메뉴 건너뛰기




Volumn 277, Issue 17, 2010, Pages 3552-3563

Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model

Author keywords

anoikis; galectin; glycosylation; integrin; pancreatic carcinoma

Indexed keywords

CASPASE 8; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GALECTIN 1; GALECTIN 3; MESSENGER RNA;

EID: 77955778590     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07764.x     Document Type: Article
Times cited : (125)

References (58)
  • 1
    • 0035487104 scopus 로고    scopus 로고
    • The INK4aARF network in tumour suppression
    • Sherr CJ (2001) The INK4aARF network in tumour suppression. Nat Rev Mol Cell Biol 2, 731 737.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 731-737
    • Sherr, C.J.1
  • 2
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of INK4ARF in cancer and aging
    • Kim WY Sharpless NE (2006) The regulation of INK4ARF in cancer and aging. Cell 127, 265 275.
    • (2006) Cell , vol.127 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2
  • 5
    • 0002638114 scopus 로고    scopus 로고
    • Glycoproteins: Structure and function
    • Gabius, H-J. Gabius, S. eds. Chapman & Hall
    • Sharon N Lis H (1997) Glycoproteins: structure and function. In Glycosciences: Status and Perspectives (Gabius H-J Gabius S eds pp 133 162. Chapman & Hall
    • (1997) Glycosciences: Status and Perspectives , pp. 133-162
    • Sharon, N.1    Lis, H.2
  • 6
    • 0032953692 scopus 로고    scopus 로고
    • Eukaryotic glycosylation: Whim of nature or multipurpose tool?
    • Reuter G Gabius H-J (1999) Eukaryotic glycosylation: whim of nature or multipurpose tool? Cell Mol Life Sci 55, 368 422.
    • (1999) Cell Mol Life Sci , vol.55 , pp. 368-422
    • Reuter, G.1    Gabius, H.-J.2
  • 8
  • 10
    • 0029797439 scopus 로고    scopus 로고
    • Sialic acids: Structure-analysis-metabolism-occurrence-recognition
    • Reuter G Gabius H-J (1996) Sialic acids: structure-analysis-metabolism- occurrence-recognition. Biol Chem Hoppe Seyler 377, 325 342.
    • (1996) Biol Chem Hoppe Seyler , vol.377 , pp. 325-342
    • Reuter, G.1    Gabius, H.-J.2
  • 11
    • 77953778927 scopus 로고    scopus 로고
    • O-Glycosylation: Structural diversity and functions
    • Gabius, H-J. ed. Wiley-VCH
    • Patsos G Corfield A (2009) O-Glycosylation: structural diversity and functions. In The Sugar Code. Fundamentals of Glycosciences (Gabius H-J ed pp 111 137. Wiley-VCH
    • (2009) The Sugar Code. Fundamentals of Glycosciences , pp. 111-137
    • Patsos, G.1    Corfield, A.2
  • 13
    • 33646879955 scopus 로고    scopus 로고
    • Cell surface glycans: The why and how of their functionality as biochemical signals in lectin-mediated information transfer
    • Gabius H-J (2006) Cell surface glycans: the why and how of their functionality as biochemical signals in lectin-mediated information transfer. Crit Rev Immunol 26, 43 79.
    • (2006) Crit Rev Immunol , vol.26 , pp. 43-79
    • Gabius, H.-J.1
  • 14
    • 33646554216 scopus 로고    scopus 로고
    • A guide to signaling pathways connecting protein-glycan interaction with the emerging versatile effector functionality of mammalian lectins
    • Villalobo A, Nogales-González A Gabius H-J (2006) A guide to signaling pathways connecting protein-glycan interaction with the emerging versatile effector functionality of mammalian lectins. Trends Glycosci Glycotechnol 18, 1 37.
    • (2006) Trends Glycosci Glycotechnol , vol.18 , pp. 1-37
    • Villalobo, A.1    Nogales-González, A.2    Gabius, H.-J.3
  • 16
    • 0036436051 scopus 로고    scopus 로고
    • Thermodynamic binding studies of cell surface carbohydrate epitopes to galectins-1, -3, and -7: Evidence for differential binding specificities
    • Ahmad N, Gabius H-J, Kaltner H, André S, Kuwabara I, Liu F-T, Oscarson S, Norberg T Brewer CF (2002) Thermodynamic binding studies of cell surface carbohydrate epitopes to galectins-1, -3, and -7: evidence for differential binding specificities. Can J Chem 80, 1096 1104.
