bajpai, S.1    Feng, Y.2    Krishnamurthy, R.3    Longmore, G.D.4    Wirtz, D.5
  • 19
    • 70149106789 scopus 로고    scopus 로고
    • Constitutive activation of nuclear factor-κB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines
    • Yamaguchi, N. et al. Constitutive activation of nuclear factor-κB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines. Cancer Sci. 100, 1668-1674 (2009).
    • (2009) Cancer Sci , vol.100 , pp. 1668-1674
    • Yamaguchi, N.1
  • 20
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-κB a good target for cancer therapy? Hopes and pitfalls
    • Baud, V. & Karin, M. Is NF-κB a good target for cancer therapy? Hopes and pitfalls. Nat. Rev. Drug Discov. 8, 33-40 (2009).
    • (2009) Nat. Rev. Drug Discov , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 21
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-κB transcription factors
    • Pahl, H. L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18, 6853-6866 (1999).
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl H., .L.1
  • 22
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden, M. S. & Ghosh, S. Signaling to NF-κB. Genes Dev. 18, 2195-2224 (2004).
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 24
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-κB system: A treasure trove for drug development
    • Karin, M., Yamamoto, Y. & Wang, Q. M. The IKK NF-κB system: a treasure trove for drug development. Nat. Rev. Drug Discov. 3, 17-26 (2004).
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 25
    • 33750432183 scopus 로고    scopus 로고
    • Nuclear factor-κB and inhibitor of κb kinase pathways in oncogenic initiation and progression
    • Basseres, D. S. & Baldwin, A. S. Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression. Oncogene 25, 6817-6830 (2006).
    • (2006) Oncogene , vol.25 , pp. 6817-6830
    • Basseres, D.S.1    Baldwin, A.S.2
  • 26
    • 77953544249 scopus 로고    scopus 로고
    • Four human breast cancer cell lines with biallelic inactivating α-catenin gene mutations
    • Hollestelle, A. et al. Four human breast cancer cell lines with biallelic inactivating α-catenin gene mutations. Breast Cancer Res. Treat. 122, 125-133 (2010).
    • (2010) Breast Cancer Res. Treat , vol.122 , pp. 125-133
    • Hollestelle, A.1
  • 27
    • 0025260779 scopus 로고
    • Regulation of tumor necrosis factor α transcription in macrophages: Involvement of four κb-like motifs and of constitutive and inducible forms of NF-κB
    • Collart, M. A., Baeuerle, P. & Vassalli, P. Regulation of tumor necrosis factor α transcription in macrophages: involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB. Mol. Cell Biol. 10, 1498-1506 (1990).
    • (1990) Mol. Cell Biol , vol.10 , pp. 1498-1506
    • Collart, M.A.1    Baeuerle, P.2    Vassalli, P.3
  • 28
    • 0027384590 scopus 로고
    • NF-κB subunit-specific regulation of the interleukin-8 promoter
    • Kunsch, C. & Rosen, C. A. NF-κB subunit-specific regulation of the interleukin-8 promoter. Mol. Cell Biol. 13, 6137-6146 (1993).
    • (1993) Mol. Cell Biol , vol.13 , pp. 6137-6146
    • Kunsch, C.1    Rosen, C.A.2
  • 29
    • 0031596140 scopus 로고    scopus 로고
    • Nuclear factor κb/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1β- stimulated synovial fibroblasts
    • Vincenti, M. P., Coon, C. I. & Brinckerhoff, C. E. Nuclear factor κB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1β- stimulated synovial fibroblasts. Arthritis Rheum. 41, 1987-1994 (1998).
    • (1998) Arthritis Rheum , vol.41 , pp. 1987-1994
    • Vincenti, M.P.1    Coon, C.I.2    Brinckerhoff, C.E.3
  • 30
    • 77649105325 scopus 로고    scopus 로고
    • A role for NRAGE in NF-κB activation through the non-canonical BMP pathway
    • Matluk, N., Rochira, J. A., Karaczyn, A., Adams, T. & Verdi, J. M. A role for NRAGE in NF-κB activation through the non-canonical BMP pathway. BMC Biol. 8, 7 (2010).
    • (2010) BMC Biol , vol.8 , pp. 7
    • Matluk, N.1    Rochira, J.A.2    Karaczyn, A.3    Adams, T.4    Verdi, J.M.5
  • 31
    • 58249084923 scopus 로고    scopus 로고
    • α-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic
    • Lien, W. H., Gelfand, V. I. & Vasioukhin, V. α-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic. J. Cell Biol. 183, 989-997 (2008).
