Natural single amino acid polymorphism (F19Y) in human galectin-8: Detection of structural alterations and increased growth-regulatory activity on tumor cells

FEBS Journal

Volumn 281, Issue 5, 2014, Pages 1446-1464

  Ruiz, Federico M ^a   Scholz, Barbara A ^b   Buzamet, Eliza ^c   Kopitz, Jürgen ^d   André, Sabine ^b   Menéndez, Margarita ^c   Romero, Antonio ^a   Solís, Dolores ^c   Gabius, Hans Joachim ^b  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b UNIVERSITY OF MUNICH   (Germany)

^c INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^d UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

agglutination; carcinoma; ganglioside; lectin; proliferation; sandwich

Indexed keywords

CARBOHYDRATE; GALECTIN 8; PROTEIN VARIANT;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING KINETICS; CANCER CELL CULTURE; CIRCULAR DICHROISM; COLON ADENOCARCINOMA; CONTROLLED STUDY; CRYSTALLOGRAPHY; CYTOLOGY; ERYTHROLEUKEMIA; GROWTH REGULATION; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VITRO STUDY; MOLECULAR RECOGNITION; NEUROBLASTOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; THERMODYNAMICS; THERMOSTABILITY; TUMOR GROWTH; WILD TYPE;

AGGLUTINATION; CARCINOMA; GANGLIOSIDE; LECTIN; PROLIFERATION; Β-SANDWICH;

AMINO ACID SUBSTITUTION; CELL LINE, TUMOR; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; GALECTINS; GROWTH SUBSTANCES; HUMANS; HYDRODYNAMICS; LACTOSE; LIGANDS; MODELS, MOLECULAR; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; THERMODYNAMICS;

EID: 84895420067     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12716     Document Type: Article

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