    • (2002) Can J Chem , vol.80 , pp. 1096-1104
    • Ahmad, N.1    Gabius, H.-J.2    Kaltner, H.3    André, S.4    Kuwabara, I.5    Liu, F.-T.6    Oscarson, S.7    Norberg, T.8    Brewer, C.F.9
  • 17
    • 33646863285 scopus 로고    scopus 로고
    • Interaction profile of galectin-5 with free saccharides and mammalian glycoproteins: Probing its fine specificity and the effect of naturally clustered ligand presentation
    • Wu AM, Singh T, Wu JH, Lensch M, André S Gabius H-J (2006) Interaction profile of galectin-5 with free saccharides and mammalian glycoproteins: probing its fine specificity and the effect of naturally clustered ligand presentation. Glycobiology 16, 524 537.
    • (2006) Glycobiology , vol.16 , pp. 524-537
    • Wu, A.M.1    Singh, T.2    Wu, J.H.3    Lensch, M.4    André, S.5    Gabius, H.-J.6
  • 18
    • 48649102319 scopus 로고    scopus 로고
    • Calix[n]arene-based glycoclusters: Bioactivity of thiourea-linked galactoselactose moieties as inhibitors of binding of medically relevant lectins to a glycoprotein and cell-surface glycoconjugates and selectivity among human adhesiongrowth-regulatory galectins
    • André S, Sansone F, Kaltner H, Casnati A, Kopitz J, Gabius H-J Ungaro R (2008) Calix[n]arene-based glycoclusters: bioactivity of thiourea-linked galactoselactose moieties as inhibitors of binding of medically relevant lectins to a glycoprotein and cell-surface glycoconjugates and selectivity among human adhesiongrowth-regulatory galectins. ChemBioChem 9, 1649 1661.
    • (2008) ChemBioChem , vol.9 , pp. 1649-1661
    • André, S.1    Sansone, F.2    Kaltner, H.3    Casnati, A.4    Kopitz, J.5    Gabius, H.-J.6    Ungaro, R.7
  • 19
    • 68149131940 scopus 로고    scopus 로고
    • From structural to functional glycomics: Core substitutions as molecular switches for shape and lectin affinity of N-glycans
    • André S, Koár T, Kojima S, Unverzagt C Gabius H-J (2009) From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans. Biol Chem 390, 557 565.
    • (2009) Biol Chem , vol.390 , pp. 557-565
    • André, S.1    Koár, T.2    Kojima, S.3    Unverzagt, C.4    Gabius, H.-J.5
  • 21
    • 0035929631 scopus 로고    scopus 로고
    • Negative regulation of neuroblastoma cell growth by carbohydrate- dependent surface binding of galectin-1 and functional divergence from galectin-3
    • Kopitz J, von Reitzenstein C, André S, Kaltner H, Uhl J, Ehemann V, Cantz M Gabius H-J (2001) Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3. J Biol Chem 276, 35917 35923.
    • (2001) J Biol Chem , vol.276 , pp. 35917-35923
    • Kopitz, J.1    Von Reitzenstein, C.2    André, S.3    Kaltner, H.4    Uhl, J.5    Ehemann, V.6    Cantz, M.7    Gabius, H.-J.8
  • 22
    • 19944431311 scopus 로고    scopus 로고
    • Determination of structural and functional overlapdivergence of five proto-type galectins by analysis of the growth-regulatory interaction with ganglioside GM1 in silico and in vitro on human neuroblastoma cells
    • André S, Kaltner H, Lensch M, Russwurm R, Siebert H-C, Fallsehr C, Tajkhorshid E, Heck AJR, von Knebel Doeberitz M, Gabius H-J et al. (2005) Determination of structural and functional overlapdivergence of five proto-type galectins by analysis of the growth-regulatory interaction with ganglioside GM1 in silico and in vitro on human neuroblastoma cells. Int J Cancer 114, 46 57.