    • (2008) J. Cell Biol , vol.183 , pp. 989-997
    • Lien, W.H.1    Gelfand, V.I.2    Vasioukhin, V.3
  • 32
    • 8844237615 scopus 로고    scopus 로고
    • Polyubiquitin chains: Polymeric protein signals
    • Pickart, C. M. & Fushman, D. Polyubiquitin chains: polymeric protein signals. Curr. Opin. Chem. Biol. 8, 610-616 (2004).
    • (2004) Curr. Opin. Chem. Biol , vol.8 , pp. 610-616
    • Pickart, C.M.1    Fushman, D.2
  • 33
    • 0035936002 scopus 로고    scopus 로고
    • Transcription of the RelB gene is regulated by NF-κB
    • Bren, G. D. et al. Transcription of the RelB gene is regulated by NF-κB. Oncogene 20, 7722-7733 (2001).
    • (2001) Oncogene , vol.20 , pp. 7722-7733
    • Bren, G.D.1
  • 34
    • 79151483638 scopus 로고    scopus 로고
    • An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
    • Gyorffy, B. et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res. Treat. 123, 725-731 (2010).
    • (2010) Breast Cancer Res. Treat , vol.123 , pp. 725-731
    • Gyorffy, B.1
  • 35
    • 77951139631 scopus 로고    scopus 로고
    • Genome remodelling in a basal-like breast cancer metastasis and xenograft
    • Ding, L. et al. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 464, 999-1005 (2010).
    • (2010) Nature , vol.464 , pp. 999-1005
    • Ding, L.1
  • 36
    • 33144490246 scopus 로고    scopus 로고
    • Links between κ-catenin, NF-κB, and squamous cell carcinoma in skin
    • Kobielak, A. & Fuchs, E. Links between catenin, NF-κB, and squamous cell carcinoma in skin. Proc. Natl Acad. Sci. USA 103, 2322-2327 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 2322-2327
    • Kobielak, A.1    Fuchs, E.2
  • 37
    • 0033537767 scopus 로고    scopus 로고
    • Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
    • Hu, Y. et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 284, 316-320 (1999).
    • (1999) Science , vol.284 , pp. 316-320
    • Hu, Y.1
  • 38
    • 84872587266 scopus 로고    scopus 로고
    • Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation
    • Yan, J. et al. Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation. Cell 152, 304-315 (2013).
    • (2013) Cell , vol.152 , pp. 304-315
    • Yan, J.1
  • 39
    • 80052014052 scopus 로고    scopus 로고
    • Inflammation meets cancer, with NF-κB as the matchmaker
    • Ben-Neriah, Y. & Karin, M. Inflammation meets cancer, with NF-κB as the matchmaker. Nat. Immunol. 12, 715-723 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 715-723
    • Ben-Neriah, Y.1    Karin, M.2
  • 40
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-κB: Players, pathways, perspectives
    • Gilmore, T. D. Introduction to NF-κB: players, pathways, perspectives. Oncogene 25, 6680-6684 (2006).
    • (2006) Oncogene , vol.25 , pp. 6680-6684
    • Gilmore, T.D.1
  • 41
    • 0036546501 scopus 로고    scopus 로고
    • NF-κB in cancer: From innocent bystander to major culprit
    • Karin, M., Cao, Y., Greten, F. R. & Li, Z. W. NF-κB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2, 301-310 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.W.4
  • 42
    • 0035868342 scopus 로고    scopus 로고
    • Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN
    • Pianetti, S., Arsura, M., Romieu-Mourez, R., Coffey, R. J. & Sonenshein, G. E. Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN. Oncogene 20, 1287-1299 (2001).
    • (2001) Oncogene , vol.20 , pp. 1287-1299
    • Pianetti, S.1    Arsura, M.2    Romieu-Mourez, R.3    Coffey, R.J.4    Sonenshein, G.E.5
  • 43
    • 0035177216 scopus 로고    scopus 로고
    • Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
    • Elenbaas, B. et al. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev. 15, 50-65 (2001).
    • (2001) Genes Dev , vol.15 , pp. 50-65
    • Elenbaas, B.1
  • 44
    • 0344375083 scopus 로고    scopus 로고
    • Lentivirus-delivered stable gene silencing by RNAi in primary cells
    • Stewart, S. A. et al. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9, 493-501 (2003).
    • (2003) RNA , vol.9 , pp. 493-501
    • Stewart, S.A.1
  • 45
    • 69549116880 scopus 로고    scopus 로고
    • The E3 ligase TRAF6 regulates Akt ubiquitination and activation
    • Yang, W. L. et al. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325, 1134-1138 (2009).
    • (2009) Science , vol.325 , pp. 1134-1138
    • Yang, W.L.1
  • 46
    • 84865840957 scopus 로고    scopus 로고
    • PTPN14 is required for the density-dependent control of YAP1
    • Wang, W. et al. PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 26, 1959-1971 (2012).
    • (2012) Genes Dev , vol.26 , pp. 1959-1971
    • Wang, W.1


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