    • (2005) Int J Cancer , vol.114 , pp. 46-57
    • André, S.1    Kaltner, H.2    Lensch, M.3    Russwurm, R.4    Siebert, H.-C.5    Fallsehr, C.6    Tajkhorshid, E.7    Heck, A.J.R.8    Von Knebel Doeberitz, M.9    Gabius, H.-J.10
  • 23
    • 4544295231 scopus 로고    scopus 로고
    • Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity
    • Elad-Sfadia G, Haklai R, Balan E Kloog Y (2004) Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity. J Biol Chem 279, 34922 34930.
    • (2004) J Biol Chem , vol.279 , pp. 34922-34930
    • Elad-Sfadia, G.1    Haklai, R.2    Balan, E.3    Kloog, Y.4
  • 24
    • 0033173291 scopus 로고    scopus 로고
    • Lack of elevated MAP kinase (ERK) activity in pancreatic carcinomas despite oncogenic K-Ras expression
    • Yip-Schneider MT, Lin A, Barnard D, Sweeney CJ Marshall MS (1999) Lack of elevated MAP kinase (ERK) activity in pancreatic carcinomas despite oncogenic K-Ras expression. Int J Oncol 15, 271 279.
    • (1999) Int J Oncol , vol.15 , pp. 271-279
    • Yip-Schneider, M.T.1    Lin, A.2    Barnard, D.3    Sweeney, C.J.4    Marshall, M.S.5
  • 25
    • 0033566695 scopus 로고    scopus 로고
    • Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells
    • Kim H-R, Lin H-M, Biliran H Raz A (1999) Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells. Cancer Res 59, 4148 4154.
    • (1999) Cancer Res , vol.59 , pp. 4148-4154
    • Kim, H.-R.1    Lin, H.-M.2    Biliran, H.3    Raz, A.4
  • 26
    • 0031886393 scopus 로고    scopus 로고
    • Localization of galectin-3 in normal and diseased pancreatic tissue
    • Schaffert C, Pour PM Chaney WG (1998) Localization of galectin-3 in normal and diseased pancreatic tissue. Int J Pancreatol 23, 1 9.
    • (1998) Int J Pancreatol , vol.23 , pp. 1-9
    • Schaffert, C.1    Pour, P.M.2    Chaney, W.G.3
  • 30
    • 1642483757 scopus 로고    scopus 로고
    • Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes
    • Ahmad N, Gabius H-J, André S, Kaltner H, Sabesan S, Roy R, Liu B, Macaluso F Brewer CF (2004) Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes. J Biol Chem 279, 10841 10847.
    • (2004) J Biol Chem , vol.279 , pp. 10841-10847
    • Ahmad, N.1    Gabius, H.-J.2    André, S.3    Kaltner, H.4    Sabesan, S.5    Roy, R.6    Liu, B.7    MacAluso, F.8    Brewer, C.F.9
  • 31
    • 64249146003 scopus 로고    scopus 로고
    • Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: Possible role in suppressing experimental autoimmune encephalomyelitis
    • Wang J, Lu ZH, Gabius H-J, Rohowsky-Kochan C, Ledeen RW Wu G (2009) Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis. J Immunol 182, 4036 4045.
    • (2009) J Immunol , vol.182 , pp. 4036-4045
    • Wang, J.1    Lu, Z.H.2    Gabius, H.-J.3    Rohowsky-Kochan, C.4    Ledeen, R.W.5    Wu, G.6
  • 32
    • 0035017215 scopus 로고    scopus 로고
    • Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures
    • Lahm H, André S, Hoeflich A, Fischer JR, Sordat B, Kaltner H, Wolf E Gabius H-J (2001) Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures. J Cancer Res Clin Oncol 127, 375 386.
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 375-386
    • Lahm, H.1    André, S.2    Hoeflich, A.3    Fischer, J.R.4    Sordat, B.5    Kaltner, H.6    Wolf, E.7    Gabius, H.-J.8
  • 36
    • 0033613211 scopus 로고    scopus 로고
    • Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes
    • Bernerd F, Sarasin A Magnaldo T (1999) Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. Proc Natl Acad Sci USA 96, 11329 11334.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11329-11334
    • Bernerd, F.1    Sarasin, A.2    Magnaldo, T.3
  • 37
    • 0036479302 scopus 로고    scopus 로고
    • Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release
    • Kuwabara I, Kuwabara Y, Yang RY, Schuler M, Green DR, Zuraw BL, Hsu DK Liu F-T (2002) Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J Biol Chem 277, 3487 3497.
    • (2002) J Biol Chem , vol.277 , pp. 3487-3497
    • Kuwabara, I.1    Kuwabara, Y.2    Yang, R.Y.3    Schuler, M.4    Green, D.R.5    Zuraw, B.L.6    Hsu, D.K.7    Liu, F.-T.8
  • 40
    • 66249106029 scopus 로고    scopus 로고
    • Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): A gene-dependent effect on the cell surface glycan profile
    • Patsos G, André S, Roeckel N, Gromes R, Gebert J, Kopitz J Gabius H-J (2009) Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile. Glycobiology 19, 726 734.
    • (2009) Glycobiology , vol.19 , pp. 726-734
    • Patsos, G.1    André, S.2    Roeckel, N.3    Gromes, R.4    Gebert, J.5    Kopitz, J.6    Gabius, H.-J.7
  • 43
    • 10644285602 scopus 로고    scopus 로고
    • Differential expression profiling of human pancreatic adenocarcinoma and healthy pancreatic tissue
    • Lu Z, Hu L, Evers S, Chen J Shen Y (2004) Differential expression profiling of human pancreatic adenocarcinoma and healthy pancreatic tissue. Proteomics 4, 3975 3988.
    • (2004) Proteomics , vol.4 , pp. 3975-3988
    • Lu, Z.1    Hu, L.2    Evers, S.3    Chen, J.4    Shen, Y.5
  • 47
    • 9144241047 scopus 로고    scopus 로고
    • Highly expressed genes in pancreatic ductal adenocarcinomas: A comprehensive characterization and comparison of the transcription profiles obtained from three major technologies
    • Iacobuzio-Donahue CA, Ashfaq R, Maitra A, Adsay NV, Shen-Ong GL, Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE et al. (2003) Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res 63, 8614 8622.
    • (2003) Cancer Res , vol.63 , pp. 8614-8622
    • Iacobuzio-Donahue, C.A.1    Ashfaq, R.2    Maitra, A.3    Adsay, N.V.4    Shen-Ong, G.L.5    Berg, K.6    Hollingsworth, M.A.7    Cameron, J.L.8    Yeo, C.J.9    Kern, S.E.10
  • 48
    • 10844252383 scopus 로고    scopus 로고
    • Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry
    • Shen J, Person MD, Zhu J, Abbruzzese JL Li D (2004) Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. Cancer Res 64, 9018 9026.
    • (2004) Cancer Res , vol.64 , pp. 9018-9026
    • Shen, J.1    Person, M.D.2    Zhu, J.3    Abbruzzese, J.L.4    Li, D.5
  • 51
    • 0021684886 scopus 로고
    • Biochemical characterization of endogenous carbohydrate-binding proteins from spontaneous murine rhabdomyosarcoma, mammary adenocarcinoma, and ovarian teratoma
    • Gabius H-J, Engelhardt R, Rehm S Cramer F (1984) Biochemical characterization of endogenous carbohydrate-binding proteins from spontaneous murine rhabdomyosarcoma, mammary adenocarcinoma, and ovarian teratoma. J Natl Cancer Inst 73, 1349 1357.
    • (1984) J Natl Cancer Inst , vol.73 , pp. 1349-1357
    • Gabius, H.-J.1    Engelhardt, R.2    Rehm, S.3    Cramer, F.4
  • 52
    • 33747134305 scopus 로고    scopus 로고
    • Glycosyldisulfides from dynamic combinatorial libraries as O-glycoside mimetics for plant and endogenous lectins: Their reactivities in solid-phase and cell assays and conformational analysis by molecular dynamics simulations
    • André S, Pei Z, Siebert H-C, Ramström O Gabius H-J (2006) Glycosyldisulfides from dynamic combinatorial libraries as O-glycoside mimetics for plant and endogenous lectins: their reactivities in solid-phase and cell assays and conformational analysis by molecular dynamics simulations. Bioorg Med Chem 14, 6314 6326.
    • (2006) Bioorg Med Chem , vol.14 , pp. 6314-6326
    • André, S.1    Pei, Z.2    Siebert, H.-C.3    Ramström, O.4    Gabius, H.-J.5
  • 53
    • 0345329271 scopus 로고    scopus 로고
    • New aspects of galectin functionality in nuclei of cultured bone marrow stromal and epidermal cells: Biotinylated galectins as tool to detect specific binding sites
    • Purkrabková T, Smetana K Jr., Dvoránková B, Holiková Z, Böck C, Lensch M, André S, Pytlík R, Liu F-T, Klíma J et al. (2003) New aspects of galectin functionality in nuclei of cultured bone marrow stromal and epidermal cells: biotinylated galectins as tool to detect specific binding sites. Biol Cell 95, 535 545.
    • (2003) Biol Cell , vol.95 , pp. 535-545
    • Purkrabková, T.1    Smetana, Jr.K.2    Dvoránková, B.3    Holiková, Z.4    Böck, C.5    Lensch, M.6    André, S.7    Pytlík, R.8    Liu, F.-T.9    Klíma, J.10
  • 54
    • 0036135133 scopus 로고    scopus 로고
    • Galectin-1 and galectin-3 in fetal development of bovine respiratory and digestive tracts. Comparison of cell type-specific expression profiles and subcellular localization
    • Kaltner H, Seyrek K, Heck A, Sinowatz F Gabius H-J (2002) Galectin-1 and galectin-3 in fetal development of bovine respiratory and digestive tracts. Comparison of cell type-specific expression profiles and subcellular localization. Cell Tissue Res 307, 35 46.
    • (2002) Cell Tissue Res , vol.307 , pp. 35-46
    • Kaltner, H.1    Seyrek, K.2    Heck, A.3    Sinowatz, F.4    Gabius, H.-J.5
  • 55
    • 50249165294 scopus 로고    scopus 로고
    • Cell-type-specific expression of murine multifunctional galectin-3 and its association with follicular atresialuteolysis in contrast to pro-apoptotic galectins-1 and -7
    • Lohr M, Kaltner H, Lensch M, André S, Sinowatz F Gabius H-J (2008) Cell-type-specific expression of murine multifunctional galectin-3 and its association with follicular atresialuteolysis in contrast to pro-apoptotic galectins-1 and -7. Histochem Cell Biol 130, 567 581.
    • (2008) Histochem Cell Biol , vol.130 , pp. 567-581
    • Lohr, M.1    Kaltner, H.2    Lensch, M.3    André, S.4    Sinowatz, F.5    Gabius, H.-J.6
  • 56
    • 69749085173 scopus 로고    scopus 로고
    • Immunohistochemical fingerprinting of the network of seven adhesiongrowth-regulatory lectins in human skin and detection of distinct tumour-associated alterations
    • ada Z, Smetana K Jr., Lacina L, Plzáková Z, tork J, Kaltner H, Russwurm R, Lensch M, André S Gabius H-J (2009) Immunohistochemical fingerprinting of the network of seven adhesiongrowth-regulatory lectins in human skin and detection of distinct tumour-associated alterations. Folia Biol (Praha) 55, 145 152.
    • (2009) Folia Biol (Praha) , vol.55 , pp. 145-152
    • Ada, Z.1    Smetana, Jr.K.2    Lacina, L.3    Plzáková, Z.4    Tork, J.5    Kaltner, H.6    Russwurm, R.7    Lensch, M.8    André, S.9    Gabius, H.-J.10
  • 57
    • 58449107116 scopus 로고    scopus 로고
    • Phosphorylated human lectin galectin-3: Analysis of ligand binding by histochemical monitoring of normalmalignant squamous epithelia and by isothermal titration calorimetry
    • Szabo P, Dam TK, Smetana K Jr., Dvoránková B, Kübler D, Brewer CF Gabius H-J (2009) Phosphorylated human lectin galectin-3: analysis of ligand binding by histochemical monitoring of normalmalignant squamous epithelia and by isothermal titration calorimetry. Anat Histol Embryol 38, 68 75.
    • (2009) Anat Histol Embryol , vol.38 , pp. 68-75
    • Szabo, P.1    Dam, T.K.2    Smetana, Jr.K.3    Dvoránková, B.4    Kübler, D.5    Brewer, C.F.6    Gabius, H.-J.7
  • 58
    • 33846241804 scopus 로고    scopus 로고
    • Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco)peptide libraries
    • André S, Maljaars CEP, Halkes KM, Gabius H-J Kamerling JP (2007) Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco)peptide libraries. Bioorg Med Chem Lett 17, 793 798.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 793-798
    • André, S.1    Maljaars, C.E.P.2    Halkes, K.M.3    Gabius, H.-J.4    Kamerling, J.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.